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B8IBS4

- FTHS_METNO

UniProt

B8IBS4 - FTHS_METNO

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Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Methylobacterium nodulans (strain ORS2060 / LMG 21967)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi65 – 728ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMNOD460265:GCZK-4504-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetaseUniRule annotation
Short name:
FHSUniRule annotation
Short name:
FTHFSUniRule annotation
Gene namesi
Name:fhsUniRule annotation
Ordered Locus Names:Mnod_4459
OrganismiMethylobacterium nodulans (strain ORS2060 / LMG 21967)
Taxonomic identifieri460265 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesMethylobacteriaceaeMethylobacterium
ProteomesiUP000008207: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 558558Formate--tetrahydrofolate ligasePRO_1000185258Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi460265.Mnod_4459.

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiIANSVSM.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B8IBS4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPTDIEIARA ATLQPISAIA EKIGIPDAAL HPHGRHIAKI DHAHIASLEA
60 70 80 90 100
KPEGKLILVT AISPTPAGEG KTTTTVGLGD ALNRIGKKAV ICLREPSLGP
110 120 130 140 150
CFGMKGGAAG GGKSQVVPME AINLHFTGDF HAITSAHSLA AALIDNHVYW
160 170 180 190 200
GNELNIDVRR IAWRRVVDMN DRALRSITQS LGGVANGYPR EDGFDITVAS
210 220 230 240 250
EVMAVFCLAR DLADLEARLG RIVVAETRDR KAVTLADLKA TGAMAVLLKD
260 270 280 290 300
ALQPNLVQTL EGSPALIHGG PFANIAHGCN SVIATRTGLR LGEYAVTEAG
310 320 330 340 350
FGADLGAEKF IDIKCRQTGL SPSAVVIVAT LRALKMHGGV EKKALGTENI
360 370 380 390 400
AALEKGFVNL ARHVENVRRF GLPVVVAVNH FHTDTEAELA TLKALCRDKL
410 420 430 440 450
DVEAITCRHW AEGGAGAEEL ARAVVALAEG GAPKTPNFVY PEDAKLTDKI
460 470 480 490 500
RTIAQTLYGA ADIQVESKAA TKLAQFEKDG YGKLPVCMAK TQYSFSTDPN
510 520 530 540 550
LMGAPSGHVV AVRDVRLSAG AGFVVVICGE IMTMPGLPKV PAAEGIHLDA

NGQIEGLF
Length:558
Mass (Da):58,827
Last modified:March 3, 2009 - v1
Checksum:i0460F027EF610558
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001349 Genomic DNA. Translation: ACL59328.1.
RefSeqiYP_002499631.1. NC_011894.1.

Genome annotation databases

EnsemblBacteriaiACL59328; ACL59328; Mnod_4459.
GeneIDi7302202.
KEGGimno:Mnod_4459.
PATRICi22550738. VBIMetNod76414_5073.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001349 Genomic DNA. Translation: ACL59328.1 .
RefSeqi YP_002499631.1. NC_011894.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 460265.Mnod_4459.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACL59328 ; ACL59328 ; Mnod_4459 .
GeneIDi 7302202.
KEGGi mno:Mnod_4459.
PATRICi 22550738. VBIMetNod76414_5073.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi IANSVSM.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci MNOD460265:GCZK-4504-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of chromosome of Methylobacterium nodulans ORS 2060."
    US DOE Joint Genome Institute
    Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Sims D., Brettin T., Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N., Ivanova N., Marx C.J., Richardson P.
    Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ORS2060 / LMG 21967.

Entry informationi

Entry nameiFTHS_METNO
AccessioniPrimary (citable) accession number: B8IBS4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 3, 2009
Last modified: November 26, 2014
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3