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Protein
Submitted name:

Maleylacetoacetate isomerase

Gene

A2cp1_3570

Organism
Anaeromyxobacter dehalogenans (strain 2CP-1 / ATCC BAA-258)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei11 – 111GlutathioneCombined sources
Binding sitei16 – 161GlutathioneCombined sources
Binding sitei38 – 381GlutathioneCombined sources
Binding sitei42 – 421GlutathioneCombined sources
Binding sitei54 – 541Glutathione; via amide nitrogen and carbonyl oxygenCombined sources
Binding sitei139 – 1391GlutathioneCombined sources

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

IsomeraseImported

Enzyme and pathway databases

BioCyciADEH455488:GH35-3619-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Maleylacetoacetate isomeraseImported
Gene namesi
Ordered Locus Names:A2cp1_3570Imported
OrganismiAnaeromyxobacter dehalogenans (strain 2CP-1 / ATCC BAA-258)Imported
Taxonomic identifieri455488 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaMyxococcalesCystobacterineaeAnaeromyxobacteraceaeAnaeromyxobacter
ProteomesiUP000007089 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4IGJX-ray1.48A/B1-220[»]
4KAEX-ray1.50A/B1-220[»]
4KDYX-ray1.50A/B1-220[»]
ProteinModelPortaliB8J605.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni70 – 712Glutathione bindingCombined sources
Regioni106 – 1105Glutathione bindingCombined sources

Phylogenomic databases

eggNOGiCOG0625.
HOGENOMiHOG000125758.
KOiK01801.
OMAiRAQVRMI.
OrthoDBiEOG6WT8DX.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR005955. Mal_ac_isom.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF13417. GST_N_3. 1 hit.
[Graphical view]
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
TIGRFAMsiTIGR01262. maiA. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B8J605-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLRLYSYWR SSSAWRVRLG LALKGLAYEY RAVDLLAQEQ FQAAHQARNP
60 70 80 90 100
MSQVPVLEVE EDGRTHLLVQ SMAILEWLEE RHPEPALLPP DLWGRARVRA
110 120 130 140 150
LAEHVNSGTQ PMQNALVLRM LREKVPGWDR EWARFFIARG LAALETAVRD
160 170 180 190 200
GAGRFSHGDA PTLADCYLVP QLYNARRFGL DLEPYPTLRR VDEACAALAP
210 220
FQAAHPDRQP DAPPPDRRTP
Length:220
Mass (Da):24,997
Last modified:March 3, 2009 - v1
Checksum:iC7372DFECE10BD63
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001359 Genomic DNA. Translation: ACL66900.1.
RefSeqiWP_015934684.1. NC_011891.1.

Genome annotation databases

EnsemblBacteriaiACL66900; ACL66900; A2cp1_3570.
KEGGiacp:A2cp1_3570.
PATRICi20914115. VBIAnaDeh28364_3622.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001359 Genomic DNA. Translation: ACL66900.1.
RefSeqiWP_015934684.1. NC_011891.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4IGJX-ray1.48A/B1-220[»]
4KAEX-ray1.50A/B1-220[»]
4KDYX-ray1.50A/B1-220[»]
ProteinModelPortaliB8J605.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACL66900; ACL66900; A2cp1_3570.
KEGGiacp:A2cp1_3570.
PATRICi20914115. VBIAnaDeh28364_3622.

Phylogenomic databases

eggNOGiCOG0625.
HOGENOMiHOG000125758.
KOiK01801.
OMAiRAQVRMI.
OrthoDBiEOG6WT8DX.

Enzyme and pathway databases

BioCyciADEH455488:GH35-3619-MONOMER.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR005955. Mal_ac_isom.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF13417. GST_N_3. 1 hit.
[Graphical view]
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
TIGRFAMsiTIGR01262. maiA. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequence of Anaeromyxobacter dehalogenans 2CP-1."
    Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Saunders E., Brettin T., Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N., Ovchinnikova G., Beliaev A.S., Richardson P.
    Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 2CP-1 / ATCC BAA-258Imported.
  2. "Crystal structure of Maleylacetoacetate isomerase from Anaeromyxobacter dehalogenans 2CP-1, target EFI-507175."
    Kim J., Toro R., Bhosle R., Al Obaidi N.F., Morisco L.L., Wasserman S.R., Sojitra S., Washington E., Scott Glenn A., Chowdhury S., Evans B., Hammonds J., Hillerich B., Love J., Seidel R.D., Imker H.J., Armstrong R.N., Gerlt J.A., Almo S.C.
    Submitted (DEC-2012) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.48 ANGSTROMS).
  3. "Crystal structure of Maleylacetoacetate isomerase from Anaeromyxobacter dehalogenans 2CP-1, TARGET EFI-507175, with bound dicarboxyethyl glutathione and citrate in the active site."
    Kim J., Toro R., Bhosle R., Al Obaidi N.F., Morisco L.L., Wasserman S.R., Sojitra S., Washington E., Scott Glenn A., Chowdhury S., Evans B., Hammonds J., Hillerich B., Love J., Seidel R.D., Imker H.J., Stead M., Gerlt J.A., Almo S.C., Enzyme Function Initiative
    Submitted (APR-2013) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.50 ANGSTROMS).
  4. "Crystal structure of maleylacetoacetate isomerase from Anaeromyxobacter dehalogenans 2CP-1, Target EFI-507175, with bound GSH in the active site."
    Kim J., Toro R., Bhosle R., Al Obaidi N.F., Morisco L.L., Wasserman S.R., Sojitra S., Washington E., Scott Glenn A., Chowdhury S., Evans B., Hammonds J., Hillerich B., Love J., Seidel R.D., Imker H.J., Stead M., Gerlt J.A., Almo S.C., Enzyme Function Initiative
    Submitted (APR-2013) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.50 ANGSTROMS) IN COMPLEX WITH GLUTATHIONE.

Entry informationi

Entry nameiB8J605_ANAD2
AccessioniPrimary (citable) accession number: B8J605
Entry historyi
Integrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: July 22, 2015
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.