Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Pheromone-processing carboxypeptidase kex1

Gene

kex1

Organism
Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006) (Penicillium stipitatum)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death (By similarity).By similarity

Catalytic activityi

Preferential release of a C-terminal arginine or lysine residue.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei170 – 1701By similarity
Active sitei370 – 3701By similarity
Active sitei432 – 4321By similarity

GO - Molecular functioni

  1. serine-type carboxypeptidase activity Source: InterPro

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Protease

Keywords - Biological processi

Apoptosis

Protein family/group databases

MEROPSiS10.A67.

Names & Taxonomyi

Protein namesi
Recommended name:
Pheromone-processing carboxypeptidase kex1 (EC:3.4.16.6)
Alternative name(s):
Carboxypeptidase D
Gene namesi
Name:kex1
ORF Names:TSTA_034750
OrganismiTalaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006) (Penicillium stipitatum)
Taxonomic identifieri441959 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesTrichocomaceaeTalaromyces
ProteomesiUP000001745 Componenti: Unassembled WGS sequence

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini19 – 504486LumenalSequence AnalysisAdd
BLAST
Transmembranei505 – 52521HelicalSequence AnalysisAdd
BLAST
Topological domaini526 – 62499CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. Golgi apparatus Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence AnalysisAdd
BLAST
Chaini19 – 624606Pheromone-processing carboxypeptidase kex1PRO_0000411947Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi106 – 1061N-linked (GlcNAc...)Sequence Analysis
Glycosylationi421 – 4211N-linked (GlcNAc...)Sequence Analysis
Glycosylationi429 – 4291N-linked (GlcNAc...)Sequence Analysis
Glycosylationi478 – 4781N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S10 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

InParanoidiB8M719.
OrthoDBiEOG7TJ3SJ.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

B8M719-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLGKALLLLL SSPICALAQS AADYYVKSIP GQPDGPLLKM HAGHIEVDAQ
60 70 80 90 100
TNGHLFFWHF QNRHIANRQR TIIWLNGGPG CSSMDGALME IGPYRVKDDH
110 120 130 140 150
TLVYNNGSWD EFANLLFIDQ PVGTGFSYVN TNSFLHDLDH VSSHMVTFLD
160 170 180 190 200
KWFAMFPEYE SDDLYIAGES WAGQYIPHIA RAIVARNKNI DSKQQPWVLK
210 220 230 240 250
GLLIGNGWIS PLDQYPATMQ YAYAEGLVKE GSSTATSLDA MNDACAQKLA
260 270 280 290 300
DPGSQNMIRI GQCESVLDSL MRLTRTSEEE CVNMYDIRLK DASCGRTWPP
310 320 330 340 350
DLDPMTRYLQ RTEVRSALNL DREQTNSWTE CNDQVGFNLR LENPGVPAVH
360 370 380 390 400
LLPDLIESGV KILLFSGDRD LICNHLGTEQ LIHNMKWSGG TGFETKPGVW
410 420 430 440 450
APRRDWTFEG DAAGYYQQAR NLTYVLFYNA SHMVPYDWPR RTRDMVDRFI
460 470 480 490 500
NVDIANIGGT PADSRLDGEK LPQTSVGNTT SSTSESDQVD QEKLKDAEWK
510 520 530 540 550
AYAKSGEAAL IVVIIGVSVW GFFIWRARQR ASRGSSPSKK GYRSVYPGGS
560 570 580 590 600
NNTSSSDGAG LLSRFRNNTN NNASSDLEAR DFDEAELDSL SPGLQNARER
610 620
DHYVIGEEDE EDEDIGNGAK SSLH
Length:624
Mass (Da):69,578
Last modified:March 3, 2009 - v1
Checksum:i3E159C6AAC95C58F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EQ962654 Genomic DNA. Translation: EED20239.1.
RefSeqiXP_002480673.1. XM_002480628.1.

Genome annotation databases

GeneIDi8104317.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EQ962654 Genomic DNA. Translation: EED20239.1.
RefSeqiXP_002480673.1. XM_002480628.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiS10.A67.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi8104317.

Phylogenomic databases

InParanoidiB8M719.
OrthoDBiEOG7TJ3SJ.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of Talaromyces stipitatus strain ATCC 10500."
    Fedorova N.D., Joardar V.S., Maiti R., Schobel S., Amedeo P., Galens K., Inman J.M., Galinsky K.J., White O.R., Whitty B.R., Wortman J.R., Nierman W.C.
    Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006.

Entry informationi

Entry nameiKEX1_TALSN
AccessioniPrimary (citable) accession number: B8M719
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: March 3, 2009
Last modified: March 4, 2015
This is version 28 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.