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B8LWT1

- DPEP2_TALSN

UniProt

B8LWT1 - DPEP2_TALSN

Protein

Putative dipeptidase TSTA_079200

Gene

TSTA_079200

Organism
Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006) (Penicillium stipitatum)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 25 (01 Oct 2014)
      Sequence version 1 (03 Mar 2009)
      Previous versions | rss
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    Functioni

    Hydrolyzes a wide range of dipeptides.By similarity

    Catalytic activityi

    Hydrolysis of dipeptides.PROSITE-ProRule annotation

    Cofactori

    Zinc.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi92 – 921Zinc 1; catalyticPROSITE-ProRule annotation
    Metal bindingi94 – 941Zinc 1; catalyticPROSITE-ProRule annotation
    Metal bindingi208 – 2081Zinc 1; catalyticPROSITE-ProRule annotation
    Metal bindingi208 – 2081Zinc 2; catalyticPROSITE-ProRule annotation
    Binding sitei235 – 2351SubstratePROSITE-ProRule annotation
    Metal bindingi279 – 2791Zinc 2; catalyticPROSITE-ProRule annotation
    Metal bindingi300 – 3001Zinc 2; catalyticPROSITE-ProRule annotation
    Binding sitei311 – 3111SubstratePROSITE-ProRule annotation
    Binding sitei371 – 3711SubstratePROSITE-ProRule annotation

    GO - Molecular functioni

    1. dipeptidase activity Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW
    3. metallopeptidase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Dipeptidase, Hydrolase, Metalloprotease, Protease

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative dipeptidase TSTA_079200 (EC:3.4.13.19)
    Gene namesi
    ORF Names:TSTA_079200
    OrganismiTalaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006) (Penicillium stipitatum)
    Taxonomic identifieri441959 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesTrichocomaceaeTalaromyces
    ProteomesiUP000001745: Unassembled WGS sequence

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 470470Putative dipeptidase TSTA_079200PRO_0000411219Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi143 ↔ 237PROSITE-ProRule annotation
    Glycosylationi188 – 1881N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Structurei

    3D structure databases

    ProteinModelPortaliB8LWT1.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei40 – 6021HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase M19 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    OrthoDBiEOG7XM371.

    Family and domain databases

    InterProiIPR008257. Renal_dipep_fam.
    [Graphical view]
    PANTHERiPTHR10443. PTHR10443. 1 hit.
    PfamiPF01244. Peptidase_M19. 1 hit.
    [Graphical view]
    PROSITEiPS51365. RENAL_DIPEPTIDASE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B8LWT1-1 [UniParc]FASTAAdd to Basket

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    MATLNTRGND IALNILSSTT ESSQAVVLSR ARGSPNSQRA WLFGLGTLGI    50
    ILASVLLNPF TSTQESPLNI DPTDYAARTK HILSTTPLID GHNDLPYLIR 100
    TELKHQIYND RFTFNTGLLS NTDRKKLRDG MVGGQFWSAY IHCPKDSETN 150
    KDVPLDEATW TLRDTLEQID ITKRFVDEFP DLFQFCSNSS CAREAFANGK 200
    IGSFIGIEGA HQIGNSLASL RQLYDLGARY ITTTHNCDNV FGTAASTVSA 250
    GGEDKGLTLF GEEYVAEMNR LGMMLDLSHV SHETMRDTLR LSEAPVIFSH 300
    TGAYALSKTL RFAPDDVLKA TAEKGGIIMI TFINRFLRPD DPDAATIHDV 350
    VDHIWHVAQV AGWDHVGVGS DFDGTPVTPR GLEDVSKYPR LVELLMERGA 400
    TDDQIRKFAG DNILRVWSEV EKAAERIQVE GRKPNEAIWE GRTWVRSEMS 450
    PPIMFRDSIG RRIPSYLGEP 470
    Length:470
    Mass (Da):52,221
    Last modified:March 3, 2009 - v1
    Checksum:iEA8D2B1EAA5F4B18
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    EQ962652 Genomic DNA. Translation: EED24564.1.
    RefSeqiXP_002341951.1. XM_002341910.1.

    Genome annotation databases

    GeneIDi8105978.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    EQ962652 Genomic DNA. Translation: EED24564.1 .
    RefSeqi XP_002341951.1. XM_002341910.1.

    3D structure databases

    ProteinModelPortali B8LWT1.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 8105978.

    Phylogenomic databases

    OrthoDBi EOG7XM371.

    Family and domain databases

    InterProi IPR008257. Renal_dipep_fam.
    [Graphical view ]
    PANTHERi PTHR10443. PTHR10443. 1 hit.
    Pfami PF01244. Peptidase_M19. 1 hit.
    [Graphical view ]
    PROSITEi PS51365. RENAL_DIPEPTIDASE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of Talaromyces stipitatus strain ATCC 10500."
      Fedorova N.D., Joardar V.S., Maiti R., Schobel S., Amedeo P., Galens K., Inman J.M., Galinsky K.J., White O.R., Whitty B.R., Wortman J.R., Nierman W.C.
      Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006.

    Entry informationi

    Entry nameiDPEP2_TALSN
    AccessioniPrimary (citable) accession number: B8LWT1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 27, 2011
    Last sequence update: March 3, 2009
    Last modified: October 1, 2014
    This is version 25 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3