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B8ILM4 (B8ILM4_METNO) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 22. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
4-hydroxy-3-methylbut-2-enyl diphosphate reductase 2 HAMAP MF_00191
EC=1.17.1.2 HAMAP MF_00191
Gene names
Name:ispH2 HAMAP MF_00191
Ordered Locus Names:Mnod_7260
OrganismMethylobacterium nodulans (strain ORS2060 / LMG 21967) [Complete proteome] [HAMAP]
Taxonomic identifier460265 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Methylobacteriaceae › Methylobacterium

Protein attributes

Sequence length333 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) By similarity. HAMAP MF_00191 SAAS SAAS003451

Catalytic activity

Dimethylallyl diphosphate + NAD(P)+ + H2O = (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + NAD(P)H. HAMAP MF_00191 SAAS SAAS003451

Isopentenyl diphosphate + NAD(P)+ + H2O = (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + NAD(P)H. HAMAP MF_00191 SAAS SAAS003451

Cofactor

Binds 1 3Fe-4S cluster By similarity. HAMAP MF_00191

Pathway

Isoprenoid biosynthesis; dimethylallyl diphosphate biosynthesis; dimethylallyl diphosphate from (2E)-4-hydroxy-3-methylbutenyl diphosphate: step 1/1. HAMAP MF_00191 SAAS SAAS003451

Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 6/6. HAMAP MF_00191 SAAS SAAS003451

Sequence similarities

Belongs to the IspH family. HAMAP MF_00191

Sequences

Sequence LengthMass (Da)Tools
B8ILM4 [UniParc].

Last modified March 3, 2009. Version 1.
Checksum: 8D428DD95C9689EE

FASTA33336,038
        10         20         30         40         50         60 
MSAPVNQTDT GAVAPAKPPL EIMLCAPRGF CAGVVRAIDV VERALAIYGP PVYVRHEIVH 

        70         80         90        100        110        120 
NKYVVESLKR KGAVFVAELD EVPDGDAPVI FSAHGVAKTV PQTAESRGLT TIDATCPLVT 

       130        140        150        160        170        180 
KVHREAEIHH KRGRHVLLVG HSGHPEVVGT MGQLPAGSIT LVEDLEQIQA LEPANRDNLA 

       190        200        210        220        230        240 
WVTQTTLSVD DTHHIVEALK KKFPAIVGPH KDDICYATTN RQEAVKQVAP LVDALIVVGS 

       250        260        270        280        290        300 
SNSSNSQRLR EVAERAGCPI TRLVLRAEEI DWDAFTNIRR LGLTAGASAP EVLVEEIIDA 

       310        320        330 
FATRYTVTVD TVSTTTEDMV FPLPRELRSE AAE

« Hide

References

[1]"Complete sequence of chromosome of Methylobacterium nodulans ORS 2060."
Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Sims D., Brettin T., Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N., Ivanova N., Marx C.J., Richardson P.
Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ORS2060 / LMG 21967.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001349 Genomic DNA. Translation: ACL61999.1.
RefSeqYP_002502302.1. NC_011894.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGB8ILM4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID7302832.
GenomeReviewsGene locus Mnod_7260 in contig CP001349_GR.
KEGGmno:Mnod_7260.
PATRIC22556215. VBIMetNod76414_7773.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG335228.
OMAWGAPVYV.
ProtClustDBPRK01045.

Family and domain databases

HAMAPMF_00191. IspH.
[Tree]
InterProIPR003451. LytB.
[Graphical view]
KOK03527.
PfamPF02401. LYTB. 1 hit.
[Graphical view]
TIGRFAMsTIGR00216. IspH_lytB. 1 hit.
ProtoNetSearch...

Entry information

Entry nameB8ILM4_METNO
AccessionPrimary (citable) accession number: B8ILM4
Entry history
Integrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: December 14, 2011
This is version 22 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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