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B8MLU5

- LIPA_TALSN

UniProt

B8MLU5 - LIPA_TALSN

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Protein

Lipoyl synthase, mitochondrial

Gene
TSTA_101110
Organism
Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006) (Penicillium stipitatum)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives By similarity.UniRule annotation

Catalytic activityi

Protein N(6)-(octanoyl)lysine + 2 sulfur-(sulfur carrier) + 2 S-adenosyl-L-methionine = protein N(6)-(lipoyl)lysine + 2 (sulfur carrier) + 2 L-methionine + 2 5'-deoxyadenosine.UniRule annotation

Cofactori

Binds 2 4Fe-4S clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi146 – 1461Iron-sulfur 1 (4Fe-4S) By similarity
Metal bindingi151 – 1511Iron-sulfur 1 (4Fe-4S) By similarity
Metal bindingi157 – 1571Iron-sulfur 1 (4Fe-4S) By similarity
Metal bindingi177 – 1771Iron-sulfur 2 (4Fe-4S-S-AdoMet) By similarity
Metal bindingi181 – 1811Iron-sulfur 2 (4Fe-4S-S-AdoMet) By similarity
Metal bindingi184 – 1841Iron-sulfur 2 (4Fe-4S-S-AdoMet) By similarity

GO - Molecular functioni

  1. 4 iron, 4 sulfur cluster binding Source: UniProtKB-HAMAP
  2. lipoate synthase activity Source: UniProtKB-HAMAP
  3. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. protein lipoylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Ligandi

4Fe-4S, Iron, Iron-sulfur, Metal-binding, S-adenosyl-L-methionine

Enzyme and pathway databases

UniPathwayiUPA00538; UER00593.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipoyl synthase, mitochondrial (EC:2.8.1.8)
Alternative name(s):
Lipoate synthase
Short name:
LS
Short name:
Lip-syn
Lipoic acid synthase
Gene namesi
ORF Names:TSTA_101110
OrganismiTalaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006) (Penicillium stipitatum)
Taxonomic identifieri441959 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesTrichocomaceaeTalaromyces
ProteomesiUP000001745: Unassembled WGS sequence

Subcellular locationi

Mitochondrion Reviewed prediction UniRule annotation

GO - Cellular componenti

  1. mitochondrion Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 3434Mitochondrion Reviewed predictionAdd
BLAST
Chaini35 – 422388Lipoyl synthase, mitochondrialUniRule annotationPRO_0000398294Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliB8MLU5.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

OrthoDBiEOG79KPR7.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00206. Lipoyl_synth.
InterProiIPR013785. Aldolase_TIM.
IPR006638. Elp3/MiaB/NifB.
IPR003698. Lipoyl_synth.
IPR007197. rSAM.
[Graphical view]
PANTHERiPTHR10949. PTHR10949. 1 hit.
PfamiPF04055. Radical_SAM. 1 hit.
[Graphical view]
PIRSFiPIRSF005963. Lipoyl_synth. 1 hit.
SMARTiSM00729. Elp3. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00510. lipA. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

B8MLU5-1 [UniParc]FASTAAdd to Basket

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MAASSTRLRC LYASSAPAWK KSPSQSIISL SRHYATTSST TPSLNPDESS    50
SSSSSTIPKR RKTTTFRDKL NAGPSFADFV TGGNGNNASL DPEEAYALEK 100
VMIPGPAGRK KEHTRLPSWL KTPIPDSTNY KRIKKDLRGL DLHTVCEEAR 150
CPNISDCWGG SDKSAATATI MLMGDTCTRG CRFCSVKTLR TPGPLDPHEP 200
ENTAEALSRW GLGDDLPDGG AHHFAETVIK IKQKAPGILV ECLTGDFAGD 250
LDMVSLVAKS GLDVYAHNVE TVEALTPHVR DRRATFKQSL RVLEAAKRAK 300
PSLITKTSMM LGFGETEDQL WDALRQLRAS NVDVVTFGQY MRPTKRHMAV 350
HEYVTPDKFE LWRQRALEMG FLYVASGPLV RSSYKAGEAF IENVLKKRRG 400
VGNTPGAEVA SAKDVPVDVL GK 422
Length:422
Mass (Da):46,127
Last modified:March 3, 2009 - v1
Checksum:i9F9C7823717AFD54
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
EQ962658 Genomic DNA. Translation: EED13871.1.
RefSeqiXP_002486109.1. XM_002486064.1.

Genome annotation databases

GeneIDi8101799.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
EQ962658 Genomic DNA. Translation: EED13871.1 .
RefSeqi XP_002486109.1. XM_002486064.1.

3D structure databases

ProteinModelPortali B8MLU5.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 8101799.

Phylogenomic databases

OrthoDBi EOG79KPR7.

Enzyme and pathway databases

UniPathwayi UPA00538 ; UER00593 .

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_00206. Lipoyl_synth.
InterProi IPR013785. Aldolase_TIM.
IPR006638. Elp3/MiaB/NifB.
IPR003698. Lipoyl_synth.
IPR007197. rSAM.
[Graphical view ]
PANTHERi PTHR10949. PTHR10949. 1 hit.
Pfami PF04055. Radical_SAM. 1 hit.
[Graphical view ]
PIRSFi PIRSF005963. Lipoyl_synth. 1 hit.
SMARTi SM00729. Elp3. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00510. lipA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of Talaromyces stipitatus strain ATCC 10500."
    Fedorova N.D., Joardar V.S., Maiti R., Schobel S., Amedeo P., Galens K., Inman J.M., Galinsky K.J., White O.R., Whitty B.R., Wortman J.R., Nierman W.C.
    Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006.

Entry informationi

Entry nameiLIPA_TALSN
AccessioniPrimary (citable) accession number: B8MLU5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 5, 2010
Last sequence update: March 3, 2009
Last modified: June 11, 2014
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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