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B8JDY8

- GCSPA_ANAD2

UniProt

B8JDY8 - GCSPA_ANAD2

Protein

Probable glycine dehydrogenase (decarboxylating) subunit 1

Gene

gcvPA

Organism
Anaeromyxobacter dehalogenans (strain 2CP-1 / ATCC BAA-258)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 38 (01 Oct 2014)
      Sequence version 1 (03 Mar 2009)
      Previous versions | rss
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    Functioni

    The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

    Catalytic activityi

    Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

    GO - Molecular functioni

    1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glycine catabolic process Source: InterPro
    2. nucleoside metabolic process Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Enzyme and pathway databases

    BioCyciADEH455488:GH35-2747-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable glycine dehydrogenase (decarboxylating) subunit 1UniRule annotation (EC:1.4.4.2UniRule annotation)
    Alternative name(s):
    Glycine cleavage system P-protein subunit 1UniRule annotation
    Glycine decarboxylase subunit 1UniRule annotation
    Glycine dehydrogenase (aminomethyl-transferring) subunit 1UniRule annotation
    Gene namesi
    Name:gcvPAUniRule annotation
    Ordered Locus Names:A2cp1_2716
    OrganismiAnaeromyxobacter dehalogenans (strain 2CP-1 / ATCC BAA-258)
    Taxonomic identifieri455488 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaMyxococcalesCystobacterineaeAnaeromyxobacteraceaeAnaeromyxobacter
    ProteomesiUP000007089: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 445445Probable glycine dehydrogenase (decarboxylating) subunit 1PRO_1000147974Add
    BLAST

    Interactioni

    Subunit structurei

    The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotation

    Protein-protein interaction databases

    STRINGi455488.A2cp1_2716.

    Structurei

    3D structure databases

    ProteinModelPortaliB8JDY8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GcvP family. N-terminal subunit subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0403.
    HOGENOMiHOG000132025.
    KOiK00282.
    OMAiLPMHASE.
    OrthoDBiEOG6XWV3B.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    HAMAPiMF_00712. GcvPA.
    InterProiIPR023010. GcvPA.
    IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11773. PTHR11773. 1 hit.
    PfamiPF02347. GDC-P. 1 hit.
    [Graphical view]
    PIRSFiPIRSF006815. GcvPA. 1 hit.
    SUPFAMiSSF53383. SSF53383. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B8JDY8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRYHPHTPDD VRAMLDVVGA ERVDDLFRSI PQALRLDRPL DLPPAADEIA    50
    LFSELRRLAA RNETAHPPFV GAGCYPHHVP PVVDQLLLRG EFFTAYTPYQ 100
    PEISQGTLQA LFEWQTFVCL LTGMDVSNAS MYDGATATAE AALMAGRITG 150
    RDKVVVSAAL HPEYRKVLAT YLRSTGDEIV TVPFGADGRT DLAALAQAVD 200
    GRTACVILGY PNFLGVVDAL PEAAALARAA GALTVAATAE AVSLGLLQAP 250
    GALGADVAVG TFQSFGNPMS FGGPAPGFFA TREKSLRQMP GRVAGATVDK 300
    QGRRGFVLTL STREQHIRRE KATSNICTNS GLCALASTIH LSLLGKRGLA 350
    ELARLNHGRA RMLRDAMERA GCRPVFSGPY FNEQVFDVGD AEAVVAKLAK 400
    RGIVAGAPLA RWYPDAPHAK GALLCAATEL HGPELIQLFA STVRS 445
    Length:445
    Mass (Da):47,421
    Last modified:March 3, 2009 - v1
    Checksum:i026BC5F02B6A1712
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001359 Genomic DNA. Translation: ACL66053.1.
    RefSeqiYP_002493119.1. NC_011891.1.

    Genome annotation databases

    EnsemblBacteriaiACL66053; ACL66053; A2cp1_2716.
    GeneIDi7299717.
    KEGGiacp:A2cp1_2716.
    PATRICi20912349. VBIAnaDeh28364_2755.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001359 Genomic DNA. Translation: ACL66053.1 .
    RefSeqi YP_002493119.1. NC_011891.1.

    3D structure databases

    ProteinModelPortali B8JDY8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 455488.A2cp1_2716.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACL66053 ; ACL66053 ; A2cp1_2716 .
    GeneIDi 7299717.
    KEGGi acp:A2cp1_2716.
    PATRICi 20912349. VBIAnaDeh28364_2755.

    Phylogenomic databases

    eggNOGi COG0403.
    HOGENOMi HOG000132025.
    KOi K00282.
    OMAi LPMHASE.
    OrthoDBi EOG6XWV3B.

    Enzyme and pathway databases

    BioCyci ADEH455488:GH35-2747-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    HAMAPi MF_00712. GcvPA.
    InterProi IPR023010. GcvPA.
    IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11773. PTHR11773. 1 hit.
    Pfami PF02347. GDC-P. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF006815. GcvPA. 1 hit.
    SUPFAMi SSF53383. SSF53383. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of Anaeromyxobacter dehalogenans 2CP-1."
      Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Saunders E., Brettin T., Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N., Ovchinnikova G., Beliaev A.S., Richardson P.
      Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 2CP-1 / ATCC BAA-258.

    Entry informationi

    Entry nameiGCSPA_ANAD2
    AccessioniPrimary (citable) accession number: B8JDY8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 28, 2009
    Last sequence update: March 3, 2009
    Last modified: October 1, 2014
    This is version 38 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3