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Protein

Probable dipeptidyl-aminopeptidase B

Gene

dapB

Organism
Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006) (Penicillium stipitatum)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Type IV dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.By similarity

Catalytic activityi

Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei753Charge relay systemBy similarity1
Active sitei830Charge relay systemBy similarity1
Active sitei863Charge relay systemBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionAminopeptidase, Hydrolase, Protease, Serine protease

Protein family/group databases

ESTHERipenmq-dapb DPP4N_Peptidase_S9
MEROPSiS09.006

Names & Taxonomyi

Protein namesi
Recommended name:
Probable dipeptidyl-aminopeptidase B (EC:3.4.14.5)
Short name:
DPAP B
Gene namesi
Name:dapB
ORF Names:TSTA_003660
OrganismiTalaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006) (Penicillium stipitatum)
Taxonomic identifieri441959 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesTrichocomaceaeTalaromyces
Proteomesi
  • UP000001745 Componenti: Unassembled WGS sequence

Organism-specific databases

EuPathDBiFungiDB:TSTA_003660

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 90CytoplasmicSequence analysisAdd BLAST90
Transmembranei91 – 111Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini112 – 900VacuolarSequence analysisAdd BLAST789

Keywords - Cellular componenti

Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004121641 – 900Probable dipeptidyl-aminopeptidase BAdd BLAST900

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi150N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi195N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi348N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi410N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi514N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi639N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi644N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi812N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi441959.XP_002487962.1

Structurei

3D structure databases

ProteinModelPortaliB8MTH6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S9B family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2100 Eukaryota
COG1506 LUCA
InParanoidiB8MTH6
OMAiNHGIYGG
OrthoDBiEOG092C0PZJ

Family and domain databases

Gene3Di2.140.10.30, 1 hit
3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR001375 Peptidase_S9
IPR002469 Peptidase_S9B_N
IPR038554 Peptidase_S9B_N_sf
PfamiView protein in Pfam
PF00930 DPPIV_N, 1 hit
PF00326 Peptidase_S9, 1 hit
SUPFAMiSSF53474 SSF53474, 1 hit

Sequencei

Sequence statusi: Complete.

B8MTH6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARTDQGLGA ESEPLTNQSH RHSNSFSSTD SLSTDGSLFG DDMNATQFQK
60 70 80 90 100
STQLPEETPY RDIEEGVEGE PESDILSHPR DKSKRSRGSR WIWVIGLLCL
110 120 130 140 150
GGWILAFILF WGRRNNNSDI SSSVAAVHDA ESATGATSYG KPLTLDSVLN
160 170 180 190 200
GSWGRRKHSI SWVAGPDGED GLLLERGEDG KKGYLRVESI LSRQNETDAD
210 220 230 240 250
DGLILMESGT IEANGKYLQP SETWPSPNFK SVLVAVDAVS NWRYSFTATY
260 270 280 290 300
WLFDVKTQTA QPLDPDAPKG RIQLASWSPN SDAVVFTRDN NLYLRRLDST
310 320 330 340 350
TVTQITKDGG KDVFNGIPDW VYEEEVYGSD TATWWSNDGK YVAFLRTNES
360 370 380 390 400
MVPEFPIEYY MSRLSGKHPS PGLEKYPDVR KIKYPKAGAP NPVVTLQFYD
410 420 430 440 450
VESTDVFSVN VSGGFADDDR LITEVVWASE TKVLVKEFNR ESDVVRTVLI
460 470 480 490 500
DVGSRSGDVI RVDNFAQDDG GWAEVTQSTT FIPADPANGR PDDGYLDIVV
510 520 530 540 550
HDGYDHWGYF TPVNNSQPIL LTSGPWEVVD TQPAVDLRNG IVYLVATKES
560 570 580 590 600
PTQRHVYSVK LDGSDFQAMT DTSKAGYYDV SFSIGGGYAL LSYEGPHIPW
610 620 630 640 650
QKLVNTPSNQ QHFEEVIEQN EHLFSMIEKY ALPAEIYQNI TIDNITLQVV
660 670 680 690 700
ERRPPHFNPI KKYPVLFWLY GGPGSQSVDR KFMVDFQSYV SSTLGYIVVT
710 720 730 740 750
VDGRGTGHIG RIARTIVRGN LGFWEARDQI ETAKAWAKKP YVDKDHIAIW
760 770 780 790 800
GWSYGGFMTL KTLEQDAGQT FQYGMAVSPV TDWRFYDSIY TERYMHTPEH
810 820 830 840 850
NPTGYEHSAI SNMTALQQNV RFLIMHGTAD DNVHFQNTLS LIDKLDMGGV
860 870 880 890 900
ENYDVHVYPD SDHSIYFHNA HKMVYDRLSS WLVNAFTDEW HHVGSALAAT
Length:900
Mass (Da):101,025
Last modified:March 3, 2009 - v1
Checksum:i178445E1C9D9EAD4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EQ962660 Genomic DNA Translation: EED12308.1
RefSeqiXP_002487962.1, XM_002487917.1

Genome annotation databases

EnsemblFungiiEED12308; EED12308; TSTA_003660
GeneIDi8098062

Similar proteinsi

Entry informationi

Entry nameiDAPB_TALSN
AccessioniPrimary (citable) accession number: B8MTH6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: March 3, 2009
Last modified: March 28, 2018
This is version 43 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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