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B8LWT1 (DPEP2_TALSN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 22. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein attributes

Sequence length470 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Hydrolyzes a wide range of dipeptides By similarity.

Catalytic activity

Hydrolysis of dipeptides.

Cofactor

Zinc By similarity.

Subcellular location

Membrane; Single-pass membrane protein Potential.

Sequence similarities

Belongs to the peptidase M19 family.

Ontologies

Keywords
   Cellular componentMembrane
   DomainTransmembrane
Transmembrane helix
   LigandMetal-binding
Zinc
   Molecular functionDipeptidase
Hydrolase
Metalloprotease
Protease
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processproteolysis

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functiondipeptidase activity

Inferred from electronic annotation. Source: UniProtKB-KW

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

metallopeptidase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 470470Putative dipeptidase TSTA_079200
PRO_0000411219

Regions

Transmembrane40 – 6021Helical; Potential

Sites

Metal binding921Zinc 1; catalytic By similarity
Metal binding941Zinc 1; catalytic By similarity
Metal binding2081Zinc 1; catalytic By similarity
Metal binding2081Zinc 2; catalytic By similarity
Metal binding2791Zinc 2; catalytic By similarity
Metal binding3001Zinc 2; catalytic By similarity
Binding site2351Substrate By similarity
Binding site3111Substrate By similarity
Binding site3711Substrate By similarity

Amino acid modifications

Glycosylation1881N-linked (GlcNAc...) Potential
Disulfide bond143 ↔ 237 By similarity

Sequences

Sequence LengthMass (Da)Tools
B8LWT1 [UniParc].

Last modified March 3, 2009. Version 1.
Checksum: EA8D2B1EAA5F4B18

FASTA47052,221
        10         20         30         40         50         60 
MATLNTRGND IALNILSSTT ESSQAVVLSR ARGSPNSQRA WLFGLGTLGI ILASVLLNPF 

        70         80         90        100        110        120 
TSTQESPLNI DPTDYAARTK HILSTTPLID GHNDLPYLIR TELKHQIYND RFTFNTGLLS 

       130        140        150        160        170        180 
NTDRKKLRDG MVGGQFWSAY IHCPKDSETN KDVPLDEATW TLRDTLEQID ITKRFVDEFP 

       190        200        210        220        230        240 
DLFQFCSNSS CAREAFANGK IGSFIGIEGA HQIGNSLASL RQLYDLGARY ITTTHNCDNV 

       250        260        270        280        290        300 
FGTAASTVSA GGEDKGLTLF GEEYVAEMNR LGMMLDLSHV SHETMRDTLR LSEAPVIFSH 

       310        320        330        340        350        360 
TGAYALSKTL RFAPDDVLKA TAEKGGIIMI TFINRFLRPD DPDAATIHDV VDHIWHVAQV 

       370        380        390        400        410        420 
AGWDHVGVGS DFDGTPVTPR GLEDVSKYPR LVELLMERGA TDDQIRKFAG DNILRVWSEV 

       430        440        450        460        470 
EKAAERIQVE GRKPNEAIWE GRTWVRSEMS PPIMFRDSIG RRIPSYLGEP 

« Hide

References

[1]"Genome sequence of Talaromyces stipitatus strain ATCC 10500."
Fedorova N.D., Joardar V.S., Maiti R., Schobel S., Amedeo P., Galens K., Inman J.M., Galinsky K.J., White O.R., Whitty B.R., Wortman J.R., Nierman W.C.
Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
EQ962652 Genomic DNA. Translation: EED24564.1.
RefSeqXP_002341951.1. XM_002341910.1.

3D structure databases

ProteinModelPortalB8LWT1.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID8105978.

Phylogenomic databases

OrthoDBEOG7XM371.

Family and domain databases

InterProIPR028536. Dpep1-like.
IPR008257. Renal_dipep_fam.
[Graphical view]
PANTHERPTHR10443. PTHR10443. 1 hit.
PTHR10443:SF12. PTHR10443:SF12. 1 hit.
PfamPF01244. Peptidase_M19. 1 hit.
[Graphical view]
PROSITEPS51365. RENAL_DIPEPTIDASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDPEP2_TALSN
AccessionPrimary (citable) accession number: B8LWT1
Entry history
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: March 3, 2009
Last modified: February 19, 2014
This is version 22 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries