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B8M044

- CBPYA_TALSN

UniProt

B8M044 - CBPYA_TALSN

Protein

Carboxypeptidase Y homolog A

Gene

cpyA

Organism
Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006) (Penicillium stipitatum)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 28 (01 Oct 2014)
      Sequence version 1 (03 Mar 2009)
      Previous versions | rss
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    Functioni

    Vacuolar carboxypeptidase involved in degradation of small peptides. Digests preferentially peptides containing an aliphatic or hydrophobic residue in P1' position, as well as methionine, leucine or phenylalanine in P1 position of ester substrate By similarity.By similarity

    Catalytic activityi

    Release of a C-terminal amino acid with broad specificity.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei276 – 2761PROSITE-ProRule annotation
    Active sitei467 – 4671PROSITE-ProRule annotation
    Active sitei529 – 5291PROSITE-ProRule annotation

    GO - Molecular functioni

    1. serine-type carboxypeptidase activity Source: InterPro

    Keywords - Molecular functioni

    Carboxypeptidase, Hydrolase, Protease

    Protein family/group databases

    MEROPSiS10.001.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Carboxypeptidase Y homolog A (EC:3.4.16.5)
    Gene namesi
    Name:cpyA
    ORF Names:TSTA_083730
    OrganismiTalaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006) (Penicillium stipitatum)
    Taxonomic identifieri441959 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesTrichocomaceaeTalaromyces
    ProteomesiUP000001745: Unassembled WGS sequence

    Subcellular locationi

    Vacuole By similarity

    GO - Cellular componenti

    1. vacuole Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Vacuole

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1717Sequence AnalysisAdd
    BLAST
    Propeptidei18 – 134117By similarityPRO_0000407480Add
    BLAST
    Chaini135 – 553419Carboxypeptidase Y homolog APRO_0000407481Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi189 ↔ 428By similarity
    Glycosylationi220 – 2201N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi323 ↔ 337By similarity
    Disulfide bondi347 ↔ 370By similarity
    Disulfide bondi354 ↔ 363By similarity
    Disulfide bondi392 ↔ 398By similarity
    Glycosylationi518 – 5181N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Zymogen

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase S10 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    OrthoDBiEOG7XDBR1.

    Family and domain databases

    Gene3Di3.40.50.1820. 2 hits.
    InterProiIPR029058. AB_hydrolase.
    IPR001563. Peptidase_S10.
    IPR018202. Peptidase_S10_AS.
    IPR008442. Propeptide_carboxypepY.
    [Graphical view]
    PANTHERiPTHR11802. PTHR11802. 1 hit.
    PfamiPF05388. Carbpep_Y_N. 1 hit.
    PF00450. Peptidase_S10. 1 hit.
    [Graphical view]
    PRINTSiPR00724. CRBOXYPTASEC.
    SUPFAMiSSF53474. SSF53474. 1 hit.
    PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    B8M044-1 [UniParc]FASTAAdd to Basket

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    MRVLSTTLLI GAAAAAVSPP QQVLQAPEEA VENTHKSSPS LAESLSQPLR    50
    ELKEELKLLT NEVEEVWEEV SNIFPGALDN IFFSSAKKHT RRPDSHWDHI 100
    IRGSDVQNIW VENENGEKER EVGGRLEAFD LRVKAVDPSS LGIDPDVKQY 150
    SGYLDDNEND KHLFYWFFES RNDPKTDPVV LWLNGGPGCS SLTGLFFELG 200
    PSSIGKNIKP IYNPYSWNSN TSVIFLDQPV NVGFSYSGNS VSETSAAAKD 250
    VYALLTLFFK QFPEYSSQDF HIAGESYAGH YIPSFASEIL SHKKRNINLK 300
    SVLIGNGLTD GLTQYEYYRP MACGDGGYPA VLDETTCRSM DNALGRCQSM 350
    IQSCYDSESA WTCVPASIYC NNALLGPYQR TGQNVYDVRK PCEDSSLCYA 400
    DLEYVSTYLN QAEVMKALGA EVDSFDSCNF DINRNFLFKG DWMKPFHKLV 450
    PGLLEEIPVL IYAGDADFIC NWLGNKAWTD ALEWAGHEEY AATELEDLEI 500
    VDNKHKGKKI GQVKSSGNLT FMRLFGGGHM VPYDQPEASL EFFNRWIGGE 550
    WTK 553
    Length:553
    Mass (Da):61,898
    Last modified:March 3, 2009 - v1
    Checksum:iA1EB9702FD8701F4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    EQ962653 Genomic DNA. Translation: EED21141.1.
    RefSeqiXP_002478104.1. XM_002478059.1.

    Genome annotation databases

    GeneIDi8101466.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    EQ962653 Genomic DNA. Translation: EED21141.1 .
    RefSeqi XP_002478104.1. XM_002478059.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi S10.001.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 8101466.

    Phylogenomic databases

    OrthoDBi EOG7XDBR1.

    Family and domain databases

    Gene3Di 3.40.50.1820. 2 hits.
    InterProi IPR029058. AB_hydrolase.
    IPR001563. Peptidase_S10.
    IPR018202. Peptidase_S10_AS.
    IPR008442. Propeptide_carboxypepY.
    [Graphical view ]
    PANTHERi PTHR11802. PTHR11802. 1 hit.
    Pfami PF05388. Carbpep_Y_N. 1 hit.
    PF00450. Peptidase_S10. 1 hit.
    [Graphical view ]
    PRINTSi PR00724. CRBOXYPTASEC.
    SUPFAMi SSF53474. SSF53474. 1 hit.
    PROSITEi PS00131. CARBOXYPEPT_SER_SER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of Talaromyces stipitatus strain ATCC 10500."
      Fedorova N.D., Joardar V.S., Maiti R., Schobel S., Amedeo P., Galens K., Inman J.M., Galinsky K.J., White O.R., Whitty B.R., Wortman J.R., Nierman W.C.
      Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006.

    Entry informationi

    Entry nameiCBPYA_TALSN
    AccessioniPrimary (citable) accession number: B8M044
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 3, 2011
    Last sequence update: March 3, 2009
    Last modified: October 1, 2014
    This is version 28 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3