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B8J0C2

- FTHS_DESDA

UniProt

B8J0C2 - FTHS_DESDA

Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Desulfovibrio desulfuricans (strain ATCC 27774 / DSM 6949)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 31 (01 Oct 2014)
      Sequence version 1 (03 Mar 2009)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi74 – 818ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. folic acid-containing compound biosynthetic process Source: InterPro
    2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciDDES525146:GIWF-1337-MONOMER.
    UniPathwayiUPA00193.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
    Alternative name(s):
    Formyltetrahydrofolate synthetaseUniRule annotation
    Short name:
    FHSUniRule annotation
    Short name:
    FTHFSUniRule annotation
    Gene namesi
    Name:fhsUniRule annotation
    Ordered Locus Names:Ddes_1296
    OrganismiDesulfovibrio desulfuricans (strain ATCC 27774 / DSM 6949)
    Taxonomic identifieri525146 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfovibrionalesDesulfovibrionaceaeDesulfovibrio
    ProteomesiUP000002598: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 591591Formate--tetrahydrofolate ligasePRO_1000185254Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi525146.Ddes_1296.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2759.
    HOGENOMiHOG000040280.
    KOiK01938.
    OrthoDBiEOG6PCPSP.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    HAMAPiMF_01543. FTHFS.
    InterProiIPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF01268. FTHFS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B8J0C2-1 [UniParc]FASTAAdd to Basket

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    MTLDPTKHPD WKIALDAESR MKTVETLAAE LGLEKAELLP YGHYMGKVEQ    50
    QAVMQRLKDR PNGKYIDVTA ITPTPLGEGK STTTIGLVQG LARRGRRSSA 100
    AIRQPSGGPT MGMKGSAAGG GLSQCIPLTP YSLNFTGDLH AVGAAHNLGM 150
    TALTSRMQHE RNYDDATLEK LSGMARLNID PTRINTGWVM DFCVQALRNI 200
    IIGIEGDGRR NDGFMMRSHF DITVASEVMC ILSIARDLRD LRERMGRMVL 250
    AHDRNGKPVT TSDLGVAGAM TAWLVEAAKP NLIQTIEGQP VFVHTGPFAN 300
    IALGQSSVIA DRVALKLSDY HVTESGFAAE MGYEKFWNLK CHYSGLVPDA 350
    AVVVATVRAL KNHGGAPQPK PGQALPEPYT REDVGLVEAG CANLLHHLGI 400
    VRRSGVPAVV CINKFHTDTK AEVDAIRRIC EQAGARVALS EHWEKGGEGA 450
    LELADAVTDA CNEKNEFRPL YNWNSPLTER ITTIAQEVYG ADGVEFEPLA 500
    AQRLKDLQER PDADELGVCM VKTQYSLSDK PALKGVPKGW RLHVRDVLFF 550
    GGAGLVAPVS GDISLMPGTG SKPAFRNIDV DVETGKVTGL F 591
    Length:591
    Mass (Da):63,964
    Last modified:March 3, 2009 - v1
    Checksum:i5DE7F8F29F1E03F5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001358 Genomic DNA. Translation: ACL49199.1.
    RefSeqiWP_012624923.1. NC_011883.1.
    YP_002479877.1. NC_011883.1.

    Genome annotation databases

    EnsemblBacteriaiACL49199; ACL49199; Ddes_1296.
    GeneIDi7284988.
    KEGGidds:Ddes_1296.
    PATRICi21736306. VBIDesDes50650_1507.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001358 Genomic DNA. Translation: ACL49199.1 .
    RefSeqi WP_012624923.1. NC_011883.1.
    YP_002479877.1. NC_011883.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 525146.Ddes_1296.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACL49199 ; ACL49199 ; Ddes_1296 .
    GeneIDi 7284988.
    KEGGi dds:Ddes_1296.
    PATRICi 21736306. VBIDesDes50650_1507.

    Phylogenomic databases

    eggNOGi COG2759.
    HOGENOMi HOG000040280.
    KOi K01938.
    OrthoDBi EOG6PCPSP.

    Enzyme and pathway databases

    UniPathwayi UPA00193 .
    BioCyci DDES525146:GIWF-1337-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    HAMAPi MF_01543. FTHFS.
    InterProi IPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF01268. FTHFS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of Desulfovibrio desulfuricans subsp. desulfuricans str. ATCC 27774."
      US DOE Joint Genome Institute
      Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Tice H., Bruce D., Goodwin L., Pitluck S., Sims D., Lu M., Kiss H., Meineke L., Brettin T., Detter J.C., Han C., Larimer F., Land M., Hauser L.
      , Kyrpides N., Ovchinnikova G., Hazen T.C.
      Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 27774 / DSM 6949.

    Entry informationi

    Entry nameiFTHS_DESDA
    AccessioniPrimary (citable) accession number: B8J0C2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 28, 2009
    Last sequence update: March 3, 2009
    Last modified: October 1, 2014
    This is version 31 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3