Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Histone-lysine N-methyltransferase

Gene

whsc1

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].SAAS annotation

GO - Molecular functioni

  1. histone-lysine N-methyltransferase activity Source: InterPro
  2. zinc ion binding Source: InterPro

GO - Biological processi

  1. cartilage development Source: ZFIN
  2. embryonic skeletal system development Source: ZFIN
  3. histone H3-K36 methylation Source: ZFIN
Complete GO annotation...

Keywords - Molecular functioni

MethyltransferaseUniRule annotationSAAS annotation, Transferase

Keywords - Ligandi

Metal-binding, S-adenosyl-L-methionineSAAS annotation, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferaseSAAS annotation (EC:2.1.1.43SAAS annotation)
Gene namesi
Name:whsc1Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
ProteomesiUP000000437: Chromosome 13

Organism-specific databases

ZFINiZDB-GENE-030131-2581. whsc1.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

NucleusSAAS annotation

Family & Domainsi

Sequence similaritiesi

Contains 1 SET domain.UniRule annotation
Contains 1 post-SET domain.UniRule annotation
Contains SET domain.SAAS annotation
Contains post-SET domain.SAAS annotation

Keywords - Domaini

Zinc-fingerSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00780000121845.
HOVERGENiHBG106834.
InParanoidiB8JIA4.
KOiK11424.
OMAiFWTHQGR.
OrthoDBiEOG7Z69BG.
PhylomeDBiB8JIA4.
TreeFamiTF329088.

Family and domain databases

Gene3Di3.30.40.10. 3 hits.
InterProiIPR006560. AWS_dom.
IPR003616. Post-SET_dom.
IPR000313. PWWP_dom.
IPR001214. SET_dom.
IPR019786. Zinc_finger_PHD-type_CS.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF00628. PHD. 1 hit.
PF00855. PWWP. 2 hits.
PF00856. SET. 1 hit.
[Graphical view]
SMARTiSM00570. AWS. 1 hit.
SM00249. PHD. 5 hits.
SM00508. PostSET. 1 hit.
SM00293. PWWP. 2 hits.
SM00184. RING. 2 hits.
SM00317. SET. 1 hit.
[Graphical view]
SUPFAMiSSF57903. SSF57903. 2 hits.
PROSITEiPS51215. AWS. 1 hit.
PS50868. POST_SET. 1 hit.
PS50812. PWWP. 2 hits.
PS50280. SET. 1 hit.
PS01359. ZF_PHD_1. 2 hits.
PS50016. ZF_PHD_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B8JIA4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTDSKGGSLP AMPEPKSPTS MKQLSDSPGG RNGLVDGITD PTMLMNKAAT
60 70 80 90 100
QLAATPQESV PQMIGSHGHN HTHEHLKDLT SRLLNGDTEK IPKLCAAPAG
110 120 130 140 150
QPLLKGVEPV SQHASPPRKT SVSPELTVKI TKCVVNLGGK PNRYEVDYTE
160 170 180 190 200
EKAEETDAPL RLPEGVLTSP TARRDRQKKK GMVRKRIPPY PILTHAASSD
210 220 230 240 250
QSPLLHPTIN SNDITIEPCG LPVESIEHTH GDMPTCVTAF PDEQPLSDCE
260 270 280 290 300
ETVDAQGVDE TDDAQGENDV KESYTETQSN VHFSVGDVIW TKVSGYPWWP
310 320 330 340 350
CMITTDPEFN MHFRSKVNSR TGLLYHVQYF GDTPERGYVF EKCIVTFSGK
360 370 380 390 400
HQYQSLSRSN QLPINISGRK RAVPRKFRQK WEIGVSQAKE ALGLLTEERL
410 420 430 440 450
AKFSFVYEDG KAQLNPHMLQ VLEEQRNQGL QEEPVQREPQ ELVSLTPPDS
460 470 480 490 500
THSSPTNSST TSTIPSLFSN PIDSSTSSGK TALPRKARKP SVKTNRRKQR
510 520 530 540 550
SSTIEWIVTE ASSAKQMPLT ESTVQCEVNT EHKKKGKTNA GKRPYRKKDL
560 570 580 590 600
LCIDLDLQPK ASQKKPRHIR QKFPAAPNSV KKRKIKAGVS ICDTLNTVST
610 620 630 640 650
SAGLSEVKAS APSTKLWEKE DASSKGMKKV CKRSRESKQD VTLQPKKKSK
660 670 680 690 700
LEKDFKKWKC PKAASSAPAA VPAPRGRRRK TDRDENRKRS KKASKEEPPP
710 720 730 740 750
KAKRGRKRKE ESGRQSFPAS KKCRPSSYAE PERPDSPSDS TDESHPSKKA
760 770 780 790 800
ERTPGAKKES VCLVCEQTGE DIVTCAGQCY GTYHLHCIGV ERSAEKILCT
810 820 830 840 850
ACSTGVHVCF TCKKSEGEVR RCCALHCGRF YHEACVRLSA LTVFENRGFR
860 870 880 890 900
CPLHTCLSCH YSGRAACKAT KGKMMRCLRC PVAYHVGDLC VAAGSEMISS
910 920 930 940 950
SAIVCTNHFR AKKGYSHHSH VNVSWCFICS KGGRLLCCES CPAAFHPDCL
960 970 980 990 1000
NIAMPDGSWF CNDCRSGKKP KYRDVIWVKL GNYRWWPAEI RHPKNIPTNI
1010 1020 1030 1040 1050
QHLRHEIGEF PVFFFGSKDY FWTHQGRVFP YMEGDRGSKY QQTGIGKVFK
1060 1070 1080 1090 1100
NALLDAETRF KEIEMEREAK EAHENNKKPP PFKYIKVNKP CGRVQVYTAD
1110 1120 1130 1140 1150
ISEIPKCNCK PSTERPCSFE SECLNRMLLY ECHPQVCPAG ERCQNQDFTK
1160 1170 1180 1190 1200
RLYPETKIIR TAGKGWGLIS LRDIKKGEFV NEYVGELIDE EECRSRIRHA
1210 1220 1230 1240 1250
QENDITHFYM LTIDKDRIID AGPKGNYSRF MNHSCQPNCE TQKWTVNGDT
1260 1270 1280 1290 1300
RVGLFAVCDI PAGTELTFNY NLDCLGNEKT VCRCGAPNCS GFLGDRPKNG
1310 1320 1330 1340 1350
HTSEPKAKLQ KKKPKRKRAR NEGKKSEDEC FRCGDGGQLV LCDKKGCTKA
1360 1370 1380 1390 1400
YHLSCLDRTK RPFGRWDCPW HHCDVCGKNS AAFCQLCPNS FCKAHQEGAL
1410 1420 1430 1440 1450
RSHPLTGQLC CQEHEDSDIR PQTETAQLPP PTKPRKYRRR AEAKTTSKAP
1460
LKKRPRKNAE V
Length:1,461
Mass (Da):163,792
Last modified:March 3, 2009 - v1
Checksum:i4D7815F3AF48B62D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR556722 Genomic DNA. No translation available.
CT573111 Genomic DNA. No translation available.
RefSeqiNP_001076020.1. NM_001082551.1.
UniGeneiDr.78031.

Genome annotation databases

EnsembliENSDART00000009499; ENSDARP00000002944; ENSDARG00000026225.
GeneIDi100000709.
KEGGidre:100000709.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR556722 Genomic DNA. No translation available.
CT573111 Genomic DNA. No translation available.
RefSeqiNP_001076020.1. NM_001082551.1.
UniGeneiDr.78031.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000009499; ENSDARP00000002944; ENSDARG00000026225.
GeneIDi100000709.
KEGGidre:100000709.

Organism-specific databases

CTDi7468.
ZFINiZDB-GENE-030131-2581. whsc1.

Phylogenomic databases

GeneTreeiENSGT00780000121845.
HOVERGENiHBG106834.
InParanoidiB8JIA4.
KOiK11424.
OMAiFWTHQGR.
OrthoDBiEOG7Z69BG.
PhylomeDBiB8JIA4.
TreeFamiTF329088.

Miscellaneous databases

NextBioi20784754.
PROiB8JIA4.

Family and domain databases

Gene3Di3.30.40.10. 3 hits.
InterProiIPR006560. AWS_dom.
IPR003616. Post-SET_dom.
IPR000313. PWWP_dom.
IPR001214. SET_dom.
IPR019786. Zinc_finger_PHD-type_CS.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF00628. PHD. 1 hit.
PF00855. PWWP. 2 hits.
PF00856. SET. 1 hit.
[Graphical view]
SMARTiSM00570. AWS. 1 hit.
SM00249. PHD. 5 hits.
SM00508. PostSET. 1 hit.
SM00293. PWWP. 2 hits.
SM00184. RING. 2 hits.
SM00317. SET. 1 hit.
[Graphical view]
SUPFAMiSSF57903. SSF57903. 2 hits.
PROSITEiPS51215. AWS. 1 hit.
PS50868. POST_SET. 1 hit.
PS50812. PWWP. 2 hits.
PS50280. SET. 1 hit.
PS01359. ZF_PHD_1. 2 hits.
PS50016. ZF_PHD_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The zebrafish reference genome sequence and its relationship to the human genome."
    Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.
    , White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., Clee C., Oliver K., Clark R., Riddle C., Eliott D., Threadgold G., Harden G., Ware D., Mortimer B., Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.
    Nature 496:498-503(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TuebingenImported.
  2. Ensembl
    Submitted (AUG-2013) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: TuebingenImported.

Entry informationi

Entry nameiB8JIA4_DANRE
AccessioniPrimary (citable) accession number: B8JIA4
Entry historyi
Integrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: February 4, 2015
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.