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B8JIA4

- B8JIA4_DANRE

UniProt

B8JIA4 - B8JIA4_DANRE

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Protein
Submitted name: Uncharacterized protein
Gene
whsc1
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein predictedi

Functioni

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].SAAS annotations

GO - Molecular functioni

  1. histone-lysine N-methyltransferase activity Source: InterPro
  2. zinc ion binding Source: InterPro

GO - Biological processi

  1. cartilage development Source: ZFIN
  2. embryonic skeletal system development Source: ZFIN
  3. histone H3-K36 methylation Source: ZFIN
Complete GO annotation...

Keywords - Molecular functioni

MethyltransferaseUniRule annotation, Transferase

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:whsc1Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
ProteomesiUP000000437: Chromosome 13

Organism-specific databases

ZFINiZDB-GENE-030131-2581. whsc1.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

NucleusSAAS annotations

Family & Domainsi

Sequence similaritiesi

Contains 1 SET domain.UniRule annotation
Contains 1 post-SET domain.UniRule annotation
Contains SET domain.SAAS annotations
Contains post-SET domain.SAAS annotations

Keywords - Domaini

Zinc-fingerSAAS annotations

Phylogenomic databases

GeneTreeiENSGT00740000114921.
HOVERGENiHBG106834.
KOiK11424.
OMAiFESECLN.
OrthoDBiEOG7Z69BG.
PhylomeDBiB8JIA4.
TreeFamiTF329088.

Family and domain databases

Gene3Di3.30.40.10. 3 hits.
InterProiIPR006560. AWS.
IPR003616. Post-SET_dom.
IPR000313. PWWP_dom.
IPR001214. SET_dom.
IPR019786. Zinc_finger_PHD-type_CS.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF00628. PHD. 1 hit.
PF00855. PWWP. 2 hits.
PF00856. SET. 1 hit.
[Graphical view]
SMARTiSM00570. AWS. 1 hit.
SM00249. PHD. 5 hits.
SM00508. PostSET. 1 hit.
SM00293. PWWP. 2 hits.
SM00184. RING. 2 hits.
SM00317. SET. 1 hit.
[Graphical view]
SUPFAMiSSF57903. SSF57903. 2 hits.
PROSITEiPS51215. AWS. 1 hit.
PS50868. POST_SET. 1 hit.
PS50812. PWWP. 2 hits.
PS50280. SET. 1 hit.
PS01359. ZF_PHD_1. 2 hits.
PS50016. ZF_PHD_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B8JIA4-1 [UniParc]FASTAAdd to Basket

« Hide

MTDSKGGSLP AMPEPKSPTS MKQLSDSPGG RNGLVDGITD PTMLMNKAAT     50
QLAATPQESV PQMIGSHGHN HTHEHLKDLT SRLLNGDTEK IPKLCAAPAG 100
QPLLKGVEPV SQHASPPRKT SVSPELTVKI TKCVVNLGGK PNRYEVDYTE 150
EKAEETDAPL RLPEGVLTSP TARRDRQKKK GMVRKRIPPY PILTHAASSD 200
QSPLLHPTIN SNDITIEPCG LPVESIEHTH GDMPTCVTAF PDEQPLSDCE 250
ETVDAQGVDE TDDAQGENDV KESYTETQSN VHFSVGDVIW TKVSGYPWWP 300
CMITTDPEFN MHFRSKVNSR TGLLYHVQYF GDTPERGYVF EKCIVTFSGK 350
HQYQSLSRSN QLPINISGRK RAVPRKFRQK WEIGVSQAKE ALGLLTEERL 400
AKFSFVYEDG KAQLNPHMLQ VLEEQRNQGL QEEPVQREPQ ELVSLTPPDS 450
THSSPTNSST TSTIPSLFSN PIDSSTSSGK TALPRKARKP SVKTNRRKQR 500
SSTIEWIVTE ASSAKQMPLT ESTVQCEVNT EHKKKGKTNA GKRPYRKKDL 550
LCIDLDLQPK ASQKKPRHIR QKFPAAPNSV KKRKIKAGVS ICDTLNTVST 600
SAGLSEVKAS APSTKLWEKE DASSKGMKKV CKRSRESKQD VTLQPKKKSK 650
LEKDFKKWKC PKAASSAPAA VPAPRGRRRK TDRDENRKRS KKASKEEPPP 700
KAKRGRKRKE ESGRQSFPAS KKCRPSSYAE PERPDSPSDS TDESHPSKKA 750
ERTPGAKKES VCLVCEQTGE DIVTCAGQCY GTYHLHCIGV ERSAEKILCT 800
ACSTGVHVCF TCKKSEGEVR RCCALHCGRF YHEACVRLSA LTVFENRGFR 850
CPLHTCLSCH YSGRAACKAT KGKMMRCLRC PVAYHVGDLC VAAGSEMISS 900
SAIVCTNHFR AKKGYSHHSH VNVSWCFICS KGGRLLCCES CPAAFHPDCL 950
NIAMPDGSWF CNDCRSGKKP KYRDVIWVKL GNYRWWPAEI RHPKNIPTNI 1000
QHLRHEIGEF PVFFFGSKDY FWTHQGRVFP YMEGDRGSKY QQTGIGKVFK 1050
NALLDAETRF KEIEMEREAK EAHENNKKPP PFKYIKVNKP CGRVQVYTAD 1100
ISEIPKCNCK PSTERPCSFE SECLNRMLLY ECHPQVCPAG ERCQNQDFTK 1150
RLYPETKIIR TAGKGWGLIS LRDIKKGEFV NEYVGELIDE EECRSRIRHA 1200
QENDITHFYM LTIDKDRIID AGPKGNYSRF MNHSCQPNCE TQKWTVNGDT 1250
RVGLFAVCDI PAGTELTFNY NLDCLGNEKT VCRCGAPNCS GFLGDRPKNG 1300
HTSEPKAKLQ KKKPKRKRAR NEGKKSEDEC FRCGDGGQLV LCDKKGCTKA 1350
YHLSCLDRTK RPFGRWDCPW HHCDVCGKNS AAFCQLCPNS FCKAHQEGAL 1400
RSHPLTGQLC CQEHEDSDIR PQTETAQLPP PTKPRKYRRR AEAKTTSKAP 1450
LKKRPRKNAE V 1461
Length:1,461
Mass (Da):163,792
Last modified:March 3, 2009 - v1
Checksum:i4D7815F3AF48B62D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR556722 Genomic DNA. No translation available.
CT573111 Genomic DNA. No translation available.
RefSeqiNP_001076020.1. NM_001082551.1.
UniGeneiDr.78031.

Genome annotation databases

EnsembliENSDART00000009499; ENSDARP00000002944; ENSDARG00000026225.
GeneIDi100000709.
KEGGidre:100000709.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR556722 Genomic DNA. No translation available.
CT573111 Genomic DNA. No translation available.
RefSeqi NP_001076020.1. NM_001082551.1.
UniGenei Dr.78031.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSDART00000009499 ; ENSDARP00000002944 ; ENSDARG00000026225 .
GeneIDi 100000709.
KEGGi dre:100000709.

Organism-specific databases

CTDi 7468.
ZFINi ZDB-GENE-030131-2581. whsc1.

Phylogenomic databases

GeneTreei ENSGT00740000114921.
HOVERGENi HBG106834.
KOi K11424.
OMAi FESECLN.
OrthoDBi EOG7Z69BG.
PhylomeDBi B8JIA4.
TreeFami TF329088.

Miscellaneous databases

NextBioi 20784754.
PROi B8JIA4.

Family and domain databases

Gene3Di 3.30.40.10. 3 hits.
InterProi IPR006560. AWS.
IPR003616. Post-SET_dom.
IPR000313. PWWP_dom.
IPR001214. SET_dom.
IPR019786. Zinc_finger_PHD-type_CS.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view ]
Pfami PF00628. PHD. 1 hit.
PF00855. PWWP. 2 hits.
PF00856. SET. 1 hit.
[Graphical view ]
SMARTi SM00570. AWS. 1 hit.
SM00249. PHD. 5 hits.
SM00508. PostSET. 1 hit.
SM00293. PWWP. 2 hits.
SM00184. RING. 2 hits.
SM00317. SET. 1 hit.
[Graphical view ]
SUPFAMi SSF57903. SSF57903. 2 hits.
PROSITEi PS51215. AWS. 1 hit.
PS50868. POST_SET. 1 hit.
PS50812. PWWP. 2 hits.
PS50280. SET. 1 hit.
PS01359. ZF_PHD_1. 2 hits.
PS50016. ZF_PHD_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The zebrafish reference genome sequence and its relationship to the human genome."
    Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.
    , White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., Clee C., Oliver K., Clark R., Riddle C., Eliott D., Threadgold G., Harden G., Ware D., Mortimer B., Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.
    Nature 496:498-503(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TuebingenImported.
  2. Ensembl
    Submitted (AUG-2013) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: TuebingenImported.

Entry informationi

Entry nameiB8JIA4_DANRE
AccessioniPrimary (citable) accession number: B8JIA4
Entry historyi
Integrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: July 9, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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