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B8JIA4

- B8JIA4_DANRE

UniProt

B8JIA4 - B8JIA4_DANRE

Protein
Submitted name:

Uncharacterized protein

Gene

whsc1

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed - Annotation score: 2 out of 5- Protein predictedi
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    • History
      Entry version 48 (01 Oct 2014)
      Sequence version 1 (03 Mar 2009)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].SAAS annotation

    GO - Molecular functioni

    1. histone-lysine N-methyltransferase activity Source: InterPro
    2. zinc ion binding Source: InterPro

    GO - Biological processi

    1. cartilage development Source: ZFIN
    2. embryonic skeletal system development Source: ZFIN
    3. histone H3-K36 methylation Source: ZFIN

    Keywords - Molecular functioni

    MethyltransferaseUniRule annotation, Transferase

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Uncharacterized proteinImported
    Gene namesi
    Name:whsc1Imported
    OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
    Taxonomic identifieri7955 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
    ProteomesiUP000000437: Chromosome 13

    Organism-specific databases

    ZFINiZDB-GENE-030131-2581. whsc1.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-KW

    Keywords - Cellular componenti

    NucleusSAAS annotation

    Family & Domainsi

    Sequence similaritiesi

    Contains 1 SET domain.UniRule annotation
    Contains 1 post-SET domain.UniRule annotation
    Contains SET domain.SAAS annotation
    Contains post-SET domain.SAAS annotation

    Keywords - Domaini

    Zinc-fingerSAAS annotation

    Phylogenomic databases

    GeneTreeiENSGT00740000114921.
    HOVERGENiHBG106834.
    KOiK11424.
    OMAiFESECLN.
    OrthoDBiEOG7Z69BG.
    PhylomeDBiB8JIA4.
    TreeFamiTF329088.

    Family and domain databases

    Gene3Di3.30.40.10. 3 hits.
    InterProiIPR006560. AWS.
    IPR003616. Post-SET_dom.
    IPR000313. PWWP_dom.
    IPR001214. SET_dom.
    IPR019786. Zinc_finger_PHD-type_CS.
    IPR011011. Znf_FYVE_PHD.
    IPR001965. Znf_PHD.
    IPR019787. Znf_PHD-finger.
    IPR001841. Znf_RING.
    IPR013083. Znf_RING/FYVE/PHD.
    [Graphical view]
    PfamiPF00628. PHD. 1 hit.
    PF00855. PWWP. 2 hits.
    PF00856. SET. 1 hit.
    [Graphical view]
    SMARTiSM00570. AWS. 1 hit.
    SM00249. PHD. 5 hits.
    SM00508. PostSET. 1 hit.
    SM00293. PWWP. 2 hits.
    SM00184. RING. 2 hits.
    SM00317. SET. 1 hit.
    [Graphical view]
    SUPFAMiSSF57903. SSF57903. 2 hits.
    PROSITEiPS51215. AWS. 1 hit.
    PS50868. POST_SET. 1 hit.
    PS50812. PWWP. 2 hits.
    PS50280. SET. 1 hit.
    PS01359. ZF_PHD_1. 2 hits.
    PS50016. ZF_PHD_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B8JIA4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTDSKGGSLP AMPEPKSPTS MKQLSDSPGG RNGLVDGITD PTMLMNKAAT     50
    QLAATPQESV PQMIGSHGHN HTHEHLKDLT SRLLNGDTEK IPKLCAAPAG 100
    QPLLKGVEPV SQHASPPRKT SVSPELTVKI TKCVVNLGGK PNRYEVDYTE 150
    EKAEETDAPL RLPEGVLTSP TARRDRQKKK GMVRKRIPPY PILTHAASSD 200
    QSPLLHPTIN SNDITIEPCG LPVESIEHTH GDMPTCVTAF PDEQPLSDCE 250
    ETVDAQGVDE TDDAQGENDV KESYTETQSN VHFSVGDVIW TKVSGYPWWP 300
    CMITTDPEFN MHFRSKVNSR TGLLYHVQYF GDTPERGYVF EKCIVTFSGK 350
    HQYQSLSRSN QLPINISGRK RAVPRKFRQK WEIGVSQAKE ALGLLTEERL 400
    AKFSFVYEDG KAQLNPHMLQ VLEEQRNQGL QEEPVQREPQ ELVSLTPPDS 450
    THSSPTNSST TSTIPSLFSN PIDSSTSSGK TALPRKARKP SVKTNRRKQR 500
    SSTIEWIVTE ASSAKQMPLT ESTVQCEVNT EHKKKGKTNA GKRPYRKKDL 550
    LCIDLDLQPK ASQKKPRHIR QKFPAAPNSV KKRKIKAGVS ICDTLNTVST 600
    SAGLSEVKAS APSTKLWEKE DASSKGMKKV CKRSRESKQD VTLQPKKKSK 650
    LEKDFKKWKC PKAASSAPAA VPAPRGRRRK TDRDENRKRS KKASKEEPPP 700
    KAKRGRKRKE ESGRQSFPAS KKCRPSSYAE PERPDSPSDS TDESHPSKKA 750
    ERTPGAKKES VCLVCEQTGE DIVTCAGQCY GTYHLHCIGV ERSAEKILCT 800
    ACSTGVHVCF TCKKSEGEVR RCCALHCGRF YHEACVRLSA LTVFENRGFR 850
    CPLHTCLSCH YSGRAACKAT KGKMMRCLRC PVAYHVGDLC VAAGSEMISS 900
    SAIVCTNHFR AKKGYSHHSH VNVSWCFICS KGGRLLCCES CPAAFHPDCL 950
    NIAMPDGSWF CNDCRSGKKP KYRDVIWVKL GNYRWWPAEI RHPKNIPTNI 1000
    QHLRHEIGEF PVFFFGSKDY FWTHQGRVFP YMEGDRGSKY QQTGIGKVFK 1050
    NALLDAETRF KEIEMEREAK EAHENNKKPP PFKYIKVNKP CGRVQVYTAD 1100
    ISEIPKCNCK PSTERPCSFE SECLNRMLLY ECHPQVCPAG ERCQNQDFTK 1150
    RLYPETKIIR TAGKGWGLIS LRDIKKGEFV NEYVGELIDE EECRSRIRHA 1200
    QENDITHFYM LTIDKDRIID AGPKGNYSRF MNHSCQPNCE TQKWTVNGDT 1250
    RVGLFAVCDI PAGTELTFNY NLDCLGNEKT VCRCGAPNCS GFLGDRPKNG 1300
    HTSEPKAKLQ KKKPKRKRAR NEGKKSEDEC FRCGDGGQLV LCDKKGCTKA 1350
    YHLSCLDRTK RPFGRWDCPW HHCDVCGKNS AAFCQLCPNS FCKAHQEGAL 1400
    RSHPLTGQLC CQEHEDSDIR PQTETAQLPP PTKPRKYRRR AEAKTTSKAP 1450
    LKKRPRKNAE V 1461
    Length:1,461
    Mass (Da):163,792
    Last modified:March 3, 2009 - v1
    Checksum:i4D7815F3AF48B62D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR556722 Genomic DNA. No translation available.
    CT573111 Genomic DNA. No translation available.
    RefSeqiNP_001076020.1. NM_001082551.1.
    UniGeneiDr.78031.

    Genome annotation databases

    EnsembliENSDART00000009499; ENSDARP00000002944; ENSDARG00000026225.
    GeneIDi100000709.
    KEGGidre:100000709.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR556722 Genomic DNA. No translation available.
    CT573111 Genomic DNA. No translation available.
    RefSeqi NP_001076020.1. NM_001082551.1.
    UniGenei Dr.78031.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSDART00000009499 ; ENSDARP00000002944 ; ENSDARG00000026225 .
    GeneIDi 100000709.
    KEGGi dre:100000709.

    Organism-specific databases

    CTDi 7468.
    ZFINi ZDB-GENE-030131-2581. whsc1.

    Phylogenomic databases

    GeneTreei ENSGT00740000114921.
    HOVERGENi HBG106834.
    KOi K11424.
    OMAi FESECLN.
    OrthoDBi EOG7Z69BG.
    PhylomeDBi B8JIA4.
    TreeFami TF329088.

    Miscellaneous databases

    NextBioi 20784754.
    PROi B8JIA4.

    Family and domain databases

    Gene3Di 3.30.40.10. 3 hits.
    InterProi IPR006560. AWS.
    IPR003616. Post-SET_dom.
    IPR000313. PWWP_dom.
    IPR001214. SET_dom.
    IPR019786. Zinc_finger_PHD-type_CS.
    IPR011011. Znf_FYVE_PHD.
    IPR001965. Znf_PHD.
    IPR019787. Znf_PHD-finger.
    IPR001841. Znf_RING.
    IPR013083. Znf_RING/FYVE/PHD.
    [Graphical view ]
    Pfami PF00628. PHD. 1 hit.
    PF00855. PWWP. 2 hits.
    PF00856. SET. 1 hit.
    [Graphical view ]
    SMARTi SM00570. AWS. 1 hit.
    SM00249. PHD. 5 hits.
    SM00508. PostSET. 1 hit.
    SM00293. PWWP. 2 hits.
    SM00184. RING. 2 hits.
    SM00317. SET. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57903. SSF57903. 2 hits.
    PROSITEi PS51215. AWS. 1 hit.
    PS50868. POST_SET. 1 hit.
    PS50812. PWWP. 2 hits.
    PS50280. SET. 1 hit.
    PS01359. ZF_PHD_1. 2 hits.
    PS50016. ZF_PHD_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The zebrafish reference genome sequence and its relationship to the human genome."
      Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.
      , White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., Clee C., Oliver K., Clark R., Riddle C., Eliott D., Threadgold G., Harden G., Ware D., Mortimer B., Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.
      Nature 496:498-503(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: TuebingenImported.
    2. Ensembl
      Submitted (AUG-2013) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: TuebingenImported.

    Entry informationi

    Entry nameiB8JIA4_DANRE
    AccessioniPrimary (citable) accession number: B8JIA4
    Entry historyi
    Integrated into UniProtKB/TrEMBL: March 3, 2009
    Last sequence update: March 3, 2009
    Last modified: October 1, 2014
    This is version 48 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Caution

    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3