Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Myotubularin-related protein 2

Gene

Mtmr2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity Source: MGI
  • phosphatidylinositol-3-phosphatase activity Source: MGI
  • phosphatidylinositol phosphate phosphatase activity Source: MGI
  • protein homodimerization activity Source: MGI

GO - Biological processi

  • dendritic spine maintenance Source: Ensembl
  • dephosphorylation Source: MGI
  • inositol phosphate dephosphorylation Source: MGI
  • myelin assembly Source: MGI
  • negative regulation of excitatory postsynaptic membrane potential Source: Ensembl
  • negative regulation of myelination Source: MGI
  • negative regulation of receptor catabolic process Source: Ensembl
  • negative regulation of receptor internalization Source: Ensembl
  • neuron development Source: MGI
  • phosphatidylinositol dephosphorylation Source: MGI
  • phosphatidylinositol metabolic process Source: MGI
  • positive regulation of early endosome to late endosome transport Source: Ensembl
  • protein tetramerization Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Myotubularin-related protein 2Imported
Gene namesi
Name:Mtmr2Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1924366. Mtmr2.

Subcellular locationi

GO - Cellular componenti

  • axon Source: Ensembl
  • cytoplasm Source: MGI
  • cytosol Source: MGI
  • dendritic spine Source: Ensembl
  • extracellular exosome Source: MGI
  • neuronal postsynaptic density Source: Ensembl
  • nucleus Source: MGI
  • synaptic membrane Source: Ensembl
  • synaptic vesicle Source: Ensembl
  • vacuolar membrane Source: MGI
Complete GO annotation...

Expressioni

Gene expression databases

BgeeiB8JJF3.
ExpressionAtlasiB8JJF3. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliB8JJF3.
SMRiB8JJF3. Positions 1-105.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00760000118832.
HOGENOMiHOG000200754.
HOVERGENiHBG085155.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR004182. GRAM.
IPR030587. MTMR1/MTMR2.
IPR030564. Myotubularin_fam.
IPR011993. PH_like_dom.
[Graphical view]
PANTHERiPTHR10807. PTHR10807. 1 hit.
PTHR10807:SF40. PTHR10807:SF40. 1 hit.
PfamiPF02893. GRAM. 1 hit.
[Graphical view]
SMARTiSM00568. GRAM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

B8JJF3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEPALLPGE NIKDMAKDVT YICPFTGAVR GTLTVTSYRL YFKSMERDPP
60 70 80 90 100
FVLDASLGVI SRVEKIGGAS SRGENSYGLE TVCKDIRNLR FAHKPEGRTR

RSIFE
Length:105
Mass (Da):11,759
Last modified:March 3, 2009 - v1
Checksum:iFC518BD55740FF18
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei105 – 1051Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CT010488 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSMUST00000152532; ENSMUSP00000114509; ENSMUSG00000031918.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CT010488 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortaliB8JJF3.
SMRiB8JJF3. Positions 1-105.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000152532; ENSMUSP00000114509; ENSMUSG00000031918.

Organism-specific databases

MGIiMGI:1924366. Mtmr2.

Phylogenomic databases

GeneTreeiENSGT00760000118832.
HOGENOMiHOG000200754.
HOVERGENiHBG085155.

Miscellaneous databases

NextBioi35547836.
SOURCEiSearch...

Gene expression databases

BgeeiB8JJF3.
ExpressionAtlasiB8JJF3. baseline and differential.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR004182. GRAM.
IPR030587. MTMR1/MTMR2.
IPR030564. Myotubularin_fam.
IPR011993. PH_like_dom.
[Graphical view]
PANTHERiPTHR10807. PTHR10807. 1 hit.
PTHR10807:SF40. PTHR10807:SF40. 1 hit.
PfamiPF02893. GRAM. 1 hit.
[Graphical view]
SMARTiSM00568. GRAM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  2. "A tissue-specific atlas of mouse protein phosphorylation and expression."
    Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R., Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.
    Cell 143:1174-1189(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  3. Ensembl
    Submitted (JUN-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiB8JJF3_MOUSE
AccessioniPrimary (citable) accession number: B8JJF3
Entry historyi
Integrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: May 27, 2015
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.