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Protein

Methionyl-tRNA formyltransferase

Gene

fmt

Organism
Desulfovibrio desulfuricans (strain ATCC 27774 / DSM 6949)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.UniRule annotation

Catalytic activityi

10-formyltetrahydrofolate + L-methionyl-tRNA(fMet) = tetrahydrofolate + N-formylmethionyl-tRNA(fMet).UniRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionTransferase
Biological processProtein biosynthesis

Enzyme and pathway databases

BioCyciDDES525146:G1GUN-13-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Methionyl-tRNA formyltransferaseUniRule annotation (EC:2.1.2.9UniRule annotation)
Gene namesi
Name:fmtUniRule annotation
Ordered Locus Names:Ddes_0012
OrganismiDesulfovibrio desulfuricans (strain ATCC 27774 / DSM 6949)
Taxonomic identifieri525146 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfovibrionalesDesulfovibrionaceaeDesulfovibrio
Proteomesi
  • UP000002598 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001900211 – 337Methionyl-tRNA formyltransferaseAdd BLAST337

Interactioni

Protein-protein interaction databases

STRINGi525146.Ddes_0012

Structurei

3D structure databases

ProteinModelPortaliB8J1H5
SMRiB8J1H5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni116 – 119Tetrahydrofolate (THF) bindingUniRule annotation4

Sequence similaritiesi

Belongs to the Fmt family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CAE Bacteria
COG0223 LUCA
HOGENOMiHOG000261177
KOiK00604
OMAiLRIVFMG
OrthoDBiPOG091H01YM

Family and domain databases

Gene3Di3.10.25.10, 1 hit
HAMAPiMF_00182 Formyl_trans, 1 hit
InterProiView protein in InterPro
IPR005794 Fmt
IPR005793 Formyl_trans_C
IPR037022 Formyl_trans_C_sf
IPR002376 Formyl_transf_N
IPR036477 Formyl_transf_N_sf
IPR011034 Formyl_transferase-like_C_sf
PfamiView protein in Pfam
PF02911 Formyl_trans_C, 1 hit
PF00551 Formyl_trans_N, 1 hit
SUPFAMiSSF50486 SSF50486, 1 hit
SSF53328 SSF53328, 1 hit
TIGRFAMsiTIGR00460 fmt, 1 hit

Sequencei

Sequence statusi: Complete.

B8J1H5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQEKDCRIV FMGTPGFAAA SLRRLAAWPR AHIVAVYTQP DRPAGRGQKL
60 70 80 90 100
AMSAVKKLAL ELGIPVCQPA SLKGAEAQAE LAAFRPDVLA VAAYGLILPD
110 120 130 140 150
AVLDMPRLAP VNVHASILPG LRGAAPIQRA VMEGWQPGAR AGISIMRIGS
160 170 180 190 200
RLDAGPVYAM GDTPIGEHTS GSLHDALAEL GAELLVTVLD DLMEGRAVAV
210 220 230 240 250
EQDESLATHA AKLGKRDGYI NWTRSAAEAH AQIRGVTPRP GARTVLHLDA
260 270 280 290 300
GTDFEARSMP LIVSPGTIGE TAAGTAPGSV RHDGQDISIA CGDCWYTLGM
310 320 330
VRPEGRKDMP VRDLLNGSLK NLPQGVCGEA RSPEESL
Length:337
Mass (Da):35,445
Last modified:March 3, 2009 - v1
Checksum:iAC17A42EB6DC27B5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001358 Genomic DNA Translation: ACL47932.1
RefSeqiWP_012623664.1, NC_011883.1

Genome annotation databases

EnsemblBacteriaiACL47932; ACL47932; Ddes_0012
KEGGidds:Ddes_0012

Similar proteinsi

Entry informationi

Entry nameiFMT_DESDA
AccessioniPrimary (citable) accession number: B8J1H5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 3, 2009
Last modified: March 28, 2018
This is version 53 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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