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B8LWT1

- DPEP2_TALSN

UniProt

B8LWT1 - DPEP2_TALSN

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Protein
Putative dipeptidase TSTA_079200
Gene
TSTA_079200
Organism
Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006) (Penicillium stipitatum)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Hydrolyzes a wide range of dipeptides By similarity.

Catalytic activityi

Hydrolysis of dipeptides.

Cofactori

Zinc By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi92 – 921Zinc 1; catalytic By similarity
Metal bindingi94 – 941Zinc 1; catalytic By similarity
Metal bindingi208 – 2081Zinc 1; catalytic By similarity
Metal bindingi208 – 2081Zinc 2; catalytic By similarity
Binding sitei235 – 2351Substrate By similarity
Metal bindingi279 – 2791Zinc 2; catalytic By similarity
Metal bindingi300 – 3001Zinc 2; catalytic By similarity
Binding sitei311 – 3111Substrate By similarity
Binding sitei371 – 3711Substrate By similarity

GO - Molecular functioni

  1. dipeptidase activity Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. metallopeptidase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Dipeptidase, Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Putative dipeptidase TSTA_079200 (EC:3.4.13.19)
Gene namesi
ORF Names:TSTA_079200
OrganismiTalaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006) (Penicillium stipitatum)
Taxonomic identifieri441959 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesTrichocomaceaeTalaromyces
ProteomesiUP000001745: Unassembled WGS sequence

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei40 – 6021Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 470470Putative dipeptidase TSTA_079200
PRO_0000411219Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi143 ↔ 237 By similarity
Glycosylationi188 – 1881N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliB8LWT1.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M19 family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

OrthoDBiEOG7XM371.

Family and domain databases

InterProiIPR008257. Renal_dipep_fam.
[Graphical view]
PANTHERiPTHR10443. PTHR10443. 1 hit.
PfamiPF01244. Peptidase_M19. 1 hit.
[Graphical view]
PROSITEiPS51365. RENAL_DIPEPTIDASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B8LWT1-1 [UniParc]FASTAAdd to Basket

« Hide

MATLNTRGND IALNILSSTT ESSQAVVLSR ARGSPNSQRA WLFGLGTLGI    50
ILASVLLNPF TSTQESPLNI DPTDYAARTK HILSTTPLID GHNDLPYLIR 100
TELKHQIYND RFTFNTGLLS NTDRKKLRDG MVGGQFWSAY IHCPKDSETN 150
KDVPLDEATW TLRDTLEQID ITKRFVDEFP DLFQFCSNSS CAREAFANGK 200
IGSFIGIEGA HQIGNSLASL RQLYDLGARY ITTTHNCDNV FGTAASTVSA 250
GGEDKGLTLF GEEYVAEMNR LGMMLDLSHV SHETMRDTLR LSEAPVIFSH 300
TGAYALSKTL RFAPDDVLKA TAEKGGIIMI TFINRFLRPD DPDAATIHDV 350
VDHIWHVAQV AGWDHVGVGS DFDGTPVTPR GLEDVSKYPR LVELLMERGA 400
TDDQIRKFAG DNILRVWSEV EKAAERIQVE GRKPNEAIWE GRTWVRSEMS 450
PPIMFRDSIG RRIPSYLGEP 470
Length:470
Mass (Da):52,221
Last modified:March 3, 2009 - v1
Checksum:iEA8D2B1EAA5F4B18
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
EQ962652 Genomic DNA. Translation: EED24564.1.
RefSeqiXP_002341951.1. XM_002341910.1.

Genome annotation databases

GeneIDi8105978.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
EQ962652 Genomic DNA. Translation: EED24564.1 .
RefSeqi XP_002341951.1. XM_002341910.1.

3D structure databases

ProteinModelPortali B8LWT1.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 8105978.

Phylogenomic databases

OrthoDBi EOG7XM371.

Family and domain databases

InterProi IPR008257. Renal_dipep_fam.
[Graphical view ]
PANTHERi PTHR10443. PTHR10443. 1 hit.
Pfami PF01244. Peptidase_M19. 1 hit.
[Graphical view ]
PROSITEi PS51365. RENAL_DIPEPTIDASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of Talaromyces stipitatus strain ATCC 10500."
    Fedorova N.D., Joardar V.S., Maiti R., Schobel S., Amedeo P., Galens K., Inman J.M., Galinsky K.J., White O.R., Whitty B.R., Wortman J.R., Nierman W.C.
    Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006.

Entry informationi

Entry nameiDPEP2_TALSN
AccessioniPrimary (citable) accession number: B8LWT1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: March 3, 2009
Last modified: June 11, 2014
This is version 24 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi