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Protein

DNA mismatch repair protein MutS

Gene

mutS

Organism
Desulfovibrio desulfuricans (strain ATCC 27774 / DSM 6949)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi646 – 6538ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

DNA damage, DNA repair

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciDDES525146:GIWF-1212-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA mismatch repair protein MutSUniRule annotation
Gene namesi
Name:mutSUniRule annotation
Ordered Locus Names:Ddes_1181
OrganismiDesulfovibrio desulfuricans (strain ATCC 27774 / DSM 6949)
Taxonomic identifieri525146 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfovibrionalesDesulfovibrionaceaeDesulfovibrio
ProteomesiUP000002598 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 927927DNA mismatch repair protein MutSPRO_1000118680Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi525146.Ddes_1181.

Family & Domainsi

Sequence similaritiesi

Belongs to the DNA mismatch repair MutS family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0249.
HOGENOMiHOG000221407.
KOiK03555.
OMAiCLLLFRM.
OrthoDBiEOG6Q5NPV.

Family and domain databases

Gene3Di3.30.420.110. 1 hit.
3.40.1170.10. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00096. MutS.
InterProiIPR005748. DNA_mismatch_repair_MutS-1.
IPR007695. DNA_mismatch_repair_MutS-lik_N.
IPR000432. DNA_mismatch_repair_MutS_C.
IPR007861. DNA_mismatch_repair_MutS_clamp.
IPR007696. DNA_mismatch_repair_MutS_core.
IPR016151. DNA_mismatch_repair_MutS_N.
IPR007860. DNA_mmatch_repair_MutS_con_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01624. MutS_I. 1 hit.
PF05188. MutS_II. 1 hit.
PF05192. MutS_III. 1 hit.
PF05190. MutS_IV. 1 hit.
PF00488. MutS_V. 1 hit.
[Graphical view]
SMARTiSM00534. MUTSac. 1 hit.
SM00533. MUTSd. 1 hit.
[Graphical view]
SUPFAMiSSF48334. SSF48334. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF53150. SSF53150. 1 hit.
SSF55271. SSF55271. 1 hit.
TIGRFAMsiTIGR01070. mutS1. 1 hit.
PROSITEiPS00486. DNA_MISMATCH_REPAIR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B8J008-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEPTFKMTP MFEHYMSIKA DYPDALLFYR MGDFYELFFD DAELAARELQ
60 70 80 90 100
ITLTSRSRDP NNPIPMCGVP WHAVDTYVAQ LVDKGYHIAI CDQVEDPKTS
110 120 130 140 150
KGLVKRAVTS VKTPGTVLDD ANLSTKSHNY LGALCPGSDA EKGGFAWLDV
160 170 180 190 200
STGQWSGVDF RRQTELWQWV LKMAPRELLV PEGFQPPART LLEGIRLVRL
210 220 230 240 250
PLSRFDLKRS TERVLAAQGV REAAALGLEG REEIMRACGA LLAYLAQTQM
260 270 280 290 300
RSPEHLQPFL RLDLSRRLII DEVTERNLEI FTRLNGRKGK GTLRHVLDET
310 320 330 340 350
MTPMGGRLLE DMLRHPWREI SPIVRIQDAV EWFYVDDGRR TALREALNGV
360 370 380 390 400
YDMERLSTRI SLNQGSPRDF IALRNSLAAL PQVFTALIEP TTSLLLRPDQ
410 420 430 440 450
EKDASENTSQ ENGLTQPRAL TELLKTWDAM EDCAQLLQSA LVDNPPPVIT
460 470 480 490 500
DGGLFKSGYN AELDRLLDLA EHGEQKLQAM LAEEQSTTGI AKLKLGYNRV
510 520 530 540 550
FGYYFEVSRA AHSGTVPYHF IRRQSLANAE RFTTEALKNL EEELLSASDK
560 570 580 590 600
RKALEYTLFQ DLRQHMADQR ERIAHMAQLI AHLDYWQSLA QVGRLNNWCR
610 620 630 640 650
PGLETDGNLT IREGRHPVVE AMIGRANFVP NDFRLDEKRR LCLLTGPNMA
660 670 680 690 700
GKSTVLRQVA IICLLAQMGS MVPATSARLG LVDRLFSRVG ASDNLAQGQS
710 720 730 740 750
TFMVEMMETA RILRQATKRS LIILDEIGRG TSTYDGVALA WAMVEDLSRR
760 770 780 790 800
AQGELRTLFA THYHELTALE GRVDGVFTMN IAISEYSGDI LFLHKLVPGP
810 820 830 840 850
ADRSYGVEVA RLAGVPGPVV QRARAILANL ERGRDVARKA VVSAVCLPGI
860 870 880 890 900
DLPETGPEED MPVLQAAPPR SEHPVIELLR QIEPEELSPL DALKTLMEWK
910 920
KLWSAQPGSA EQGESPDKHD EGKNSRG
Length:927
Mass (Da):103,825
Last modified:March 3, 2009 - v1
Checksum:iC5B9B38A6612CD86
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001358 Genomic DNA. Translation: ACL49085.1.
RefSeqiWP_012624810.1. NC_011883.1.
YP_002479763.1. NC_011883.1.

Genome annotation databases

EnsemblBacteriaiACL49085; ACL49085; Ddes_1181.
KEGGidds:Ddes_1181.
PATRICi21736046. VBIDesDes50650_1384.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001358 Genomic DNA. Translation: ACL49085.1.
RefSeqiWP_012624810.1. NC_011883.1.
YP_002479763.1. NC_011883.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi525146.Ddes_1181.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACL49085; ACL49085; Ddes_1181.
KEGGidds:Ddes_1181.
PATRICi21736046. VBIDesDes50650_1384.

Phylogenomic databases

eggNOGiCOG0249.
HOGENOMiHOG000221407.
KOiK03555.
OMAiCLLLFRM.
OrthoDBiEOG6Q5NPV.

Enzyme and pathway databases

BioCyciDDES525146:GIWF-1212-MONOMER.

Family and domain databases

Gene3Di3.30.420.110. 1 hit.
3.40.1170.10. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00096. MutS.
InterProiIPR005748. DNA_mismatch_repair_MutS-1.
IPR007695. DNA_mismatch_repair_MutS-lik_N.
IPR000432. DNA_mismatch_repair_MutS_C.
IPR007861. DNA_mismatch_repair_MutS_clamp.
IPR007696. DNA_mismatch_repair_MutS_core.
IPR016151. DNA_mismatch_repair_MutS_N.
IPR007860. DNA_mmatch_repair_MutS_con_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01624. MutS_I. 1 hit.
PF05188. MutS_II. 1 hit.
PF05192. MutS_III. 1 hit.
PF05190. MutS_IV. 1 hit.
PF00488. MutS_V. 1 hit.
[Graphical view]
SMARTiSM00534. MUTSac. 1 hit.
SM00533. MUTSd. 1 hit.
[Graphical view]
SUPFAMiSSF48334. SSF48334. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF53150. SSF53150. 1 hit.
SSF55271. SSF55271. 1 hit.
TIGRFAMsiTIGR01070. mutS1. 1 hit.
PROSITEiPS00486. DNA_MISMATCH_REPAIR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequence of Desulfovibrio desulfuricans subsp. desulfuricans str. ATCC 27774."
    US DOE Joint Genome Institute
    Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Tice H., Bruce D., Goodwin L., Pitluck S., Sims D., Lu M., Kiss H., Meineke L., Brettin T., Detter J.C., Han C., Larimer F., Land M., Hauser L.
    , Kyrpides N., Ovchinnikova G., Hazen T.C.
    Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 27774 / DSM 6949.

Entry informationi

Entry nameiMUTS_DESDA
AccessioniPrimary (citable) accession number: B8J008
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 3, 2009
Last modified: May 27, 2015
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.