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B8JE78

- LPXB_ANAD2

UniProt

B8JE78 - LPXB_ANAD2

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Protein

Lipid-A-disaccharide synthase

Gene
lpxB, A2cp1_2806
Organism
Anaeromyxobacter dehalogenans (strain 2CP-1 / ATCC BAA-258)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity.UniRule annotation

Catalytic activityi

UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. lipid A biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciADEH455488:GH35-2843-MONOMER.
UniPathwayiUPA00359; UER00481.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid-A-disaccharide synthase (EC:2.4.1.182)
Gene namesi
Name:lpxB
Ordered Locus Names:A2cp1_2806
OrganismiAnaeromyxobacter dehalogenans (strain 2CP-1 / ATCC BAA-258)
Taxonomic identifieri455488 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaMyxococcalesCystobacterineaeMyxococcaceaeAnaeromyxobacter
ProteomesiUP000007089: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 383383Lipid-A-disaccharide synthaseUniRule annotationPRO_1000191460Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi455488.A2cp1_2806.

Structurei

3D structure databases

ProteinModelPortaliB8JE78.

Family & Domainsi

Sequence similaritiesi

Belongs to the LpxB family.

Phylogenomic databases

eggNOGiCOG0763.
HOGENOMiHOG000018004.
KOiK00748.
OMAiRRSEIRH.
OrthoDBiEOG6FBWZR.

Family and domain databases

HAMAPiMF_00392. LpxB.
InterProiIPR003835. Glyco_trans_19.
[Graphical view]
PfamiPF02684. LpxB. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00215. lpxB. 1 hit.

Sequencei

Sequence statusi: Complete.

B8JE78-1 [UniParc]FASTAAdd to Basket

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MLYSPRLTDQ ILIVAGEASA DLHAARTLHE LQRLRPGITA FGVGGPRLRE    50
AGLEALAPAE DISVMGLAEV LPRIPRILGI LRMLGRAAAE RRPRAALLVD 100
LPDFNLRLAA RLKKLGIPVV YYVSPTIWAW RQGRAKKIAR VVDRMLCILP 150
FEERFYEGTG VSARFVGHPF AERPPPGPAE AYRSALGLPA SRTTIAMVPG 200
SRPSELKRLL PPMLQAAERL RAAHPDAQFV VPVAPTLDRA ALEPYLAAHR 250
TLEVRLVDGR TEEVVGASDA ALVKSGTSTL EAGLMLRPMV VVYKLSWLSY 300
AVARMLVKIA HVALVNILAG RGIVPELLQG DASPERMAAE VERLLGDRAA 350
REAQIAALRE VRASLGEPGA PLRVAEEVLG VMR 383
Length:383
Mass (Da):41,563
Last modified:March 3, 2009 - v1
Checksum:i15B37DFA38E85FBB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001359 Genomic DNA. Translation: ACL66143.1.
RefSeqiYP_002493209.1. NC_011891.1.

Genome annotation databases

EnsemblBacteriaiACL66143; ACL66143; A2cp1_2806.
GeneIDi7298879.
KEGGiacp:A2cp1_2806.
PATRICi20912541. VBIAnaDeh28364_2845.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001359 Genomic DNA. Translation: ACL66143.1 .
RefSeqi YP_002493209.1. NC_011891.1.

3D structure databases

ProteinModelPortali B8JE78.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 455488.A2cp1_2806.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACL66143 ; ACL66143 ; A2cp1_2806 .
GeneIDi 7298879.
KEGGi acp:A2cp1_2806.
PATRICi 20912541. VBIAnaDeh28364_2845.

Phylogenomic databases

eggNOGi COG0763.
HOGENOMi HOG000018004.
KOi K00748.
OMAi RRSEIRH.
OrthoDBi EOG6FBWZR.

Enzyme and pathway databases

UniPathwayi UPA00359 ; UER00481 .
BioCyci ADEH455488:GH35-2843-MONOMER.

Family and domain databases

HAMAPi MF_00392. LpxB.
InterProi IPR003835. Glyco_trans_19.
[Graphical view ]
Pfami PF02684. LpxB. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00215. lpxB. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of Anaeromyxobacter dehalogenans 2CP-1."
    Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Saunders E., Brettin T., Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N., Ovchinnikova G., Beliaev A.S., Richardson P.
    Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 2CP-1 / ATCC BAA-258.

Entry informationi

Entry nameiLPXB_ANAD2
AccessioniPrimary (citable) accession number: B8JE78
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 3, 2009
Last modified: May 14, 2014
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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