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B8J6I7

- B8J6I7_ANAD2

UniProt

B8J6I7 - B8J6I7_ANAD2

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Protein
Acetyltransferase component of pyruvate dehydrogenase complex
Gene
A2cp1_1826
Organism
Anaeromyxobacter dehalogenans (strain 2CP-1 / ATCC BAA-258)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2 By similarity.UniRule annotation

Catalytic activityi

Acetyl-CoA + enzyme N(6)-(dihydrolipoyl)lysine = CoA + enzyme N(6)-(S-acetyldihydrolipoyl)lysine.UniRule annotation

Cofactori

Binds 1 lipoyl cofactor covalently By similarity.UniRule annotation
Binds 2 lipoyl cofactors covalently By similarity.UniRule annotation
Binds 3 lipoyl cofactors covalently By similarity.UniRule annotation

GO - Molecular functioni

  1. dihydrolipoyllysine-residue acetyltransferase activity Source: InterPro

GO - Biological processi

  1. glycolytic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

AcyltransferaseUniRule annotation, Transferase

Keywords - Biological processi

GlycolysisUniRule annotation

Keywords - Ligandi

PyruvateImported

Enzyme and pathway databases

BioCyciADEH455488:GH35-1844-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyltransferase component of pyruvate dehydrogenase complexUniRule annotation (EC:2.3.1.12UniRule annotation)
Gene namesi
Ordered Locus Names:A2cp1_1826Imported
OrganismiAnaeromyxobacter dehalogenans (strain 2CP-1 / ATCC BAA-258)Imported
Taxonomic identifieri455488 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaMyxococcalesCystobacterineaeMyxococcaceaeAnaeromyxobacter
ProteomesiUP000007089: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. pyruvate dehydrogenase complex Source: InterPro
Complete GO annotation...

Interactioni

Subunit structurei

Forms a 24-polypeptide structural core with octahedral symmetry By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi455488.A2cp1_1826.

Structurei

3D structure databases

ProteinModelPortaliB8J6I7.
SMRiB8J6I7. Positions 4-78, 312-552.

Family & Domainsi

Sequence similaritiesi

Belongs to the 2-oxoacid dehydrogenase family.UniRule annotation
Contains 2 lipoyl-binding domains.UniRule annotation

Keywords - Domaini

LipoylUniRule annotationSAAS annotations

Phylogenomic databases

eggNOGiCOG0508.
HOGENOMiHOG000281562.
KOiK00627.
OMAiVKVPNIG.
OrthoDBiEOG610413.

Family and domain databases

Gene3Di3.30.559.10. 1 hit.
4.10.320.10. 1 hit.
InterProiIPR003016. 2-oxoA_DH_lipoyl-BS.
IPR001078. 2-oxoacid_DH_actylTfrase.
IPR006256. AcTrfase_Pyrv_DH_cplx.
IPR000089. Biotin_lipoyl.
IPR023213. CAT-like_dom.
IPR004167. E3-bd.
IPR011053. Single_hybrid_motif.
[Graphical view]
PfamiPF00198. 2-oxoacid_dh. 1 hit.
PF00364. Biotin_lipoyl. 2 hits.
PF02817. E3_binding. 1 hit.
[Graphical view]
SUPFAMiSSF47005. SSF47005. 1 hit.
SSF51230. SSF51230. 2 hits.
TIGRFAMsiTIGR01348. PDHac_trf_long. 1 hit.
PROSITEiPS50968. BIOTINYL_LIPOYL. 2 hits.
PS00189. LIPOYL. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B8J6I7-1 [UniParc]FASTAAdd to Basket

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MRTIEVKVPN IGDYKDVPVI DVLVKPGEQV DADAPLVTLE SDKATLDVPA    50
PAAGTIREVK VKVGDRVSEG SLVVTLEASD GQAKAEAPAA PAQAAPPKPA 100
AAAPAPAPSP APAAPSAPPA AASPAGAPRT VEVKVPNIGD FKDVPVIEVL 150
VKPGDRVEAD APLATLESEK ATLDVPAPAA GTIREVALKA GDKVSEGSLV 200
AILDAVAPAA ATTAAAPAPS QPAAAPAAKA AAPPPAPSPA APPVAPETGA 250
QGQVPHASPS VRKLARELGV NLGRVEGSGP RGRILQDDVQ KFVKASLARL 300
ESGGGGGGAL DLAPWPKVDF TRFGPVERQP LSRIRKLSRT NLARNWVMIP 350
HVTQFDEADI TELERFRVEL NREHEKQGVK VTLLAFLVKA CVAAMRRFPE 400
LNASLDGDEL VLKRYFHVGF AADTPQGLVV PVLKDADQKG VLQLAKELGE 450
LAAKARDGKL SPADVQGGCF SISSLGGIGG TAFTPIINAP EVAILGVSRS 500
AMRPVWDGTQ FQPRLMLPLS LSYDHRVIDG ALAARITTYL AQLLGDMRRI 550
VL 552
Length:552
Mass (Da):57,234
Last modified:March 3, 2009 - v1
Checksum:i6953F3DABE95ED07
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001359 Genomic DNA. Translation: ACL65168.1.
RefSeqiWP_012633090.1. NC_011891.1.
YP_002492234.1. NC_011891.1.

Genome annotation databases

EnsemblBacteriaiACL65168; ACL65168; A2cp1_1826.
GeneIDi7296352.
KEGGiacp:A2cp1_1826.
PATRICi20910533. VBIAnaDeh28364_1857.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001359 Genomic DNA. Translation: ACL65168.1 .
RefSeqi WP_012633090.1. NC_011891.1.
YP_002492234.1. NC_011891.1.

3D structure databases

ProteinModelPortali B8J6I7.
SMRi B8J6I7. Positions 4-78, 312-552.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 455488.A2cp1_1826.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACL65168 ; ACL65168 ; A2cp1_1826 .
GeneIDi 7296352.
KEGGi acp:A2cp1_1826.
PATRICi 20910533. VBIAnaDeh28364_1857.

Phylogenomic databases

eggNOGi COG0508.
HOGENOMi HOG000281562.
KOi K00627.
OMAi VKVPNIG.
OrthoDBi EOG610413.

Enzyme and pathway databases

BioCyci ADEH455488:GH35-1844-MONOMER.

Family and domain databases

Gene3Di 3.30.559.10. 1 hit.
4.10.320.10. 1 hit.
InterProi IPR003016. 2-oxoA_DH_lipoyl-BS.
IPR001078. 2-oxoacid_DH_actylTfrase.
IPR006256. AcTrfase_Pyrv_DH_cplx.
IPR000089. Biotin_lipoyl.
IPR023213. CAT-like_dom.
IPR004167. E3-bd.
IPR011053. Single_hybrid_motif.
[Graphical view ]
Pfami PF00198. 2-oxoacid_dh. 1 hit.
PF00364. Biotin_lipoyl. 2 hits.
PF02817. E3_binding. 1 hit.
[Graphical view ]
SUPFAMi SSF47005. SSF47005. 1 hit.
SSF51230. SSF51230. 2 hits.
TIGRFAMsi TIGR01348. PDHac_trf_long. 1 hit.
PROSITEi PS50968. BIOTINYL_LIPOYL. 2 hits.
PS00189. LIPOYL. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of Anaeromyxobacter dehalogenans 2CP-1."
    Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Saunders E., Brettin T., Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N., Ovchinnikova G., Beliaev A.S., Richardson P.
    Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 2CP-1 / ATCC BAA-258.

Entry informationi

Entry nameiB8J6I7_ANAD2
AccessioniPrimary (citable) accession number: B8J6I7
Entry historyi
Integrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: September 3, 2014
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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