B8IUC0 (B8IUC0_METNO) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Shikimate dehydrogenase 1 HAMAP MF_00222
EC=1.1.1.25 HAMAP MF_00222

Gene names

Name:	aroE1 HAMAP MF_00222
Ordered Locus Names:	Mnod_0118

Organism

Methylobacterium nodulans (strain ORS2060 / LMG 21967) [Complete proteome] [HAMAP]

Taxonomic identifier

460265 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Methylobacteriaceae › Methylobacterium

Protein attributes

Sequence length	291 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Shikimate + NADP+ = 3-dehydroshikimate + NADPH. HAMAP MF_00222
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7. HAMAP MF_00222
Sequence similarities	Belongs to the shikimate dehydrogenase family. HAMAP MF_00222

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis HAMAP MF_00222
Ligand	NADP HAMAP MF_00222
Molecular function	Oxidoreductase HAMAP MF_00222 SAAS SAAS022893
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	nucleotide binding Inferred from electronic annotation. Source: InterPro shikimate 3-dehydrogenase (NADP+) activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Nucleotide binding	135 – 139	5	NADP By similarity HAMAP MF_00222
Sites
	Active site	75	1	Proton acceptor By similarity HAMAP MF_00222

Sequences

	Sequence		Length	Mass (Da)
	B8IUC0 [UniParc]. Last modified March 3, 2009. Version 1. Checksum: F84FD67DF673E29F	FASTA	291	30,500
	10 20 30 40 50 60 MSAPSRILLG LIGTGIQASR TPPMHEHEGD AQGLRVLYQT IDLERLGLGP EALPELLTAA 70 80 90 100 110 120 ERMGFAGLNI THPCKQAVIP HLDALSPDAA ALGAVNTVVL REGRRVGHNT DWWGFAESFR 130 140 150 160 170 180 RNLPGAALGR VVQLGAGGAG AAVAHALLTL GVQDLAIADV DPTRAEQVAE GLCGRFGAGR 190 200 210 220 230 240 ARASTDLAAD MAQADGLAHC TPTGMAAHPG LPLPAELLRP ALWVAEIVYF PIETELLRVA 250 260 270 280 290 RGLGCRTLDG GGMAVFQAVE AFRLFTGREP DPARMLRHFA ELGDKAAKTA A

References

[1]

"Complete sequence of chromosome of Methylobacterium nodulans ORS 2060." Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Sims D., Brettin T., Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N., Ivanova N., Marx C.J., Richardson P. Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ORS2060 / LMG 21967.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001349 Genomic DNA. Translation: ACL55165.1.
RefSeq	YP_002495468.1. NC_011894.1.
3D structure databases
ProteinModelPortal	B8IUC0.
SMR	B8IUC0. Positions 7-282.
ModBase	Search...
Protein-protein interaction databases
STRING	B8IUC0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	7304353.
GenomeReviews	Gene locus Mnod_0118 in contig CP001349_GR.
KEGG	mno:Mnod_0118.
PATRIC	22542470. VBIMetNod76414_0986.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG553408.
OMA	HEHEGDA.
ProtClustDB	PRK12549.
Family and domain databases
HAMAP	MF_00222. Shikimate_DH_AroE. [Tree]
InterPro	IPR016040. NAD(P)-bd_dom. IPR013708. Shikimate_DH-bd_N. IPR022893. Shikimate_quinate_DH. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00014.
Pfam	PF08501. Shikimate_dh_N. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

B8IUC0_METNO

Accession

Primary (citable) accession number: B8IUC0

Entry history

Integrated into UniProtKB/TrEMBL:	March 3, 2009
Last sequence update:	March 3, 2009
Last modified:	December 14, 2011
This is version 24 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)