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B8MTH6 (DAPB_TALSN) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 28. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable dipeptidyl-aminopeptidase B

Short name=DPAP B
EC=3.4.14.5
Gene names
Name:dapB
ORF Names:TSTA_003660
OrganismTalaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006) (Penicillium stipitatum) [Complete proteome]
Taxonomic identifier441959 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesTrichocomaceaeTalaromyces

Protein attributes

Sequence length900 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Type IV dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline By similarity.

Catalytic activity

Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.

Subcellular location

Vacuole membrane; Single-pass type II membrane protein By similarity. Note: Lysosome-like vacuoles By similarity.

Sequence similarities

Belongs to the peptidase S9B family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 900900Probable dipeptidyl-aminopeptidase B
PRO_0000412164

Regions

Topological domain1 – 9090Cytoplasmic Potential
Transmembrane91 – 11121Helical; Signal-anchor for type II membrane protein; Potential
Topological domain112 – 900789Vacuolar Potential

Sites

Active site7531Charge relay system By similarity
Active site8301Charge relay system By similarity
Active site8631Charge relay system By similarity

Amino acid modifications

Glycosylation1501N-linked (GlcNAc...) Potential
Glycosylation1951N-linked (GlcNAc...) Potential
Glycosylation3481N-linked (GlcNAc...) Potential
Glycosylation4101N-linked (GlcNAc...) Potential
Glycosylation5141N-linked (GlcNAc...) Potential
Glycosylation6391N-linked (GlcNAc...) Potential
Glycosylation6441N-linked (GlcNAc...) Potential
Glycosylation8121N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
B8MTH6 [UniParc].

Last modified March 3, 2009. Version 1.
Checksum: 178445E1C9D9EAD4

FASTA900101,025
        10         20         30         40         50         60 
MARTDQGLGA ESEPLTNQSH RHSNSFSSTD SLSTDGSLFG DDMNATQFQK STQLPEETPY 

        70         80         90        100        110        120 
RDIEEGVEGE PESDILSHPR DKSKRSRGSR WIWVIGLLCL GGWILAFILF WGRRNNNSDI 

       130        140        150        160        170        180 
SSSVAAVHDA ESATGATSYG KPLTLDSVLN GSWGRRKHSI SWVAGPDGED GLLLERGEDG 

       190        200        210        220        230        240 
KKGYLRVESI LSRQNETDAD DGLILMESGT IEANGKYLQP SETWPSPNFK SVLVAVDAVS 

       250        260        270        280        290        300 
NWRYSFTATY WLFDVKTQTA QPLDPDAPKG RIQLASWSPN SDAVVFTRDN NLYLRRLDST 

       310        320        330        340        350        360 
TVTQITKDGG KDVFNGIPDW VYEEEVYGSD TATWWSNDGK YVAFLRTNES MVPEFPIEYY 

       370        380        390        400        410        420 
MSRLSGKHPS PGLEKYPDVR KIKYPKAGAP NPVVTLQFYD VESTDVFSVN VSGGFADDDR 

       430        440        450        460        470        480 
LITEVVWASE TKVLVKEFNR ESDVVRTVLI DVGSRSGDVI RVDNFAQDDG GWAEVTQSTT 

       490        500        510        520        530        540 
FIPADPANGR PDDGYLDIVV HDGYDHWGYF TPVNNSQPIL LTSGPWEVVD TQPAVDLRNG 

       550        560        570        580        590        600 
IVYLVATKES PTQRHVYSVK LDGSDFQAMT DTSKAGYYDV SFSIGGGYAL LSYEGPHIPW 

       610        620        630        640        650        660 
QKLVNTPSNQ QHFEEVIEQN EHLFSMIEKY ALPAEIYQNI TIDNITLQVV ERRPPHFNPI 

       670        680        690        700        710        720 
KKYPVLFWLY GGPGSQSVDR KFMVDFQSYV SSTLGYIVVT VDGRGTGHIG RIARTIVRGN 

       730        740        750        760        770        780 
LGFWEARDQI ETAKAWAKKP YVDKDHIAIW GWSYGGFMTL KTLEQDAGQT FQYGMAVSPV 

       790        800        810        820        830        840 
TDWRFYDSIY TERYMHTPEH NPTGYEHSAI SNMTALQQNV RFLIMHGTAD DNVHFQNTLS 

       850        860        870        880        890        900 
LIDKLDMGGV ENYDVHVYPD SDHSIYFHNA HKMVYDRLSS WLVNAFTDEW HHVGSALAAT 

« Hide

References

[1]"Genome sequence of Talaromyces stipitatus strain ATCC 10500."
Fedorova N.D., Joardar V.S., Maiti R., Schobel S., Amedeo P., Galens K., Inman J.M., Galinsky K.J., White O.R., Whitty B.R., Wortman J.R., Nierman W.C.
Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
EQ962660 Genomic DNA. Translation: EED12308.1.
RefSeqXP_002487962.1. XM_002487917.1.

3D structure databases

ProteinModelPortalB8MTH6.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

MEROPSS09.006.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID8098062.

Phylogenomic databases

OrthoDBEOG72VHFG.

Family and domain databases

Gene3D2.140.10.30. 1 hit.
3.40.50.1820. 1 hit.
InterProIPR029058. AB_hydrolase.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B.
[Graphical view]
PfamPF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view]
SUPFAMSSF53474. SSF53474. 1 hit.
ProtoNetSearch...

Entry information

Entry nameDAPB_TALSN
AccessionPrimary (citable) accession number: B8MTH6
Entry history
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: March 3, 2009
Last modified: June 11, 2014
This is version 28 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries