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B8IJD1 (MSRA_METNO) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 39. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Peptide methionine sulfoxide reductase MsrA

Short name=Protein-methionine-S-oxide reductase
EC=1.8.4.11
Alternative name(s):
Peptide-methionine (S)-S-oxide reductase
Short name=Peptide Met(O) reductase
Gene names
Name:msrA
Ordered Locus Names:Mnod_1140
OrganismMethylobacterium nodulans (strain ORS2060 / LMG 21967) [Complete proteome] [HAMAP]
Taxonomic identifier460265 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesMethylobacteriaceaeMethylobacterium

Protein attributes

Sequence length221 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine By similarity. HAMAP-Rule MF_01401

Catalytic activity

Peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin. HAMAP-Rule MF_01401

L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin. HAMAP-Rule MF_01401

Sequence similarities

Belongs to the MsrA Met sulfoxide reductase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 221221Peptide methionine sulfoxide reductase MsrA HAMAP-Rule MF_01401
PRO_1000184565

Sites

Active site541 By similarity

Sequences

Sequence LengthMass (Da)Tools
B8IJD1 [UniParc].

Last modified March 3, 2009. Version 1.
Checksum: E3A4FECBC9D2C508

FASTA22124,123
        10         20         30         40         50         60 
MLFFRKRAEM PAPDQILPGR PTPLPTAERH FVNGRPLKGP YPEGIETALF GLGCFWGAER 

        70         80         90        100        110        120 
KFWQLGDGIW VTAVGYAAGT TPNPTYEEVC TGLTGHNEVV LVAYDPAAMP FERLLKTFWE 

       130        140        150        160        170        180 
SHDPTQGMRQ GNDVGTQYRS GLYVADAERR AQAEASRDAY GEALRAKGYG PITTEIRDPG 

       190        200        210        220 
PFYFAEAYHQ QYLAKNPAGY CGLGGTGVAC PIGTGVRNAA E 

« Hide

References

[1]"Complete sequence of chromosome of Methylobacterium nodulans ORS 2060."
US DOE Joint Genome Institute
Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Sims D., Brettin T., Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N., Ivanova N., Marx C.J., Richardson P.
Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ORS2060 / LMG 21967.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001349 Genomic DNA. Translation: ACL56146.1.
RefSeqYP_002496449.1. NC_011894.1.

3D structure databases

ProteinModelPortalB8IJD1.
SMRB8IJD1. Positions 12-211.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING460265.Mnod_1140.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACL56146; ACL56146; Mnod_1140.
GeneID7304452.
KEGGmno:Mnod_1140.
PATRIC22544496. VBIMetNod76414_1987.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0225.
HOGENOMHOG000263862.
KOK07304.
OMAWQLGDGI.
OrthoDBEOG6091JX.

Enzyme and pathway databases

BioCycMNOD460265:GCZK-1151-MONOMER.

Family and domain databases

Gene3D3.30.1060.10. 1 hit.
HAMAPMF_01401. MsrA.
InterProIPR028427. Met_Sox_Rdtase.
IPR002569. Met_Sox_Rdtase_MsrA.
[Graphical view]
PANTHERPTHR10173. PTHR10173. 1 hit.
PfamPF01625. PMSR. 1 hit.
[Graphical view]
SUPFAMSSF55068. SSF55068. 1 hit.
TIGRFAMsTIGR00401. msrA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMSRA_METNO
AccessionPrimary (citable) accession number: B8IJD1
Entry history
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 3, 2009
Last modified: May 14, 2014
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families