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B8J605

- B8J605_ANAD2

UniProt

B8J605 - B8J605_ANAD2

Protein
Submitted name:

Maleylacetoacetate isomerase

Gene

A2cp1_3570

Organism
Anaeromyxobacter dehalogenans (strain 2CP-1 / ATCC BAA-258)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 38 (01 Oct 2014)
      Sequence version 1 (03 Mar 2009)
      Previous versions | rss
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    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei11 – 111GlutathioneImported
    Binding sitei16 – 161GlutathioneImported
    Binding sitei35 – 351Citrate
    Binding sitei38 – 381GlutathioneImported
    Binding sitei42 – 421GlutathioneImported
    Binding sitei54 – 541Glutathione; via amide nitrogen and carbonyl oxygenImported
    Binding sitei139 – 1391GlutathioneImported

    GO - Molecular functioni

    1. isomerase activity Source: UniProtKB-KW

    GO - Biological processi

    1. aromatic amino acid family metabolic process Source: InterPro

    Keywords - Molecular functioni

    IsomeraseImported

    Enzyme and pathway databases

    BioCyciADEH455488:GH35-3619-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Maleylacetoacetate isomeraseImported
    Gene namesi
    Ordered Locus Names:A2cp1_3570Imported
    OrganismiAnaeromyxobacter dehalogenans (strain 2CP-1 / ATCC BAA-258)Imported
    Taxonomic identifieri455488 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaMyxococcalesCystobacterineaeAnaeromyxobacteraceaeAnaeromyxobacter
    ProteomesiUP000007089: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: InterPro

    Interactioni

    Protein-protein interaction databases

    STRINGi455488.A2cp1_3570.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4IGJX-ray1.48A/B1-220[»]
    4KAEX-ray1.50A/B1-220[»]
    4KDYX-ray1.50A/B1-220[»]
    ProteinModelPortaliB8J605.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni70 – 712Glutathione bindingImported
    Regioni106 – 1105Glutathione bindingImported

    Phylogenomic databases

    eggNOGiCOG0625.
    HOGENOMiHOG000125758.
    KOiK01801.
    OMAiDICLAAQ.
    OrthoDBiEOG6WT8DX.

    Family and domain databases

    Gene3Di1.20.1050.10. 1 hit.
    3.40.30.10. 1 hit.
    InterProiIPR010987. Glutathione-S-Trfase_C-like.
    IPR004045. Glutathione_S-Trfase_N.
    IPR005955. Mal_ac_isom.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view]
    PfamiPF13417. GST_N_3. 1 hit.
    [Graphical view]
    SUPFAMiSSF47616. SSF47616. 1 hit.
    SSF52833. SSF52833. 1 hit.
    TIGRFAMsiTIGR01262. maiA. 1 hit.
    PROSITEiPS50405. GST_CTER. 1 hit.
    PS50404. GST_NTER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B8J605-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTLRLYSYWR SSSAWRVRLG LALKGLAYEY RAVDLLAQEQ FQAAHQARNP    50
    MSQVPVLEVE EDGRTHLLVQ SMAILEWLEE RHPEPALLPP DLWGRARVRA 100
    LAEHVNSGTQ PMQNALVLRM LREKVPGWDR EWARFFIARG LAALETAVRD 150
    GAGRFSHGDA PTLADCYLVP QLYNARRFGL DLEPYPTLRR VDEACAALAP 200
    FQAAHPDRQP DAPPPDRRTP 220
    Length:220
    Mass (Da):24,997
    Last modified:March 3, 2009 - v1
    Checksum:iC7372DFECE10BD63
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001359 Genomic DNA. Translation: ACL66900.1.
    RefSeqiYP_002493966.1. NC_011891.1.

    Genome annotation databases

    EnsemblBacteriaiACL66900; ACL66900; A2cp1_3570.
    GeneIDi7299620.
    KEGGiacp:A2cp1_3570.
    PATRICi20914115. VBIAnaDeh28364_3622.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001359 Genomic DNA. Translation: ACL66900.1 .
    RefSeqi YP_002493966.1. NC_011891.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4IGJ X-ray 1.48 A/B 1-220 [» ]
    4KAE X-ray 1.50 A/B 1-220 [» ]
    4KDY X-ray 1.50 A/B 1-220 [» ]
    ProteinModelPortali B8J605.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 455488.A2cp1_3570.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACL66900 ; ACL66900 ; A2cp1_3570 .
    GeneIDi 7299620.
    KEGGi acp:A2cp1_3570.
    PATRICi 20914115. VBIAnaDeh28364_3622.

    Phylogenomic databases

    eggNOGi COG0625.
    HOGENOMi HOG000125758.
    KOi K01801.
    OMAi DICLAAQ.
    OrthoDBi EOG6WT8DX.

    Enzyme and pathway databases

    BioCyci ADEH455488:GH35-3619-MONOMER.

    Family and domain databases

    Gene3Di 1.20.1050.10. 1 hit.
    3.40.30.10. 1 hit.
    InterProi IPR010987. Glutathione-S-Trfase_C-like.
    IPR004045. Glutathione_S-Trfase_N.
    IPR005955. Mal_ac_isom.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view ]
    Pfami PF13417. GST_N_3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47616. SSF47616. 1 hit.
    SSF52833. SSF52833. 1 hit.
    TIGRFAMsi TIGR01262. maiA. 1 hit.
    PROSITEi PS50405. GST_CTER. 1 hit.
    PS50404. GST_NTER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of Anaeromyxobacter dehalogenans 2CP-1."
      Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Saunders E., Brettin T., Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N., Ovchinnikova G., Beliaev A.S., Richardson P.
      Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 2CP-1 / ATCC BAA-258Imported.
    2. "Crystal structure of Maleylacetoacetate isomerase from Anaeromyxobacter dehalogenans 2CP-1, target EFI-507175."
      Kim J., Toro R., Bhosle R., Al Obaidi N.F., Morisco L.L., Wasserman S.R., Sojitra S., Washington E., Scott Glenn A., Chowdhury S., Evans B., Hammonds J., Hillerich B., Love J., Seidel R.D., Imker H.J., Armstrong R.N., Gerlt J.A., Almo S.C.
      Submitted (DEC-2012) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (1.48 ANGSTROMS).
    3. "Crystal structure of Maleylacetoacetate isomerase from Anaeromyxobacter dehalogenans 2CP-1, TARGET EFI-507175, with bound dicarboxyethyl glutathione and citrate in the active site."
      Kim J., Toro R., Bhosle R., Al Obaidi N.F., Morisco L.L., Wasserman S.R., Sojitra S., Washington E., Scott Glenn A., Chowdhury S., Evans B., Hammonds J., Hillerich B., Love J., Seidel R.D., Imker H.J., Stead M., Gerlt J.A., Almo S.C., Enzyme Function Initiative
      Submitted (APR-2013) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (1.50 ANGSTROMS).
    4. "Crystal structure of maleylacetoacetate isomerase from Anaeromyxobacter dehalogenans 2CP-1, Target EFI-507175, with bound GSH in the active site."
      Kim J., Toro R., Bhosle R., Al Obaidi N.F., Morisco L.L., Wasserman S.R., Sojitra S., Washington E., Scott Glenn A., Chowdhury S., Evans B., Hammonds J., Hillerich B., Love J., Seidel R.D., Imker H.J., Stead M., Gerlt J.A., Almo S.C., Enzyme Function Initiative
      Submitted (APR-2013) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (1.50 ANGSTROMS) IN COMPLEX WITH GLUTATHIONE.

    Entry informationi

    Entry nameiB8J605_ANAD2
    AccessioniPrimary (citable) accession number: B8J605
    Entry historyi
    Integrated into UniProtKB/TrEMBL: March 3, 2009
    Last sequence update: March 3, 2009
    Last modified: October 1, 2014
    This is version 38 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported, Complete proteomeImported

    External Data

    Dasty 3