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Protein

Pheromone-processing carboxypeptidase kex1

Gene

kex1

Organism
Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006) (Penicillium stipitatum)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death (By similarity).By similarity

Catalytic activityi

Preferential release of a C-terminal arginine or lysine residue.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei170By similarity1
Active sitei370By similarity1
Active sitei432By similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Protease

Keywords - Biological processi

Apoptosis

Protein family/group databases

ESTHERitalsn-kex1. Carboxypeptidase_S10.
MEROPSiS10.A67.

Names & Taxonomyi

Protein namesi
Recommended name:
Pheromone-processing carboxypeptidase kex1 (EC:3.4.16.6)
Alternative name(s):
Carboxypeptidase D
Gene namesi
Name:kex1
ORF Names:TSTA_034750
OrganismiTalaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006) (Penicillium stipitatum)
Taxonomic identifieri441959 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesTrichocomaceaeTalaromyces
Proteomesi
  • UP000001745 Componenti: Unassembled WGS sequence

Organism-specific databases

EuPathDBiFungiDB:TSTA_034750.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini19 – 504LumenalSequence analysisAdd BLAST486
Transmembranei505 – 525HelicalSequence analysisAdd BLAST21
Topological domaini526 – 624CytoplasmicSequence analysisAdd BLAST99

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000041194719 – 624Pheromone-processing carboxypeptidase kex1Add BLAST606

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi106N-linked (GlcNAc...)Sequence analysis1
Glycosylationi421N-linked (GlcNAc...)Sequence analysis1
Glycosylationi429N-linked (GlcNAc...)Sequence analysis1
Glycosylationi478N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi441959.XP_002480673.1.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S10 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1282. Eukaryota.
COG2939. LUCA.
InParanoidiB8M719.
OrthoDBiEOG092C255X.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

B8M719-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLGKALLLLL SSPICALAQS AADYYVKSIP GQPDGPLLKM HAGHIEVDAQ
60 70 80 90 100
TNGHLFFWHF QNRHIANRQR TIIWLNGGPG CSSMDGALME IGPYRVKDDH
110 120 130 140 150
TLVYNNGSWD EFANLLFIDQ PVGTGFSYVN TNSFLHDLDH VSSHMVTFLD
160 170 180 190 200
KWFAMFPEYE SDDLYIAGES WAGQYIPHIA RAIVARNKNI DSKQQPWVLK
210 220 230 240 250
GLLIGNGWIS PLDQYPATMQ YAYAEGLVKE GSSTATSLDA MNDACAQKLA
260 270 280 290 300
DPGSQNMIRI GQCESVLDSL MRLTRTSEEE CVNMYDIRLK DASCGRTWPP
310 320 330 340 350
DLDPMTRYLQ RTEVRSALNL DREQTNSWTE CNDQVGFNLR LENPGVPAVH
360 370 380 390 400
LLPDLIESGV KILLFSGDRD LICNHLGTEQ LIHNMKWSGG TGFETKPGVW
410 420 430 440 450
APRRDWTFEG DAAGYYQQAR NLTYVLFYNA SHMVPYDWPR RTRDMVDRFI
460 470 480 490 500
NVDIANIGGT PADSRLDGEK LPQTSVGNTT SSTSESDQVD QEKLKDAEWK
510 520 530 540 550
AYAKSGEAAL IVVIIGVSVW GFFIWRARQR ASRGSSPSKK GYRSVYPGGS
560 570 580 590 600
NNTSSSDGAG LLSRFRNNTN NNASSDLEAR DFDEAELDSL SPGLQNARER
610 620
DHYVIGEEDE EDEDIGNGAK SSLH
Length:624
Mass (Da):69,578
Last modified:March 3, 2009 - v1
Checksum:i3E159C6AAC95C58F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EQ962654 Genomic DNA. Translation: EED20239.1.
RefSeqiXP_002480673.1. XM_002480628.1.

Genome annotation databases

EnsemblFungiiEED20239; EED20239; TSTA_034750.
GeneIDi8104317.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EQ962654 Genomic DNA. Translation: EED20239.1.
RefSeqiXP_002480673.1. XM_002480628.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi441959.XP_002480673.1.

Protein family/group databases

ESTHERitalsn-kex1. Carboxypeptidase_S10.
MEROPSiS10.A67.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiEED20239; EED20239; TSTA_034750.
GeneIDi8104317.

Organism-specific databases

EuPathDBiFungiDB:TSTA_034750.

Phylogenomic databases

eggNOGiKOG1282. Eukaryota.
COG2939. LUCA.
InParanoidiB8M719.
OrthoDBiEOG092C255X.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiKEX1_TALSN
AccessioniPrimary (citable) accession number: B8M719
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: March 3, 2009
Last modified: September 7, 2016
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.