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Protein

Phosphoglycerate kinase

Gene

pgk

Organism
Desulfovibrio desulfuricans (strain ATCC 27774 / DSM 6949)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.UniRule annotation

Pathwayi: glycolysis

This protein is involved in step 2 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Phosphoglycerate kinase (pgk)
  3. 2,3-bisphosphoglycerate-independent phosphoglycerate mutase (gpmI)
  4. Enolase (eno)
  5. Pyruvate kinase (Ddes_1103)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei36SubstrateUniRule annotation1
Binding sitei112SubstrateUniRule annotation1
Binding sitei145SubstrateUniRule annotation1
Binding sitei196ATPUniRule annotation1
Binding sitei318ATPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi344 – 347ATPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processGlycolysis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciDDES525146:G1GUN-498-MONOMER
UniPathwayiUPA00109; UER00185

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoglycerate kinaseUniRule annotation (EC:2.7.2.3UniRule annotation)
Gene namesi
Name:pgkUniRule annotation
Ordered Locus Names:Ddes_0479
OrganismiDesulfovibrio desulfuricans (strain ATCC 27774 / DSM 6949)
Taxonomic identifieri525146 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfovibrionalesDesulfovibrionaceaeDesulfovibrio
Proteomesi
  • UP000002598 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001928251 – 389Phosphoglycerate kinaseAdd BLAST389

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi525146.Ddes_0479

Structurei

3D structure databases

SMRiB8J4D3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni21 – 23Substrate bindingUniRule annotation3
Regioni59 – 62Substrate bindingUniRule annotation4

Sequence similaritiesi

Belongs to the phosphoglycerate kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105BZA Bacteria
COG0126 LUCA
HOGENOMiHOG000227107
KOiK00927
OMAiDMIFDIG
OrthoDBiPOG091H00YN

Family and domain databases

Gene3Di3.40.50.1260, 3 hits
HAMAPiMF_00145 Phosphoglyc_kinase, 1 hit
InterProiView protein in InterPro
IPR001576 Phosphoglycerate_kinase
IPR015911 Phosphoglycerate_kinase_CS
IPR015824 Phosphoglycerate_kinase_N
IPR036043 Phosphoglycerate_kinase_sf
PANTHERiPTHR11406 PTHR11406, 1 hit
PfamiView protein in Pfam
PF00162 PGK, 1 hit
PIRSFiPIRSF000724 Pgk, 1 hit
PRINTSiPR00477 PHGLYCKINASE
SUPFAMiSSF53748 SSF53748, 1 hit
PROSITEiView protein in PROSITE
PS00111 PGLYCERATE_KINASE, 1 hit

Sequencei

Sequence statusi: Complete.

B8J4D3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPVTKMQDLD LGGKTVVIRE DLNVPMKDGI ITNDKRIRAA LPTIQLALEK
60 70 80 90 100
GAGVIVLSHL GRPTEGQYDQ QFSLAPVADR LAQLLGQPVT LAKSLDEAKT
110 120 130 140 150
APGQVTLLEN VRFLPGEKKN DPELAAKLAG LGDVYVMDAF GSAHRAHAST
160 170 180 190 200
EGAVRTAAVA CAGPLLQAEL EAFDKVLDNP ARPVVAIVGG AKVSTKLTLL
210 220 230 240 250
ENLLEKVDVL IVGGGIANTF LAAAGYMVGK SLYEEDLLPE AQKIMALAKT
260 270 280 290 300
LNKELPLPVD VITAEELAPR QQTMLHAVGD VPGDQMILDI GPETLTLYEK
310 320 330 340 350
FLSKAATVVW NGPVGAFEIE PFGDGTKALA EYLSDSKAFV VVGGGDSVAA
360 370 380
VEKYGLADRM GYISTGGGAS LELLEGKKLP SVAALEDRA
Length:389
Mass (Da):40,940
Last modified:March 3, 2009 - v1
Checksum:i2FFE21676BEED2D8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001358 Genomic DNA Translation: ACL48391.1
RefSeqiWP_012624119.1, NC_011883.1

Genome annotation databases

EnsemblBacteriaiACL48391; ACL48391; Ddes_0479
KEGGidds:Ddes_0479

Similar proteinsi

Entry informationi

Entry nameiPGK_DESDA
AccessioniPrimary (citable) accession number: B8J4D3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 3, 2009
Last modified: March 28, 2018
This is version 48 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health