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B8MTH6

- DAPB_TALSN

UniProt

B8MTH6 - DAPB_TALSN

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Protein

Probable dipeptidyl-aminopeptidase B

Gene
dapB, TSTA_003660
Organism
Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006) (Penicillium stipitatum)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Type IV dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline By similarity.

Catalytic activityi

Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei753 – 7531Charge relay system By similarity
Active sitei830 – 8301Charge relay system By similarity
Active sitei863 – 8631Charge relay system By similarity

GO - Molecular functioni

  1. aminopeptidase activity Source: UniProtKB-KW
  2. serine-type peptidase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Aminopeptidase, Hydrolase, Protease, Serine protease

Protein family/group databases

MEROPSiS09.006.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable dipeptidyl-aminopeptidase B (EC:3.4.14.5)
Short name:
DPAP B
Gene namesi
Name:dapB
ORF Names:TSTA_003660
OrganismiTalaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006) (Penicillium stipitatum)
Taxonomic identifieri441959 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesTrichocomaceaeTalaromyces
ProteomesiUP000001745: Unassembled WGS sequence

Subcellular locationi

Vacuole membrane; Single-pass type II membrane protein By similarity
Note: Lysosome-like vacuoles By similarity.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 9090Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei91 – 11121Helical; Signal-anchor for type II membrane protein; Reviewed predictionAdd
BLAST
Topological domaini112 – 900789Vacuolar Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. vacuolar membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 900900Probable dipeptidyl-aminopeptidase BPRO_0000412164Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi150 – 1501N-linked (GlcNAc...) Reviewed prediction
Glycosylationi195 – 1951N-linked (GlcNAc...) Reviewed prediction
Glycosylationi348 – 3481N-linked (GlcNAc...) Reviewed prediction
Glycosylationi410 – 4101N-linked (GlcNAc...) Reviewed prediction
Glycosylationi514 – 5141N-linked (GlcNAc...) Reviewed prediction
Glycosylationi639 – 6391N-linked (GlcNAc...) Reviewed prediction
Glycosylationi644 – 6441N-linked (GlcNAc...) Reviewed prediction
Glycosylationi812 – 8121N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliB8MTH6.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S9B family.

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

OrthoDBiEOG72VHFG.

Family and domain databases

Gene3Di2.140.10.30. 1 hit.
3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B.
[Graphical view]
PfamiPF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequencei

Sequence statusi: Complete.

B8MTH6-1 [UniParc]FASTAAdd to Basket

« Hide

MARTDQGLGA ESEPLTNQSH RHSNSFSSTD SLSTDGSLFG DDMNATQFQK    50
STQLPEETPY RDIEEGVEGE PESDILSHPR DKSKRSRGSR WIWVIGLLCL 100
GGWILAFILF WGRRNNNSDI SSSVAAVHDA ESATGATSYG KPLTLDSVLN 150
GSWGRRKHSI SWVAGPDGED GLLLERGEDG KKGYLRVESI LSRQNETDAD 200
DGLILMESGT IEANGKYLQP SETWPSPNFK SVLVAVDAVS NWRYSFTATY 250
WLFDVKTQTA QPLDPDAPKG RIQLASWSPN SDAVVFTRDN NLYLRRLDST 300
TVTQITKDGG KDVFNGIPDW VYEEEVYGSD TATWWSNDGK YVAFLRTNES 350
MVPEFPIEYY MSRLSGKHPS PGLEKYPDVR KIKYPKAGAP NPVVTLQFYD 400
VESTDVFSVN VSGGFADDDR LITEVVWASE TKVLVKEFNR ESDVVRTVLI 450
DVGSRSGDVI RVDNFAQDDG GWAEVTQSTT FIPADPANGR PDDGYLDIVV 500
HDGYDHWGYF TPVNNSQPIL LTSGPWEVVD TQPAVDLRNG IVYLVATKES 550
PTQRHVYSVK LDGSDFQAMT DTSKAGYYDV SFSIGGGYAL LSYEGPHIPW 600
QKLVNTPSNQ QHFEEVIEQN EHLFSMIEKY ALPAEIYQNI TIDNITLQVV 650
ERRPPHFNPI KKYPVLFWLY GGPGSQSVDR KFMVDFQSYV SSTLGYIVVT 700
VDGRGTGHIG RIARTIVRGN LGFWEARDQI ETAKAWAKKP YVDKDHIAIW 750
GWSYGGFMTL KTLEQDAGQT FQYGMAVSPV TDWRFYDSIY TERYMHTPEH 800
NPTGYEHSAI SNMTALQQNV RFLIMHGTAD DNVHFQNTLS LIDKLDMGGV 850
ENYDVHVYPD SDHSIYFHNA HKMVYDRLSS WLVNAFTDEW HHVGSALAAT 900
Length:900
Mass (Da):101,025
Last modified:March 3, 2009 - v1
Checksum:i178445E1C9D9EAD4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
EQ962660 Genomic DNA. Translation: EED12308.1.
RefSeqiXP_002487962.1. XM_002487917.1.

Genome annotation databases

GeneIDi8098062.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
EQ962660 Genomic DNA. Translation: EED12308.1 .
RefSeqi XP_002487962.1. XM_002487917.1.

3D structure databases

ProteinModelPortali B8MTH6.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi S09.006.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 8098062.

Phylogenomic databases

OrthoDBi EOG72VHFG.

Family and domain databases

Gene3Di 2.140.10.30. 1 hit.
3.40.50.1820. 1 hit.
InterProi IPR029058. AB_hydrolase.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B.
[Graphical view ]
Pfami PF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view ]
SUPFAMi SSF53474. SSF53474. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of Talaromyces stipitatus strain ATCC 10500."
    Fedorova N.D., Joardar V.S., Maiti R., Schobel S., Amedeo P., Galens K., Inman J.M., Galinsky K.J., White O.R., Whitty B.R., Wortman J.R., Nierman W.C.
    Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006.

Entry informationi

Entry nameiDAPB_TALSN
AccessioniPrimary (citable) accession number: B8MTH6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: March 3, 2009
Last modified: June 11, 2014
This is version 28 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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