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B8M044 (CBPYA_TALSN) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 27. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Carboxypeptidase Y homolog A

EC=3.4.16.5
Gene names
Name:cpyA
ORF Names:TSTA_083730
OrganismTalaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006) (Penicillium stipitatum) [Complete proteome]
Taxonomic identifier441959 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesTrichocomaceaeTalaromyces

Protein attributes

Sequence length553 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Vacuolar carboxypeptidase involved in degradation of small peptides. Digests preferentially peptides containing an aliphatic or hydrophobic residue in P1' position, as well as methionine, leucine or phenylalanine in P1 position of ester substrate By similarity.

Catalytic activity

Release of a C-terminal amino acid with broad specificity.

Subcellular location

Vacuole By similarity.

Sequence similarities

Belongs to the peptidase S10 family.

Ontologies

Keywords
   Cellular componentVacuole
   DomainSignal
   Molecular functionCarboxypeptidase
Hydrolase
Protease
   PTMDisulfide bond
Glycoprotein
Zymogen
   Technical termComplete proteome
Gene Ontology (GO)
   Cellular_componentvacuole

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionserine-type carboxypeptidase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1717 Potential
Propeptide18 – 134117 By similarity
PRO_0000407480
Chain135 – 553419Carboxypeptidase Y homolog A
PRO_0000407481

Sites

Active site2761 By similarity
Active site4671 By similarity
Active site5291 By similarity

Amino acid modifications

Glycosylation2201N-linked (GlcNAc...) Potential
Glycosylation5181N-linked (GlcNAc...) Potential
Disulfide bond189 ↔ 428 By similarity
Disulfide bond323 ↔ 337 By similarity
Disulfide bond347 ↔ 370 By similarity
Disulfide bond354 ↔ 363 By similarity
Disulfide bond392 ↔ 398 By similarity

Sequences

Sequence LengthMass (Da)Tools
B8M044 [UniParc].

Last modified March 3, 2009. Version 1.
Checksum: A1EB9702FD8701F4

FASTA55361,898
        10         20         30         40         50         60 
MRVLSTTLLI GAAAAAVSPP QQVLQAPEEA VENTHKSSPS LAESLSQPLR ELKEELKLLT 

        70         80         90        100        110        120 
NEVEEVWEEV SNIFPGALDN IFFSSAKKHT RRPDSHWDHI IRGSDVQNIW VENENGEKER 

       130        140        150        160        170        180 
EVGGRLEAFD LRVKAVDPSS LGIDPDVKQY SGYLDDNEND KHLFYWFFES RNDPKTDPVV 

       190        200        210        220        230        240 
LWLNGGPGCS SLTGLFFELG PSSIGKNIKP IYNPYSWNSN TSVIFLDQPV NVGFSYSGNS 

       250        260        270        280        290        300 
VSETSAAAKD VYALLTLFFK QFPEYSSQDF HIAGESYAGH YIPSFASEIL SHKKRNINLK 

       310        320        330        340        350        360 
SVLIGNGLTD GLTQYEYYRP MACGDGGYPA VLDETTCRSM DNALGRCQSM IQSCYDSESA 

       370        380        390        400        410        420 
WTCVPASIYC NNALLGPYQR TGQNVYDVRK PCEDSSLCYA DLEYVSTYLN QAEVMKALGA 

       430        440        450        460        470        480 
EVDSFDSCNF DINRNFLFKG DWMKPFHKLV PGLLEEIPVL IYAGDADFIC NWLGNKAWTD 

       490        500        510        520        530        540 
ALEWAGHEEY AATELEDLEI VDNKHKGKKI GQVKSSGNLT FMRLFGGGHM VPYDQPEASL 

       550 
EFFNRWIGGE WTK 

« Hide

References

[1]"Genome sequence of Talaromyces stipitatus strain ATCC 10500."
Fedorova N.D., Joardar V.S., Maiti R., Schobel S., Amedeo P., Galens K., Inman J.M., Galinsky K.J., White O.R., Whitty B.R., Wortman J.R., Nierman W.C.
Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
EQ962653 Genomic DNA. Translation: EED21141.1.
RefSeqXP_002478104.1. XM_002478059.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein family/group databases

MEROPSS10.001.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID8101466.

Phylogenomic databases

OrthoDBEOG7XDBR1.

Family and domain databases

Gene3D3.40.50.1820. 2 hits.
InterProIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
IPR008442. Propeptide_carboxypepY.
[Graphical view]
PANTHERPTHR11802. PTHR11802. 1 hit.
PfamPF05388. Carbpep_Y_N. 1 hit.
PF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSPR00724. CRBOXYPTASEC.
SUPFAMSSF53474. SSF53474. 1 hit.
PROSITEPS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCBPYA_TALSN
AccessionPrimary (citable) accession number: B8M044
Entry history
Integrated into UniProtKB/Swiss-Prot: May 3, 2011
Last sequence update: March 3, 2009
Last modified: June 11, 2014
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries