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Protein

S-adenosylmethionine:tRNA ribosyltransferase-isomerase

Gene

queA

Organism
Anaeromyxobacter dehalogenans (strain 2CP-1 / ATCC BAA-258)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + 7-aminomethyl-7-carbaguanosine(34) in tRNA = L-methionine + adenine + epoxyqueuosine(34) in tRNA.UniRule annotation

Pathwayi: tRNA-queuosine biosynthesis

This protein is involved in the pathway tRNA-queuosine biosynthesis, which is part of tRNA modification.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway tRNA-queuosine biosynthesis and in tRNA modification.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processQueuosine biosynthesis
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciADEH455488:G1GUO-1415-MONOMER
UniPathwayiUPA00392

Names & Taxonomyi

Protein namesi
Recommended name:
S-adenosylmethionine:tRNA ribosyltransferase-isomeraseUniRule annotation (EC:2.4.99.17UniRule annotation)
Alternative name(s):
Queuosine biosynthesis protein QueAUniRule annotation
Gene namesi
Name:queAUniRule annotation
Ordered Locus Names:A2cp1_1406
OrganismiAnaeromyxobacter dehalogenans (strain 2CP-1 / ATCC BAA-258)
Taxonomic identifieri455488 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaMyxococcalesCystobacterineaeAnaeromyxobacteraceaeAnaeromyxobacter
Proteomesi
  • UP000007089 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001191381 – 345S-adenosylmethionine:tRNA ribosyltransferase-isomeraseAdd BLAST345

Proteomic databases

PRIDEiB8JH48

Interactioni

Subunit structurei

Monomer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliB8JH48
SMRiB8JH48
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the QueA family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000004403
KOiK07568
OMAiYSYGDGM
OrthoDBiPOG091H00ZG

Family and domain databases

HAMAPiMF_00113 QueA, 1 hit
InterProiView protein in InterPro
IPR003699 QueA
IPR036100 QueA_sf
PANTHERiPTHR30307 PTHR30307, 1 hit
PfamiView protein in Pfam
PF02547 Queuosine_synth, 1 hit
SUPFAMiSSF111337 SSF111337, 1 hit
TIGRFAMsiTIGR00113 queA, 1 hit

Sequencei

Sequence statusi: Complete.

B8JH48-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLSDFDFAL PEGLVAQAPV TPRDASRLMV LAPEEGSPAH RGFADLPELL
60 70 80 90 100
APGDLLVFND TRVIPARLLG HKASGGKVEL LLCEPLEGGL GRRWRAMGQA
110 120 130 140 150
SKPIREGAVL TFDGLEARVD DVEGEGFYRV TLDRQGPELE AALGRAGRIP
160 170 180 190 200
LPPYIRRAPD AEDAARYQTI WARAPGSAAA PTAGLHFTEP LLARLAARGI
210 220 230 240 250
RRTAVTLHVG PGTFLPIRGD DLDLHRMHGE RYEVSPAAAA ELAATRARGG
260 270 280 290 300
RIVAVGTTSV RTLESAWRDG AVAAGPGRTE LFIRPGHPFH AVDAMVTNFH
310 320 330 340
LPRSTLLVLV CAFGGQGRVL AAYREAVARG YRFFSYGDAM LLLRR
Length:345
Mass (Da):37,183
Last modified:March 3, 2009 - v1
Checksum:i64975B0D4CDCD345
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001359 Genomic DNA Translation: ACL64750.1
RefSeqiWP_012632707.1, NC_011891.1

Genome annotation databases

EnsemblBacteriaiACL64750; ACL64750; A2cp1_1406
KEGGiacp:A2cp1_1406

Similar proteinsi

Entry informationi

Entry nameiQUEA_ANAD2
AccessioniPrimary (citable) accession number: B8JH48
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 3, 2009
Last modified: April 25, 2018
This is version 56 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
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Main funding by: National Institutes of Health