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B8IBS4

- FTHS_METNO

UniProt

B8IBS4 - FTHS_METNO

Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Methylobacterium nodulans (strain ORS2060 / LMG 21967)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 33 (01 Oct 2014)
      Sequence version 1 (03 Mar 2009)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi65 – 728ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. folic acid-containing compound biosynthetic process Source: InterPro
    2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciMNOD460265:GCZK-4504-MONOMER.
    UniPathwayiUPA00193.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
    Alternative name(s):
    Formyltetrahydrofolate synthetaseUniRule annotation
    Short name:
    FHSUniRule annotation
    Short name:
    FTHFSUniRule annotation
    Gene namesi
    Name:fhsUniRule annotation
    Ordered Locus Names:Mnod_4459
    OrganismiMethylobacterium nodulans (strain ORS2060 / LMG 21967)
    Taxonomic identifieri460265 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesMethylobacteriaceaeMethylobacterium
    ProteomesiUP000008207: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 558558Formate--tetrahydrofolate ligasePRO_1000185258Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi460265.Mnod_4459.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2759.
    HOGENOMiHOG000040280.
    KOiK01938.
    OMAiIANSVSM.
    OrthoDBiEOG6PCPSP.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    HAMAPiMF_01543. FTHFS.
    InterProiIPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF01268. FTHFS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B8IBS4-1 [UniParc]FASTAAdd to Basket

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    MPTDIEIARA ATLQPISAIA EKIGIPDAAL HPHGRHIAKI DHAHIASLEA    50
    KPEGKLILVT AISPTPAGEG KTTTTVGLGD ALNRIGKKAV ICLREPSLGP 100
    CFGMKGGAAG GGKSQVVPME AINLHFTGDF HAITSAHSLA AALIDNHVYW 150
    GNELNIDVRR IAWRRVVDMN DRALRSITQS LGGVANGYPR EDGFDITVAS 200
    EVMAVFCLAR DLADLEARLG RIVVAETRDR KAVTLADLKA TGAMAVLLKD 250
    ALQPNLVQTL EGSPALIHGG PFANIAHGCN SVIATRTGLR LGEYAVTEAG 300
    FGADLGAEKF IDIKCRQTGL SPSAVVIVAT LRALKMHGGV EKKALGTENI 350
    AALEKGFVNL ARHVENVRRF GLPVVVAVNH FHTDTEAELA TLKALCRDKL 400
    DVEAITCRHW AEGGAGAEEL ARAVVALAEG GAPKTPNFVY PEDAKLTDKI 450
    RTIAQTLYGA ADIQVESKAA TKLAQFEKDG YGKLPVCMAK TQYSFSTDPN 500
    LMGAPSGHVV AVRDVRLSAG AGFVVVICGE IMTMPGLPKV PAAEGIHLDA 550
    NGQIEGLF 558
    Length:558
    Mass (Da):58,827
    Last modified:March 3, 2009 - v1
    Checksum:i0460F027EF610558
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001349 Genomic DNA. Translation: ACL59328.1.
    RefSeqiYP_002499631.1. NC_011894.1.

    Genome annotation databases

    EnsemblBacteriaiACL59328; ACL59328; Mnod_4459.
    GeneIDi7302202.
    KEGGimno:Mnod_4459.
    PATRICi22550738. VBIMetNod76414_5073.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001349 Genomic DNA. Translation: ACL59328.1 .
    RefSeqi YP_002499631.1. NC_011894.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 460265.Mnod_4459.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACL59328 ; ACL59328 ; Mnod_4459 .
    GeneIDi 7302202.
    KEGGi mno:Mnod_4459.
    PATRICi 22550738. VBIMetNod76414_5073.

    Phylogenomic databases

    eggNOGi COG2759.
    HOGENOMi HOG000040280.
    KOi K01938.
    OMAi IANSVSM.
    OrthoDBi EOG6PCPSP.

    Enzyme and pathway databases

    UniPathwayi UPA00193 .
    BioCyci MNOD460265:GCZK-4504-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    HAMAPi MF_01543. FTHFS.
    InterProi IPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF01268. FTHFS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of chromosome of Methylobacterium nodulans ORS 2060."
      US DOE Joint Genome Institute
      Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Sims D., Brettin T., Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N., Ivanova N., Marx C.J., Richardson P.
      Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ORS2060 / LMG 21967.

    Entry informationi

    Entry nameiFTHS_METNO
    AccessioniPrimary (citable) accession number: B8IBS4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 28, 2009
    Last sequence update: March 3, 2009
    Last modified: October 1, 2014
    This is version 33 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3