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B8N076

- DAPB_ASPFN

UniProt

B8N076 - DAPB_ASPFN

Protein

Probable dipeptidyl-aminopeptidase B

Gene

dapB

Organism
Aspergillus flavus (strain ATCC 200026 / FGSC A1120 / NRRL 3357 / JCM 12722 / SRRC 167)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 34 (01 Oct 2014)
      Sequence version 1 (03 Mar 2009)
      Previous versions | rss
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    Functioni

    Type IV dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.By similarity

    Catalytic activityi

    Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei754 – 7541Charge relay systemBy similarity
    Active sitei831 – 8311Charge relay systemBy similarity
    Active sitei864 – 8641Charge relay systemBy similarity

    GO - Molecular functioni

    1. aminopeptidase activity Source: UniProtKB-KW
    2. serine-type peptidase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Aminopeptidase, Hydrolase, Protease, Serine protease

    Protein family/group databases

    MEROPSiS09.006.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable dipeptidyl-aminopeptidase B (EC:3.4.14.5)
    Short name:
    DPAP B
    Gene namesi
    Name:dapB
    ORF Names:AFLA_087160
    OrganismiAspergillus flavus (strain ATCC 200026 / FGSC A1120 / NRRL 3357 / JCM 12722 / SRRC 167)
    Taxonomic identifieri332952 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
    ProteomesiUP000001875: Unassembled WGS sequence

    Subcellular locationi

    Vacuole membrane By similarity; Single-pass type II membrane protein By similarity
    Note: Lysosome-like vacuoles.By similarity

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. vacuolar membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane, Vacuole

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 916916Probable dipeptidyl-aminopeptidase BPRO_0000412134Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi349 – 3491N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi640 – 6401N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi808 – 8081N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi813 – 8131N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Interactioni

    Protein-protein interaction databases

    STRINGi5059.CADAFLAP00001495.

    Structurei

    3D structure databases

    ProteinModelPortaliB8N076.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 9292CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini114 – 916803VacuolarSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei93 – 11321Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase S9B family.Curated

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    HOGENOMiHOG000189891.
    KOiK01282.
    OMAiETKFWYQ.
    OrthoDBiEOG72VHFG.

    Family and domain databases

    Gene3Di2.140.10.30. 1 hit.
    3.40.50.1820. 1 hit.
    InterProiIPR029058. AB_hydrolase.
    IPR001375. Peptidase_S9.
    IPR002469. Peptidase_S9B.
    [Graphical view]
    PfamiPF00930. DPPIV_N. 1 hit.
    PF00326. Peptidase_S9. 1 hit.
    [Graphical view]
    SUPFAMiSSF53474. SSF53474. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B8N076-1 [UniParc]FASTAAdd to Basket

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    MGRTGDLENA EFFPMTRRRS TSGTSSRSST DSGLSVDTAY LEDNKHNNFA    50
    NGTSGLTDET KYRDVEDAEA DVDEPFLPTS SKKLGSGSRT RQIFWALVIL 100
    CLGGWVLALV LFLTHGRASS QTASETLQQQ ESDSGSTSAG RPVTLQQVLT 150
    GSWNPRAHAI SWIAGPDGED GLLVQRAEVD KEGYMRVDDI RSQEGDDVDS 200
    QSGRILIDKA AVRVNGETLM PTFTWPSPDL NKVLLMSNHE KNWRYSFTGR 250
    YWIFDVATQT AQPLDPSVPD GRVQLALWSP SSDAVVFVRD NNMYLRKLSS 300
    ESVVSITKDG GEDLFYGIPD WVYEEEVITD KSVTWWSNDG KYVAFLRTNE 350
    SAVPEFPVQY FVSRPSGKRP PPGLENYPEV RQIKYPKAGS PNPVVNLLFY 400
    DVEKDEVFPV DVPDDFPDDD RIIIEVLWAS EGKVIVRATN RESDRVKVFL 450
    IDTKSRTGKL VRFEDIANLD GGWVEPSHYT KFIPADPSNG RPDDGYIDTV 500
    IHDGYDHLAY FTPLDNPDPI MLTTGEWEVV EAPSAVDLRR GIVYFVATKE 550
    SPTQRHVYRV HLDGSNLQAL TDTSKPGFYD VSFSDGAGYA LLSYNGPSVP 600
    WQAIINTGGD EITFEKTIEK NPRLASMVET YALPTEIYQN VTIDGFTLQL 650
    VERRPPHFNP AKKYPVVFQL YNGPTSQRVD RKFTIDFQSY IASNLGYIVV 700
    TLDARGTGYS GRKVRCAVRG NLGHYEAHDQ ITTAKMWAKK PYVDETRMAI 750
    WGWSYGGFMT LKVLEQDAGE TFQYGMAVAP VTDWRFYDSV YTERYMHTPE 800
    HNPSGYENST ITNVSALSKA TRFLLIHGAS DDNVHIQNTL TFVDKLDLLN 850
    VQNYDMHFYP DSDHNIYFHN AHFMIYERLS NWLINAFNGE WHQIANPVPE 900
    DSIWDSVKRS VPAFAH 916
    Length:916
    Mass (Da):103,230
    Last modified:March 3, 2009 - v1
    Checksum:i483BB24C1B0F377E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    EQ963472 Genomic DNA. Translation: EED58018.1.
    RefSeqiXP_002373630.1. XM_002373589.1.

    Genome annotation databases

    EnsemblFungiiCADAFLAT00001495; CADAFLAP00001495; CADAFLAG00001495.
    GeneIDi7917520.
    KEGGiafv:AFLA_087160.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    EQ963472 Genomic DNA. Translation: EED58018.1 .
    RefSeqi XP_002373630.1. XM_002373589.1.

    3D structure databases

    ProteinModelPortali B8N076.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 5059.CADAFLAP00001495.

    Protein family/group databases

    MEROPSi S09.006.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii CADAFLAT00001495 ; CADAFLAP00001495 ; CADAFLAG00001495 .
    GeneIDi 7917520.
    KEGGi afv:AFLA_087160.

    Phylogenomic databases

    HOGENOMi HOG000189891.
    KOi K01282.
    OMAi ETKFWYQ.
    OrthoDBi EOG72VHFG.

    Family and domain databases

    Gene3Di 2.140.10.30. 1 hit.
    3.40.50.1820. 1 hit.
    InterProi IPR029058. AB_hydrolase.
    IPR001375. Peptidase_S9.
    IPR002469. Peptidase_S9B.
    [Graphical view ]
    Pfami PF00930. DPPIV_N. 1 hit.
    PF00326. Peptidase_S9. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53474. SSF53474. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of Aspergillus flavus strain NRRL 3357."
      Payne W.G.A., Dean R.A., Nierman W.C., Amedeo P., Caler E.G.A., Fedorova N.D., Maiti R., Joardar V., Inman J., Galinsky K.J., Yu J., Bhatnagar D., Cleveland T.E.
      Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 200026 / FGSC A1120 / NRRL 3357 / JCM 12722 / SRRC 167.

    Entry informationi

    Entry nameiDAPB_ASPFN
    AccessioniPrimary (citable) accession number: B8N076
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 27, 2011
    Last sequence update: March 3, 2009
    Last modified: October 1, 2014
    This is version 34 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3