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B8IKE6 (B8IKE6_METNO) Unreviewed, UniProtKB/TrEMBL

Last modified January 25, 2012. Version 24. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Pyruvate dehydrogenase E1 component PIRNR PIRNR000156
EC=1.2.4.1 PIRNR PIRNR000156
Gene names
Ordered Locus Names:Mnod_7191
OrganismMethylobacterium nodulans (strain ORS2060 / LMG 21967) [Complete proteome] [HAMAP]
Taxonomic identifier460265 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Methylobacteriaceae › Methylobacterium

Protein attributes

Sequence length889 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity. PIRNR PIRNR000156

Catalytic activity

Pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2. PIRNR PIRNR000156

Cofactor

Thiamine pyrophosphate By similarity. PIRNR PIRNR000156

Sequences

Sequence LengthMass (Da)Tools
B8IKE6 [UniParc].

Last modified March 3, 2009. Version 1.
Checksum: DD39E3641106E347

FASTA88999,411
        10         20         30         40         50         60 
MERSRDLDTR DPDPIETREW LDSLDGVLEV EGPDRAHFLI EQVIEEARKK GAPVPYSANT 

        70         80         90        100        110        120 
AYLNTIPVEA QPRHPGDRAI EHRIRSAIRW NAIALILRAN KESSELGGHI ASFQSAATLY 

       130        140        150        160        170        180 
DTGFMHFWRA ASETHGGDLI YIQGHSSPGI YARAYLEGRL TEEQLLNFRQ EVGGQGLSSY 

       190        200        210        220        230        240 
PHPWLMPDFW QFPTVSMGLG PLMAIYQARY LRYLHHRGLA DTDGRKVWAF MGDGEMDEPE 

       250        260        270        280        290        300 
SLGAISLASR EKLDNLIFVV NCNLQRLDGP VRGNGKIIQE LEANFRGAGW NVIKVLWGSG 

       310        320        330        340        350        360 
WDQLLARDTS GMLARLMAEC VDGEYQDFKS KNGAYIREHF FGRYPETKAL VADWSDEDIW 

       370        380        390        400        410        420 
RLTRGGHDPS KVYAAYDAAV KHKGQPTVIL AKTVKGYGMG EAGEGQNITH QQKKMGEAVL 

       430        440        450        460        470        480 
KQFRDRFQID LSDEQIGGIP FIRFPEGSPE HRYLMARRQA LGGPLPARRQ KSQSLAVPPL 

       490        500        510        520        530        540 
SAFEAQLKET AGREISTTMA FVRVLNTLLR DKEIGKRIVP IVPDESRTFG MEGMFRQFGI 

       550        560        570        580        590        600 
FSQVGQLYRP EDANQLMYYK EDKTGQMLQE GINEAGAMSS WIAAATAYSH SDAPTIPFYI 

       610        620        630        640        650        660 
YYSMFGFQRV GDLAWAAGDL RARGFLIGGT AGRTTLNGEG LQHEDGHSHL ISATIPNCIS 

       670        680        690        700        710        720 
YDPTFSYEVA VIVQDGLRRM YAEQEDVFYY ITLMNENYAH PGMPEGAEAG ILKGMYLFRE 

       730        740        750        760        770        780 
GQGSGPRVQL LGSGTILREV IAGAELLQQD FGIAADIWSC PSFTELRREA MAVERWNLLH 

       790        800        810        820        830        840 
PTETPKKSYV ETCLSGRSGP VIAATDYMRL FADQIRPFVP GRYRVLGTDG FGRSDYRVRL 

       850        860        870        880 
RDFFEVDRRW VAVAALKSLA EDGKVPAAKV AEAIAKYGID PAKPAPWTV

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References

[1]"Complete sequence of chromosome of Methylobacterium nodulans ORS 2060."
Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Sims D., Brettin T., Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N., Ivanova N., Marx C.J., Richardson P.
Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ORS2060 / LMG 21967.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001349 Genomic DNA. Translation: ACL61931.1.
RefSeqYP_002502234.1. NC_011894.1.

3D structure databases

ProteinModelPortalB8IKE6.
SMRB8IKE6. Positions 62-886.
ModBaseSearch...

Protein-protein interaction databases

STRINGB8IKE6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID7304733.
GenomeReviewsGene locus Mnod_7191 in contig CP001349_GR.
KEGGmno:Mnod_7191.
PATRIC22556067. VBIMetNod76414_7700.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG289271.
OMAQEVGGQG.
ProtClustDBPRK09405.

Family and domain databases

InterProIPR004660. 2-oxoA_DH_E1.
IPR009014. Transketo_C/Pyr-ferredox_oxred.
IPR015941. Transketolase-like_C.
IPR005474. Transketolase_N.
[Graphical view]
Gene3DG3DSA:3.40.50.920. Transketo_C_like. 1 hit.
KOK00163.
PANTHERPTHR11624:SF37. PTHR11624:SF37. 1 hit.
PfamPF00456. Transketolase_N. 2 hits.
[Graphical view]
PIRSFPIRSF000156. Pyruvate_dh_E1. 1 hit.
SUPFAMSSF52922. Transketo_C_like. 1 hit.
TIGRFAMsTIGR00759. AceE. 1 hit.
ProtoNetSearch...

Entry information

Entry nameB8IKE6_METNO
AccessionPrimary (citable) accession number: B8IKE6
Entry history
Integrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: January 25, 2012
This is version 24 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry info