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Protein

Probable glycine dehydrogenase (decarboxylating) subunit 1

Gene

gcvPA

Organism
Anaeromyxobacter dehalogenans (strain 2CP-1 / ATCC BAA-258)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N6-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N6-dihydrolipoyl-L-lysine + CO2.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase

Enzyme and pathway databases

BioCyciADEH455488:G1GUO-2742-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 1UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-protein subunit 1UniRule annotation
Glycine decarboxylase subunit 1UniRule annotation
Glycine dehydrogenase (aminomethyl-transferring) subunit 1UniRule annotation
Gene namesi
Name:gcvPAUniRule annotation
Ordered Locus Names:A2cp1_2716
OrganismiAnaeromyxobacter dehalogenans (strain 2CP-1 / ATCC BAA-258)
Taxonomic identifieri455488 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaMyxococcalesCystobacterineaeAnaeromyxobacteraceaeAnaeromyxobacter
Proteomesi
  • UP000007089 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001479741 – 445Probable glycine dehydrogenase (decarboxylating) subunit 1Add BLAST445

Proteomic databases

PRIDEiB8JDY8

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliB8JDY8
SMRiB8JDY8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family. N-terminal subunit subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000132025
KOiK00282
OMAiMYDGASA
OrthoDBiPOG091H0JKN

Family and domain databases

CDDicd00613 GDC-P, 1 hit
Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
HAMAPiMF_00712 GcvPA, 1 hit
InterProiView protein in InterPro
IPR023010 GcvPA
IPR020581 GDC_P
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PANTHERiPTHR42806 PTHR42806, 1 hit
PfamiView protein in Pfam
PF02347 GDC-P, 1 hit
PIRSFiPIRSF006815 GcvPA, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit

Sequencei

Sequence statusi: Complete.

B8JDY8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRYHPHTPDD VRAMLDVVGA ERVDDLFRSI PQALRLDRPL DLPPAADEIA
60 70 80 90 100
LFSELRRLAA RNETAHPPFV GAGCYPHHVP PVVDQLLLRG EFFTAYTPYQ
110 120 130 140 150
PEISQGTLQA LFEWQTFVCL LTGMDVSNAS MYDGATATAE AALMAGRITG
160 170 180 190 200
RDKVVVSAAL HPEYRKVLAT YLRSTGDEIV TVPFGADGRT DLAALAQAVD
210 220 230 240 250
GRTACVILGY PNFLGVVDAL PEAAALARAA GALTVAATAE AVSLGLLQAP
260 270 280 290 300
GALGADVAVG TFQSFGNPMS FGGPAPGFFA TREKSLRQMP GRVAGATVDK
310 320 330 340 350
QGRRGFVLTL STREQHIRRE KATSNICTNS GLCALASTIH LSLLGKRGLA
360 370 380 390 400
ELARLNHGRA RMLRDAMERA GCRPVFSGPY FNEQVFDVGD AEAVVAKLAK
410 420 430 440
RGIVAGAPLA RWYPDAPHAK GALLCAATEL HGPELIQLFA STVRS
Length:445
Mass (Da):47,421
Last modified:March 3, 2009 - v1
Checksum:i026BC5F02B6A1712
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001359 Genomic DNA Translation: ACL66053.1
RefSeqiWP_012633820.1, NC_011891.1

Genome annotation databases

EnsemblBacteriaiACL66053; ACL66053; A2cp1_2716
KEGGiacp:A2cp1_2716

Similar proteinsi

Entry informationi

Entry nameiGCSPA_ANAD2
AccessioniPrimary (citable) accession number: B8JDY8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 3, 2009
Last modified: May 23, 2018
This is version 57 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
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Main funding by: National Institutes of Health