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B8J0C2 (FTHS_DESDA) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 29. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Formate--tetrahydrofolate ligase

EC=6.3.4.3
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name=FHS
Short name=FTHFS
Gene names
Name:fhs
Ordered Locus Names:Ddes_1296
OrganismDesulfovibrio desulfuricans (strain ATCC 27774 / DSM 6949) [Complete proteome] [HAMAP]
Taxonomic identifier525146 [NCBI]
Taxonomic lineageBacteriaProteobacteriaDeltaproteobacteriaDesulfovibrionalesDesulfovibrionaceaeDesulfovibrio

Protein attributes

Sequence length591 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. HAMAP-Rule MF_01543

Pathway

One-carbon metabolism; tetrahydrofolate interconversion. HAMAP-Rule MF_01543

Sequence similarities

Belongs to the formate--tetrahydrofolate ligase family.

Ontologies

Keywords
   Biological processOne-carbon metabolism
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processfolic acid-containing compound biosynthetic process

Inferred from electronic annotation. Source: InterPro

tetrahydrofolate interconversion

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

formate-tetrahydrofolate ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 591591Formate--tetrahydrofolate ligase HAMAP-Rule MF_01543
PRO_1000185254

Regions

Nucleotide binding74 – 818ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
B8J0C2 [UniParc].

Last modified March 3, 2009. Version 1.
Checksum: 5DE7F8F29F1E03F5

FASTA59163,964
        10         20         30         40         50         60 
MTLDPTKHPD WKIALDAESR MKTVETLAAE LGLEKAELLP YGHYMGKVEQ QAVMQRLKDR 

        70         80         90        100        110        120 
PNGKYIDVTA ITPTPLGEGK STTTIGLVQG LARRGRRSSA AIRQPSGGPT MGMKGSAAGG 

       130        140        150        160        170        180 
GLSQCIPLTP YSLNFTGDLH AVGAAHNLGM TALTSRMQHE RNYDDATLEK LSGMARLNID 

       190        200        210        220        230        240 
PTRINTGWVM DFCVQALRNI IIGIEGDGRR NDGFMMRSHF DITVASEVMC ILSIARDLRD 

       250        260        270        280        290        300 
LRERMGRMVL AHDRNGKPVT TSDLGVAGAM TAWLVEAAKP NLIQTIEGQP VFVHTGPFAN 

       310        320        330        340        350        360 
IALGQSSVIA DRVALKLSDY HVTESGFAAE MGYEKFWNLK CHYSGLVPDA AVVVATVRAL 

       370        380        390        400        410        420 
KNHGGAPQPK PGQALPEPYT REDVGLVEAG CANLLHHLGI VRRSGVPAVV CINKFHTDTK 

       430        440        450        460        470        480 
AEVDAIRRIC EQAGARVALS EHWEKGGEGA LELADAVTDA CNEKNEFRPL YNWNSPLTER 

       490        500        510        520        530        540 
ITTIAQEVYG ADGVEFEPLA AQRLKDLQER PDADELGVCM VKTQYSLSDK PALKGVPKGW 

       550        560        570        580        590 
RLHVRDVLFF GGAGLVAPVS GDISLMPGTG SKPAFRNIDV DVETGKVTGL F 

« Hide

References

[1]"Complete sequence of Desulfovibrio desulfuricans subsp. desulfuricans str. ATCC 27774."
US DOE Joint Genome Institute
Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Tice H., Bruce D., Goodwin L., Pitluck S., Sims D., Lu M., Kiss H., Meineke L., Brettin T., Detter J.C., Han C., Larimer F., Land M., Hauser L. expand/collapse author list , Kyrpides N., Ovchinnikova G., Hazen T.C.
Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 27774 / DSM 6949.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001358 Genomic DNA. Translation: ACL49199.1.
RefSeqYP_002479877.1. NC_011883.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING525146.Ddes_1296.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACL49199; ACL49199; Ddes_1296.
GeneID7284988.
KEGGdds:Ddes_1296.
PATRIC21736306. VBIDesDes50650_1507.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2759.
HOGENOMHOG000040280.
KOK01938.
OrthoDBEOG6PCPSP.

Enzyme and pathway databases

BioCycDDES525146:GIWF-1337-MONOMER.
UniPathwayUPA00193.

Family and domain databases

Gene3D3.40.50.300. 2 hits.
HAMAPMF_01543. FTHFS.
InterProIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFTHS_DESDA
AccessionPrimary (citable) accession number: B8J0C2
Entry history
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 3, 2009
Last modified: May 14, 2014
This is version 29 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways