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Protein

Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase

Gene

cobT

Organism
Clostridium cellulolyticum (strain ATCC 35319 / DSM 5812 / JCM 6584 / H10)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB).UniRule annotation

Catalytic activityi

Beta-nicotinate D-ribonucleotide + 5,6-dimethylbenzimidazole = nicotinate + alpha-ribazole 5'-phosphate.UniRule annotation

Pathwayi: alpha-ribazole biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes alpha-ribazole from 5,6-dimethylbenzimidazole.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase (cobT)
  2. no protein annotated in this organism
This subpathway is part of the pathway alpha-ribazole biosynthesis, which is itself part of Nucleoside biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes alpha-ribazole from 5,6-dimethylbenzimidazole, the pathway alpha-ribazole biosynthesis and in Nucleoside biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei316 – 3161Proton acceptorUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Cobalamin biosynthesis

Enzyme and pathway databases

BioCyciCCEL394503:GJET-667-MONOMER.
UniPathwayiUPA00061; UER00516.

Names & Taxonomyi

Protein namesi
Recommended name:
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferaseUniRule annotation (EC:2.4.2.21UniRule annotation)
Short name:
NN:DBI PRTUniRule annotation
Alternative name(s):
N(1)-alpha-phosphoribosyltransferaseUniRule annotation
Gene namesi
Name:cobTUniRule annotation
Ordered Locus Names:Ccel_0646
OrganismiClostridium cellulolyticum (strain ATCC 35319 / DSM 5812 / JCM 6584 / H10)
Taxonomic identifieri394503 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesRuminococcaceaeRuminiclostridium
Proteomesi
  • UP000001349 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 352352Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferasePRO_1000125103Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi394503.Ccel_0646.

Structurei

3D structure databases

ProteinModelPortaliB8I7A3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CobT family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CUP. Bacteria.
COG2038. LUCA.
HOGENOMiHOG000263499.
KOiK00768.
OMAiMNNMATF.
OrthoDBiPOG091H0031.

Family and domain databases

CDDicd02439. DMB-PRT_CobT. 1 hit.
Gene3Di1.10.1610.10. 1 hit.
HAMAPiMF_00230. CobT. 1 hit.
InterProiIPR003200. Nict_dMeBzImd_PRibTrfase-like.
IPR023195. Nict_dMeBzImd_PRibTrfase_N.
IPR017846. Nict_dMeBzImd_PRibTrfase_pro.
[Graphical view]
PfamiPF02277. DBI_PRT. 1 hit.
[Graphical view]
SUPFAMiSSF52733. SSF52733. 1 hit.
TIGRFAMsiTIGR03160. cobT_DBIPRT. 1 hit.

Sequencei

Sequence statusi: Complete.

B8I7A3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTFEEAINSI KELNIETMQK AQKRLDNLTK PLGSLGRLEE IVKQLAGITG
60 70 80 90 100
ELFPCVKNKK IVIMCADNGV VEEGVSSCPK SVTSSVTQNF LKGFTGVNVL
110 120 130 140 150
SRHSRADIVV VDVGVDDDID CPGVINRKIR KGTWNIMKGP AMTRNEAIKA
160 170 180 190 200
IETGIEIVGK LKEKGVNLLG TGEMGVGNTT TSSAVASVLI GNDIGEMVGK
210 220 230 240 250
GAGLTQKGLI NKIEIIKNAI DINKPNPSDP IDVLAKVGGF DIAALTGCFL
260 270 280 290 300
GAAAYRLPVM IDGFISATAA LAAIKIKPEC RNYILPSHGS AEPGNKKIME
310 320 330 340 350
ALDMSPMLLL EMRLGEGSGA ALAFHIIDAA VAAYNEMGTF GDAKIEQYKP

LE
Length:352
Mass (Da):37,325
Last modified:March 3, 2009 - v1
Checksum:iAF8D6FEA59D01099
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001348 Genomic DNA. Translation: ACL75027.1.
RefSeqiWP_015924196.1. NC_011898.1.

Genome annotation databases

EnsemblBacteriaiACL75027; ACL75027; Ccel_0646.
KEGGicce:Ccel_0646.
PATRICi19432083. VBICloCel57783_0668.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001348 Genomic DNA. Translation: ACL75027.1.
RefSeqiWP_015924196.1. NC_011898.1.

3D structure databases

ProteinModelPortaliB8I7A3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi394503.Ccel_0646.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACL75027; ACL75027; Ccel_0646.
KEGGicce:Ccel_0646.
PATRICi19432083. VBICloCel57783_0668.

Phylogenomic databases

eggNOGiENOG4105CUP. Bacteria.
COG2038. LUCA.
HOGENOMiHOG000263499.
KOiK00768.
OMAiMNNMATF.
OrthoDBiPOG091H0031.

Enzyme and pathway databases

UniPathwayiUPA00061; UER00516.
BioCyciCCEL394503:GJET-667-MONOMER.

Family and domain databases

CDDicd02439. DMB-PRT_CobT. 1 hit.
Gene3Di1.10.1610.10. 1 hit.
HAMAPiMF_00230. CobT. 1 hit.
InterProiIPR003200. Nict_dMeBzImd_PRibTrfase-like.
IPR023195. Nict_dMeBzImd_PRibTrfase_N.
IPR017846. Nict_dMeBzImd_PRibTrfase_pro.
[Graphical view]
PfamiPF02277. DBI_PRT. 1 hit.
[Graphical view]
SUPFAMiSSF52733. SSF52733. 1 hit.
TIGRFAMsiTIGR03160. cobT_DBIPRT. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCOBT_CLOCE
AccessioniPrimary (citable) accession number: B8I7A3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 3, 2009
Last modified: September 7, 2016
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.