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B8IDK1 (B8IDK1_METNO) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 23. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Coproporphyrinogen-III oxidase, aerobic HAMAP MF_00333
Short name=Coprogen oxidase HAMAP MF_00333
Short name=Coproporphyrinogenase HAMAP MF_00333
EC=1.3.3.3 HAMAP MF_00333
Gene names
Name:hemF HAMAP MF_00333
Ordered Locus Names:Mnod_6599
OrganismMethylobacterium nodulans (strain ORS2060 / LMG 21967) [Complete proteome] [HAMAP]
Taxonomic identifier460265 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Methylobacteriaceae › Methylobacterium

Protein attributes

Sequence length299 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III By similarity. HAMAP MF_00333 SAAS SAAS018375

Catalytic activity

Coproporphyrinogen-III + O2 + 2 H+ = protoporphyrinogen-IX + 2 CO2 + 2 H2O. HAMAP MF_00333 SAAS SAAS018375

Pathway

Porphyrin metabolism; protoporphyrin-IX biosynthesis; protoporphyrinogen-IX from coproporphyrinogen-III (O2 route): step 1/1. HAMAP MF_00333 SAAS SAAS018375

Subunit structure

Homodimer By similarity. HAMAP MF_00333 SAAS SAAS018375

Subcellular location

Cytoplasm By similarity HAMAP MF_00333.

Sequence similarities

Belongs to the aerobic coproporphyrinogen-III oxidase family. HAMAP MF_00333

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region73 – 8210Important for dimerization By similarity HAMAP MF_00333
Region133 – 1353Substrate binding By similarity HAMAP MF_00333
Region264 – 29936Important for dimerization By similarity HAMAP MF_00333
Region282 – 2876Substrate binding By similarity HAMAP MF_00333

Sites

Active site1311Proton donor By similarity HAMAP MF_00333
Binding site1171Substrate By similarity HAMAP MF_00333
Site1991Important for dimerization By similarity HAMAP MF_00333

Sequences

Sequence LengthMass (Da)Tools
B8IDK1 [UniParc].

Last modified March 3, 2009. Version 1.
Checksum: 4547F1603B4571E6

FASTA29933,407
        10         20         30         40         50         60 
MSIDASLDID GLKQEATRWF SGLRDRICAA FEALEAEATG PFDPEATAPG RFVRTPWERT 

        70         80         90        100        110        120 
DHSGAPGGGG IMAMLRGRVF EKAGVHVSAV HGEFAPEFRI QIPGAAEDPR FFATGISLIA 

       130        140        150        160        170        180 
HPWNPNVPTV HMNTRFVVTT KAWFGGGADL TPVLDRRRRQ DDPDTVAFHA ALKAACERHP 

       190        200        210        220        230        240 
GADYARYKAW CDEYFHLKHR NEPRGVGGIF YDYHWTGDPQ ADLALTREVG EAFLSVYPEI 

       250        260        270        280        290 
VRRNLATPWT EADRHEQQVQ RGRYVEFNLL YDRGTIFGLK TGGNVDSILS SMPPTVRWP

« Hide

References

[1]"Complete sequence of chromosome of Methylobacterium nodulans ORS 2060."
Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Sims D., Brettin T., Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N., Ivanova N., Marx C.J., Richardson P.
Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ORS2060 / LMG 21967.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001349 Genomic DNA. Translation: ACL61367.1.
RefSeqYP_002501670.1. NC_011894.1.

3D structure databases

ProteinModelPortalB8IDK1.
ModBaseSearch...

Protein-protein interaction databases

STRINGB8IDK1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID7308439.
GenomeReviewsGene locus Mnod_6599 in contig CP001349_GR.
KEGGmno:Mnod_6599.
PATRIC22554939. VBIMetNod76414_7148.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG631180.
OMAVKAYLLD.
ProtClustDBPRK05330.

Family and domain databases

HAMAPMF_00333. Coprogen_oxidas.
[Tree]
InterProIPR001260. Coprogen_oxidase_aer.
IPR018375. Coprogen_oxidase_CS.
[Graphical view]
Gene3DG3DSA:3.40.1500.10. Coprogen_oxidas. 1 hit.
KOK00228.
PANTHERPTHR10755. Coprogen_oxidas. 1 hit.
PfamPF01218. Coprogen_oxidas. 1 hit.
[Graphical view]
PIRSFPIRSF000166. Coproporphyri_ox. 1 hit.
PRINTSPR00073. COPRGNOXDASE.
SUPFAMSSF102886. Coprogen_oxidas. 1 hit.
PROSITEPS01021. COPROGEN_OXIDASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameB8IDK1_METNO
AccessionPrimary (citable) accession number: B8IDK1
Entry history
Integrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: December 14, 2011
This is version 23 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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