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B8MZI5 (AMPP2_ASPFN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 6, 2013. Version 29. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Probable Xaa-Pro aminopeptidase AFLA_084750
EC=3.4.11.9
Alternative name(s):
Aminoacylproline aminopeptidase
Prolidase
Gene names
ORF Names:AFLA_084750
OrganismAspergillus flavus (strain ATCC 200026 / FGSC A1120 / NRRL 3357 / JCM 12722 / SRRC 167) [Complete proteome]
Taxonomic identifier332952 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Eurotiomycetes › Eurotiomycetidae › Eurotiales › Trichocomaceae › mitosporic Trichocomaceae › Aspergillus ›

Protein attributes

Sequence length491 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides By similarity.

Catalytic activity

Release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide.

Cofactor

Binds 2 manganese ions per subunit By similarity.

Sequence similarities

Belongs to the peptidase M24B family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 491491Probable Xaa-Pro aminopeptidase AFLA_084750
PRO_0000411825

Sites

Metal binding2711Manganese 2 By similarity
Metal binding2821Manganese 1 By similarity
Metal binding2821Manganese 2 By similarity
Metal binding4191Manganese 1 By similarity
Metal binding4581Manganese 1 By similarity
Metal binding4581Manganese 2 By similarity

Sequences

Sequence LengthMass (Da)Tools
B8MZI5 [UniParc].

Last modified March 3, 2009. Version 1.
Checksum: 596864579BD5EEC0

FASTA49155,816
        10         20         30         40         50         60 
MRVSEPSDVV IRSDDTCHIH LTWSGSERRS AAKQHARKVA MKLGVSSGLI YLVGQPTVNW 

        70         80         90        100        110        120 
GDSDQPQPFR QRRYFYYLSG IDEPDCYLTY DIQADLLTLY VPDFDLRRAV WMGPTLTIEE 

       130        140        150        160        170        180 
AHKQSDVDRV NFFAALQHDL EWWTTKNKGT RPIYVLHDSQ QPLIPSKRLW LDNERLLPAM 

       190        200        210        220        230        240 
NAARVIKDEY ELRMIRQANY ISGLAHRKIL EDIHRMSTEA EIESSFLATC VSHGAKNQSY 

       250        260        270        280        290        300 
AIIAGSGENA AVLHYVKNNE PLDGRQLVCL DAGAEWRCYA SDVTRTIPLW TDWPSERARN 

       310        320        330        340        350        360 
IYRVVEEMQE ECIRRIRKGV RFRDLQLLAH DIAIKGLQKL DILTNDCTSA IYESGASAVF 

       370        380        390        400        410        420 
FPHGLGHHVG LEVHDVSKRP ITALDGNQAN WGNHNFVPLL TDSSWSVPLL DEGMVVTIEP 

       430        440        450        460        470        480 
GIYFNRLALL NAQNQPLAKY INFDEAEKYI PIGGVRIEDD ILVTAKGYEN LTTAPKGEEM 

       490 
LEIIRRGIDN S

« Hide

References

[1]"Genome sequence of Aspergillus flavus strain NRRL 3357."
Payne W.G.A., Dean R.A., Nierman W.C., Amedeo P., Caler E.G.A., Fedorova N.D., Maiti R., Joardar V., Inman J., Galinsky K.J., Yu J., Bhatnagar D., Cleveland T.E.
Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 200026 / FGSC A1120 / NRRL 3357 / JCM 12722 / SRRC 167.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		EQ963472 Genomic DNA. Translation: EED57777.1.
RefSeqXP_002373389.1. XM_002373348.1.

3D structure databases

ProteinModelPortalB8MZI5.
ModBaseSearch...

Protein family/group databases

MEROPSM24.A09.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiCADAFLAT00001254; CADAFLAP00001254; CADAFLAG00001254.
GeneID7913164.
KEGGafv:AFLA_084750.

Phylogenomic databases

HOGENOMHOG000008763.
KOK14213.

Family and domain databases

Gene3D3.90.230.10. 1 hit.
InterProIPR007865. Aminopep_P_N.
IPR000994. Pept_M24_structural-domain.
IPR001131. Peptidase_M24B_aminopep-P_CS.
[Graphical view]
PfamPF05195. AMP_N. 1 hit.
PF00557. Peptidase_M24. 1 hit.
[Graphical view]
SMARTSM01011. AMP_N. 1 hit.
[Graphical view]
SUPFAMSSF55920. Peptidase_M24_cat_core. 1 hit.
PROSITEPS00491. PROLINE_PEPTIDASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameAMPP2_ASPFN
AccessionPrimary (citable) accession number: B8MZI5
Entry history
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: March 3, 2009
Last modified: March 6, 2013
This is version 29 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Peptidase families

Classification of peptidase families and list of entries

SIMILARITY comments

Index of protein domains and families

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