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B8IP71

- PUR5_METNO

UniProt

B8IP71 - PUR5_METNO

Protein

Phosphoribosylformylglycinamidine cyclo-ligase

Gene

purM

Organism
Methylobacterium nodulans (strain ORS2060 / LMG 21967)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 38 (01 Oct 2014)
      Sequence version 1 (03 Mar 2009)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. phosphoribosylformylglycinamidine cyclo-ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Purine biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciMNOD460265:GCZK-5605-MONOMER.
    UniPathwayiUPA00074; UER00129.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphoribosylformylglycinamidine cyclo-ligaseUniRule annotation (EC:6.3.3.1UniRule annotation)
    Alternative name(s):
    AIR synthaseUniRule annotation
    AIRSUniRule annotation
    Phosphoribosyl-aminoimidazole synthetaseUniRule annotation
    Gene namesi
    Name:purMUniRule annotation
    Ordered Locus Names:Mnod_5547
    OrganismiMethylobacterium nodulans (strain ORS2060 / LMG 21967)
    Taxonomic identifieri460265 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesMethylobacteriaceaeMethylobacterium
    ProteomesiUP000008207: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 355355Phosphoribosylformylglycinamidine cyclo-ligasePRO_1000148286Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi460265.Mnod_5547.

    Structurei

    3D structure databases

    ProteinModelPortaliB8IP71.
    SMRiB8IP71. Positions 47-342.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the AIR synthase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0150.
    HOGENOMiHOG000229090.
    KOiK01933.
    OMAiNPQENDI.
    OrthoDBiEOG61CM1V.

    Family and domain databases

    Gene3Di3.30.1330.10. 1 hit.
    3.90.650.10. 1 hit.
    HAMAPiMF_00741_B. AIRS_B.
    InterProiIPR010918. AIR_synth_C_dom.
    IPR000728. AIR_synth_N_dom.
    IPR004733. PurM_cligase.
    IPR016188. PurM_N-like.
    [Graphical view]
    PfamiPF00586. AIRS. 1 hit.
    PF02769. AIRS_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF55326. SSF55326. 1 hit.
    SSF56042. SSF56042. 1 hit.
    TIGRFAMsiTIGR00878. purM. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B8IP71-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTGERGLTYA EAGVDIDAGN AMVEAIKPLV RSTRRPGADA EIGGFGGLFD    50
    LKAAGFKDPI LVAANDGVGT KVKIAIETGR HDTIGIDLVA MCVNDIVVQG 100
    AEPLFFLDYY ATGKLVPGVG ADIVRGIAEG CRQAGCALIG GETAEMPGLY 150
    DGSDYDLAGF SVGAAERGAL LPRPGIAPGD LVLGLPSSGV HSNGFSLVRR 200
    IVAASGLGWD APAPFAPGRS LGEALLTPTR IYVRPLLAAL KATGAGAIKA 250
    LAHITGGGFP DNLPRVLPEG VGIALDLDEI AVPPVFGWLA RTGKVAEAEM 300
    LRTFNCGIGM VVVVAADRIA SVEAALREAG EAPVRLGRIT PRGEAPVTFS 350
    GSLAL 355
    Length:355
    Mass (Da):36,228
    Last modified:March 3, 2009 - v1
    Checksum:i01DF13AEF52EF4AB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001349 Genomic DNA. Translation: ACL60389.1.
    RefSeqiYP_002500692.1. NC_011894.1.

    Genome annotation databases

    EnsemblBacteriaiACL60389; ACL60389; Mnod_5547.
    GeneIDi7306974.
    KEGGimno:Mnod_5547.
    PATRICi22552925. VBIMetNod76414_6155.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001349 Genomic DNA. Translation: ACL60389.1 .
    RefSeqi YP_002500692.1. NC_011894.1.

    3D structure databases

    ProteinModelPortali B8IP71.
    SMRi B8IP71. Positions 47-342.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 460265.Mnod_5547.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACL60389 ; ACL60389 ; Mnod_5547 .
    GeneIDi 7306974.
    KEGGi mno:Mnod_5547.
    PATRICi 22552925. VBIMetNod76414_6155.

    Phylogenomic databases

    eggNOGi COG0150.
    HOGENOMi HOG000229090.
    KOi K01933.
    OMAi NPQENDI.
    OrthoDBi EOG61CM1V.

    Enzyme and pathway databases

    UniPathwayi UPA00074 ; UER00129 .
    BioCyci MNOD460265:GCZK-5605-MONOMER.

    Family and domain databases

    Gene3Di 3.30.1330.10. 1 hit.
    3.90.650.10. 1 hit.
    HAMAPi MF_00741_B. AIRS_B.
    InterProi IPR010918. AIR_synth_C_dom.
    IPR000728. AIR_synth_N_dom.
    IPR004733. PurM_cligase.
    IPR016188. PurM_N-like.
    [Graphical view ]
    Pfami PF00586. AIRS. 1 hit.
    PF02769. AIRS_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55326. SSF55326. 1 hit.
    SSF56042. SSF56042. 1 hit.
    TIGRFAMsi TIGR00878. purM. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of chromosome of Methylobacterium nodulans ORS 2060."
      US DOE Joint Genome Institute
      Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Sims D., Brettin T., Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N., Ivanova N., Marx C.J., Richardson P.
      Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ORS2060 / LMG 21967.

    Entry informationi

    Entry nameiPUR5_METNO
    AccessioniPrimary (citable) accession number: B8IP71
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 28, 2009
    Last sequence update: March 3, 2009
    Last modified: October 1, 2014
    This is version 38 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3