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B8J0P3 (UPPP_DESDA) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 33. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Undecaprenyl-diphosphatase

EC=3.6.1.27
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene names
Name:uppP
Ordered Locus Names:Ddes_1418
OrganismDesulfovibrio desulfuricans (strain ATCC 27774 / DSM 6949) [Complete proteome] [HAMAP]
Taxonomic identifier525146 [NCBI]
Taxonomic lineageBacteriaProteobacteriaDeltaproteobacteriaDesulfovibrionalesDesulfovibrionaceaeDesulfovibrio

Protein attributes

Sequence length265 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006

Catalytic activity

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Sequence similarities

Belongs to the UppP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 265265Undecaprenyl-diphosphatase HAMAP-Rule MF_01006
PRO_1000148809

Regions

Transmembrane42 – 6221Helical; Potential
Transmembrane82 – 10221Helical; Potential
Transmembrane108 – 12821Helical; Potential
Transmembrane157 – 17721Helical; Potential
Transmembrane181 – 20121Helical; Potential
Transmembrane217 – 23721Helical; Potential
Transmembrane244 – 26421Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
B8J0P3 [UniParc].

Last modified March 3, 2009. Version 1.
Checksum: E29F53BA5D4A5D9D

FASTA26528,826
        10         20         30         40         50         60 
MDNLLTALIL SIVEGLTEFL PVSSSGHLIL AGDLLGFVGE KAATFDVVIQ LGAIMAVVVL 

        70         80         90        100        110        120 
YWKRFWGLVR PQPYARFAGR RGIVLLMLTS LPACILGLLL HAYIKEYLFR PATVLIALVV 

       130        140        150        160        170        180 
GAICMILVEK RKFKPTCISL DDMTPRLALG IGCFQCLALW PGFSRSAATI MGGMLLGAKR 

       190        200        210        220        230        240 
PLAAEYSFIA AVPIMVAATG YDLLKNLSMF TAADIPFFLV GMIGSFVSAL LAVKVFVALV 

       250        260 
GRMTLIPFAC YRLLIAPFVY YFMVN 

« Hide

References

[1]"Complete sequence of Desulfovibrio desulfuricans subsp. desulfuricans str. ATCC 27774."
US DOE Joint Genome Institute
Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Tice H., Bruce D., Goodwin L., Pitluck S., Sims D., Lu M., Kiss H., Meineke L., Brettin T., Detter J.C., Han C., Larimer F., Land M., Hauser L. expand/collapse author list , Kyrpides N., Ovchinnikova G., Hazen T.C.
Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 27774 / DSM 6949.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001358 Genomic DNA. Translation: ACL49320.1.
RefSeqYP_002479998.1. NC_011883.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING525146.Ddes_1418.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACL49320; ACL49320; Ddes_1418.
GeneID7285114.
KEGGdds:Ddes_1418.
PATRIC21736584. VBIDesDes50650_1642.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1968.
HOGENOMHOG000218356.
KOK06153.
OrthoDBEOG6QP13M.
ProtClustDBPRK00281.

Enzyme and pathway databases

BioCycDDES525146:GIWF-1463-MONOMER.

Family and domain databases

HAMAPMF_01006. Undec_diphosphatase.
InterProIPR003824. UppP.
[Graphical view]
PfamPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsTIGR00753. undec_PP_bacA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameUPPP_DESDA
AccessionPrimary (citable) accession number: B8J0P3
Entry history
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 3, 2009
Last modified: February 19, 2014
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families