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Protein

Probable dipeptidyl-aminopeptidase B

Gene

dapB

Organism
Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006) (Penicillium stipitatum)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Type IV dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.By similarity

Catalytic activityi

Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei753 – 7531Charge relay systemBy similarity
Active sitei830 – 8301Charge relay systemBy similarity
Active sitei863 – 8631Charge relay systemBy similarity

GO - Molecular functioni

  1. aminopeptidase activity Source: UniProtKB-KW
  2. serine-type peptidase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Aminopeptidase, Hydrolase, Protease, Serine protease

Protein family/group databases

MEROPSiS09.006.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable dipeptidyl-aminopeptidase B (EC:3.4.14.5)
Short name:
DPAP B
Gene namesi
Name:dapB
ORF Names:TSTA_003660
OrganismiTalaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006) (Penicillium stipitatum)
Taxonomic identifieri441959 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesTrichocomaceaeTalaromyces
ProteomesiUP000001745 Componenti: Unassembled WGS sequence

Subcellular locationi

Vacuole membrane By similarity; Single-pass type II membrane protein By similarity
Note: Lysosome-like vacuoles.By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 9090CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei91 – 11121Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
BLAST
Topological domaini112 – 900789VacuolarSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. vacuolar membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 900900Probable dipeptidyl-aminopeptidase BPRO_0000412164Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi150 – 1501N-linked (GlcNAc...)Sequence Analysis
Glycosylationi195 – 1951N-linked (GlcNAc...)Sequence Analysis
Glycosylationi348 – 3481N-linked (GlcNAc...)Sequence Analysis
Glycosylationi410 – 4101N-linked (GlcNAc...)Sequence Analysis
Glycosylationi514 – 5141N-linked (GlcNAc...)Sequence Analysis
Glycosylationi639 – 6391N-linked (GlcNAc...)Sequence Analysis
Glycosylationi644 – 6441N-linked (GlcNAc...)Sequence Analysis
Glycosylationi812 – 8121N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliB8MTH6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S9B family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

InParanoidiB8MTH6.
OrthoDBiEOG72VHFG.

Family and domain databases

Gene3Di2.140.10.30. 1 hit.
3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B.
[Graphical view]
PfamiPF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequencei

Sequence statusi: Complete.

B8MTH6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARTDQGLGA ESEPLTNQSH RHSNSFSSTD SLSTDGSLFG DDMNATQFQK
60 70 80 90 100
STQLPEETPY RDIEEGVEGE PESDILSHPR DKSKRSRGSR WIWVIGLLCL
110 120 130 140 150
GGWILAFILF WGRRNNNSDI SSSVAAVHDA ESATGATSYG KPLTLDSVLN
160 170 180 190 200
GSWGRRKHSI SWVAGPDGED GLLLERGEDG KKGYLRVESI LSRQNETDAD
210 220 230 240 250
DGLILMESGT IEANGKYLQP SETWPSPNFK SVLVAVDAVS NWRYSFTATY
260 270 280 290 300
WLFDVKTQTA QPLDPDAPKG RIQLASWSPN SDAVVFTRDN NLYLRRLDST
310 320 330 340 350
TVTQITKDGG KDVFNGIPDW VYEEEVYGSD TATWWSNDGK YVAFLRTNES
360 370 380 390 400
MVPEFPIEYY MSRLSGKHPS PGLEKYPDVR KIKYPKAGAP NPVVTLQFYD
410 420 430 440 450
VESTDVFSVN VSGGFADDDR LITEVVWASE TKVLVKEFNR ESDVVRTVLI
460 470 480 490 500
DVGSRSGDVI RVDNFAQDDG GWAEVTQSTT FIPADPANGR PDDGYLDIVV
510 520 530 540 550
HDGYDHWGYF TPVNNSQPIL LTSGPWEVVD TQPAVDLRNG IVYLVATKES
560 570 580 590 600
PTQRHVYSVK LDGSDFQAMT DTSKAGYYDV SFSIGGGYAL LSYEGPHIPW
610 620 630 640 650
QKLVNTPSNQ QHFEEVIEQN EHLFSMIEKY ALPAEIYQNI TIDNITLQVV
660 670 680 690 700
ERRPPHFNPI KKYPVLFWLY GGPGSQSVDR KFMVDFQSYV SSTLGYIVVT
710 720 730 740 750
VDGRGTGHIG RIARTIVRGN LGFWEARDQI ETAKAWAKKP YVDKDHIAIW
760 770 780 790 800
GWSYGGFMTL KTLEQDAGQT FQYGMAVSPV TDWRFYDSIY TERYMHTPEH
810 820 830 840 850
NPTGYEHSAI SNMTALQQNV RFLIMHGTAD DNVHFQNTLS LIDKLDMGGV
860 870 880 890 900
ENYDVHVYPD SDHSIYFHNA HKMVYDRLSS WLVNAFTDEW HHVGSALAAT
Length:900
Mass (Da):101,025
Last modified:March 3, 2009 - v1
Checksum:i178445E1C9D9EAD4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EQ962660 Genomic DNA. Translation: EED12308.1.
RefSeqiXP_002487962.1. XM_002487917.1.

Genome annotation databases

GeneIDi8098062.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EQ962660 Genomic DNA. Translation: EED12308.1.
RefSeqiXP_002487962.1. XM_002487917.1.

3D structure databases

ProteinModelPortaliB8MTH6.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiS09.006.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi8098062.

Phylogenomic databases

InParanoidiB8MTH6.
OrthoDBiEOG72VHFG.

Family and domain databases

Gene3Di2.140.10.30. 1 hit.
3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B.
[Graphical view]
PfamiPF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of Talaromyces stipitatus strain ATCC 10500."
    Fedorova N.D., Joardar V.S., Maiti R., Schobel S., Amedeo P., Galens K., Inman J.M., Galinsky K.J., White O.R., Whitty B.R., Wortman J.R., Nierman W.C.
    Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006.

Entry informationi

Entry nameiDAPB_TALSN
AccessioniPrimary (citable) accession number: B8MTH6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: March 3, 2009
Last modified: January 7, 2015
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.