B8ILM3 (KHSE_METNO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Homoserine kinase
Short name=HK
Short name=HSK
EC=2.7.1.39

Gene names

Name:	thrB
Ordered Locus Names:	Mnod_7259

Organism

Methylobacterium nodulans (strain ORS2060 / LMG 21967) [Complete proteome] [HAMAP]

Taxonomic identifier

460265 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Methylobacteriaceae › Methylobacterium › Methylobacterium nodulans

Protein attributes

Sequence length	321 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + L-homoserine = ADP + O-phospho-L-homoserine. HAMAP-Rule MF_00301
Pathway	Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 4/5. HAMAP-Rule MF_00301
Sequence similarities	Belongs to the pseudomonas-type ThrB family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Threonine biosynthesis
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	threonine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW homoserine kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 321	321	Homoserine kinase HAMAP-Rule MF_00301		PRO_1000196945

Sequences

	Sequence		Length	Mass (Da)
	B8ILM3 [UniParc]. Last modified March 3, 2009. Version 1. Checksum: 71144CCF549B28A1	FASTA	321	35,234
	10 20 30 40 50 60 MAVYTEVPDE ALGAFLSDYN IGGLLSYKGI AEGVENTNFF LHTTAGSYIL TLYEKRVAEQ 70 80 90 100 110 120 DLPFFLGLME HLAARGLACP QPIRTRAGTA LGRLCGRPAV IVSFLEGVSV RRPGTRHCRA 130 140 150 160 170 180 LGRALAGLHA AGADFPMRRP NALSVEAWRP LFAQAEAQAD RVAPNLAERT RADLARLEEA 190 200 210 220 230 240 WPSDLPGGVI HADLFTDNVF FIGDEVSGLI DFYFACTDAF AYDLAICLNA WCFEPDGSFN 250 260 270 280 290 300 RTKGQAMIAA YQSARPLEPR EVASLPLLCQ GAALRFMLTR LVDWLNVPPG ALVKPKDPLE 310 320 YDRKLAFHRR VTDAAEYGWS P

References

[1]

"Complete sequence of chromosome of Methylobacterium nodulans ORS 2060." US DOE Joint Genome Institute Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Sims D., Brettin T., Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N., Ivanova N., Marx C.J., Richardson P. Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ORS2060 / LMG 21967.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001349 Genomic DNA. Translation: ACL61998.1.
RefSeq	YP_002502301.1. NC_011894.1.
3D structure databases
ProteinModelPortal	B8ILM3.
SMR	B8ILM3. Positions 5-319.
ModBase	Search...
Protein-protein interaction databases
STRING	460265.Mnod_7259.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ACL61998; ACL61998; Mnod_7259.
GeneID	7302831.
KEGG	mno:Mnod_7259.
PATRIC	22556213. VBIMetNod76414_7772.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG2334.
HOGENOM	HOG000004810.
KO	K02204.
OMA	PDNVFFL.
ProtClustDB	CLSK2331237.
Enzyme and pathway databases
BioCyc	MNOD460265:GCZK-7343-MONOMER.
UniPathway	UPA00050; UER00064.
Family and domain databases
HAMAP	MF_00301. Homoser_kinase_2.
InterPro	IPR002575. Aminoglycoside_PTrfase. IPR005280. Homoserine_kinase_ThrB. IPR011009. Kinase-like_dom. [Graphical view]
Pfam	PF01636. APH. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
TIGRFAMs	TIGR00938. thrB_alt. 1 hit.
ProtoNet	Search...

Entry information

Entry name

KHSE_METNO

Accession

Primary (citable) accession number: B8ILM3

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 28, 2009
Last sequence update:	March 3, 2009
Last modified:	May 29, 2013
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program