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Protein

Probable dipeptidyl-aminopeptidase B

Gene

dapB

Organism
Aspergillus flavus (strain ATCC 200026 / FGSC A1120 / NRRL 3357 / JCM 12722 / SRRC 167)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Type IV dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.By similarity

Catalytic activityi

Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei754 – 7541Charge relay systemBy similarity
Active sitei831 – 8311Charge relay systemBy similarity
Active sitei864 – 8641Charge relay systemBy similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Aminopeptidase, Hydrolase, Protease, Serine protease

Protein family/group databases

ESTHERiaspor-q2upw4. DPP4N_Peptidase_S9.
MEROPSiS09.006.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable dipeptidyl-aminopeptidase B (EC:3.4.14.5)
Short name:
DPAP B
Gene namesi
Name:dapB
ORF Names:AFLA_087160
OrganismiAspergillus flavus (strain ATCC 200026 / FGSC A1120 / NRRL 3357 / JCM 12722 / SRRC 167)
Taxonomic identifieri332952 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000001875 Componenti: Unassembled WGS sequence

Organism-specific databases

EuPathDBiFungiDB:AFLA_087160.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 9292CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei93 – 11321Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
BLAST
Topological domaini114 – 916803VacuolarSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 916916Probable dipeptidyl-aminopeptidase BPRO_0000412134Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi349 – 3491N-linked (GlcNAc...)Sequence Analysis
Glycosylationi640 – 6401N-linked (GlcNAc...)Sequence Analysis
Glycosylationi808 – 8081N-linked (GlcNAc...)Sequence Analysis
Glycosylationi813 – 8131N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliB8N076.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S9B family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000189891.
KOiK01282.
OMAiQENASGY.
OrthoDBiEOG72VHFG.

Family and domain databases

Gene3Di2.140.10.30. 1 hit.
3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B.
[Graphical view]
PfamiPF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequencei

Sequence statusi: Complete.

B8N076-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGRTGDLENA EFFPMTRRRS TSGTSSRSST DSGLSVDTAY LEDNKHNNFA
60 70 80 90 100
NGTSGLTDET KYRDVEDAEA DVDEPFLPTS SKKLGSGSRT RQIFWALVIL
110 120 130 140 150
CLGGWVLALV LFLTHGRASS QTASETLQQQ ESDSGSTSAG RPVTLQQVLT
160 170 180 190 200
GSWNPRAHAI SWIAGPDGED GLLVQRAEVD KEGYMRVDDI RSQEGDDVDS
210 220 230 240 250
QSGRILIDKA AVRVNGETLM PTFTWPSPDL NKVLLMSNHE KNWRYSFTGR
260 270 280 290 300
YWIFDVATQT AQPLDPSVPD GRVQLALWSP SSDAVVFVRD NNMYLRKLSS
310 320 330 340 350
ESVVSITKDG GEDLFYGIPD WVYEEEVITD KSVTWWSNDG KYVAFLRTNE
360 370 380 390 400
SAVPEFPVQY FVSRPSGKRP PPGLENYPEV RQIKYPKAGS PNPVVNLLFY
410 420 430 440 450
DVEKDEVFPV DVPDDFPDDD RIIIEVLWAS EGKVIVRATN RESDRVKVFL
460 470 480 490 500
IDTKSRTGKL VRFEDIANLD GGWVEPSHYT KFIPADPSNG RPDDGYIDTV
510 520 530 540 550
IHDGYDHLAY FTPLDNPDPI MLTTGEWEVV EAPSAVDLRR GIVYFVATKE
560 570 580 590 600
SPTQRHVYRV HLDGSNLQAL TDTSKPGFYD VSFSDGAGYA LLSYNGPSVP
610 620 630 640 650
WQAIINTGGD EITFEKTIEK NPRLASMVET YALPTEIYQN VTIDGFTLQL
660 670 680 690 700
VERRPPHFNP AKKYPVVFQL YNGPTSQRVD RKFTIDFQSY IASNLGYIVV
710 720 730 740 750
TLDARGTGYS GRKVRCAVRG NLGHYEAHDQ ITTAKMWAKK PYVDETRMAI
760 770 780 790 800
WGWSYGGFMT LKVLEQDAGE TFQYGMAVAP VTDWRFYDSV YTERYMHTPE
810 820 830 840 850
HNPSGYENST ITNVSALSKA TRFLLIHGAS DDNVHIQNTL TFVDKLDLLN
860 870 880 890 900
VQNYDMHFYP DSDHNIYFHN AHFMIYERLS NWLINAFNGE WHQIANPVPE
910
DSIWDSVKRS VPAFAH
Length:916
Mass (Da):103,230
Last modified:March 3, 2009 - v1
Checksum:i483BB24C1B0F377E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EQ963472 Genomic DNA. Translation: EED58018.1.
RefSeqiXP_002373630.1. XM_002373589.1.

Genome annotation databases

EnsemblFungiiCADAFLAT00001495; CADAFLAP00001495; CADAFLAG00001495.
GeneIDi7917520.
KEGGiafv:AFLA_087160.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EQ963472 Genomic DNA. Translation: EED58018.1.
RefSeqiXP_002373630.1. XM_002373589.1.

3D structure databases

ProteinModelPortaliB8N076.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

ESTHERiaspor-q2upw4. DPP4N_Peptidase_S9.
MEROPSiS09.006.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCADAFLAT00001495; CADAFLAP00001495; CADAFLAG00001495.
GeneIDi7917520.
KEGGiafv:AFLA_087160.

Organism-specific databases

EuPathDBiFungiDB:AFLA_087160.

Phylogenomic databases

HOGENOMiHOG000189891.
KOiK01282.
OMAiQENASGY.
OrthoDBiEOG72VHFG.

Family and domain databases

Gene3Di2.140.10.30. 1 hit.
3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B.
[Graphical view]
PfamiPF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of Aspergillus flavus strain NRRL 3357."
    Payne W.G.A., Dean R.A., Nierman W.C., Amedeo P., Caler E.G.A., Fedorova N.D., Maiti R., Joardar V., Inman J., Galinsky K.J., Yu J., Bhatnagar D., Cleveland T.E.
    Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 200026 / FGSC A1120 / NRRL 3357 / JCM 12722 / SRRC 167.

Entry informationi

Entry nameiDAPB_ASPFN
AccessioniPrimary (citable) accession number: B8N076
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: March 3, 2009
Last modified: July 22, 2015
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.