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Protein
Submitted name:

Adenylate cyclase type 3

Gene

Adcy3

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotationSAAS annotation

Keywords - Ligandi

Nucleotide-bindingSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Adenylate cyclase type 3Imported
Gene namesi
Name:Adcy3Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:99675. Adcy3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei78 – 10023HelicalSequence analysisAdd
BLAST
Transmembranei106 – 12621HelicalSequence analysisAdd
BLAST
Transmembranei138 – 15720HelicalSequence analysisAdd
BLAST
Transmembranei169 – 18517HelicalSequence analysisAdd
BLAST
Transmembranei190 – 21021HelicalSequence analysisAdd
BLAST
Transmembranei230 – 24718HelicalSequence analysisAdd
BLAST
Transmembranei632 – 65221HelicalSequence analysisAdd
BLAST
Transmembranei664 – 68623HelicalSequence analysisAdd
BLAST
Transmembranei707 – 73226HelicalSequence analysisAdd
BLAST
Transmembranei752 – 76918HelicalSequence analysisAdd
BLAST
Transmembranei776 – 79419HelicalSequence analysisAdd
BLAST
Transmembranei840 – 85718HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PeptideAtlasiB8JK56.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000020984.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini319 – 446128Guanylate cyclaseInterPro annotationAdd
BLAST
Domaini923 – 1075153Guanylate cyclaseInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.UniRule annotationSAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG3619. Eukaryota.
COG2114. LUCA.
GeneTreeiENSGT00760000119042.
HOVERGENiHBG050458.
TreeFamiTF313845.

Family and domain databases

Gene3Di3.30.70.1230. 2 hits.
InterProiIPR001054. A/G_cyclase.
IPR018297. A/G_cyclase_CS.
IPR032628. AC_N.
IPR030672. Adcy.
IPR029787. Nucleotide_cyclase.
[Graphical view]
PfamiPF16214. AC_N. 1 hit.
PF00211. Guanylate_cyc. 2 hits.
[Graphical view]
PIRSFiPIRSF039050. Ade_cyc. 1 hit.
SMARTiSM00044. CYCc. 2 hits.
[Graphical view]
SUPFAMiSSF55073. SSF55073. 2 hits.
PROSITEiPS00452. GUANYLATE_CYCLASE_1. 2 hits.
PS50125. GUANYLATE_CYCLASE_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B8JK56-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRNQGFSDP EYSAEYSAEY SVSLPSDPDR GVGRTHEISV RNSGSCLCLP
60 70 80 90 100
RFMRLTFVPE SLENLYQTYF KRQRHETLLV LVVFAALFDC YVVVMCAVVF
110 120 130 140 150
SSDKLAPLMV AGFGLVLDII LFVLCKKGLL PDRVSRKVVP YLLWLLISAQ
160 170 180 190 200
IFSYLGLNFS RAHAASDTVG WQAFFVFSFF ITLPLSLSPI VIISVVSCVV
210 220 230 240 250
HTLVLGVTVA QQQQDELEGM QLLREILANV FLYLCAIIVG IMSYYMADRK
260 270 280 290 300
HRKAFLEARQ SLEVKMNLEE QSQQQENLML SILPKHVADE MLKDMKKDES
310 320 330 340 350
QKDQQQFNTM YMYRHENVSI LFADIVGFTQ LSSACSAQEL VKLLNELFAR
360 370 380 390 400
FDKLAAKYHQ LRIKILGDCY YCICGLPDYR EDHAVCSILM GLAMVEAISY
410 420 430 440 450
VREKTKTGVD MRVGVHTGTV LGGVLGQKRW QYDVWSTDVT VANKMEAGGI
460 470 480 490 500
PGRVHISQST MDCLKGEFDV EPGDGGSRCD YLDEKGIETY LIIASKPEVK
510 520 530 540 550
KTAQNGLNGS AVPNGAPASS KPSSPALIET KEPNGSAHAS GSTSEEAEEQ
560 570 580 590 600
EAQADNPSFP NPRRRLRLQD LADRVVDASE DEHELNQLLN EALLERESAQ
610 620 630 640 650
VVKKRNTFLL TMRFMDPEME TRYSVEKEKQ SGAAFSCSCV VLFCTAMVEI
660 670 680 690 700
LIDPWLMTNY VTFVVGEVLL LILTICSMAA IFPRSFPKKL VAFSSWIDRT
710 720 730 740 750
RWARNTWAML AIFILVMANV VDMLSCLQYY MGPYNMTAGM ELDGGCMENP
760 770 780 790 800
KYYNYVAVLS LIATIMLVQV SHMVKLTLML LVTGAVTALN LYAWCPVFDE
810 820 830 840 850
YDHKRFQEKD SPMVALEKMQ VLATPGLNGT DRLPLVPSKY SMTVMMFVMM
860 870 880 890 900
LSFYYFSRHV EKLARTLFLW KIEVHDQKER VYEMRRWNEA LVTNMLPEHV
910 920 930 940 950
ARHFLGSKKR DEELYSQSYD EIGVMFASLP NFADFYTEES INNGGIECLR
960 970 980 990 1000
FLNEIISDFD SLLDNPKFRV ITKIKTIGST YMAASGVTPD VNTNGFTSSS
1010 1020 1030 1040 1050
KEEKSDKERW QHLADLADFA LAMKDTLTNI NNQSFNNFML RIGMNKGGVL
1060 1070 1080 1090 1100
AGVIGARKPH YDIWGNTVNV ASRMESTGVM GNIQVVEETQ VILREYGFRF
1110 1120 1130 1140
VRRGPIFVKG KGELLTFFLK GRDRPAAFPN GSSVTLPHQV VDNP
Length:1,144
Mass (Da):128,998
Last modified:March 3, 2009 - v1
Checksum:i989F69F858CEC87C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CT572999 Genomic DNA. No translation available.
RefSeqiNP_001153008.1. NM_001159536.1.
NP_001153009.1. NM_001159537.1.
UniGeneiMm.489807.

Genome annotation databases

EnsembliENSMUST00000124505; ENSMUSP00000122073; ENSMUSG00000020654.
ENSMUST00000152065; ENSMUSP00000115644; ENSMUSG00000020654.
GeneIDi104111.
UCSCiuc007mxk.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CT572999 Genomic DNA. No translation available.
RefSeqiNP_001153008.1. NM_001159536.1.
NP_001153009.1. NM_001159537.1.
UniGeneiMm.489807.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000020984.

Proteomic databases

PeptideAtlasiB8JK56.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000124505; ENSMUSP00000122073; ENSMUSG00000020654.
ENSMUST00000152065; ENSMUSP00000115644; ENSMUSG00000020654.
GeneIDi104111.
UCSCiuc007mxk.2. mouse.

Organism-specific databases

CTDi109.
MGIiMGI:99675. Adcy3.

Phylogenomic databases

eggNOGiKOG3619. Eukaryota.
COG2114. LUCA.
GeneTreeiENSGT00760000119042.
HOVERGENiHBG050458.
TreeFamiTF313845.

Miscellaneous databases

ChiTaRSiAdcy3. mouse.
SOURCEiSearch...

Family and domain databases

Gene3Di3.30.70.1230. 2 hits.
InterProiIPR001054. A/G_cyclase.
IPR018297. A/G_cyclase_CS.
IPR032628. AC_N.
IPR030672. Adcy.
IPR029787. Nucleotide_cyclase.
[Graphical view]
PfamiPF16214. AC_N. 1 hit.
PF00211. Guanylate_cyc. 2 hits.
[Graphical view]
PIRSFiPIRSF039050. Ade_cyc. 1 hit.
SMARTiSM00044. CYCc. 2 hits.
[Graphical view]
SUPFAMiSSF55073. SSF55073. 2 hits.
PROSITEiPS00452. GUANYLATE_CYCLASE_1. 2 hits.
PS50125. GUANYLATE_CYCLASE_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  3. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiB8JK56_MOUSE
AccessioniPrimary (citable) accession number: B8JK56
Entry historyi
Integrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: July 6, 2016
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.