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B8M719 (KEX1_TALSN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 22. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Pheromone-processing carboxypeptidase kex1

EC=3.4.16.6
Alternative name(s):
Carboxypeptidase D
Gene names
Name:kex1
ORF Names:TSTA_034750
OrganismTalaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006) (Penicillium stipitatum) [Complete proteome]
Taxonomic identifier441959 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesTrichocomaceaeTalaromyces

Protein attributes

Sequence length624 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death By similarity.

Catalytic activity

Preferential release of a C-terminal arginine or lysine residue.

Subcellular location

Golgi apparatustrans-Golgi network membrane; Single-pass type I membrane protein By similarity.

Sequence similarities

Belongs to the peptidase S10 family.

Ontologies

Keywords
   Biological processApoptosis
   Cellular componentGolgi apparatus
Membrane
   DomainSignal
Transmembrane
Transmembrane helix
   Molecular functionCarboxypeptidase
Hydrolase
Protease
   PTMGlycoprotein
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processapoptotic process

Inferred from electronic annotation. Source: UniProtKB-KW

proteolysis

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentGolgi apparatus

Inferred from electronic annotation. Source: UniProtKB-SubCell

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionserine-type carboxypeptidase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1818 Potential
Chain19 – 624606Pheromone-processing carboxypeptidase kex1
PRO_0000411947

Regions

Topological domain19 – 504486Lumenal Potential
Transmembrane505 – 52521Helical; Potential
Topological domain526 – 62499Cytoplasmic Potential

Sites

Active site1701 By similarity
Active site3701 By similarity
Active site4321 By similarity

Amino acid modifications

Glycosylation1061N-linked (GlcNAc...) Potential
Glycosylation4211N-linked (GlcNAc...) Potential
Glycosylation4291N-linked (GlcNAc...) Potential
Glycosylation4781N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
B8M719 [UniParc].

Last modified March 3, 2009. Version 1.
Checksum: 3E159C6AAC95C58F

FASTA62469,578
        10         20         30         40         50         60 
MLGKALLLLL SSPICALAQS AADYYVKSIP GQPDGPLLKM HAGHIEVDAQ TNGHLFFWHF 

        70         80         90        100        110        120 
QNRHIANRQR TIIWLNGGPG CSSMDGALME IGPYRVKDDH TLVYNNGSWD EFANLLFIDQ 

       130        140        150        160        170        180 
PVGTGFSYVN TNSFLHDLDH VSSHMVTFLD KWFAMFPEYE SDDLYIAGES WAGQYIPHIA 

       190        200        210        220        230        240 
RAIVARNKNI DSKQQPWVLK GLLIGNGWIS PLDQYPATMQ YAYAEGLVKE GSSTATSLDA 

       250        260        270        280        290        300 
MNDACAQKLA DPGSQNMIRI GQCESVLDSL MRLTRTSEEE CVNMYDIRLK DASCGRTWPP 

       310        320        330        340        350        360 
DLDPMTRYLQ RTEVRSALNL DREQTNSWTE CNDQVGFNLR LENPGVPAVH LLPDLIESGV 

       370        380        390        400        410        420 
KILLFSGDRD LICNHLGTEQ LIHNMKWSGG TGFETKPGVW APRRDWTFEG DAAGYYQQAR 

       430        440        450        460        470        480 
NLTYVLFYNA SHMVPYDWPR RTRDMVDRFI NVDIANIGGT PADSRLDGEK LPQTSVGNTT 

       490        500        510        520        530        540 
SSTSESDQVD QEKLKDAEWK AYAKSGEAAL IVVIIGVSVW GFFIWRARQR ASRGSSPSKK 

       550        560        570        580        590        600 
GYRSVYPGGS NNTSSSDGAG LLSRFRNNTN NNASSDLEAR DFDEAELDSL SPGLQNARER 

       610        620 
DHYVIGEEDE EDEDIGNGAK SSLH 

« Hide

References

[1]"Genome sequence of Talaromyces stipitatus strain ATCC 10500."
Fedorova N.D., Joardar V.S., Maiti R., Schobel S., Amedeo P., Galens K., Inman J.M., Galinsky K.J., White O.R., Whitty B.R., Wortman J.R., Nierman W.C.
Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
EQ962654 Genomic DNA. Translation: EED20239.1.
RefSeqXP_002480673.1. XM_002480628.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein family/group databases

MEROPSS10.007.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID8104317.

Phylogenomic databases

OrthoDBEOG7TJ3SJ.

Family and domain databases

InterProIPR001563. Peptidase_S10.
[Graphical view]
PANTHERPTHR11802. PTHR11802. 1 hit.
PfamPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSPR00724. CRBOXYPTASEC.
ProtoNetSearch...

Entry information

Entry nameKEX1_TALSN
AccessionPrimary (citable) accession number: B8M719
Entry history
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: March 3, 2009
Last modified: February 19, 2014
This is version 22 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries