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B8IEE3 (B8IEE3_METNO) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 22. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Ferrochelatase HAMAP MF_00323 RuleBase RU000607
EC=4.99.1.1 HAMAP MF_00323 RuleBase RU000607
Alternative name(s):
Heme synthase HAMAP MF_00323
Protoheme ferro-lyase HAMAP MF_00323
Gene names
Name:hemH HAMAP MF_00323
Ordered Locus Names:Mnod_4648
OrganismMethylobacterium nodulans (strain ORS2060 / LMG 21967) [Complete proteome] [HAMAP]
Taxonomic identifier460265 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Methylobacteriaceae › Methylobacterium

Protein attributes

Sequence length360 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the ferrous insertion into protoporphyrin IX By similarity. HAMAP MF_00323 RuleBase RU000607 SAAS SAAS001015

Catalytic activity

Protoheme + 2 H+ = protoporphyrin + Fe2+. HAMAP MF_00323 RuleBase RU000607 SAAS SAAS001015

Pathway

Porphyrin metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1. HAMAP MF_00323 RuleBase RU000607 SAAS SAAS001015

Subcellular location

Cytoplasm By similarity HAMAP MF_00323.

Sequence similarities

Belongs to the ferrochelatase family. HAMAP MF_00323 RuleBase RU004185

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Metal binding2291Iron By similarity HAMAP MF_00323
Metal binding3101Iron By similarity HAMAP MF_00323

Sequences

Sequence LengthMass (Da)Tools
B8IEE3 [UniParc].

Last modified March 3, 2009. Version 1.
Checksum: DC20D405EA0C474F

FASTA36040,683
        10         20         30         40         50         60 
MNEVTKAAVL ERGATPVPPA SAGVRPEGHP RVAWGRVGVL LMNLGTPEGT GYWPMRRYLK 

        70         80         90        100        110        120 
EFLSDRRVIE VPRAIWWPLL NLVILTKRPG PKGRDYASVW NTDLDEGPLK TITRGQAQKL 

       130        140        150        160        170        180 
QAAMGDRVVV DWAMRYGKPE VEGRIRALLD QGCDRILLVP LYPQYAAATS ATACDQAFRA 

       190        200        210        220        230        240 
LMKMRWQPTV RVSPPYHDDP VYIEAVVSAI RRDLAKLDFE PEVILTSFHG VPKSYLLKGD 

       250        260        270        280        290        300 
PYHCQCVKTG RLIREALGYS PERMRVTFQS RFGNEEWLKP YTDETVKELA AQGVKRLAIV 

       310        320        330        340        350        360 
APGFMADCLE TLEELDGENR HYFEAGGGEH FAYLPCLNDG PEGMRVIEHI VRRELRGWIE

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References

[1]"Complete sequence of chromosome of Methylobacterium nodulans ORS 2060."
Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Sims D., Brettin T., Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N., Ivanova N., Marx C.J., Richardson P.
Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ORS2060 / LMG 21967.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001349 Genomic DNA. Translation: ACL59515.1.
RefSeqYP_002499818.1. NC_011894.1.

3D structure databases

ProteinModelPortalB8IEE3.
ModBaseSearch...

Protein-protein interaction databases

STRINGB8IEE3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID7305807.
GenomeReviewsGene locus Mnod_4648 in contig CP001349_GR.
KEGGmno:Mnod_4648.
PATRIC22551144. VBIMetNod76414_5276.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG697135.
OMAIRPAKSA.
ProtClustDBCLSK979865.

Family and domain databases

HAMAPMF_00323. Ferrochelatase.
[Tree]
InterProIPR001015. Ferrochelatase.
IPR019772. Ferrochelatase_AS.
[Graphical view]
KOK01772.
PANTHERPTHR11108. Ferrochelatase. 1 hit.
PfamPF00762. Ferrochelatase. 1 hit.
[Graphical view]
TIGRFAMsTIGR00109. HemH. 1 hit.
PROSITEPS00534. FERROCHELATASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameB8IEE3_METNO
AccessionPrimary (citable) accession number: B8IEE3
Entry history
Integrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: December 14, 2011
This is version 22 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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