Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

B8N076 (DAPB_ASPFN) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 33. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable dipeptidyl-aminopeptidase B

Short name=DPAP B
EC=3.4.14.5
Gene names
Name:dapB
ORF Names:AFLA_087160
OrganismAspergillus flavus (strain ATCC 200026 / FGSC A1120 / NRRL 3357 / JCM 12722 / SRRC 167) [Complete proteome]
Taxonomic identifier332952 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus

Protein attributes

Sequence length916 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Type IV dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline By similarity.

Catalytic activity

Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.

Subcellular location

Vacuole membrane; Single-pass type II membrane protein By similarity. Note: Lysosome-like vacuoles By similarity.

Sequence similarities

Belongs to the peptidase S9B family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 916916Probable dipeptidyl-aminopeptidase B
PRO_0000412134

Regions

Topological domain1 – 9292Cytoplasmic Potential
Transmembrane93 – 11321Helical; Signal-anchor for type II membrane protein; Potential
Topological domain114 – 916803Vacuolar Potential

Sites

Active site7541Charge relay system By similarity
Active site8311Charge relay system By similarity
Active site8641Charge relay system By similarity

Amino acid modifications

Glycosylation3491N-linked (GlcNAc...) Potential
Glycosylation6401N-linked (GlcNAc...) Potential
Glycosylation8081N-linked (GlcNAc...) Potential
Glycosylation8131N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
B8N076 [UniParc].

Last modified March 3, 2009. Version 1.
Checksum: 483BB24C1B0F377E

FASTA916103,230
        10         20         30         40         50         60 
MGRTGDLENA EFFPMTRRRS TSGTSSRSST DSGLSVDTAY LEDNKHNNFA NGTSGLTDET 

        70         80         90        100        110        120 
KYRDVEDAEA DVDEPFLPTS SKKLGSGSRT RQIFWALVIL CLGGWVLALV LFLTHGRASS 

       130        140        150        160        170        180 
QTASETLQQQ ESDSGSTSAG RPVTLQQVLT GSWNPRAHAI SWIAGPDGED GLLVQRAEVD 

       190        200        210        220        230        240 
KEGYMRVDDI RSQEGDDVDS QSGRILIDKA AVRVNGETLM PTFTWPSPDL NKVLLMSNHE 

       250        260        270        280        290        300 
KNWRYSFTGR YWIFDVATQT AQPLDPSVPD GRVQLALWSP SSDAVVFVRD NNMYLRKLSS 

       310        320        330        340        350        360 
ESVVSITKDG GEDLFYGIPD WVYEEEVITD KSVTWWSNDG KYVAFLRTNE SAVPEFPVQY 

       370        380        390        400        410        420 
FVSRPSGKRP PPGLENYPEV RQIKYPKAGS PNPVVNLLFY DVEKDEVFPV DVPDDFPDDD 

       430        440        450        460        470        480 
RIIIEVLWAS EGKVIVRATN RESDRVKVFL IDTKSRTGKL VRFEDIANLD GGWVEPSHYT 

       490        500        510        520        530        540 
KFIPADPSNG RPDDGYIDTV IHDGYDHLAY FTPLDNPDPI MLTTGEWEVV EAPSAVDLRR 

       550        560        570        580        590        600 
GIVYFVATKE SPTQRHVYRV HLDGSNLQAL TDTSKPGFYD VSFSDGAGYA LLSYNGPSVP 

       610        620        630        640        650        660 
WQAIINTGGD EITFEKTIEK NPRLASMVET YALPTEIYQN VTIDGFTLQL VERRPPHFNP 

       670        680        690        700        710        720 
AKKYPVVFQL YNGPTSQRVD RKFTIDFQSY IASNLGYIVV TLDARGTGYS GRKVRCAVRG 

       730        740        750        760        770        780 
NLGHYEAHDQ ITTAKMWAKK PYVDETRMAI WGWSYGGFMT LKVLEQDAGE TFQYGMAVAP 

       790        800        810        820        830        840 
VTDWRFYDSV YTERYMHTPE HNPSGYENST ITNVSALSKA TRFLLIHGAS DDNVHIQNTL 

       850        860        870        880        890        900 
TFVDKLDLLN VQNYDMHFYP DSDHNIYFHN AHFMIYERLS NWLINAFNGE WHQIANPVPE 

       910 
DSIWDSVKRS VPAFAH 

« Hide

References

[1]"Genome sequence of Aspergillus flavus strain NRRL 3357."
Payne W.G.A., Dean R.A., Nierman W.C., Amedeo P., Caler E.G.A., Fedorova N.D., Maiti R., Joardar V., Inman J., Galinsky K.J., Yu J., Bhatnagar D., Cleveland T.E.
Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 200026 / FGSC A1120 / NRRL 3357 / JCM 12722 / SRRC 167.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
EQ963472 Genomic DNA. Translation: EED58018.1.
RefSeqXP_002373630.1. XM_002373589.1.

3D structure databases

ProteinModelPortalB8N076.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING5059.CADAFLAP00001495.

Protein family/group databases

MEROPSS09.006.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiCADAFLAT00001495; CADAFLAP00001495; CADAFLAG00001495.
GeneID7917520.
KEGGafv:AFLA_087160.

Phylogenomic databases

HOGENOMHOG000189891.
KOK01282.
OMAETKFWYQ.
OrthoDBEOG72VHFG.

Family and domain databases

Gene3D2.140.10.30. 1 hit.
3.40.50.1820. 1 hit.
InterProIPR029058. AB_hydrolase.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B.
[Graphical view]
PfamPF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view]
SUPFAMSSF53474. SSF53474. 1 hit.
ProtoNetSearch...

Entry information

Entry nameDAPB_ASPFN
AccessionPrimary (citable) accession number: B8N076
Entry history
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: March 3, 2009
Last modified: June 11, 2014
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries