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Protein

Trans-aconitate 2-methyltransferase

Gene

tam

Organism
Methylobacterium nodulans (strain LMG 21967 / CNCM I-2342 / ORS 2060)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + trans-aconitate = S-adenosyl-L-homocysteine + (E)-3-(methoxycarbonyl)pent-2-enedioate.UniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Ligandi

S-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Trans-aconitate 2-methyltransferaseUniRule annotation (EC:2.1.1.144UniRule annotation)
Gene namesi
Name:tamUniRule annotation
Ordered Locus Names:Mnod_5925
OrganismiMethylobacterium nodulans (strain LMG 21967 / CNCM I-2342 / ORS 2060)
Taxonomic identifieri460265 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesMethylobacteriaceaeMethylobacterium
Proteomesi
  • UP000008207 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001966561 – 258Trans-aconitate 2-methyltransferaseAdd BLAST258

Interactioni

Protein-protein interaction databases

STRINGi460265.Mnod_5925.

Structurei

3D structure databases

ProteinModelPortaliB8ISV4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the methyltransferase superfamily. Tam family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107R6G. Bacteria.
COG4106. LUCA.
HOGENOMiHOG000125295.
KOiK00598.
OMAiETTYLHV.
OrthoDBiPOG091H08XS.

Family and domain databases

Gene3Di1.10.150.290. 1 hit.
3.40.50.150. 1 hit.
HAMAPiMF_00560. Tran_acon_Me_trans. 1 hit.
InterProiIPR029063. SAM-dependent_MTases.
IPR023506. Trans-aconitate_MeTrfase.
IPR023149. Trans_acon_MeTrfase_C.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.

Sequencei

Sequence statusi: Complete.

B8ISV4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADWDAAQYL KFADERTRPA ADLLARVPLA APARVVDLGC GPGNSTELLV
60 70 80 90 100
ARYPEAAILG LDTSPGMLAE ARRRLPGVAF EQADVASLNP EPPPDLLFAN
110 120 130 140 150
AVLQWLPHHA SLLPRLARSL APGGCLAVQM PDNLEEPSHR LMRRVAGEPP
160 170 180 190 200
FAARLAAAAA SRTRIASFSE YDAWLTAAGC TVDIWRTTYV HALAGHRGIV
210 220 230 240 250
EWVRGTGLRP FLDPLDAEAQ AEFLARYEAA LAEAYPPQAD GRVLLPFPRL

FLVARRTR
Length:258
Mass (Da):28,028
Last modified:March 3, 2009 - v1
Checksum:iD7A7DBC6DED94274
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001349 Genomic DNA. Translation: ACL60753.1.
RefSeqiWP_015932348.1. NC_011894.1.

Genome annotation databases

EnsemblBacteriaiACL60753; ACL60753; Mnod_5925.
KEGGimno:Mnod_5925.
PATRICi22553643. VBIMetNod76414_6506.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001349 Genomic DNA. Translation: ACL60753.1.
RefSeqiWP_015932348.1. NC_011894.1.

3D structure databases

ProteinModelPortaliB8ISV4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi460265.Mnod_5925.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACL60753; ACL60753; Mnod_5925.
KEGGimno:Mnod_5925.
PATRICi22553643. VBIMetNod76414_6506.

Phylogenomic databases

eggNOGiENOG4107R6G. Bacteria.
COG4106. LUCA.
HOGENOMiHOG000125295.
KOiK00598.
OMAiETTYLHV.
OrthoDBiPOG091H08XS.

Family and domain databases

Gene3Di1.10.150.290. 1 hit.
3.40.50.150. 1 hit.
HAMAPiMF_00560. Tran_acon_Me_trans. 1 hit.
InterProiIPR029063. SAM-dependent_MTases.
IPR023506. Trans-aconitate_MeTrfase.
IPR023149. Trans_acon_MeTrfase_C.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiTAM_METNO
AccessioniPrimary (citable) accession number: B8ISV4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 3, 2009
Last modified: November 2, 2016
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.