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B8IP71

- PUR5_METNO

UniProt

B8IP71 - PUR5_METNO

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Protein
Phosphoribosylformylglycinamidine cyclo-ligase
Gene
purM, Mnod_5547
Organism
Methylobacterium nodulans (strain ORS2060 / LMG 21967)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. phosphoribosylformylglycinamidine cyclo-ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Purine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMNOD460265:GCZK-5605-MONOMER.
UniPathwayiUPA00074; UER00129.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoribosylformylglycinamidine cyclo-ligase (EC:6.3.3.1)
Alternative name(s):
AIR synthase
AIRS
Phosphoribosyl-aminoimidazole synthetase
Gene namesi
Name:purM
Ordered Locus Names:Mnod_5547
OrganismiMethylobacterium nodulans (strain ORS2060 / LMG 21967)
Taxonomic identifieri460265 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesMethylobacteriaceaeMethylobacterium
ProteomesiUP000008207: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 355355Phosphoribosylformylglycinamidine cyclo-ligaseUniRule annotation
PRO_1000148286Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi460265.Mnod_5547.

Structurei

3D structure databases

ProteinModelPortaliB8IP71.
SMRiB8IP71. Positions 47-342.

Family & Domainsi

Sequence similaritiesi

Belongs to the AIR synthase family.

Phylogenomic databases

eggNOGiCOG0150.
HOGENOMiHOG000229090.
KOiK01933.
OMAiNPQENDI.
OrthoDBiEOG61CM1V.

Family and domain databases

Gene3Di3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPiMF_00741_B. AIRS_B.
InterProiIPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view]
PfamiPF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view]
SUPFAMiSSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsiTIGR00878. purM. 1 hit.

Sequencei

Sequence statusi: Complete.

B8IP71-1 [UniParc]FASTAAdd to Basket

« Hide

MTGERGLTYA EAGVDIDAGN AMVEAIKPLV RSTRRPGADA EIGGFGGLFD    50
LKAAGFKDPI LVAANDGVGT KVKIAIETGR HDTIGIDLVA MCVNDIVVQG 100
AEPLFFLDYY ATGKLVPGVG ADIVRGIAEG CRQAGCALIG GETAEMPGLY 150
DGSDYDLAGF SVGAAERGAL LPRPGIAPGD LVLGLPSSGV HSNGFSLVRR 200
IVAASGLGWD APAPFAPGRS LGEALLTPTR IYVRPLLAAL KATGAGAIKA 250
LAHITGGGFP DNLPRVLPEG VGIALDLDEI AVPPVFGWLA RTGKVAEAEM 300
LRTFNCGIGM VVVVAADRIA SVEAALREAG EAPVRLGRIT PRGEAPVTFS 350
GSLAL 355
Length:355
Mass (Da):36,228
Last modified:March 3, 2009 - v1
Checksum:i01DF13AEF52EF4AB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001349 Genomic DNA. Translation: ACL60389.1.
RefSeqiYP_002500692.1. NC_011894.1.

Genome annotation databases

EnsemblBacteriaiACL60389; ACL60389; Mnod_5547.
GeneIDi7306974.
KEGGimno:Mnod_5547.
PATRICi22552925. VBIMetNod76414_6155.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001349 Genomic DNA. Translation: ACL60389.1 .
RefSeqi YP_002500692.1. NC_011894.1.

3D structure databases

ProteinModelPortali B8IP71.
SMRi B8IP71. Positions 47-342.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 460265.Mnod_5547.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACL60389 ; ACL60389 ; Mnod_5547 .
GeneIDi 7306974.
KEGGi mno:Mnod_5547.
PATRICi 22552925. VBIMetNod76414_6155.

Phylogenomic databases

eggNOGi COG0150.
HOGENOMi HOG000229090.
KOi K01933.
OMAi NPQENDI.
OrthoDBi EOG61CM1V.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00129 .
BioCyci MNOD460265:GCZK-5605-MONOMER.

Family and domain databases

Gene3Di 3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPi MF_00741_B. AIRS_B.
InterProi IPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view ]
Pfami PF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view ]
SUPFAMi SSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsi TIGR00878. purM. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of chromosome of Methylobacterium nodulans ORS 2060."
    US DOE Joint Genome Institute
    Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Sims D., Brettin T., Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N., Ivanova N., Marx C.J., Richardson P.
    Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ORS2060 / LMG 21967.

Entry informationi

Entry nameiPUR5_METNO
AccessioniPrimary (citable) accession number: B8IP71
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 3, 2009
Last modified: May 14, 2014
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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