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B8N076

- DAPB_ASPFN

UniProt

B8N076 - DAPB_ASPFN

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Protein

Probable dipeptidyl-aminopeptidase B

Gene
dapB, AFLA_087160
Organism
Aspergillus flavus (strain ATCC 200026 / FGSC A1120 / NRRL 3357 / JCM 12722 / SRRC 167)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Type IV dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline By similarity.

Catalytic activityi

Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei754 – 7541Charge relay system By similarity
Active sitei831 – 8311Charge relay system By similarity
Active sitei864 – 8641Charge relay system By similarity

GO - Molecular functioni

  1. aminopeptidase activity Source: UniProtKB-KW
  2. serine-type peptidase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Aminopeptidase, Hydrolase, Protease, Serine protease

Protein family/group databases

MEROPSiS09.006.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable dipeptidyl-aminopeptidase B (EC:3.4.14.5)
Short name:
DPAP B
Gene namesi
Name:dapB
ORF Names:AFLA_087160
OrganismiAspergillus flavus (strain ATCC 200026 / FGSC A1120 / NRRL 3357 / JCM 12722 / SRRC 167)
Taxonomic identifieri332952 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000001875: Unassembled WGS sequence

Subcellular locationi

Vacuole membrane; Single-pass type II membrane protein By similarity
Note: Lysosome-like vacuoles By similarity.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 9292Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei93 – 11321Helical; Signal-anchor for type II membrane protein; Reviewed predictionAdd
BLAST
Topological domaini114 – 916803Vacuolar Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. vacuolar membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 916916Probable dipeptidyl-aminopeptidase BPRO_0000412134Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi349 – 3491N-linked (GlcNAc...) Reviewed prediction
Glycosylationi640 – 6401N-linked (GlcNAc...) Reviewed prediction
Glycosylationi808 – 8081N-linked (GlcNAc...) Reviewed prediction
Glycosylationi813 – 8131N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi5059.CADAFLAP00001495.

Structurei

3D structure databases

ProteinModelPortaliB8N076.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S9B family.

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000189891.
KOiK01282.
OMAiETKFWYQ.
OrthoDBiEOG72VHFG.

Family and domain databases

Gene3Di2.140.10.30. 1 hit.
3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B.
[Graphical view]
PfamiPF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequencei

Sequence statusi: Complete.

B8N076-1 [UniParc]FASTAAdd to Basket

« Hide

MGRTGDLENA EFFPMTRRRS TSGTSSRSST DSGLSVDTAY LEDNKHNNFA    50
NGTSGLTDET KYRDVEDAEA DVDEPFLPTS SKKLGSGSRT RQIFWALVIL 100
CLGGWVLALV LFLTHGRASS QTASETLQQQ ESDSGSTSAG RPVTLQQVLT 150
GSWNPRAHAI SWIAGPDGED GLLVQRAEVD KEGYMRVDDI RSQEGDDVDS 200
QSGRILIDKA AVRVNGETLM PTFTWPSPDL NKVLLMSNHE KNWRYSFTGR 250
YWIFDVATQT AQPLDPSVPD GRVQLALWSP SSDAVVFVRD NNMYLRKLSS 300
ESVVSITKDG GEDLFYGIPD WVYEEEVITD KSVTWWSNDG KYVAFLRTNE 350
SAVPEFPVQY FVSRPSGKRP PPGLENYPEV RQIKYPKAGS PNPVVNLLFY 400
DVEKDEVFPV DVPDDFPDDD RIIIEVLWAS EGKVIVRATN RESDRVKVFL 450
IDTKSRTGKL VRFEDIANLD GGWVEPSHYT KFIPADPSNG RPDDGYIDTV 500
IHDGYDHLAY FTPLDNPDPI MLTTGEWEVV EAPSAVDLRR GIVYFVATKE 550
SPTQRHVYRV HLDGSNLQAL TDTSKPGFYD VSFSDGAGYA LLSYNGPSVP 600
WQAIINTGGD EITFEKTIEK NPRLASMVET YALPTEIYQN VTIDGFTLQL 650
VERRPPHFNP AKKYPVVFQL YNGPTSQRVD RKFTIDFQSY IASNLGYIVV 700
TLDARGTGYS GRKVRCAVRG NLGHYEAHDQ ITTAKMWAKK PYVDETRMAI 750
WGWSYGGFMT LKVLEQDAGE TFQYGMAVAP VTDWRFYDSV YTERYMHTPE 800
HNPSGYENST ITNVSALSKA TRFLLIHGAS DDNVHIQNTL TFVDKLDLLN 850
VQNYDMHFYP DSDHNIYFHN AHFMIYERLS NWLINAFNGE WHQIANPVPE 900
DSIWDSVKRS VPAFAH 916
Length:916
Mass (Da):103,230
Last modified:March 3, 2009 - v1
Checksum:i483BB24C1B0F377E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
EQ963472 Genomic DNA. Translation: EED58018.1.
RefSeqiXP_002373630.1. XM_002373589.1.

Genome annotation databases

EnsemblFungiiCADAFLAT00001495; CADAFLAP00001495; CADAFLAG00001495.
GeneIDi7917520.
KEGGiafv:AFLA_087160.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
EQ963472 Genomic DNA. Translation: EED58018.1 .
RefSeqi XP_002373630.1. XM_002373589.1.

3D structure databases

ProteinModelPortali B8N076.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5059.CADAFLAP00001495.

Protein family/group databases

MEROPSi S09.006.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADAFLAT00001495 ; CADAFLAP00001495 ; CADAFLAG00001495 .
GeneIDi 7917520.
KEGGi afv:AFLA_087160.

Phylogenomic databases

HOGENOMi HOG000189891.
KOi K01282.
OMAi ETKFWYQ.
OrthoDBi EOG72VHFG.

Family and domain databases

Gene3Di 2.140.10.30. 1 hit.
3.40.50.1820. 1 hit.
InterProi IPR029058. AB_hydrolase.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B.
[Graphical view ]
Pfami PF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view ]
SUPFAMi SSF53474. SSF53474. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of Aspergillus flavus strain NRRL 3357."
    Payne W.G.A., Dean R.A., Nierman W.C., Amedeo P., Caler E.G.A., Fedorova N.D., Maiti R., Joardar V., Inman J., Galinsky K.J., Yu J., Bhatnagar D., Cleveland T.E.
    Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 200026 / FGSC A1120 / NRRL 3357 / JCM 12722 / SRRC 167.

Entry informationi

Entry nameiDAPB_ASPFN
AccessioniPrimary (citable) accession number: B8N076
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: March 3, 2009
Last modified: June 11, 2014
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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