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B8IJD1

- MSRA_METNO

UniProt

B8IJD1 - MSRA_METNO

Protein

Peptide methionine sulfoxide reductase MsrA

Gene

msrA

Organism
Methylobacterium nodulans (strain ORS2060 / LMG 21967)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 41 (01 Oct 2014)
      Sequence version 1 (03 Mar 2009)
      Previous versions | rss
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    Functioni

    Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.UniRule annotation

    Catalytic activityi

    Peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin.UniRule annotation
    L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei54 – 541UniRule annotation

    GO - Molecular functioni

    1. peptide-methionine (S)-S-oxide reductase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. cellular protein modification process Source: UniProtKB-HAMAP
    2. protein repair Source: InterPro
    3. response to oxidative stress Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Enzyme and pathway databases

    BioCyciMNOD460265:GCZK-1151-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Peptide methionine sulfoxide reductase MsrAUniRule annotation (EC:1.8.4.11UniRule annotation)
    Short name:
    Protein-methionine-S-oxide reductaseUniRule annotation
    Alternative name(s):
    Peptide-methionine (S)-S-oxide reductaseUniRule annotation
    Short name:
    Peptide Met(O) reductaseUniRule annotation
    Gene namesi
    Name:msrAUniRule annotation
    Ordered Locus Names:Mnod_1140
    OrganismiMethylobacterium nodulans (strain ORS2060 / LMG 21967)
    Taxonomic identifieri460265 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesMethylobacteriaceaeMethylobacterium
    ProteomesiUP000008207: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 221221Peptide methionine sulfoxide reductase MsrAPRO_1000184565Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi460265.Mnod_1140.

    Structurei

    3D structure databases

    ProteinModelPortaliB8IJD1.
    SMRiB8IJD1. Positions 12-211.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the MsrA Met sulfoxide reductase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0225.
    HOGENOMiHOG000263862.
    KOiK07304.
    OMAiWQLGDGI.
    OrthoDBiEOG6091JX.

    Family and domain databases

    Gene3Di3.30.1060.10. 1 hit.
    HAMAPiMF_01401. MsrA.
    InterProiIPR028427. Met_Sox_Rdtase.
    IPR002569. Met_Sox_Rdtase_MsrA.
    [Graphical view]
    PANTHERiPTHR10173. PTHR10173. 1 hit.
    PfamiPF01625. PMSR. 1 hit.
    [Graphical view]
    SUPFAMiSSF55068. SSF55068. 1 hit.
    TIGRFAMsiTIGR00401. msrA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B8IJD1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLFFRKRAEM PAPDQILPGR PTPLPTAERH FVNGRPLKGP YPEGIETALF    50
    GLGCFWGAER KFWQLGDGIW VTAVGYAAGT TPNPTYEEVC TGLTGHNEVV 100
    LVAYDPAAMP FERLLKTFWE SHDPTQGMRQ GNDVGTQYRS GLYVADAERR 150
    AQAEASRDAY GEALRAKGYG PITTEIRDPG PFYFAEAYHQ QYLAKNPAGY 200
    CGLGGTGVAC PIGTGVRNAA E 221
    Length:221
    Mass (Da):24,123
    Last modified:March 3, 2009 - v1
    Checksum:iE3A4FECBC9D2C508
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001349 Genomic DNA. Translation: ACL56146.1.
    RefSeqiWP_015927844.1. NC_011894.1.
    YP_002496449.1. NC_011894.1.

    Genome annotation databases

    EnsemblBacteriaiACL56146; ACL56146; Mnod_1140.
    GeneIDi7304452.
    KEGGimno:Mnod_1140.
    PATRICi22544496. VBIMetNod76414_1987.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001349 Genomic DNA. Translation: ACL56146.1 .
    RefSeqi WP_015927844.1. NC_011894.1.
    YP_002496449.1. NC_011894.1.

    3D structure databases

    ProteinModelPortali B8IJD1.
    SMRi B8IJD1. Positions 12-211.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 460265.Mnod_1140.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACL56146 ; ACL56146 ; Mnod_1140 .
    GeneIDi 7304452.
    KEGGi mno:Mnod_1140.
    PATRICi 22544496. VBIMetNod76414_1987.

    Phylogenomic databases

    eggNOGi COG0225.
    HOGENOMi HOG000263862.
    KOi K07304.
    OMAi WQLGDGI.
    OrthoDBi EOG6091JX.

    Enzyme and pathway databases

    BioCyci MNOD460265:GCZK-1151-MONOMER.

    Family and domain databases

    Gene3Di 3.30.1060.10. 1 hit.
    HAMAPi MF_01401. MsrA.
    InterProi IPR028427. Met_Sox_Rdtase.
    IPR002569. Met_Sox_Rdtase_MsrA.
    [Graphical view ]
    PANTHERi PTHR10173. PTHR10173. 1 hit.
    Pfami PF01625. PMSR. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55068. SSF55068. 1 hit.
    TIGRFAMsi TIGR00401. msrA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of chromosome of Methylobacterium nodulans ORS 2060."
      US DOE Joint Genome Institute
      Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Sims D., Brettin T., Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N., Ivanova N., Marx C.J., Richardson P.
      Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ORS2060 / LMG 21967.

    Entry informationi

    Entry nameiMSRA_METNO
    AccessioniPrimary (citable) accession number: B8IJD1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 28, 2009
    Last sequence update: March 3, 2009
    Last modified: October 1, 2014
    This is version 41 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3