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Protein

Acetyltransferase component of pyruvate dehydrogenase complex

Gene

A2cp1_1826

Organism
Anaeromyxobacter dehalogenans (strain 2CP-1 / ATCC BAA-258)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.UniRule annotation

Catalytic activityi

Acetyl-CoA + enzyme N(6)-(dihydrolipoyl)lysine = CoA + enzyme N(6)-(S-acetyldihydrolipoyl)lysine.UniRule annotation

Cofactori

(R)-lipoateUniRule annotationNote: Binds 2 lipoyl cofactors covalently.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

AcyltransferaseUniRule annotation, Transferase

Keywords - Biological processi

GlycolysisUniRule annotation

Keywords - Ligandi

PyruvateImported

Enzyme and pathway databases

BioCyciADEH455488:GH35-1844-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyltransferase component of pyruvate dehydrogenase complexUniRule annotation (EC:2.3.1.12UniRule annotation)
Gene namesi
Ordered Locus Names:A2cp1_1826Imported
OrganismiAnaeromyxobacter dehalogenans (strain 2CP-1 / ATCC BAA-258)Imported
Taxonomic identifieri455488 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaMyxococcalesCystobacterineaeAnaeromyxobacteraceaeAnaeromyxobacter
ProteomesiUP000007089 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Interactioni

Subunit structurei

Forms a 24-polypeptide structural core with octahedral symmetry.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliB8J6I7.
SMRiB8J6I7. Positions 4-78, 312-552.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the 2-oxoacid dehydrogenase family.UniRule annotation
Contains 2 lipoyl-binding domains.UniRule annotation

Keywords - Domaini

LipoylUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiCOG0508.
HOGENOMiHOG000281562.
KOiK00627.
OMAiTEIMVAV.
OrthoDBiEOG610413.

Family and domain databases

Gene3Di3.30.559.10. 1 hit.
4.10.320.10. 1 hit.
InterProiIPR003016. 2-oxoA_DH_lipoyl-BS.
IPR001078. 2-oxoacid_DH_actylTfrase.
IPR006256. AcTrfase_Pyrv_DH_cplx.
IPR000089. Biotin_lipoyl.
IPR023213. CAT-like_dom.
IPR004167. E3-bd.
IPR011053. Single_hybrid_motif.
[Graphical view]
PfamiPF00198. 2-oxoacid_dh. 1 hit.
PF00364. Biotin_lipoyl. 2 hits.
PF02817. E3_binding. 1 hit.
[Graphical view]
SUPFAMiSSF47005. SSF47005. 1 hit.
SSF51230. SSF51230. 2 hits.
TIGRFAMsiTIGR01348. PDHac_trf_long. 1 hit.
PROSITEiPS50968. BIOTINYL_LIPOYL. 2 hits.
PS00189. LIPOYL. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B8J6I7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRTIEVKVPN IGDYKDVPVI DVLVKPGEQV DADAPLVTLE SDKATLDVPA
60 70 80 90 100
PAAGTIREVK VKVGDRVSEG SLVVTLEASD GQAKAEAPAA PAQAAPPKPA
110 120 130 140 150
AAAPAPAPSP APAAPSAPPA AASPAGAPRT VEVKVPNIGD FKDVPVIEVL
160 170 180 190 200
VKPGDRVEAD APLATLESEK ATLDVPAPAA GTIREVALKA GDKVSEGSLV
210 220 230 240 250
AILDAVAPAA ATTAAAPAPS QPAAAPAAKA AAPPPAPSPA APPVAPETGA
260 270 280 290 300
QGQVPHASPS VRKLARELGV NLGRVEGSGP RGRILQDDVQ KFVKASLARL
310 320 330 340 350
ESGGGGGGAL DLAPWPKVDF TRFGPVERQP LSRIRKLSRT NLARNWVMIP
360 370 380 390 400
HVTQFDEADI TELERFRVEL NREHEKQGVK VTLLAFLVKA CVAAMRRFPE
410 420 430 440 450
LNASLDGDEL VLKRYFHVGF AADTPQGLVV PVLKDADQKG VLQLAKELGE
460 470 480 490 500
LAAKARDGKL SPADVQGGCF SISSLGGIGG TAFTPIINAP EVAILGVSRS
510 520 530 540 550
AMRPVWDGTQ FQPRLMLPLS LSYDHRVIDG ALAARITTYL AQLLGDMRRI

VL
Length:552
Mass (Da):57,234
Last modified:March 3, 2009 - v1
Checksum:i6953F3DABE95ED07
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001359 Genomic DNA. Translation: ACL65168.1.
RefSeqiWP_012633090.1. NC_011891.1.
YP_002492234.1. NC_011891.1.

Genome annotation databases

EnsemblBacteriaiACL65168; ACL65168; A2cp1_1826.
KEGGiacp:A2cp1_1826.
PATRICi20910533. VBIAnaDeh28364_1857.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001359 Genomic DNA. Translation: ACL65168.1.
RefSeqiWP_012633090.1. NC_011891.1.
YP_002492234.1. NC_011891.1.

3D structure databases

ProteinModelPortaliB8J6I7.
SMRiB8J6I7. Positions 4-78, 312-552.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACL65168; ACL65168; A2cp1_1826.
KEGGiacp:A2cp1_1826.
PATRICi20910533. VBIAnaDeh28364_1857.

Phylogenomic databases

eggNOGiCOG0508.
HOGENOMiHOG000281562.
KOiK00627.
OMAiTEIMVAV.
OrthoDBiEOG610413.

Enzyme and pathway databases

BioCyciADEH455488:GH35-1844-MONOMER.

Family and domain databases

Gene3Di3.30.559.10. 1 hit.
4.10.320.10. 1 hit.
InterProiIPR003016. 2-oxoA_DH_lipoyl-BS.
IPR001078. 2-oxoacid_DH_actylTfrase.
IPR006256. AcTrfase_Pyrv_DH_cplx.
IPR000089. Biotin_lipoyl.
IPR023213. CAT-like_dom.
IPR004167. E3-bd.
IPR011053. Single_hybrid_motif.
[Graphical view]
PfamiPF00198. 2-oxoacid_dh. 1 hit.
PF00364. Biotin_lipoyl. 2 hits.
PF02817. E3_binding. 1 hit.
[Graphical view]
SUPFAMiSSF47005. SSF47005. 1 hit.
SSF51230. SSF51230. 2 hits.
TIGRFAMsiTIGR01348. PDHac_trf_long. 1 hit.
PROSITEiPS50968. BIOTINYL_LIPOYL. 2 hits.
PS00189. LIPOYL. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequence of Anaeromyxobacter dehalogenans 2CP-1."
    Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Saunders E., Brettin T., Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N., Ovchinnikova G., Beliaev A.S., Richardson P.
    Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 2CP-1 / ATCC BAA-258Imported.

Entry informationi

Entry nameiB8J6I7_ANAD2
AccessioniPrimary (citable) accession number: B8J6I7
Entry historyi
Integrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: June 24, 2015
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.