B8J008 (MUTS_DESDA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
DNA mismatch repair protein MutS

Gene names

Name:	mutS
Ordered Locus Names:	Ddes_1181

Organism

Desulfovibrio desulfuricans (strain ATCC 27774 / DSM 6949) [Complete proteome] [HAMAP]

Taxonomic identifier

525146 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › delta/epsilon subdivisions › Deltaproteobacteria › Desulfovibrionales › Desulfovibrionaceae › Desulfovibrio › Desulfovibrio desulfuricans › Desulfovibrio desulfuricans subsp. desulfuricans

Protein attributes

Sequence length	927 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity By similarity. HAMAP-Rule MF_00096
Sequence similarities	Belongs to the DNA mismatch repair MutS family.

Ontologies

Keywords
Biological process	DNA damage DNA repair
Ligand	ATP-binding DNA-binding Nucleotide-binding
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	mismatch repair Inferred from electronic annotation. Source: HAMAP
Molecular_function	ATP binding Inferred from electronic annotation. Source: HAMAP damaged DNA binding Inferred from electronic annotation. Source: HAMAP mismatched DNA binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 927	927	DNA mismatch repair protein MutS HAMAP-Rule MF_00096		PRO_1000118680
Regions
	Nucleotide binding	646 – 653	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	B8J008 [UniParc]. Last modified March 3, 2009. Version 1. Checksum: C5B9B38A6612CD86	FASTA	927	103,825
	10 20 30 40 50 60 MSEPTFKMTP MFEHYMSIKA DYPDALLFYR MGDFYELFFD DAELAARELQ ITLTSRSRDP 70 80 90 100 110 120 NNPIPMCGVP WHAVDTYVAQ LVDKGYHIAI CDQVEDPKTS KGLVKRAVTS VKTPGTVLDD 130 140 150 160 170 180 ANLSTKSHNY LGALCPGSDA EKGGFAWLDV STGQWSGVDF RRQTELWQWV LKMAPRELLV 190 200 210 220 230 240 PEGFQPPART LLEGIRLVRL PLSRFDLKRS TERVLAAQGV REAAALGLEG REEIMRACGA 250 260 270 280 290 300 LLAYLAQTQM RSPEHLQPFL RLDLSRRLII DEVTERNLEI FTRLNGRKGK GTLRHVLDET 310 320 330 340 350 360 MTPMGGRLLE DMLRHPWREI SPIVRIQDAV EWFYVDDGRR TALREALNGV YDMERLSTRI 370 380 390 400 410 420 SLNQGSPRDF IALRNSLAAL PQVFTALIEP TTSLLLRPDQ EKDASENTSQ ENGLTQPRAL 430 440 450 460 470 480 TELLKTWDAM EDCAQLLQSA LVDNPPPVIT DGGLFKSGYN AELDRLLDLA EHGEQKLQAM 490 500 510 520 530 540 LAEEQSTTGI AKLKLGYNRV FGYYFEVSRA AHSGTVPYHF IRRQSLANAE RFTTEALKNL 550 560 570 580 590 600 EEELLSASDK RKALEYTLFQ DLRQHMADQR ERIAHMAQLI AHLDYWQSLA QVGRLNNWCR 610 620 630 640 650 660 PGLETDGNLT IREGRHPVVE AMIGRANFVP NDFRLDEKRR LCLLTGPNMA GKSTVLRQVA 670 680 690 700 710 720 IICLLAQMGS MVPATSARLG LVDRLFSRVG ASDNLAQGQS TFMVEMMETA RILRQATKRS 730 740 750 760 770 780 LIILDEIGRG TSTYDGVALA WAMVEDLSRR AQGELRTLFA THYHELTALE GRVDGVFTMN 790 800 810 820 830 840 IAISEYSGDI LFLHKLVPGP ADRSYGVEVA RLAGVPGPVV QRARAILANL ERGRDVARKA 850 860 870 880 890 900 VVSAVCLPGI DLPETGPEED MPVLQAAPPR SEHPVIELLR QIEPEELSPL DALKTLMEWK 910 920 KLWSAQPGSA EQGESPDKHD EGKNSRG

References

[1]

"Complete sequence of Desulfovibrio desulfuricans subsp. desulfuricans str. ATCC 27774." US DOE Joint Genome Institute Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Tice H., Bruce D., Goodwin L., Pitluck S., Sims D., Lu M., Kiss H., Meineke L., Brettin T., Detter J.C., Han C., Larimer F., Land M., Hauser L. , Kyrpides N., Ovchinnikova G., Hazen T.C. Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 27774 / DSM 6949.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001358 Genomic DNA. Translation: ACL49085.1.
RefSeq	YP_002479763.1. NC_011883.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	525146.Ddes_1181.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ACL49085; ACL49085; Ddes_1181.
GeneID	7284863.
KEGG	dds:Ddes_1181.
PATRIC	21736046. VBIDesDes50650_1384.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0249.
HOGENOM	HOG000221407.
KO	K03555.
ProtClustDB	PRK05399.
Enzyme and pathway databases
BioCyc	DDES525146:GIWF-1212-MONOMER.
Family and domain databases
Gene3D	3.30.420.110. 1 hit. 3.40.1170.10. 1 hit.
HAMAP	MF_00096. MutS.
InterPro	IPR005748. DNA_mismatch_repair_MutS-1. IPR007695. DNA_mismatch_repair_MutS-lik_N. IPR000432. DNA_mismatch_repair_MutS_C. IPR007861. DNA_mismatch_repair_MutS_clamp. IPR007696. DNA_mismatch_repair_MutS_core. IPR016151. DNA_mismatch_repair_MutS_N. IPR007860. DNA_mmatch_repair_MutS_con_dom. [Graphical view]
PANTHER	PTHR11361:SF34. PTHR11361:SF34. 1 hit.
Pfam	PF01624. MutS_I. 1 hit. PF05188. MutS_II. 1 hit. PF05192. MutS_III. 1 hit. PF05190. MutS_IV. 1 hit. PF00488. MutS_V. 1 hit. [Graphical view]
SMART	SM00534. MUTSac. 1 hit. SM00533. MUTSd. 1 hit. [Graphical view]
SUPFAM	SSF53150. DNA_mismatch_repair_MutS_connt. 1 hit. SSF55271. DNA_mismatch_repair_MutS_N. 1 hit. SSF48334. DNA_repair_MutS_domIII. 1 hit.
TIGRFAMs	TIGR01070. mutS1. 1 hit.
PROSITE	PS00486. DNA_MISMATCH_REPAIR_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MUTS_DESDA

Accession

Primary (citable) accession number: B8J008

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 28, 2009
Last sequence update:	March 3, 2009
Last modified:	May 1, 2013
This is version 27 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program