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Protein

Putative dipeptidase TSTA_079200

Gene

TSTA_079200

Organism
Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006) (Penicillium stipitatum)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Hydrolyzes a wide range of dipeptides.By similarity

Catalytic activityi

Hydrolysis of dipeptides.PROSITE-ProRule annotation

Cofactori

Zn2+PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi92Zinc 1; catalyticPROSITE-ProRule annotation1
Metal bindingi94Zinc 1; catalyticPROSITE-ProRule annotation1
Metal bindingi208Zinc 1; catalyticPROSITE-ProRule annotation1
Metal bindingi208Zinc 2; catalyticPROSITE-ProRule annotation1
Binding sitei235SubstratePROSITE-ProRule annotation1
Metal bindingi279Zinc 2; catalyticPROSITE-ProRule annotation1
Metal bindingi300Zinc 2; catalyticPROSITE-ProRule annotation1
Binding sitei311SubstratePROSITE-ProRule annotation1
Binding sitei371SubstratePROSITE-ProRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionDipeptidase, Hydrolase, Metalloprotease, Protease
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Putative dipeptidase TSTA_079200 (EC:3.4.13.19)
Gene namesi
ORF Names:TSTA_079200
OrganismiTalaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006) (Penicillium stipitatum)
Taxonomic identifieri441959 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesTrichocomaceaeTalaromyces
Proteomesi
  • UP000001745 Componenti: Unassembled WGS sequence

Organism-specific databases

EuPathDBiFungiDB:TSTA_079200

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei40 – 60HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004112191 – 470Putative dipeptidase TSTA_079200Add BLAST470

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi143 ↔ 237PROSITE-ProRule annotation
Glycosylationi188N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiB8LWT1

Interactioni

Protein-protein interaction databases

STRINGi441959.XP_002341951.1

Structurei

3D structure databases

ProteinModelPortaliB8LWT1
SMRiB8LWT1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4127 Eukaryota
COG2355 LUCA
InParanoidiB8LWT1
OMAiEGGHSIN
OrthoDBiEOG092C2VQR

Family and domain databases

CDDicd01301 rDP_like, 1 hit
InterProiView protein in InterPro
IPR032466 Metal_Hydrolase
IPR008257 Pept_M19
PANTHERiPTHR10443 PTHR10443, 1 hit
PfamiView protein in Pfam
PF01244 Peptidase_M19, 1 hit
SUPFAMiSSF51556 SSF51556, 1 hit
PROSITEiView protein in PROSITE
PS51365 RENAL_DIPEPTIDASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

B8LWT1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATLNTRGND IALNILSSTT ESSQAVVLSR ARGSPNSQRA WLFGLGTLGI
60 70 80 90 100
ILASVLLNPF TSTQESPLNI DPTDYAARTK HILSTTPLID GHNDLPYLIR
110 120 130 140 150
TELKHQIYND RFTFNTGLLS NTDRKKLRDG MVGGQFWSAY IHCPKDSETN
160 170 180 190 200
KDVPLDEATW TLRDTLEQID ITKRFVDEFP DLFQFCSNSS CAREAFANGK
210 220 230 240 250
IGSFIGIEGA HQIGNSLASL RQLYDLGARY ITTTHNCDNV FGTAASTVSA
260 270 280 290 300
GGEDKGLTLF GEEYVAEMNR LGMMLDLSHV SHETMRDTLR LSEAPVIFSH
310 320 330 340 350
TGAYALSKTL RFAPDDVLKA TAEKGGIIMI TFINRFLRPD DPDAATIHDV
360 370 380 390 400
VDHIWHVAQV AGWDHVGVGS DFDGTPVTPR GLEDVSKYPR LVELLMERGA
410 420 430 440 450
TDDQIRKFAG DNILRVWSEV EKAAERIQVE GRKPNEAIWE GRTWVRSEMS
460 470
PPIMFRDSIG RRIPSYLGEP
Length:470
Mass (Da):52,221
Last modified:March 3, 2009 - v1
Checksum:iEA8D2B1EAA5F4B18
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EQ962652 Genomic DNA Translation: EED24564.1
RefSeqiXP_002341951.1, XM_002341910.1

Genome annotation databases

EnsemblFungiiEED24564; EED24564; TSTA_079200
GeneIDi8105978

Similar proteinsi

Entry informationi

Entry nameiDPEP2_TALSN
AccessioniPrimary (citable) accession number: B8LWT1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: March 3, 2009
Last modified: May 23, 2018
This is version 44 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health