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Protein

Integrin alpha-9

Gene

Itga9

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Integrin alpha-9/beta-1 (ITGA9:ITGB1) is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi313 – 321Sequence analysis9
Calcium bindingi374 – 382Sequence analysis9
Calcium bindingi436 – 444Sequence analysis9

GO - Molecular functioni

GO - Biological processi

  • cell adhesion Source: MGI
  • integrin-mediated signaling pathway Source: UniProtKB-KW
  • neutrophil chemotaxis Source: MGI
  • wound healing Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Integrin, Receptor

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-216083. Integrin cell surface interactions.
R-MMU-3000178. ECM proteoglycans.
R-MMU-445144. Signal transduction by L1.

Names & Taxonomyi

Protein namesi
Recommended name:
Integrin alpha-9Curated
Gene namesi
Name:Itga9Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:104756. Itga9.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini29 – 981ExtracellularCuratedAdd BLAST953
Transmembranei982 – 1002HelicalSequence analysisAdd BLAST21
Topological domaini1003 – 1036CytoplasmicCuratedAdd BLAST34

GO - Cellular componenti

  • basal plasma membrane Source: MGI
  • integrin alpha9-beta1 complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Sequence analysisAdd BLAST28
ChainiPRO_000043191429 – 1036Integrin alpha-9Sequence analysisAdd BLAST1008

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi88 ↔ 98By similarity
Disulfide bondi143 ↔ 163By similarity
Disulfide bondi180 ↔ 195By similarity
Glycosylationi226N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi483 ↔ 492By similarity
Glycosylationi494N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi498 ↔ 556By similarity
Glycosylationi515N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi621 ↔ 626By similarity
Disulfide bondi697 ↔ 707By similarity
Glycosylationi808N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi856 ↔ 892By similarity
Disulfide bondi899 ↔ 904By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei566 – 567CleavageSequence analysis2

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiB8JK39.
PaxDbiB8JK39.
PeptideAtlasiB8JK39.
PRIDEiB8JK39.

PTM databases

iPTMnetiB8JK39.
PhosphoSitePlusiB8JK39.

Expressioni

Gene expression databases

BgeeiENSMUSG00000039115.
ExpressionAtlasiB8JK39. baseline and differential.
GenevisibleiB8JK39. MM.

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta subunit. Alpha-9 (ITGA9) associates with beta-1 (ITGB1) (Probable). Integrin ITGA9:ITGB1 interacts with FBLN5 (via N-terminus) (PubMed:11805835).1 Publication1 Publication

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000044227.

Structurei

3D structure databases

ProteinModelPortaliB8JK39.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati36 – 97FG-GAP 1PROSITE-ProRule annotationAdd BLAST62
Repeati109 – 175FG-GAP 2PROSITE-ProRule annotationAdd BLAST67
Repeati183 – 233FG-GAP 3PROSITE-ProRule annotationAdd BLAST51
Repeati234 – 290FG-GAP 4PROSITE-ProRule annotationAdd BLAST57
Repeati291 – 350FG-GAP 5PROSITE-ProRule annotationAdd BLAST60
Repeati352 – 409FG-GAP 6PROSITE-ProRule annotationAdd BLAST58
Repeati412 – 475FG-GAP 7PROSITE-ProRule annotationAdd BLAST64

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi1006 – 1010GFFKR motifBy similarity5

Sequence similaritiesi

Belongs to the integrin alpha chain family.Curated
Contains 7 FG-GAP repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3637. Eukaryota.
ENOG410XPVZ. LUCA.
GeneTreeiENSGT00760000118782.
HOGENOMiHOG000088626.
HOVERGENiHBG004538.
InParanoidiB8JK39.
KOiK06585.
OMAiHFSQPTT.
OrthoDBiEOG091G011V.
PhylomeDBiB8JK39.
TreeFamiTF105391.

Family and domain databases

InterProiIPR013517. FG-GAP.
IPR013519. Int_alpha_beta-p.
IPR000413. Integrin_alpha.
IPR013649. Integrin_alpha-2.
IPR018184. Integrin_alpha_C_CS.
IPR032695. Integrin_dom.
[Graphical view]
PfamiPF01839. FG-GAP. 2 hits.
PF08441. Integrin_alpha2. 1 hit.
[Graphical view]
PRINTSiPR01185. INTEGRINA.
SMARTiSM00191. Int_alpha. 5 hits.
[Graphical view]
SUPFAMiSSF69179. SSF69179. 3 hits.
PROSITEiPS51470. FG_GAP. 7 hits.
PS00242. INTEGRIN_ALPHA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

B8JK39-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGGPAAARTG AGGLRALLLA LVAAGVPAGA YNLDAQRPVR FQGPSGSFFG
60 70 80 90 100
YAVLEHFHDN TRWVLVGAPK ADSKYSTSVK SPGAVFKCRV HTNPDRRCTE
110 120 130 140 150
LDMARGRTRG APCGKTCRGD RDDEWMGVSL ARQPRADGRV LACAHRWKNI
160 170 180 190 200
YYEADHILPH GFCYLIPSNL QAKGKVLIPC YEEYKKKYGE EHGSCQAGIA
210 220 230 240 250
GFFTEELVVM GAPGSFYWAG TLKVLNLTDN TYFKLNDEAI MNRRYTYLGY
260 270 280 290 300
AVTAGHFSHP SITDVVGGAP QDEGIGKVYI FRADRRSGTL IKIFQASGKK
310 320 330 340 350
MGSYFGSSLC AVDLNMDGLS DLLVGAPMFS EIRDEGQVTV YLNQGHGALE
360 370 380 390 400
EQLTLTGDAA YNAHFGESIA NLGDIDDDGF PDVAVGAPKE EDFAGAVYIY
410 420 430 440 450
HGDANGIVPK YSMKLSGRRL NPTLRMFGQS ISGGIDMDGN GYPDVTIGAF
460 470 480 490 500
LSDSVVLLRA RPVITVDVSI FLPGSINITA PQCHDGQQPV NCLNVTVCFR
510 520 530 540 550
FHGKNVPGEI GLNYNLTADV AQKEKGQLPR VYFVLFGETA GQVSERLQLS
560 570 580 590 600
HMDEVCHHYV AHVKRRVQDV ISPIVFEAAY SLDEHVMGEE DRELPDLTPV
610 620 630 640 650
LRWKKGQRIS QKNQTVFERN CQSEDCAADL QLRGKLLLSS VDEKTPHLAL
660 670 680 690 700
GAVKNISLNI SISNLGDDAY DANVSFNVSR ELFFINMWQK EEMGISCELL
710 720 730 740 750
ESDFLKCSVG FPFMRSKSKY EFSVIFDTSH LSGEEEILSF IVTAQSGNLE
760 770 780 790 800
RSEALHDNTL TLTVPLVHEV DTSITGIVSP TSFVYGESVD ASNFIQLDDQ
810 820 830 840 850
ECHFQPVNIT LQVYNMGPST LPGSSVSISF PSRLSPGGAE MFQVQDMVVS
860 870 880 890 900
QEKGNCSLQR NPTPCIIPQE QENIFHTIFA FFSKSGRKVL DCEKPGSFCL
910 920 930 940 950
TLHCNLSALP KEESRTINLY MLLNTEILKK DSSSVIQFMA RAKVKVEPAL
960 970 980 990 1000
RVVEIANGNP EETLVVFEAL HNLEPRGYVV GWIIAISLLV GILIFLLLAV
1010 1020 1030
LLWKMGFFRR RYKEIIEAEK NRKENEDGWD WVQKNQ
Length:1,036
Mass (Da):114,416
Last modified:March 3, 2009 - v1
Checksum:iF14BDEA82670FFCD
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti291I → V in AAI50825 (PubMed:15489334).Curated1
Sequence conflicti918N → D in AAI50825 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC156800 Genomic DNA. No translation available.
AC159000 Genomic DNA. No translation available.
AC165257 Genomic DNA. No translation available.
CT486004 Genomic DNA. No translation available.
BC150824 mRNA. Translation: AAI50825.1.
CCDSiCCDS23604.1.
RefSeqiNP_598482.2. NM_133721.2.
UniGeneiMm.335520.

Genome annotation databases

EnsembliENSMUST00000044165; ENSMUSP00000044227; ENSMUSG00000039115.
GeneIDi104099.
KEGGimmu:104099.
UCSCiuc009rzw.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC156800 Genomic DNA. No translation available.
AC159000 Genomic DNA. No translation available.
AC165257 Genomic DNA. No translation available.
CT486004 Genomic DNA. No translation available.
BC150824 mRNA. Translation: AAI50825.1.
CCDSiCCDS23604.1.
RefSeqiNP_598482.2. NM_133721.2.
UniGeneiMm.335520.

3D structure databases

ProteinModelPortaliB8JK39.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000044227.

PTM databases

iPTMnetiB8JK39.
PhosphoSitePlusiB8JK39.

Proteomic databases

MaxQBiB8JK39.
PaxDbiB8JK39.
PeptideAtlasiB8JK39.
PRIDEiB8JK39.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000044165; ENSMUSP00000044227; ENSMUSG00000039115.
GeneIDi104099.
KEGGimmu:104099.
UCSCiuc009rzw.2. mouse.

Organism-specific databases

CTDi3680.
MGIiMGI:104756. Itga9.

Phylogenomic databases

eggNOGiKOG3637. Eukaryota.
ENOG410XPVZ. LUCA.
GeneTreeiENSGT00760000118782.
HOGENOMiHOG000088626.
HOVERGENiHBG004538.
InParanoidiB8JK39.
KOiK06585.
OMAiHFSQPTT.
OrthoDBiEOG091G011V.
PhylomeDBiB8JK39.
TreeFamiTF105391.

Enzyme and pathway databases

ReactomeiR-MMU-216083. Integrin cell surface interactions.
R-MMU-3000178. ECM proteoglycans.
R-MMU-445144. Signal transduction by L1.

Miscellaneous databases

ChiTaRSiItga9. mouse.
PROiB8JK39.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000039115.
ExpressionAtlasiB8JK39. baseline and differential.
GenevisibleiB8JK39. MM.

Family and domain databases

InterProiIPR013517. FG-GAP.
IPR013519. Int_alpha_beta-p.
IPR000413. Integrin_alpha.
IPR013649. Integrin_alpha-2.
IPR018184. Integrin_alpha_C_CS.
IPR032695. Integrin_dom.
[Graphical view]
PfamiPF01839. FG-GAP. 2 hits.
PF08441. Integrin_alpha2. 1 hit.
[Graphical view]
PRINTSiPR01185. INTEGRINA.
SMARTiSM00191. Int_alpha. 5 hits.
[Graphical view]
SUPFAMiSSF69179. SSF69179. 3 hits.
PROSITEiPS51470. FG_GAP. 7 hits.
PS00242. INTEGRIN_ALPHA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiITA9_MOUSE
AccessioniPrimary (citable) accession number: B8JK39
Secondary accession number(s): B9EKC4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 4, 2015
Last sequence update: March 3, 2009
Last modified: November 2, 2016
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.