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B8MTH6

- DAPB_TALSN

UniProt

B8MTH6 - DAPB_TALSN

Protein

Probable dipeptidyl-aminopeptidase B

Gene

dapB

Organism
Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006) (Penicillium stipitatum)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 29 (01 Oct 2014)
      Sequence version 1 (03 Mar 2009)
      Previous versions | rss
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    Functioni

    Type IV dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.By similarity

    Catalytic activityi

    Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei753 – 7531Charge relay systemBy similarity
    Active sitei830 – 8301Charge relay systemBy similarity
    Active sitei863 – 8631Charge relay systemBy similarity

    GO - Molecular functioni

    1. aminopeptidase activity Source: UniProtKB-KW
    2. serine-type peptidase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Aminopeptidase, Hydrolase, Protease, Serine protease

    Protein family/group databases

    MEROPSiS09.006.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable dipeptidyl-aminopeptidase B (EC:3.4.14.5)
    Short name:
    DPAP B
    Gene namesi
    Name:dapB
    ORF Names:TSTA_003660
    OrganismiTalaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006) (Penicillium stipitatum)
    Taxonomic identifieri441959 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesTrichocomaceaeTalaromyces
    ProteomesiUP000001745: Unassembled WGS sequence

    Subcellular locationi

    Vacuole membrane By similarity; Single-pass type II membrane protein By similarity
    Note: Lysosome-like vacuoles.By similarity

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. vacuolar membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane, Vacuole

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 900900Probable dipeptidyl-aminopeptidase BPRO_0000412164Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi150 – 1501N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi195 – 1951N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi348 – 3481N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi410 – 4101N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi514 – 5141N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi639 – 6391N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi644 – 6441N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi812 – 8121N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Structurei

    3D structure databases

    ProteinModelPortaliB8MTH6.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 9090CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini112 – 900789VacuolarSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei91 – 11121Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase S9B family.Curated

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    OrthoDBiEOG72VHFG.

    Family and domain databases

    Gene3Di2.140.10.30. 1 hit.
    3.40.50.1820. 1 hit.
    InterProiIPR029058. AB_hydrolase.
    IPR001375. Peptidase_S9.
    IPR002469. Peptidase_S9B.
    [Graphical view]
    PfamiPF00930. DPPIV_N. 1 hit.
    PF00326. Peptidase_S9. 1 hit.
    [Graphical view]
    SUPFAMiSSF53474. SSF53474. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B8MTH6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MARTDQGLGA ESEPLTNQSH RHSNSFSSTD SLSTDGSLFG DDMNATQFQK    50
    STQLPEETPY RDIEEGVEGE PESDILSHPR DKSKRSRGSR WIWVIGLLCL 100
    GGWILAFILF WGRRNNNSDI SSSVAAVHDA ESATGATSYG KPLTLDSVLN 150
    GSWGRRKHSI SWVAGPDGED GLLLERGEDG KKGYLRVESI LSRQNETDAD 200
    DGLILMESGT IEANGKYLQP SETWPSPNFK SVLVAVDAVS NWRYSFTATY 250
    WLFDVKTQTA QPLDPDAPKG RIQLASWSPN SDAVVFTRDN NLYLRRLDST 300
    TVTQITKDGG KDVFNGIPDW VYEEEVYGSD TATWWSNDGK YVAFLRTNES 350
    MVPEFPIEYY MSRLSGKHPS PGLEKYPDVR KIKYPKAGAP NPVVTLQFYD 400
    VESTDVFSVN VSGGFADDDR LITEVVWASE TKVLVKEFNR ESDVVRTVLI 450
    DVGSRSGDVI RVDNFAQDDG GWAEVTQSTT FIPADPANGR PDDGYLDIVV 500
    HDGYDHWGYF TPVNNSQPIL LTSGPWEVVD TQPAVDLRNG IVYLVATKES 550
    PTQRHVYSVK LDGSDFQAMT DTSKAGYYDV SFSIGGGYAL LSYEGPHIPW 600
    QKLVNTPSNQ QHFEEVIEQN EHLFSMIEKY ALPAEIYQNI TIDNITLQVV 650
    ERRPPHFNPI KKYPVLFWLY GGPGSQSVDR KFMVDFQSYV SSTLGYIVVT 700
    VDGRGTGHIG RIARTIVRGN LGFWEARDQI ETAKAWAKKP YVDKDHIAIW 750
    GWSYGGFMTL KTLEQDAGQT FQYGMAVSPV TDWRFYDSIY TERYMHTPEH 800
    NPTGYEHSAI SNMTALQQNV RFLIMHGTAD DNVHFQNTLS LIDKLDMGGV 850
    ENYDVHVYPD SDHSIYFHNA HKMVYDRLSS WLVNAFTDEW HHVGSALAAT 900
    Length:900
    Mass (Da):101,025
    Last modified:March 3, 2009 - v1
    Checksum:i178445E1C9D9EAD4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    EQ962660 Genomic DNA. Translation: EED12308.1.
    RefSeqiXP_002487962.1. XM_002487917.1.

    Genome annotation databases

    GeneIDi8098062.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    EQ962660 Genomic DNA. Translation: EED12308.1 .
    RefSeqi XP_002487962.1. XM_002487917.1.

    3D structure databases

    ProteinModelPortali B8MTH6.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi S09.006.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 8098062.

    Phylogenomic databases

    OrthoDBi EOG72VHFG.

    Family and domain databases

    Gene3Di 2.140.10.30. 1 hit.
    3.40.50.1820. 1 hit.
    InterProi IPR029058. AB_hydrolase.
    IPR001375. Peptidase_S9.
    IPR002469. Peptidase_S9B.
    [Graphical view ]
    Pfami PF00930. DPPIV_N. 1 hit.
    PF00326. Peptidase_S9. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53474. SSF53474. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of Talaromyces stipitatus strain ATCC 10500."
      Fedorova N.D., Joardar V.S., Maiti R., Schobel S., Amedeo P., Galens K., Inman J.M., Galinsky K.J., White O.R., Whitty B.R., Wortman J.R., Nierman W.C.
      Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006.

    Entry informationi

    Entry nameiDAPB_TALSN
    AccessioniPrimary (citable) accession number: B8MTH6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 27, 2011
    Last sequence update: March 3, 2009
    Last modified: October 1, 2014
    This is version 29 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3