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B8M719

- KEX1_TALSN

UniProt

B8M719 - KEX1_TALSN

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Protein
Pheromone-processing carboxypeptidase kex1
Gene
kex1, TSTA_034750
Organism
Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006) (Penicillium stipitatum)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death By similarity.

Catalytic activityi

Preferential release of a C-terminal arginine or lysine residue.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei170 – 1701 By similarity
Active sitei370 – 3701 By similarity
Active sitei432 – 4321 By similarity

GO - Molecular functioni

  1. serine-type carboxypeptidase activity Source: InterPro

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Protease

Keywords - Biological processi

Apoptosis

Protein family/group databases

MEROPSiS10.007.

Names & Taxonomyi

Protein namesi
Recommended name:
Pheromone-processing carboxypeptidase kex1 (EC:3.4.16.6)
Alternative name(s):
Carboxypeptidase D
Gene namesi
Name:kex1
ORF Names:TSTA_034750
OrganismiTalaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006) (Penicillium stipitatum)
Taxonomic identifieri441959 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesTrichocomaceaeTalaromyces
ProteomesiUP000001745: Unassembled WGS sequence

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini19 – 504486Lumenal Reviewed prediction
Add
BLAST
Transmembranei505 – 52521Helical; Reviewed prediction
Add
BLAST
Topological domaini526 – 62499Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. Golgi apparatus Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818 Reviewed prediction
Add
BLAST
Chaini19 – 624606Pheromone-processing carboxypeptidase kex1
PRO_0000411947Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi106 – 1061N-linked (GlcNAc...) Reviewed prediction
Glycosylationi421 – 4211N-linked (GlcNAc...) Reviewed prediction
Glycosylationi429 – 4291N-linked (GlcNAc...) Reviewed prediction
Glycosylationi478 – 4781N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S10 family.

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

OrthoDBiEOG7TJ3SJ.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

B8M719-1 [UniParc]FASTAAdd to Basket

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MLGKALLLLL SSPICALAQS AADYYVKSIP GQPDGPLLKM HAGHIEVDAQ    50
TNGHLFFWHF QNRHIANRQR TIIWLNGGPG CSSMDGALME IGPYRVKDDH 100
TLVYNNGSWD EFANLLFIDQ PVGTGFSYVN TNSFLHDLDH VSSHMVTFLD 150
KWFAMFPEYE SDDLYIAGES WAGQYIPHIA RAIVARNKNI DSKQQPWVLK 200
GLLIGNGWIS PLDQYPATMQ YAYAEGLVKE GSSTATSLDA MNDACAQKLA 250
DPGSQNMIRI GQCESVLDSL MRLTRTSEEE CVNMYDIRLK DASCGRTWPP 300
DLDPMTRYLQ RTEVRSALNL DREQTNSWTE CNDQVGFNLR LENPGVPAVH 350
LLPDLIESGV KILLFSGDRD LICNHLGTEQ LIHNMKWSGG TGFETKPGVW 400
APRRDWTFEG DAAGYYQQAR NLTYVLFYNA SHMVPYDWPR RTRDMVDRFI 450
NVDIANIGGT PADSRLDGEK LPQTSVGNTT SSTSESDQVD QEKLKDAEWK 500
AYAKSGEAAL IVVIIGVSVW GFFIWRARQR ASRGSSPSKK GYRSVYPGGS 550
NNTSSSDGAG LLSRFRNNTN NNASSDLEAR DFDEAELDSL SPGLQNARER 600
DHYVIGEEDE EDEDIGNGAK SSLH 624
Length:624
Mass (Da):69,578
Last modified:March 3, 2009 - v1
Checksum:i3E159C6AAC95C58F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
EQ962654 Genomic DNA. Translation: EED20239.1.
RefSeqiXP_002480673.1. XM_002480628.1.

Genome annotation databases

GeneIDi8104317.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
EQ962654 Genomic DNA. Translation: EED20239.1 .
RefSeqi XP_002480673.1. XM_002480628.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi S10.007.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 8104317.

Phylogenomic databases

OrthoDBi EOG7TJ3SJ.

Family and domain databases

Gene3Di 3.40.50.1820. 1 hit.
InterProi IPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
[Graphical view ]
PANTHERi PTHR11802. PTHR11802. 1 hit.
Pfami PF00450. Peptidase_S10. 1 hit.
[Graphical view ]
PRINTSi PR00724. CRBOXYPTASEC.
SUPFAMi SSF53474. SSF53474. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of Talaromyces stipitatus strain ATCC 10500."
    Fedorova N.D., Joardar V.S., Maiti R., Schobel S., Amedeo P., Galens K., Inman J.M., Galinsky K.J., White O.R., Whitty B.R., Wortman J.R., Nierman W.C.
    Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006.

Entry informationi

Entry nameiKEX1_TALSN
AccessioniPrimary (citable) accession number: B8M719
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: March 3, 2009
Last modified: June 11, 2014
This is version 24 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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