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Protein
Submitted name:

Nuclear receptor-binding SET domain protein 2

Gene

nsd2

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N6-methyl-L-lysine-[histone].SAAS annotation

GO - Molecular functioni

GO - Biological processi

  • cartilage development Source: ZFIN
  • embryonic skeletal system development Source: ZFIN
  • histone H3-K36 methylation Source: ZFIN

Keywordsi

Molecular functionMethyltransferaseSAAS annotation, Transferase
LigandMetal-binding, S-adenosyl-L-methionineSAAS annotation, Zinc

Enzyme and pathway databases

ReactomeiR-DRE-3214841 PKMTs methylate histone lysines
R-DRE-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
R-DRE-5693571 Nonhomologous End-Joining (NHEJ)
R-DRE-5693607 Processing of DNA double-strand break ends
R-DRE-69473 G2/M DNA damage checkpoint

Names & Taxonomyi

Protein namesi
Submitted name:
Nuclear receptor-binding SET domain protein 2Imported
Gene namesi
Name:nsd2Imported
Synonyms:whsc1Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 13

Organism-specific databases

ZFINiZDB-GENE-030131-2581 nsd2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusSAAS annotation

PTM / Processingi

Proteomic databases

PaxDbiB8JIA4
PeptideAtlasiB8JIA4

Expressioni

Gene expression databases

BgeeiENSDARG00000026225

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000002944

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini285 – 349PWWPInterPro annotationAdd BLAST65
Domaini923 – 967PHD-typeInterPro annotationAdd BLAST45
Domaini972 – 1034PWWPInterPro annotationAdd BLAST63
Domaini1102 – 1152AWSInterPro annotationAdd BLAST51
Domaini1154 – 1271SETInterPro annotationAdd BLAST118
Domaini1278 – 1294Post-SETInterPro annotationAdd BLAST17

Keywords - Domaini

Zinc-fingerPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG1081 Eukaryota
COG2940 LUCA
GeneTreeiENSGT00780000121845
HOVERGENiHBG106834
InParanoidiB8JIA4
KOiK11424
OMAiCMARIKY
OrthoDBiEOG091G00XD
PhylomeDBiB8JIA4
TreeFamiTF329088

Family and domain databases

Gene3Di3.30.40.10, 4 hits
InterProiView protein in InterPro
IPR006560 AWS_dom
IPR003616 Post-SET_dom
IPR000313 PWWP_dom
IPR001214 SET_dom
IPR019786 Zinc_finger_PHD-type_CS
IPR011011 Znf_FYVE_PHD
IPR001965 Znf_PHD
IPR019787 Znf_PHD-finger
IPR013083 Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF00855 PWWP, 2 hits
PF00856 SET, 1 hit
SMARTiView protein in SMART
SM00570 AWS, 1 hit
SM00249 PHD, 5 hits
SM00508 PostSET, 1 hit
SM00293 PWWP, 2 hits
SM00317 SET, 1 hit
SUPFAMiSSF57903 SSF57903, 2 hits
PROSITEiView protein in PROSITE
PS51215 AWS, 1 hit
PS50868 POST_SET, 1 hit
PS50812 PWWP, 2 hits
PS50280 SET, 1 hit
PS01359 ZF_PHD_1, 2 hits
PS50016 ZF_PHD_2, 1 hit

Sequencei

Sequence statusi: Complete.

B8JIA4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDSKGGSLP AMPEPKSPTS MKQLSDSPGG RNGLVDGITD PTMLMNKAAT
60 70 80 90 100
QLAATPQESV PQMIGSHGHN HTHEHLKDLT SRLLNGDTEK IPKLCAAPAG
110 120 130 140 150
QPLLKGVEPV SQHASPPRKT SVSPELTVKI TKCVVNLGGK PNRYEVDYTE
160 170 180 190 200
EKAEETDAPL RLPEGVLTSP TARRDRQKKK GMVRKRIPPY PILTHAASSD
210 220 230 240 250
QSPLLHPTIN SNDITIEPCG LPVESIEHTH GDMPTCVTAF PDEQPLSDCE
260 270 280 290 300
ETVDAQGVDE TDDAQGENDV KESYTETQSN VHFSVGDVIW TKVSGYPWWP
310 320 330 340 350
CMITTDPEFN MHFRSKVNSR TGLLYHVQYF GDTPERGYVF EKCIVTFSGK
360 370 380 390 400
HQYQSLSRSN QLPINISGRK RAVPRKFRQK WEIGVSQAKE ALGLLTEERL
410 420 430 440 450
AKFSFVYEDG KAQLNPHMLQ VLEEQRNQGL QEEPVQREPQ ELVSLTPPDS
460 470 480 490 500
THSSPTNSST TSTIPSLFSN PIDSSTSSGK TALPRKARKP SVKTNRRKQR
510 520 530 540 550
SSTIEWIVTE ASSAKQMPLT ESTVQCEVNT EHKKKGKTNA GKRPYRKKDL
560 570 580 590 600
LCIDLDLQPK ASQKKPRHIR QKFPAAPNSV KKRKIKAGVS ICDTLNTVST
610 620 630 640 650
SAGLSEVKAS APSTKLWEKE DASSKGMKKV CKRSRESKQD VTLQPKKKSK
660 670 680 690 700
LEKDFKKWKC PKAASSAPAA VPAPRGRRRK TDRDENRKRS KKASKEEPPP
710 720 730 740 750
KAKRGRKRKE ESGRQSFPAS KKCRPSSYAE PERPDSPSDS TDESHPSKKA
760 770 780 790 800
ERTPGAKKES VCLVCEQTGE DIVTCAGQCY GTYHLHCIGV ERSAEKILCT
810 820 830 840 850
ACSTGVHVCF TCKKSEGEVR RCCALHCGRF YHEACVRLSA LTVFENRGFR
860 870 880 890 900
CPLHTCLSCH YSGRAACKAT KGKMMRCLRC PVAYHVGDLC VAAGSEMISS
910 920 930 940 950
SAIVCTNHFR AKKGYSHHSH VNVSWCFICS KGGRLLCCES CPAAFHPDCL
960 970 980 990 1000
NIAMPDGSWF CNDCRSGKKP KYRDVIWVKL GNYRWWPAEI RHPKNIPTNI
1010 1020 1030 1040 1050
QHLRHEIGEF PVFFFGSKDY FWTHQGRVFP YMEGDRGSKY QQTGIGKVFK
1060 1070 1080 1090 1100
NALLDAETRF KEIEMEREAK EAHENNKKPP PFKYIKVNKP CGRVQVYTAD
1110 1120 1130 1140 1150
ISEIPKCNCK PSTERPCSFE SECLNRMLLY ECHPQVCPAG ERCQNQDFTK
1160 1170 1180 1190 1200
RLYPETKIIR TAGKGWGLIS LRDIKKGEFV NEYVGELIDE EECRSRIRHA
1210 1220 1230 1240 1250
QENDITHFYM LTIDKDRIID AGPKGNYSRF MNHSCQPNCE TQKWTVNGDT
1260 1270 1280 1290 1300
RVGLFAVCDI PAGTELTFNY NLDCLGNEKT VCRCGAPNCS GFLGDRPKNG
1310 1320 1330 1340 1350
HTSEPKAKLQ KKKPKRKRAR NEGKKSEDEC FRCGDGGQLV LCDKKGCTKA
1360 1370 1380 1390 1400
YHLSCLDRTK RPFGRWDCPW HHCDVCGKNS AAFCQLCPNS FCKAHQEGAL
1410 1420 1430 1440 1450
RSHPLTGQLC CQEHEDSDIR PQTETAQLPP PTKPRKYRRR AEAKTTSKAP
1460
LKKRPRKNAE V
Length:1,461
Mass (Da):163,792
Last modified:March 3, 2009 - v1
Checksum:i4D7815F3AF48B62D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR556722 Genomic DNA No translation available.
CT573111 Genomic DNA No translation available.
RefSeqiNP_001076020.1, NM_001082551.1
UniGeneiDr.78031

Genome annotation databases

EnsembliENSDART00000009499; ENSDARP00000002944; ENSDARG00000026225
GeneIDi100000709
KEGGidre:100000709

Similar proteinsi

Entry informationi

Entry nameiB8JIA4_DANRE
AccessioniPrimary (citable) accession number: B8JIA4
Entry historyiIntegrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: June 20, 2018
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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