B8M2W9 (AMPP2_TALSN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable Xaa-Pro aminopeptidase TSTA_094700
EC=3.4.11.9

Alternative name(s):
Aminoacylproline aminopeptidase
Prolidase

Gene names

ORF Names:

TSTA_094700

Organism

Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006) (Penicillium stipitatum) [Complete proteome]

Taxonomic identifier

441959 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Pezizomycotina › leotiomyceta › Eurotiomycetes › Eurotiomycetidae › Eurotiales › Trichocomaceae › Talaromyces › Talaromyces stipitatus

Protein attributes

Sequence length	503 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides By similarity.
Catalytic activity	Release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide.
Cofactor	Binds 2 manganese ions per subunit By similarity.
Sequence similarities	Belongs to the peptidase M24B family.

Ontologies

Keywords
Ligand	Manganese Metal-binding
Molecular function	Aminopeptidase Hydrolase Metalloprotease Protease
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	cellular process Inferred from electronic annotation. Source: InterPro proteolysis Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	aminopeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW manganese ion binding Inferred from electronic annotation. Source: InterPro metallopeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 503	503	Probable Xaa-Pro aminopeptidase TSTA_094700		PRO_0000411853
Sites
	Metal binding	277	1	Manganese 2 By similarity
	Metal binding	288	1	Manganese 1 By similarity
	Metal binding	288	1	Manganese 2 By similarity
	Metal binding	428	1	Manganese 1 By similarity
	Metal binding	467	1	Manganese 1 By similarity
	Metal binding	467	1	Manganese 2 By similarity

Sequences

	Sequence		Length	Mass (Da)
	B8M2W9 [UniParc]. Last modified March 3, 2009. Version 1. Checksum: 670A4356FAFBA5D8	FASTA	503	55,848
	10 20 30 40 50 60 MSPSPALHAA AFQGIGAPDI QRFHINLSVG SNVNRYPAKQ HARKVASKLG ISRGLIYLVG 70 80 90 100 110 120 KPTVFLDDSD QTIPFRQRRY FYYLSGANEP DCHLTYDIAK DHLTLYVPDF DLRQTVWMGP 130 140 150 160 170 180 TISIGEALDR YDIDNARYAG SLQTDISGWL RLRGDDSQII LLHPDHRPPI EYEQDLFETK 190 200 210 220 230 240 NLVPAMNAAR GVKDSYEIEM IRKANIVSGL AHTAVLEKIG QMTNESDIAG LFLETCMTHG 250 260 270 280 290 300 APDQAYGIIA ASGENGATLH YMKNNEDFGN RLSVCLDAGA EYECYASDVT RTFPISRTGE 310 320 330 340 350 360 WPTPEVRDIY LAVERMQEEC IRLIKPGVRF RDVHLHASRV AVEELLKLGV FQKDNSVDAI 370 380 390 400 410 420 MASGAVSVFF PHGLGHHVGL EVHDVAEQSV MAATDDSSPR TRVRGFLMQP ASAMSAALLE 430 440 450 460 470 480 ESMIVTVEPG IYFNRLALKN ARTLPIARFI DFDVVERYYP IGGVRIEDDI LVTATGYENL 490 500 TTAPKGEEAL DIIRRSSVKS SRA

References

[1]

"Genome sequence of Talaromyces stipitatus strain ATCC 10500." Fedorova N.D., Joardar V.S., Maiti R., Schobel S., Amedeo P., Galens K., Inman J.M., Galinsky K.J., White O.R., Whitty B.R., Wortman J.R., Nierman W.C. Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006.

Cross-references

Sequence databases
EMBL GenBank DDBJ	EQ962653 Genomic DNA. Translation: EED22224.1.
RefSeq	XP_002479187.1. XM_002479142.1.
3D structure databases
ProteinModelPortal	B8M2W9.
ModBase	Search...
Protein family/group databases
MEROPS	M24.A09.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	8103800.
Phylogenomic databases
OrthoDB	EOG4897VR.
Family and domain databases
Gene3D	3.90.230.10. 1 hit.
InterPro	IPR007865. Aminopep_P_N. IPR000994. Pept_M24_structural-domain. IPR001131. Peptidase_M24B_aminopep-P_CS. [Graphical view]
Pfam	PF05195. AMP_N. 1 hit. PF00557. Peptidase_M24. 1 hit. [Graphical view]
SMART	SM01011. AMP_N. 1 hit. [Graphical view]
SUPFAM	SSF55920. Peptidase_M24_cat_core. 1 hit.
PROSITE	PS00491. PROLINE_PEPTIDASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AMPP2_TALSN

Accession

Primary (citable) accession number: B8M2W9

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 27, 2011
Last sequence update:	March 3, 2009
Last modified:	March 6, 2013
This is version 25 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program