ID   B8IJE9_METNO            Unreviewed;       544 AA.
AC   B8IJE9;
DT   03-MAR-2009, integrated into UniProtKB/TrEMBL.
DT   03-MAR-2009, sequence version 1.
DT   27-MAR-2024, entry version 60.
DE   SubName: Full=AMP-dependent synthetase and ligase {ECO:0000313|EMBL:ACL56164.1};
GN   OrderedLocusNames=Mnod_1158 {ECO:0000313|EMBL:ACL56164.1};
OS   Methylobacterium nodulans (strain LMG 21967 / CNCM I-2342 / ORS 2060).
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Hyphomicrobiales;
OC   Methylobacteriaceae; Methylobacterium.
OX   NCBI_TaxID=460265 {ECO:0000313|EMBL:ACL56164.1, ECO:0000313|Proteomes:UP000008207};
RN   [1] {ECO:0000313|EMBL:ACL56164.1, ECO:0000313|Proteomes:UP000008207}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LMG 21967 / CNCM I-2342 / ORS 2060
RC   {ECO:0000313|Proteomes:UP000008207};
RG   US DOE Joint Genome Institute;
RA   Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA   Bruce D., Goodwin L., Pitluck S., Sims D., Brettin T., Detter J.C., Han C.,
RA   Larimer F., Land M., Hauser L., Kyrpides N., Ivanova N., Marx C.J.,
RA   Richardson P.;
RT   "Complete sequence of chromosome of Methylobacterium nodulans ORS 2060.";
RL   Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the ATP-dependent AMP-binding enzyme family.
CC       {ECO:0000256|ARBA:ARBA00006432}.
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DR   EMBL; CP001349; ACL56164.1; -; Genomic_DNA.
DR   AlphaFoldDB; B8IJE9; -.
DR   STRING; 460265.Mnod_1158; -.
DR   KEGG; mno:Mnod_1158; -.
DR   eggNOG; COG0365; Bacteria.
DR   HOGENOM; CLU_000022_59_10_5; -.
DR   Proteomes; UP000008207; Chromosome.
DR   GO; GO:0016878; F:acid-thiol ligase activity; IEA:UniProt.
DR   GO; GO:0016405; F:CoA-ligase activity; IEA:UniProt.
DR   Gene3D; 3.30.300.30; -; 1.
DR   Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR   InterPro; IPR025110; AMP-bd_C.
DR   InterPro; IPR045851; AMP-bd_C_sf.
DR   InterPro; IPR020845; AMP-binding_CS.
DR   InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR   InterPro; IPR042099; ANL_N_sf.
DR   PANTHER; PTHR43605:SF10; ACYL-COA SYNTHETASE MEDIUM CHAIN FAMILY MEMBER 3; 1.
DR   PANTHER; PTHR43605; ACYL-COENZYME A SYNTHETASE; 1.
DR   Pfam; PF00501; AMP-binding; 1.
DR   Pfam; PF13193; AMP-binding_C; 1.
DR   SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR   PROSITE; PS00455; AMP_BINDING; 1.
PE   3: Inferred from homology;
KW   Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000313|EMBL:ACL56164.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008207}.
FT   DOMAIN          36..406
FT                   /note="AMP-dependent synthetase/ligase"
FT                   /evidence="ECO:0000259|Pfam:PF00501"
FT   DOMAIN          456..534
FT                   /note="AMP-binding enzyme C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF13193"
SQ   SEQUENCE   544 AA;  58243 MW;  84822565ED8A9944 CRC64;
     MALFRNLLRP ATYEDFVSGF RWRIPERYNI AVDVCDRWAA ADPQRPALLD VAADGRVETW
     SFAALREASN RFANALRAQG IARGDRVAVL LPQSPAVLIA HLAIYKLGAV ALPLAVVFGP
     DALLHRLGNA GARAVVTHAG GLAKLAPLRD ALPDLALLVS TEGPGDGALG FAELLAASAP
     DFTPVDTAAD DPALMIYTSG TTGLPKGALH GHRVLLGHLP GFAMMHEFMP QPGDRMWTPA
     DWAWAGGLLN ALLPSLHHGV AVVARKAEKF EPEEVFRLMA DLAVANAFVP PTALRMLRTV
     ERPRARFDLS RLRTLASAGE MLGPETFGWA QAELRLTVNE AYGQTECNLV LASCAGLGLA
     RAGSTGKPVP GHRVAVIRPD GTPAAAGEIG QIAVARPDPV MFLGYWRDPA ATEAKFLGDC
     MTTGDQGRVD ADGYVHFVGR DDDVITSSGY RIGPGEIEDC LLRHPAVALA AAVGKPDPVR
     TEIVKAVVVL RPGYQASDAL AAEIQDFVRR RLSAHEYPRE IAFRPSLPLT TTGKIIRRVL
     RDEG
//