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B8J605

- B8J605_ANAD2

UniProt

B8J605 - B8J605_ANAD2

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Protein
Submitted name: Maleylacetoacetate isomerase
Gene
A2cp1_3570
Organism
Anaeromyxobacter dehalogenans (strain 2CP-1 / ATCC BAA-258)
Status
Unreviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei11 – 111GlutathioneImported
Binding sitei16 – 161GlutathioneImported
Binding sitei35 – 351Citrate
Binding sitei38 – 381GlutathioneImported
Binding sitei42 – 421GlutathioneImported
Binding sitei54 – 541Glutathione; via amide nitrogen and carbonyl oxygenImported
Binding sitei139 – 1391GlutathioneImported

GO - Molecular functioni

  1. isomerase activity Source: UniProtKB-KW

GO - Biological processi

  1. aromatic amino acid family metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseImported

Enzyme and pathway databases

BioCyciADEH455488:GH35-3619-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Maleylacetoacetate isomeraseImported
Gene namesi
Ordered Locus Names:A2cp1_3570Imported
OrganismiAnaeromyxobacter dehalogenans (strain 2CP-1 / ATCC BAA-258)Imported
Taxonomic identifieri455488 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaMyxococcalesCystobacterineaeMyxococcaceaeAnaeromyxobacter
ProteomesiUP000007089: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: InterPro
Complete GO annotation...

Interactioni

Protein-protein interaction databases

STRINGi455488.A2cp1_3570.

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4IGJX-ray1.48A/B1-220[»]
4KAEX-ray1.50A/B1-220[»]
4KDYX-ray1.50A/B1-220[»]
ProteinModelPortaliB8J605.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni70 – 712Glutathione bindingImported
Regioni106 – 1105Glutathione bindingImported

Phylogenomic databases

eggNOGiCOG0625.
HOGENOMiHOG000125758.
KOiK01801.
OMAiDICLAAQ.
OrthoDBiEOG6WT8DX.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR005955. Mal_ac_isom.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF13417. GST_N_3. 1 hit.
[Graphical view]
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
TIGRFAMsiTIGR01262. maiA. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B8J605-1 [UniParc]FASTAAdd to Basket

« Hide

MTLRLYSYWR SSSAWRVRLG LALKGLAYEY RAVDLLAQEQ FQAAHQARNP    50
MSQVPVLEVE EDGRTHLLVQ SMAILEWLEE RHPEPALLPP DLWGRARVRA 100
LAEHVNSGTQ PMQNALVLRM LREKVPGWDR EWARFFIARG LAALETAVRD 150
GAGRFSHGDA PTLADCYLVP QLYNARRFGL DLEPYPTLRR VDEACAALAP 200
FQAAHPDRQP DAPPPDRRTP 220
Length:220
Mass (Da):24,997
Last modified:March 3, 2009 - v1
Checksum:iC7372DFECE10BD63
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001359 Genomic DNA. Translation: ACL66900.1.
RefSeqiYP_002493966.1. NC_011891.1.

Genome annotation databases

EnsemblBacteriaiACL66900; ACL66900; A2cp1_3570.
GeneIDi7299620.
KEGGiacp:A2cp1_3570.
PATRICi20914115. VBIAnaDeh28364_3622.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001359 Genomic DNA. Translation: ACL66900.1 .
RefSeqi YP_002493966.1. NC_011891.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4IGJ X-ray 1.48 A/B 1-220 [» ]
4KAE X-ray 1.50 A/B 1-220 [» ]
4KDY X-ray 1.50 A/B 1-220 [» ]
ProteinModelPortali B8J605.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 455488.A2cp1_3570.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACL66900 ; ACL66900 ; A2cp1_3570 .
GeneIDi 7299620.
KEGGi acp:A2cp1_3570.
PATRICi 20914115. VBIAnaDeh28364_3622.

Phylogenomic databases

eggNOGi COG0625.
HOGENOMi HOG000125758.
KOi K01801.
OMAi DICLAAQ.
OrthoDBi EOG6WT8DX.

Enzyme and pathway databases

BioCyci ADEH455488:GH35-3619-MONOMER.

Family and domain databases

Gene3Di 1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProi IPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR005955. Mal_ac_isom.
IPR012336. Thioredoxin-like_fold.
[Graphical view ]
Pfami PF13417. GST_N_3. 1 hit.
[Graphical view ]
SUPFAMi SSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
TIGRFAMsi TIGR01262. maiA. 1 hit.
PROSITEi PS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequence of Anaeromyxobacter dehalogenans 2CP-1."
    Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Saunders E., Brettin T., Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N., Ovchinnikova G., Beliaev A.S., Richardson P.
    Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 2CP-1 / ATCC BAA-258.
  2. "Crystal structure of Maleylacetoacetate isomerase from Anaeromyxobacter dehalogenans 2CP-1, target EFI-507175."
    Kim J., Toro R., Bhosle R., Al Obaidi N.F., Morisco L.L., Wasserman S.R., Sojitra S., Washington E., Scott Glenn A., Chowdhury S., Evans B., Hammonds J., Hillerich B., Love J., Seidel R.D., Imker H.J., Armstrong R.N., Gerlt J.A., Almo S.C.
    Submitted (DEC-2012) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.48 ANGSTROMS).
  3. "Crystal structure of Maleylacetoacetate isomerase from Anaeromyxobacter dehalogenans 2CP-1, TARGET EFI-507175, with bound dicarboxyethyl glutathione and citrate in the active site."
    Kim J., Toro R., Bhosle R., Al Obaidi N.F., Morisco L.L., Wasserman S.R., Sojitra S., Washington E., Scott Glenn A., Chowdhury S., Evans B., Hammonds J., Hillerich B., Love J., Seidel R.D., Imker H.J., Stead M., Gerlt J.A., Almo S.C., Enzyme Function Initiative
    Submitted (APR-2013) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.50 ANGSTROMS).
  4. "Crystal structure of maleylacetoacetate isomerase from Anaeromyxobacter dehalogenans 2CP-1, Target EFI-507175, with bound GSH in the active site."
    Kim J., Toro R., Bhosle R., Al Obaidi N.F., Morisco L.L., Wasserman S.R., Sojitra S., Washington E., Scott Glenn A., Chowdhury S., Evans B., Hammonds J., Hillerich B., Love J., Seidel R.D., Imker H.J., Stead M., Gerlt J.A., Almo S.C., Enzyme Function Initiative
    Submitted (APR-2013) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.50 ANGSTROMS) IN COMPLEX WITH GLUTATHIONE.

Entry informationi

Entry nameiB8J605_ANAD2
AccessioniPrimary (citable) accession number: B8J605
Entry historyi
Integrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: September 3, 2014
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported, Complete proteome

External Data

Dasty 3

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