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B8J7G1

- PCKG_ANAD2

UniProt

B8J7G1 - PCKG_ANAD2

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Protein
Phosphoenolpyruvate carboxykinase [GTP]
Gene
pckG, A2cp1_3817
Organism
Anaeromyxobacter dehalogenans (strain 2CP-1 / ATCC BAA-258)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle By similarity.UniRule annotation

Catalytic activityi

GTP + oxaloacetate = GDP + phosphoenolpyruvate + CO2.UniRule annotation

Cofactori

Binds 1 manganese ion per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei77 – 771Substrate By similarity
Binding sitei207 – 2071Substrate; via amide nitrogen By similarity
Metal bindingi214 – 2141Manganese By similarity
Binding sitei214 – 2141Substrate By similarity
Metal bindingi234 – 2341Manganese; via tele nitrogen By similarity
Binding sitei256 – 2561Substrate By similarity
Active sitei258 – 2581 By similarity
Metal bindingi283 – 2831Manganese By similarity
Binding sitei375 – 3751GTP By similarity
Binding sitei406 – 4061GTP By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi257 – 2626GTP By similarity
Nucleotide bindingi499 – 5024GTP By similarity

GO - Molecular functioni

  1. GTP binding Source: UniProtKB-HAMAP
  2. manganese ion binding Source: UniProtKB-HAMAP
  3. phosphoenolpyruvate carboxykinase (GTP) activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. gluconeogenesis Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Gluconeogenesis

Keywords - Ligandi

GTP-binding, Manganese, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciADEH455488:GH35-3871-MONOMER.
UniPathwayiUPA00138.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoenolpyruvate carboxykinase [GTP] (EC:4.1.1.32)
Short name:
PEP carboxykinase
Short name:
PEPCK
Gene namesi
Name:pckG
Ordered Locus Names:A2cp1_3817
OrganismiAnaeromyxobacter dehalogenans (strain 2CP-1 / ATCC BAA-258)
Taxonomic identifieri455488 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaMyxococcalesCystobacterineaeMyxococcaceaeAnaeromyxobacter
ProteomesiUP000007089: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 596596Phosphoenolpyruvate carboxykinase [GTP]UniRule annotation
PRO_1000192343Add
BLAST

Interactioni

Subunit structurei

Monomer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi455488.A2cp1_3817.

Structurei

3D structure databases

ProteinModelPortaliB8J7G1.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni373 – 3753Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1274.
HOGENOMiHOG000191700.
KOiK01596.
OMAiWIELGEN.
OrthoDBiEOG6MPWQS.

Family and domain databases

Gene3Di3.40.449.10. 1 hit.
3.90.228.20. 2 hits.
HAMAPiMF_00452. PEPCK_GTP.
InterProiIPR018091. PEP_carboxykin_GTP_CS.
IPR013035. PEP_carboxykinase_C.
IPR008209. PEP_carboxykinase_GTP.
IPR008210. PEP_carboxykinase_N.
[Graphical view]
PANTHERiPTHR11561. PTHR11561. 1 hit.
PfamiPF00821. PEPCK. 1 hit.
[Graphical view]
PIRSFiPIRSF001348. PEP_carboxykinase_GTP. 1 hit.
SUPFAMiSSF68923. SSF68923. 1 hit.
PROSITEiPS00505. PEPCK_GTP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B8J7G1-1 [UniParc]FASTAAdd to Basket

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MSTSPAARPT SNAHLLGWVD EMAKLCKPDR VYWCDGSEAE KKRLTDDAVA    50
AKVLIPLDQQ KWPGCHYHHS NSSDVARVEH LTFICTPTKE QAGPTNNWME 100
PKEAYRKLGA IFDGSMKGRT MYVVPYVMGP STSPFAKVGI EITDSVYVAL 150
NMGIMARMGK VALDRLGDSD EFNRGLHSVA DCNPERRFIC HFPQDNTIWS 200
VGSGYGGNAL LGKKCLALRI ASYLAKNEGW LAEHMLILEA ESPTGEKQYV 250
AAAFPSACGK TNFAMMIPPA AFPGWKIRTV GDDISWMRVG EDGRLWAVNP 300
ENGYFGVAPG TNRKTNPNAM DSVRKDTIFT NVARTPDGDI WWEGMDHEAP 350
AELIDWKGQP WKKGSTEKAA HPNSRFTAPA KNNPAISPLV DDPKGVPISA 400
IIFGGRRSTT VPLVLEAFNW THGVYLGSTM GSETTAAATG QVGVVRRDPM 450
AMLPFIGYDC GSYLQHWLDM QSRIPNPPKI FLVNWFRKSA EGKFLWPGYG 500
DNMRVLKWML DRAAGRAPAK ETLLGYTPGD SGLDLHGLDV SKDAIAAATQ 550
IDLGEWEQEL ESQSEWFEKL GKTLPRPLAL QRELLLERVR AARKVK 596
Length:596
Mass (Da):65,869
Last modified:March 3, 2009 - v1
Checksum:i053D58D526ECC4A9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001359 Genomic DNA. Translation: ACL67141.1.
RefSeqiWP_015934890.1. NC_011891.1.
YP_002494207.1. NC_011891.1.

Genome annotation databases

EnsemblBacteriaiACL67141; ACL67141; A2cp1_3817.
GeneIDi7296193.
KEGGiacp:A2cp1_3817.
PATRICi20914591. VBIAnaDeh28364_3857.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001359 Genomic DNA. Translation: ACL67141.1 .
RefSeqi WP_015934890.1. NC_011891.1.
YP_002494207.1. NC_011891.1.

3D structure databases

ProteinModelPortali B8J7G1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 455488.A2cp1_3817.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACL67141 ; ACL67141 ; A2cp1_3817 .
GeneIDi 7296193.
KEGGi acp:A2cp1_3817.
PATRICi 20914591. VBIAnaDeh28364_3857.

Phylogenomic databases

eggNOGi COG1274.
HOGENOMi HOG000191700.
KOi K01596.
OMAi WIELGEN.
OrthoDBi EOG6MPWQS.

Enzyme and pathway databases

UniPathwayi UPA00138 .
BioCyci ADEH455488:GH35-3871-MONOMER.

Family and domain databases

Gene3Di 3.40.449.10. 1 hit.
3.90.228.20. 2 hits.
HAMAPi MF_00452. PEPCK_GTP.
InterProi IPR018091. PEP_carboxykin_GTP_CS.
IPR013035. PEP_carboxykinase_C.
IPR008209. PEP_carboxykinase_GTP.
IPR008210. PEP_carboxykinase_N.
[Graphical view ]
PANTHERi PTHR11561. PTHR11561. 1 hit.
Pfami PF00821. PEPCK. 1 hit.
[Graphical view ]
PIRSFi PIRSF001348. PEP_carboxykinase_GTP. 1 hit.
SUPFAMi SSF68923. SSF68923. 1 hit.
PROSITEi PS00505. PEPCK_GTP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of Anaeromyxobacter dehalogenans 2CP-1."
    Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Saunders E., Brettin T., Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N., Ovchinnikova G., Beliaev A.S., Richardson P.
    Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 2CP-1 / ATCC BAA-258.

Entry informationi

Entry nameiPCKG_ANAD2
AccessioniPrimary (citable) accession number: B8J7G1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 3, 2009
Last modified: September 3, 2014
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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