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Protein

Acetyltransferase component of pyruvate dehydrogenase complex

Gene

A2cp1_1826

Organism
Anaeromyxobacter dehalogenans (strain 2CP-1 / ATCC BAA-258)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.UniRule annotation

Catalytic activityi

Acetyl-CoA + enzyme N6-(dihydrolipoyl)lysine = CoA + enzyme N6-(S-acetyldihydrolipoyl)lysine.UniRule annotation

Cofactori

(R)-lipoateUniRule annotationNote: Binds 2 lipoyl cofactors covalently.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferaseUniRule annotation, Transferase
Biological processGlycolysisUniRule annotation
LigandPyruvateImported

Enzyme and pathway databases

BioCyciADEH455488:G1GUO-1835-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyltransferase component of pyruvate dehydrogenase complexUniRule annotation (EC:2.3.1.12UniRule annotation)
Gene namesi
Ordered Locus Names:A2cp1_1826Imported
OrganismiAnaeromyxobacter dehalogenans (strain 2CP-1 / ATCC BAA-258)Imported
Taxonomic identifieri455488 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaMyxococcalesCystobacterineaeAnaeromyxobacteraceaeAnaeromyxobacter
Proteomesi
  • UP000007089 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Interactioni

Subunit structurei

Forms a 24-polypeptide structural core with octahedral symmetry.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliB8J6I7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 77Lipoyl-bindingInterPro annotationAdd BLAST75
Domaini130 – 204Lipoyl-bindingInterPro annotationAdd BLAST75
Domaini256 – 293Peripheral subunit-binding (PSBD)InterPro annotationAdd BLAST38

Sequence similaritiesi

Belongs to the 2-oxoacid dehydrogenase family.UniRule annotation

Keywords - Domaini

LipoylUniRule annotationSAAS annotation

Phylogenomic databases

HOGENOMiHOG000281562
KOiK00627
OMAiTMEFESF
OrthoDBiPOG091H05OF

Family and domain databases

Gene3Di3.30.559.10, 1 hit
4.10.320.10, 1 hit
InterProiView protein in InterPro
IPR003016 2-oxoA_DH_lipoyl-BS
IPR001078 2-oxoacid_DH_actylTfrase
IPR006256 AcTrfase_Pyrv_DH_cplx
IPR000089 Biotin_lipoyl
IPR023213 CAT-like_dom_sf
IPR036625 E3-bd_dom_sf
IPR004167 PSBD
IPR011053 Single_hybrid_motif
PANTHERiPTHR43178:SF2 PTHR43178:SF2, 3 hits
PfamiView protein in Pfam
PF00198 2-oxoacid_dh, 1 hit
PF00364 Biotin_lipoyl, 2 hits
PF02817 E3_binding, 1 hit
SUPFAMiSSF47005 SSF47005, 1 hit
SSF51230 SSF51230, 2 hits
TIGRFAMsiTIGR01348 PDHac_trf_long, 1 hit
PROSITEiView protein in PROSITE
PS50968 BIOTINYL_LIPOYL, 2 hits
PS00189 LIPOYL, 2 hits
PS51826 PSBD, 1 hit

Sequencei

Sequence statusi: Complete.

B8J6I7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRTIEVKVPN IGDYKDVPVI DVLVKPGEQV DADAPLVTLE SDKATLDVPA
60 70 80 90 100
PAAGTIREVK VKVGDRVSEG SLVVTLEASD GQAKAEAPAA PAQAAPPKPA
110 120 130 140 150
AAAPAPAPSP APAAPSAPPA AASPAGAPRT VEVKVPNIGD FKDVPVIEVL
160 170 180 190 200
VKPGDRVEAD APLATLESEK ATLDVPAPAA GTIREVALKA GDKVSEGSLV
210 220 230 240 250
AILDAVAPAA ATTAAAPAPS QPAAAPAAKA AAPPPAPSPA APPVAPETGA
260 270 280 290 300
QGQVPHASPS VRKLARELGV NLGRVEGSGP RGRILQDDVQ KFVKASLARL
310 320 330 340 350
ESGGGGGGAL DLAPWPKVDF TRFGPVERQP LSRIRKLSRT NLARNWVMIP
360 370 380 390 400
HVTQFDEADI TELERFRVEL NREHEKQGVK VTLLAFLVKA CVAAMRRFPE
410 420 430 440 450
LNASLDGDEL VLKRYFHVGF AADTPQGLVV PVLKDADQKG VLQLAKELGE
460 470 480 490 500
LAAKARDGKL SPADVQGGCF SISSLGGIGG TAFTPIINAP EVAILGVSRS
510 520 530 540 550
AMRPVWDGTQ FQPRLMLPLS LSYDHRVIDG ALAARITTYL AQLLGDMRRI

VL
Length:552
Mass (Da):57,234
Last modified:March 3, 2009 - v1
Checksum:i6953F3DABE95ED07
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001359 Genomic DNA Translation: ACL65168.1
RefSeqiWP_012633090.1, NC_011891.1

Genome annotation databases

EnsemblBacteriaiACL65168; ACL65168; A2cp1_1826
KEGGiacp:A2cp1_1826

Similar proteinsi

Entry informationi

Entry nameiB8J6I7_ANAD2
AccessioniPrimary (citable) accession number: B8J6I7
Entry historyiIntegrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: March 28, 2018
This is version 65 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

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