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Protein
Submitted name:

Uncharacterized protein

Gene

dvl3a

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • canonical Wnt signaling pathway Source: GO_Central
  • convergent extension involved in axis elongation Source: ZFIN
  • intracellular signal transduction Source: InterPro
  • planar cell polarity pathway involved in neural tube closure Source: GO_Central
  • post-anal tail morphogenesis Source: ZFIN
  • Wnt signaling pathway Source: ZFIN
Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-DRE-201688. WNT mediated activation of DVL.
R-DRE-4641258. Degradation of DVL.
R-DRE-4641262. Disassembly of the destruction complex and recruitment of AXIN to the membrane.

Names & Taxonomyi

Protein namesi
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:dvl3aImported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 2

Organism-specific databases

ZFINiZDB-GENE-010319-1. dvl3a.

Subcellular locationi

GO - Cellular componenti

  • cell cortex Source: ZFIN
  • cytosol Source: GO_Central
  • spindle Source: ZFIN
Complete GO annotation...

PTM / Processingi

Proteomic databases

PaxDbiB8JMI2.
PeptideAtlasiB8JMI2.

Expressioni

Gene expression databases

BgeeiENSDARG00000015707.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000088503.

Structurei

3D structure databases

ProteinModelPortaliB8JMI2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 82DIXInterPro annotationAdd BLAST82
Domaini255 – 327PDZ (DHR)InterPro annotationAdd BLAST73
Domaini428 – 502DEPInterPro annotationAdd BLAST75

Sequence similaritiesi

Contains 1 PDZ (DHR) domain.UniRule annotation

Phylogenomic databases

eggNOGiKOG3571. Eukaryota.
ENOG410Y5G4. LUCA.
GeneTreeiENSGT00390000013552.
HOGENOMiHOG000017084.
HOVERGENiHBG005542.
InParanoidiB8JMI2.
KOiK02353.
OMAiDMTECSS.
OrthoDBiEOG091G041O.
TreeFamiTF318198.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
2.30.42.10. 1 hit.
InterProiIPR000591. DEP_dom.
IPR024580. Dishevelled_C-dom.
IPR008339. Dishevelled_fam.
IPR003351. Dishevelled_protein_dom.
IPR001158. DIX.
IPR015506. Dsh/Dvl-rel.
IPR008342. DVL3.
IPR001478. PDZ.
IPR029071. Ubiquitin-rel_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PANTHERiPTHR10878. PTHR10878. 1 hit.
PTHR10878:SF6. PTHR10878:SF6. 1 hit.
PfamiPF00610. DEP. 1 hit.
PF02377. Dishevelled. 1 hit.
PF00778. DIX. 1 hit.
PF12316. Dsh_C. 2 hits.
PF00595. PDZ. 1 hit.
[Graphical view]
PRINTSiPR01760. DISHEVELLED.
SMARTiSM00021. DAX. 1 hit.
SM00049. DEP. 1 hit.
SM00228. PDZ. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF50156. SSF50156. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS50186. DEP. 1 hit.
PS50841. DIX. 1 hit.
PS50106. PDZ. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B8JMI2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGETKVIYHL DDQETPYLVK LPIPAERVTL LDLKNALKKP NYKFFFKSMD
60 70 80 90 100
DDFGVVKEEI TDDNAKLPCY NGRVICWLVS SDGSHSDGCS VAESQSERPP
110 120 130 140 150
SHERSQGIGD SRPPSFHPKA AGSRHGVDDE TETDSVVSHR RDRDRDRSRR
160 170 180 190 200
KHSHEHSGGK QNGYSRGGRG MDLGGYDICD SRSSLMSSEL ESSSCFDSDD
210 220 230 240 250
GSTSRFSSVT EQSGSSKLMT KKPRRRRRKT RAQQMERSSS FSSITDSTMS
260 270 280 290 300
LNIITVTLNM EKYNFLGISI VGQSNERGDG GIYIGSIMKG GAVAADGRIE
310 320 330 340 350
PGDMLLQVND INFENMCNDD AVRVLREIVH KPGPVSLTVA KCWDPNPNSC
360 370 380 390 400
FALPRSEPIR PIDPAAWVSH TAAMTGVYPP YGMSPSMSTV TSTSSSISSS
410 420 430 440 450
IPETERFDDY HLSVHSDMAT VAKAMACPDS GLEVRDRMWL KITIANAFIG
460 470 480 490 500
SDVVDWLFHH VEGFTDRREA RKYASNLLKA GFIRHTVNKI TFSEQCYYIF
510 520 530 540 550
GDLSGNMAHL SLQDHDGSSG ASDQDTLAPL LHPAEAPWPA AFPYQYPAAH
560 570 580 590 600
SHLEEAGGGS AGSQQSEGSS GSNCSWSRTE GKTAAGDFRL GGGSEMGDAH
610 620 630 640 650
EFDFRRDRAP SERSGVPPSE GSVRSSRSHS YSLKQGSARG GPGSPSGRHL
660 670
AHIPPELTGS RRSCNTANGE FFVDIM
Length:676
Mass (Da):73,823
Last modified:March 3, 2009 - v1
Checksum:iBD57ED104D374D81
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU633992 Genomic DNA. No translation available.
CU638697 Genomic DNA. No translation available.
RefSeqiNP_571832.2. NM_131757.2.
UniGeneiDr.71454.

Genome annotation databases

EnsembliENSDART00000097732; ENSDARP00000088503; ENSDARG00000015707.
GeneIDi80972.
KEGGidre:80972.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU633992 Genomic DNA. No translation available.
CU638697 Genomic DNA. No translation available.
RefSeqiNP_571832.2. NM_131757.2.
UniGeneiDr.71454.

3D structure databases

ProteinModelPortaliB8JMI2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000088503.

Proteomic databases

PaxDbiB8JMI2.
PeptideAtlasiB8JMI2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000097732; ENSDARP00000088503; ENSDARG00000015707.
GeneIDi80972.
KEGGidre:80972.

Organism-specific databases

CTDi80972.
ZFINiZDB-GENE-010319-1. dvl3a.

Phylogenomic databases

eggNOGiKOG3571. Eukaryota.
ENOG410Y5G4. LUCA.
GeneTreeiENSGT00390000013552.
HOGENOMiHOG000017084.
HOVERGENiHBG005542.
InParanoidiB8JMI2.
KOiK02353.
OMAiDMTECSS.
OrthoDBiEOG091G041O.
TreeFamiTF318198.

Enzyme and pathway databases

ReactomeiR-DRE-201688. WNT mediated activation of DVL.
R-DRE-4641258. Degradation of DVL.
R-DRE-4641262. Disassembly of the destruction complex and recruitment of AXIN to the membrane.

Gene expression databases

BgeeiENSDARG00000015707.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
2.30.42.10. 1 hit.
InterProiIPR000591. DEP_dom.
IPR024580. Dishevelled_C-dom.
IPR008339. Dishevelled_fam.
IPR003351. Dishevelled_protein_dom.
IPR001158. DIX.
IPR015506. Dsh/Dvl-rel.
IPR008342. DVL3.
IPR001478. PDZ.
IPR029071. Ubiquitin-rel_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PANTHERiPTHR10878. PTHR10878. 1 hit.
PTHR10878:SF6. PTHR10878:SF6. 1 hit.
PfamiPF00610. DEP. 1 hit.
PF02377. Dishevelled. 1 hit.
PF00778. DIX. 1 hit.
PF12316. Dsh_C. 2 hits.
PF00595. PDZ. 1 hit.
[Graphical view]
PRINTSiPR01760. DISHEVELLED.
SMARTiSM00021. DAX. 1 hit.
SM00049. DEP. 1 hit.
SM00228. PDZ. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF50156. SSF50156. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS50186. DEP. 1 hit.
PS50841. DIX. 1 hit.
PS50106. PDZ. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiB8JMI2_DANRE
AccessioniPrimary (citable) accession number: B8JMI2
Entry historyi
Integrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: September 7, 2016
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.