B8M9W2 (AMPP1_TALSN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable Xaa-Pro aminopeptidase P
Short name=AMPP
Short name=Aminopeptidase P
EC=3.4.11.9

Alternative name(s):
Aminoacylproline aminopeptidase
Prolidase

Gene names

Name:	ampp
ORF Names:	TSTA_118800

Organism

Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006) (Penicillium stipitatum) [Complete proteome]

Taxonomic identifier

441959 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Pezizomycotina › leotiomyceta › Eurotiomycetes › Eurotiomycetidae › Eurotiales › Trichocomaceae › Talaromyces › Talaromyces stipitatus

Protein attributes

Sequence length	657 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides By similarity.
Catalytic activity	Release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide.
Cofactor	Binds 2 manganese ions per subunit By similarity.
Sequence similarities	Belongs to the peptidase M24B family.

Ontologies

Keywords
Ligand	Manganese Metal-binding
Molecular function	Aminopeptidase Hydrolase Metalloprotease Protease
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	cellular process Inferred from electronic annotation. Source: InterPro proteolysis Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	aminopeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW metallopeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 657	657	Probable Xaa-Pro aminopeptidase P		PRO_0000411811
Sites
	Metal binding	453	1	Manganese 2 By similarity
	Metal binding	464	1	Manganese 1 By similarity
	Metal binding	464	1	Manganese 2 By similarity
	Metal binding	562	1	Manganese 1 By similarity
	Metal binding	576	1	Manganese 1 By similarity
	Metal binding	576	1	Manganese 2 By similarity

Sequences

	Sequence		Length	Mass (Da)
	B8M9W2 [UniParc]. Last modified March 3, 2009. Version 1. Checksum: 6E3EA0AED3557264	FASTA	657	73,137
	10 20 30 40 50 60 MLFSCRAPSL LQRTALSSPL RLFAPCRPSF SRTFVTTTVR FSVEMETVNT SERLAQLREL 70 80 90 100 110 120 MKQNNLDVYI VPSEDSHQSE YIAHCDARRE FISGFTGSAG TAVISTTAAA LSTDGRYFNQ 130 140 150 160 170 180 AAKQLDSNWK LLKRGLEGVL TWQEWTAEQA EGGKIVGVDP SVITAASARK LSETLEKGGS 190 200 210 220 230 240 KLVGIEQNLV DQIWGTHRPQ RPSEKVKIHP IEYAGKPFQE KIADLRKELK TKKRAGFIVS 250 260 270 280 290 300 VLDEIAWLFN LRGNDIPYNP VFFSYAVITP DTVDLYIDDE KLSPEVKVHL GSDVVIKPYE 310 320 330 340 350 360 SIFADAKALS AKAPLTESGA PMKYLTSNKA SWALSLSFGG EKKLDEARSP ISDAKAIKNE 370 380 390 400 410 420 VELKGMRDCH IRDGAALTEY FAWLENELIN KKSTLDEVDG ADKLEQIRSK HDKFVGLSFD 430 440 450 460 470 480 TISSTGPNAA VIHYKPEKGV CSVIDPNAIY LCDSGAQYLD GTTDTTRTFH FSTPTEMEKK 490 500 510 520 530 540 AFTLVLKGLI ALDTAVFPKG TSGFALDALA RQHLWRQGLD YLHGTGHGVG AYLNVHEGPI 550 560 570 580 590 600 GVGTRIQYSE VSLSPGNVIS DEPGYYEDGK FGIRIENIIM AREVETPYKF GDKPWLGFEH 610 620 630 640 650 VTMTPIGQNL IETSLLSKEE RQWVDNYHAE VWEKTSGFFK QDELTLNWLK KETQPLK

References

[1]

"Genome sequence of Talaromyces stipitatus strain ATCC 10500." Fedorova N.D., Joardar V.S., Maiti R., Schobel S., Amedeo P., Galens K., Inman J.M., Galinsky K.J., White O.R., Whitty B.R., Wortman J.R., Nierman W.C. Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006.

Cross-references

Sequence databases
EMBL GenBank DDBJ	EQ962655 Genomic DNA. Translation: EED18114.1.
RefSeq	XP_002482106.1. XM_002482061.1.
3D structure databases
ProteinModelPortal	B8M9W2.
ModBase	Search...
Protein family/group databases
MEROPS	M24.009.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	8108554.
Phylogenomic databases
OrthoDB	EOG45F0XX.
Family and domain databases
Gene3D	3.90.230.10. 1 hit.
InterPro	IPR000587. Creatinase. IPR000994. Pept_M24_structural-domain. [Graphical view]
Pfam	PF01321. Creatinase_N. 1 hit. PF00557. Peptidase_M24. 1 hit. [Graphical view]
SUPFAM	SSF55920. Peptidase_M24_cat_core. 1 hit.
PROSITE	PS00491. PROLINE_PEPTIDASE. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AMPP1_TALSN

Accession

Primary (citable) accession number: B8M9W2

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 27, 2011
Last sequence update:	March 3, 2009
Last modified:	March 6, 2013
This is version 24 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program