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Protein

Carboxypeptidase Y homolog A

Gene

cpyA

Organism
Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006) (Penicillium stipitatum)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Vacuolar carboxypeptidase involved in degradation of small peptides. Digests preferentially peptides containing an aliphatic or hydrophobic residue in P1' position, as well as methionine, leucine or phenylalanine in P1 position of ester substrate (By similarity).By similarity

Catalytic activityi

Release of a C-terminal amino acid with broad specificity.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei276 – 2761PROSITE-ProRule annotation
Active sitei467 – 4671PROSITE-ProRule annotation
Active sitei529 – 5291PROSITE-ProRule annotation

GO - Molecular functioni

  1. serine-type carboxypeptidase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Protease

Protein family/group databases

MEROPSiS10.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Carboxypeptidase Y homolog A (EC:3.4.16.5)
Gene namesi
Name:cpyA
ORF Names:TSTA_083730
OrganismiTalaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006) (Penicillium stipitatum)
Taxonomic identifieri441959 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesTrichocomaceaeTalaromyces
ProteomesiUP000001745 Componenti: Unassembled WGS sequence

Organism-specific databases

EuPathDBiFungiDB:TSTA_083730.

Subcellular locationi

  1. Vacuole By similarity

GO - Cellular componenti

  1. vacuole Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717Sequence AnalysisAdd
BLAST
Propeptidei18 – 134117By similarityPRO_0000407480Add
BLAST
Chaini135 – 553419Carboxypeptidase Y homolog APRO_0000407481Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi189 ↔ 428By similarity
Glycosylationi220 – 2201N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi323 ↔ 337By similarity
Disulfide bondi347 ↔ 370By similarity
Disulfide bondi354 ↔ 363By similarity
Disulfide bondi392 ↔ 398By similarity
Glycosylationi518 – 5181N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S10 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

InParanoidiB8M044.
OrthoDBiEOG7XDBR1.

Family and domain databases

Gene3Di3.40.50.1820. 2 hits.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
IPR008442. Propeptide_carboxypepY.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF05388. Carbpep_Y_N. 1 hit.
PF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

B8M044-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRVLSTTLLI GAAAAAVSPP QQVLQAPEEA VENTHKSSPS LAESLSQPLR
60 70 80 90 100
ELKEELKLLT NEVEEVWEEV SNIFPGALDN IFFSSAKKHT RRPDSHWDHI
110 120 130 140 150
IRGSDVQNIW VENENGEKER EVGGRLEAFD LRVKAVDPSS LGIDPDVKQY
160 170 180 190 200
SGYLDDNEND KHLFYWFFES RNDPKTDPVV LWLNGGPGCS SLTGLFFELG
210 220 230 240 250
PSSIGKNIKP IYNPYSWNSN TSVIFLDQPV NVGFSYSGNS VSETSAAAKD
260 270 280 290 300
VYALLTLFFK QFPEYSSQDF HIAGESYAGH YIPSFASEIL SHKKRNINLK
310 320 330 340 350
SVLIGNGLTD GLTQYEYYRP MACGDGGYPA VLDETTCRSM DNALGRCQSM
360 370 380 390 400
IQSCYDSESA WTCVPASIYC NNALLGPYQR TGQNVYDVRK PCEDSSLCYA
410 420 430 440 450
DLEYVSTYLN QAEVMKALGA EVDSFDSCNF DINRNFLFKG DWMKPFHKLV
460 470 480 490 500
PGLLEEIPVL IYAGDADFIC NWLGNKAWTD ALEWAGHEEY AATELEDLEI
510 520 530 540 550
VDNKHKGKKI GQVKSSGNLT FMRLFGGGHM VPYDQPEASL EFFNRWIGGE

WTK
Length:553
Mass (Da):61,898
Last modified:March 3, 2009 - v1
Checksum:iA1EB9702FD8701F4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EQ962653 Genomic DNA. Translation: EED21141.1.
RefSeqiXP_002478104.1. XM_002478059.1.

Genome annotation databases

GeneIDi8101466.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EQ962653 Genomic DNA. Translation: EED21141.1.
RefSeqiXP_002478104.1. XM_002478059.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiS10.001.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi8101466.

Organism-specific databases

EuPathDBiFungiDB:TSTA_083730.

Phylogenomic databases

InParanoidiB8M044.
OrthoDBiEOG7XDBR1.

Family and domain databases

Gene3Di3.40.50.1820. 2 hits.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
IPR008442. Propeptide_carboxypepY.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF05388. Carbpep_Y_N. 1 hit.
PF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of Talaromyces stipitatus strain ATCC 10500."
    Fedorova N.D., Joardar V.S., Maiti R., Schobel S., Amedeo P., Galens K., Inman J.M., Galinsky K.J., White O.R., Whitty B.R., Wortman J.R., Nierman W.C.
    Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006.

Entry informationi

Entry nameiCBPYA_TALSN
AccessioniPrimary (citable) accession number: B8M044
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 3, 2011
Last sequence update: March 3, 2009
Last modified: April 29, 2015
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.