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Protein
Submitted name:

Chemokine receptor 5

Gene

CCR5

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

ReceptorImported

Names & Taxonomyi

Protein namesi
Submitted name:
Chemokine receptor 5Imported
Gene namesi
Name:CCR5Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei14 – 38HelicalSequence analysisAdd BLAST25
Transmembranei70 – 94HelicalSequence analysisAdd BLAST25
Transmembranei106 – 129HelicalSequence analysisAdd BLAST24

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PaxDbiB8LFN8.

Expressioni

Gene expression databases

BgeeiENSG00000160791.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000292303.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 147G_PROTEIN_RECEP_F1_2InterPro annotationAdd BLAST147

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOVERGENiHBG106917.

Family and domain databases

InterProiIPR002240. Chemokine_CCR5.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01110. CHEMOKINER5.
PR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

B8LFN8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
AVVHAVFALK ARTVTFGVVT SVITWVVAVF ASLPGIIFTR SQKEGLHYTC
60 70 80 90 100
SSHFPYSQYQ FWKNFQTLKI VILGLVLPLL VMVICYSGIL KTLLRCRNEK
110 120 130 140
KRHRAVRLIF TIMIVYFLFW APYNIVLLLN TFQEFFGLNN CSSSNRL
Length:147
Mass (Da):16,927
Last modified:March 3, 2009 - v1
Checksum:i6E934C9A2BACC208
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1
Non-terminal residuei147Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF202087 Genomic DNA. Translation: ABU55681.1.
UniGeneiHs.450802.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF202087 Genomic DNA. Translation: ABU55681.1.
UniGeneiHs.450802.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000292303.

Proteomic databases

PaxDbiB8LFN8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOVERGENiHBG106917.

Gene expression databases

BgeeiENSG00000160791.

Family and domain databases

InterProiIPR002240. Chemokine_CCR5.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01110. CHEMOKINER5.
PR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiB8LFN8_HUMAN
AccessioniPrimary (citable) accession number: B8LFN8
Entry historyi
Integrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: September 7, 2016
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.