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B8J008 (MUTS_DESDA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 32. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
DNA mismatch repair protein MutS
Gene names
Name:mutS
Ordered Locus Names:Ddes_1181
OrganismDesulfovibrio desulfuricans (strain ATCC 27774 / DSM 6949) [Complete proteome] [HAMAP]
Taxonomic identifier525146 [NCBI]
Taxonomic lineageBacteriaProteobacteriaDeltaproteobacteriaDesulfovibrionalesDesulfovibrionaceaeDesulfovibrio

Protein attributes

Sequence length927 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity By similarity. HAMAP-Rule MF_00096

Sequence similarities

Belongs to the DNA mismatch repair MutS family.

Ontologies

Keywords
   Biological processDNA damage
DNA repair
   LigandATP-binding
DNA-binding
Nucleotide-binding
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processmismatch repair

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

damaged DNA binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

mismatched DNA binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 927927DNA mismatch repair protein MutS HAMAP-Rule MF_00096
PRO_1000118680

Regions

Nucleotide binding646 – 6538ATP Potential

Sequences

Sequence LengthMass (Da)Tools
B8J008 [UniParc].

Last modified March 3, 2009. Version 1.
Checksum: C5B9B38A6612CD86

FASTA927103,825
        10         20         30         40         50         60 
MSEPTFKMTP MFEHYMSIKA DYPDALLFYR MGDFYELFFD DAELAARELQ ITLTSRSRDP 

        70         80         90        100        110        120 
NNPIPMCGVP WHAVDTYVAQ LVDKGYHIAI CDQVEDPKTS KGLVKRAVTS VKTPGTVLDD 

       130        140        150        160        170        180 
ANLSTKSHNY LGALCPGSDA EKGGFAWLDV STGQWSGVDF RRQTELWQWV LKMAPRELLV 

       190        200        210        220        230        240 
PEGFQPPART LLEGIRLVRL PLSRFDLKRS TERVLAAQGV REAAALGLEG REEIMRACGA 

       250        260        270        280        290        300 
LLAYLAQTQM RSPEHLQPFL RLDLSRRLII DEVTERNLEI FTRLNGRKGK GTLRHVLDET 

       310        320        330        340        350        360 
MTPMGGRLLE DMLRHPWREI SPIVRIQDAV EWFYVDDGRR TALREALNGV YDMERLSTRI 

       370        380        390        400        410        420 
SLNQGSPRDF IALRNSLAAL PQVFTALIEP TTSLLLRPDQ EKDASENTSQ ENGLTQPRAL 

       430        440        450        460        470        480 
TELLKTWDAM EDCAQLLQSA LVDNPPPVIT DGGLFKSGYN AELDRLLDLA EHGEQKLQAM 

       490        500        510        520        530        540 
LAEEQSTTGI AKLKLGYNRV FGYYFEVSRA AHSGTVPYHF IRRQSLANAE RFTTEALKNL 

       550        560        570        580        590        600 
EEELLSASDK RKALEYTLFQ DLRQHMADQR ERIAHMAQLI AHLDYWQSLA QVGRLNNWCR 

       610        620        630        640        650        660 
PGLETDGNLT IREGRHPVVE AMIGRANFVP NDFRLDEKRR LCLLTGPNMA GKSTVLRQVA 

       670        680        690        700        710        720 
IICLLAQMGS MVPATSARLG LVDRLFSRVG ASDNLAQGQS TFMVEMMETA RILRQATKRS 

       730        740        750        760        770        780 
LIILDEIGRG TSTYDGVALA WAMVEDLSRR AQGELRTLFA THYHELTALE GRVDGVFTMN 

       790        800        810        820        830        840 
IAISEYSGDI LFLHKLVPGP ADRSYGVEVA RLAGVPGPVV QRARAILANL ERGRDVARKA 

       850        860        870        880        890        900 
VVSAVCLPGI DLPETGPEED MPVLQAAPPR SEHPVIELLR QIEPEELSPL DALKTLMEWK 

       910        920 
KLWSAQPGSA EQGESPDKHD EGKNSRG 

« Hide

References

[1]"Complete sequence of Desulfovibrio desulfuricans subsp. desulfuricans str. ATCC 27774."
US DOE Joint Genome Institute
Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Tice H., Bruce D., Goodwin L., Pitluck S., Sims D., Lu M., Kiss H., Meineke L., Brettin T., Detter J.C., Han C., Larimer F., Land M., Hauser L. expand/collapse author list , Kyrpides N., Ovchinnikova G., Hazen T.C.
Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 27774 / DSM 6949.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001358 Genomic DNA. Translation: ACL49085.1.
RefSeqYP_002479763.1. NC_011883.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING525146.Ddes_1181.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACL49085; ACL49085; Ddes_1181.
GeneID7284863.
KEGGdds:Ddes_1181.
PATRIC21736046. VBIDesDes50650_1384.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0249.
HOGENOMHOG000221407.
KOK03555.
OrthoDBEOG6Q5NPV.
ProtClustDBPRK05399.

Enzyme and pathway databases

BioCycDDES525146:GIWF-1212-MONOMER.

Family and domain databases

Gene3D3.30.420.110. 1 hit.
3.40.1170.10. 1 hit.
3.40.50.300. 1 hit.
HAMAPMF_00096. MutS.
InterProIPR005748. DNA_mismatch_repair_MutS-1.
IPR007695. DNA_mismatch_repair_MutS-lik_N.
IPR000432. DNA_mismatch_repair_MutS_C.
IPR007861. DNA_mismatch_repair_MutS_clamp.
IPR007696. DNA_mismatch_repair_MutS_core.
IPR016151. DNA_mismatch_repair_MutS_N.
IPR007860. DNA_mmatch_repair_MutS_con_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERPTHR11361:SF34. PTHR11361:SF34. 1 hit.
PfamPF01624. MutS_I. 1 hit.
PF05188. MutS_II. 1 hit.
PF05192. MutS_III. 1 hit.
PF05190. MutS_IV. 1 hit.
PF00488. MutS_V. 1 hit.
[Graphical view]
SMARTSM00534. MUTSac. 1 hit.
SM00533. MUTSd. 1 hit.
[Graphical view]
SUPFAMSSF48334. SSF48334. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF53150. SSF53150. 1 hit.
SSF55271. SSF55271. 1 hit.
TIGRFAMsTIGR01070. mutS1. 1 hit.
PROSITEPS00486. DNA_MISMATCH_REPAIR_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMUTS_DESDA
AccessionPrimary (citable) accession number: B8J008
Entry history
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 3, 2009
Last modified: April 16, 2014
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families