B8M0Z4 (AMPP3_TALSN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable Xaa-Pro aminopeptidase pepP
EC=3.4.11.9

Alternative name(s):
Aminoacylproline aminopeptidase
Prolidase

Gene names

Name:	pepP
ORF Names:	TSTA_090130

Organism

Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006) (Penicillium stipitatum) [Complete proteome]

Taxonomic identifier

441959 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Pezizomycotina › leotiomyceta › Eurotiomycetes › Eurotiomycetidae › Eurotiales › Trichocomaceae › Talaromyces › Talaromyces stipitatus

Protein attributes

Sequence length	468 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides By similarity.
Catalytic activity	Release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide.
Cofactor	Binds 2 manganese ions per subunit By similarity.
Sequence similarities	Belongs to the peptidase M24B family.

Ontologies

Keywords
Ligand	Manganese Metal-binding
Molecular function	Aminopeptidase Hydrolase Metalloprotease Protease
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	cellular process Inferred from electronic annotation. Source: InterPro proteolysis Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	aminopeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW manganese ion binding Inferred from electronic annotation. Source: InterPro metallopeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 468	468	Probable Xaa-Pro aminopeptidase pepP		PRO_0000411890
Sites
	Metal binding	264	1	Manganese 2 By similarity
	Metal binding	275	1	Manganese 1 By similarity
	Metal binding	275	1	Manganese 2 By similarity
	Metal binding	398	1	Manganese 1 By similarity
	Metal binding	438	1	Manganese 1 By similarity
	Metal binding	438	1	Manganese 2 By similarity

Sequences

	Sequence		Length	Mass (Da)
	B8M0Z4 [UniParc]. Last modified March 3, 2009. Version 1. Checksum: 428A6E4138641D19	FASTA	468	52,215
	10 20 30 40 50 60 MTSTEGILAG KYPAKAHARR VVEYLRQNGF EGDGVLYLEA QKTKMIEDND SEQPFRQRRF 70 80 90 100 110 120 FFYLSGCLLP DAHLTYHISS DKLALFIPPL DPESVIWSGL PLSPTQAKEL YDVDEVLYTT 130 140 150 160 170 180 DINPTLAHLA SEVGTSGFVF AIDGQISDDI SFKNFPETDL VALKTAIEEC RVVKDAYEVA 190 200 210 220 230 240 MIRKANDVTA QAHVAVLKAT KSATNERELE AAFIGTCIAH GCREMAYHPI VASGTSSATL 250 260 270 280 290 300 HYVNNDEPLI DLTTNKKKLN LLLDAAGEYK TYCADVTRTF PLSGKFSPES RQIYDIVLEM 310 320 330 340 350 360 QTKSLAMLKE GVLWEDVHVT AHRVAIKGLL KLGILRGSEE ELLEKRISVA FFPHGLGHYL 370 380 390 400 410 420 GMDTHDTGGH ANYADKDKMF RYLRVRGKLP AGSVITVEPG VYFCRFIIEP YLKDSELSKY 430 440 450 460 IDADVLEKYW EVGGVRIEDN IHITKEGYDN LTTAPKTADQ LELMINGS

References

[1]

"Genome sequence of Talaromyces stipitatus strain ATCC 10500." Fedorova N.D., Joardar V.S., Maiti R., Schobel S., Amedeo P., Galens K., Inman J.M., Galinsky K.J., White O.R., Whitty B.R., Wortman J.R., Nierman W.C. Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006.

Cross-references

Sequence databases
EMBL GenBank DDBJ	EQ962653 Genomic DNA. Translation: EED21774.1.
RefSeq	XP_002478737.1. XM_002478692.1.
3D structure databases
ProteinModelPortal	B8M0Z4.
ModBase	Search...
Protein family/group databases
MEROPS	M24.A09.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	8108101.
Phylogenomic databases
OrthoDB	EOG4J40RD.
Family and domain databases
Gene3D	3.90.230.10. 1 hit.
InterPro	IPR007865. Aminopep_P_N. IPR000994. Pept_M24_structural-domain. [Graphical view]
Pfam	PF05195. AMP_N. 1 hit. PF00557. Peptidase_M24. 1 hit. [Graphical view]
SMART	SM01011. AMP_N. 1 hit. [Graphical view]
SUPFAM	SSF55920. Peptidase_M24_cat_core. 1 hit.
PROSITE	PS00491. PROLINE_PEPTIDASE. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AMPP3_TALSN

Accession

Primary (citable) accession number: B8M0Z4

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 27, 2011
Last sequence update:	March 3, 2009
Last modified:	March 6, 2013
This is version 25 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program