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B8J8T6 (UPPP_ANAD2) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 31. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Undecaprenyl-diphosphatase

EC=3.6.1.27
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene names
Name:uppP
Ordered Locus Names:A2cp1_0175
OrganismAnaeromyxobacter dehalogenans (strain 2CP-1 / ATCC BAA-258) [Complete proteome] [HAMAP]
Taxonomic identifier455488 [NCBI]
Taxonomic lineageBacteriaProteobacteriaDeltaproteobacteriaMyxococcalesCystobacterineaeMyxococcaceaeAnaeromyxobacter

Protein attributes

Sequence length292 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006

Catalytic activity

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Sequence similarities

Belongs to the UppP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 292292Undecaprenyl-diphosphatase HAMAP-Rule MF_01006
PRO_1000148798

Regions

Transmembrane1 – 2121Helical; Potential
Transmembrane46 – 6621Helical; Potential
Transmembrane90 – 11021Helical; Potential
Transmembrane114 – 13421Helical; Potential
Transmembrane192 – 21221Helical; Potential
Transmembrane225 – 24521Helical; Potential
Transmembrane253 – 27321Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
B8J8T6 [UniParc].

Last modified March 3, 2009. Version 1.
Checksum: F1BA655CD3D300EE

FASTA29230,436
        10         20         30         40         50         60 
MSLVSAALFG LLQALTEFLP VSSTAHLLVF GELLGHSLDD RRFRAFVTII QAGTTLAVLV 

        70         80         90        100        110        120 
YFRADIARLV AAAARGLARG RPFGTPEARL GWYIVLGTVP AALAGKLLEH RIEALGNWVI 

       130        140        150        160        170        180 
AGSLVALGLV LLAAERLASH RRRVEDVGAG DALLIGVAQA LALVPGSSRS GTTITGGMLL 

       190        200        210        220        230        240 
GFTREAAARF SFLLSVPITL AAGAYKLWST VPDLRGEAAW TVATVVGTVV SAVAGYLVID 

       250        260        270        280        290 
WLLAWLRTRT TYVFVVWRLA AGAAIAALIL SGVLPAGAEA PPPPPPALHA AP 

« Hide

References

[1]"Complete sequence of Anaeromyxobacter dehalogenans 2CP-1."
Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Saunders E., Brettin T., Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N., Ovchinnikova G., Beliaev A.S., Richardson P.
Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 2CP-1 / ATCC BAA-258.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001359 Genomic DNA. Translation: ACL63534.1.
RefSeqYP_002490600.1. NC_011891.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING455488.A2cp1_0175.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACL63534; ACL63534; A2cp1_0175.
GeneID7298410.
KEGGacp:A2cp1_0175.
PATRIC20907131. VBIAnaDeh28364_0169.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1968.
HOGENOMHOG000218357.
KOK06153.
OMASKTQIMF.
OrthoDBEOG6QP13M.
ProtClustDBCLSK944863.

Enzyme and pathway databases

BioCycADEH455488:GH35-177-MONOMER.

Family and domain databases

HAMAPMF_01006. Undec_diphosphatase.
InterProIPR003824. UppP.
[Graphical view]
PfamPF02673. BacA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameUPPP_ANAD2
AccessionPrimary (citable) accession number: B8J8T6
Entry history
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 3, 2009
Last modified: February 19, 2014
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families