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Protein

Putative dipeptidase TSTA_079200

Gene

TSTA_079200

Organism
Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006) (Penicillium stipitatum)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Hydrolyzes a wide range of dipeptides.By similarity

Catalytic activityi

Hydrolysis of dipeptides.PROSITE-ProRule annotation

Cofactori

Zn2+PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi92Zinc 1; catalyticPROSITE-ProRule annotation1
Metal bindingi94Zinc 1; catalyticPROSITE-ProRule annotation1
Metal bindingi208Zinc 1; catalyticPROSITE-ProRule annotation1
Metal bindingi208Zinc 2; catalyticPROSITE-ProRule annotation1
Binding sitei235SubstratePROSITE-ProRule annotation1
Metal bindingi279Zinc 2; catalyticPROSITE-ProRule annotation1
Metal bindingi300Zinc 2; catalyticPROSITE-ProRule annotation1
Binding sitei311SubstratePROSITE-ProRule annotation1
Binding sitei371SubstratePROSITE-ProRule annotation1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Dipeptidase, Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Putative dipeptidase TSTA_079200 (EC:3.4.13.19)
Gene namesi
ORF Names:TSTA_079200
OrganismiTalaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006) (Penicillium stipitatum)
Taxonomic identifieri441959 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesTrichocomaceaeTalaromyces
Proteomesi
  • UP000001745 Componenti: Unassembled WGS sequence

Organism-specific databases

EuPathDBiFungiDB:TSTA_079200.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei40 – 60HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004112191 – 470Putative dipeptidase TSTA_079200Add BLAST470

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi143 ↔ 237PROSITE-ProRule annotation
Glycosylationi188N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi441959.XP_002341951.1.

Structurei

3D structure databases

ProteinModelPortaliB8LWT1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M19 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4127. Eukaryota.
COG2355. LUCA.
InParanoidiB8LWT1.
OrthoDBiEOG092C2VQR.

Family and domain databases

CDDicd01301. rDP_like. 1 hit.
InterProiIPR032466. Metal_Hydrolase.
IPR008257. Renal_dipep_fam.
[Graphical view]
PANTHERiPTHR10443. PTHR10443. 1 hit.
PfamiPF01244. Peptidase_M19. 1 hit.
[Graphical view]
SUPFAMiSSF51556. SSF51556. 1 hit.
PROSITEiPS51365. RENAL_DIPEPTIDASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B8LWT1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATLNTRGND IALNILSSTT ESSQAVVLSR ARGSPNSQRA WLFGLGTLGI
60 70 80 90 100
ILASVLLNPF TSTQESPLNI DPTDYAARTK HILSTTPLID GHNDLPYLIR
110 120 130 140 150
TELKHQIYND RFTFNTGLLS NTDRKKLRDG MVGGQFWSAY IHCPKDSETN
160 170 180 190 200
KDVPLDEATW TLRDTLEQID ITKRFVDEFP DLFQFCSNSS CAREAFANGK
210 220 230 240 250
IGSFIGIEGA HQIGNSLASL RQLYDLGARY ITTTHNCDNV FGTAASTVSA
260 270 280 290 300
GGEDKGLTLF GEEYVAEMNR LGMMLDLSHV SHETMRDTLR LSEAPVIFSH
310 320 330 340 350
TGAYALSKTL RFAPDDVLKA TAEKGGIIMI TFINRFLRPD DPDAATIHDV
360 370 380 390 400
VDHIWHVAQV AGWDHVGVGS DFDGTPVTPR GLEDVSKYPR LVELLMERGA
410 420 430 440 450
TDDQIRKFAG DNILRVWSEV EKAAERIQVE GRKPNEAIWE GRTWVRSEMS
460 470
PPIMFRDSIG RRIPSYLGEP
Length:470
Mass (Da):52,221
Last modified:March 3, 2009 - v1
Checksum:iEA8D2B1EAA5F4B18
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EQ962652 Genomic DNA. Translation: EED24564.1.
RefSeqiXP_002341951.1. XM_002341910.1.

Genome annotation databases

EnsemblFungiiEED24564; EED24564; TSTA_079200.
GeneIDi8105978.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EQ962652 Genomic DNA. Translation: EED24564.1.
RefSeqiXP_002341951.1. XM_002341910.1.

3D structure databases

ProteinModelPortaliB8LWT1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi441959.XP_002341951.1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiEED24564; EED24564; TSTA_079200.
GeneIDi8105978.

Organism-specific databases

EuPathDBiFungiDB:TSTA_079200.

Phylogenomic databases

eggNOGiKOG4127. Eukaryota.
COG2355. LUCA.
InParanoidiB8LWT1.
OrthoDBiEOG092C2VQR.

Family and domain databases

CDDicd01301. rDP_like. 1 hit.
InterProiIPR032466. Metal_Hydrolase.
IPR008257. Renal_dipep_fam.
[Graphical view]
PANTHERiPTHR10443. PTHR10443. 1 hit.
PfamiPF01244. Peptidase_M19. 1 hit.
[Graphical view]
SUPFAMiSSF51556. SSF51556. 1 hit.
PROSITEiPS51365. RENAL_DIPEPTIDASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDPEP2_TALSN
AccessioniPrimary (citable) accession number: B8LWT1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: March 3, 2009
Last modified: November 30, 2016
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.