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Protein

Peptide methionine sulfoxide reductase MsrA

Gene

msrA

Organism
Methylobacterium nodulans (strain LMG 21967 / CNCM I-2342 / ORS 2060)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.UniRule annotation

Catalytic activityi

Peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin.UniRule annotation
L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei54UniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase

Names & Taxonomyi

Protein namesi
Recommended name:
Peptide methionine sulfoxide reductase MsrAUniRule annotation (EC:1.8.4.11UniRule annotation)
Short name:
Protein-methionine-S-oxide reductaseUniRule annotation
Alternative name(s):
Peptide-methionine (S)-S-oxide reductaseUniRule annotation
Short name:
Peptide Met(O) reductaseUniRule annotation
Gene namesi
Name:msrAUniRule annotation
Ordered Locus Names:Mnod_1140
OrganismiMethylobacterium nodulans (strain LMG 21967 / CNCM I-2342 / ORS 2060)
Taxonomic identifieri460265 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesMethylobacteriaceaeMethylobacterium
Proteomesi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001845651 – 221Peptide methionine sulfoxide reductase MsrAAdd BLAST221

Proteomic databases

PRIDEiB8IJD1

Interactioni

Protein-protein interaction databases

STRINGi460265.Mnod_1140

Structurei

3D structure databases

ProteinModelPortaliB8IJD1
SMRiB8IJD1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MsrA Met sulfoxide reductase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108HW8 Bacteria
COG0225 LUCA
HOGENOMiHOG000263862
KOiK07304
OMAiMRQGGDI
OrthoDBiPOG091H059H

Family and domain databases

Gene3Di3.30.1060.10, 1 hit
HAMAPiMF_01401 MsrA, 1 hit
InterProiView protein in InterPro
IPR002569 Met_Sox_Rdtase_MsrA
IPR036509 Met_Sox_Rdtase_MsrA_sf
PfamiView protein in Pfam
PF01625 PMSR, 1 hit
SUPFAMiSSF55068 SSF55068, 1 hit
TIGRFAMsiTIGR00401 msrA, 1 hit

Sequencei

Sequence statusi: Complete.

B8IJD1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLFFRKRAEM PAPDQILPGR PTPLPTAERH FVNGRPLKGP YPEGIETALF
60 70 80 90 100
GLGCFWGAER KFWQLGDGIW VTAVGYAAGT TPNPTYEEVC TGLTGHNEVV
110 120 130 140 150
LVAYDPAAMP FERLLKTFWE SHDPTQGMRQ GNDVGTQYRS GLYVADAERR
160 170 180 190 200
AQAEASRDAY GEALRAKGYG PITTEIRDPG PFYFAEAYHQ QYLAKNPAGY
210 220
CGLGGTGVAC PIGTGVRNAA E
Length:221
Mass (Da):24,123
Last modified:March 3, 2009 - v1
Checksum:iE3A4FECBC9D2C508
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001349 Genomic DNA Translation: ACL56146.1
RefSeqiWP_015927844.1, NC_011894.1

Genome annotation databases

EnsemblBacteriaiACL56146; ACL56146; Mnod_1140
KEGGimno:Mnod_1140

Entry informationi

Entry nameiMSRA_METNO
AccessioniPrimary (citable) accession number: B8IJD1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 3, 2009
Last modified: May 23, 2018
This is version 59 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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