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B8I3S9

- FTHS_CLOCE

UniProt

B8I3S9 - FTHS_CLOCE

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Protein
Formate--tetrahydrofolate ligase
Gene
fhs, Ccel_0018
Organism
Clostridium cellulolyticum (strain ATCC 35319 / DSM 5812 / JCM 6584 / H10)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi65 – 728ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCCEL394503:GJET-20-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligase (EC:6.3.4.3)
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name:
FHS
Short name:
FTHFS
Gene namesi
Name:fhs
Ordered Locus Names:Ccel_0018
OrganismiClostridium cellulolyticum (strain ATCC 35319 / DSM 5812 / JCM 6584 / H10)
Taxonomic identifieri394503 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
ProteomesiUP000001349: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 556556Formate--tetrahydrofolate ligaseUniRule annotation
PRO_1000185252Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi394503.Ccel_0018.

Structurei

3D structure databases

ProteinModelPortaliB8I3S9.
SMRiB8I3S9. Positions 4-554.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiLKHHGGV.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B8I3S9-1 [UniParc]FASTAAdd to Basket

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MQTDIQIAQR CKMHHIADIA KNLGIDTEDI EFYGNYKAKL SDKLWDKVKN    50
KKDGKLVLVT AINPTPAGEG KTTTTVGLGQ AMARIGKNAV IALREPSMGP 100
VMGIKGGAAG GGYAQVVPME DINLHFTGDM HAITAANNLL SAAIDNHLQQ 150
GNMLNIDSRQ IVWKRCMDMN DRALRNVIVG LGGKINGVPR EDGFNITVAS 200
EIMAILCLAL DIKDLKKRLG RIIIGYTYEG KPVTAHDLKV DGAMTLLLKD 250
AIKPNLVQTL EGTPALMHGG PFANIAHGCN SISATKLALK LSDYVITEAG 300
FGADLGAEKF FDIKCRFAGF KPDAVVLVAT IRALKYNGGV RKEDLKEENI 350
DALSKGFANA EKHIENLKQF GVPVMVAINH FDTDTEAEIK LIQEKCSSLG 400
VEVAFSDVFL KGGEGGIELA EKLVALTDST VSNFAPIYDE KLPIKEKVQQ 450
IVSKIYGGRN VIYNAAAEKS IAKIEEMGLD RLPICMAKTQ YSLSDNPALL 500
GRPQDFDVTV KEVRISAGAG FLVVLTGDIM TMPGLPKVPA AERIDINESG 550
VITGLF 556
Length:556
Mass (Da):59,961
Last modified:March 3, 2009 - v1
Checksum:i2A6328B365FD75A4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001348 Genomic DNA. Translation: ACL74406.1.
RefSeqiWP_012634473.1. NC_011898.1.
YP_002504386.1. NC_011898.1.

Genome annotation databases

EnsemblBacteriaiACL74406; ACL74406; Ccel_0018.
GeneIDi7308941.
KEGGicce:Ccel_0018.
PATRICi19430753. VBICloCel57783_0020.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001348 Genomic DNA. Translation: ACL74406.1 .
RefSeqi WP_012634473.1. NC_011898.1.
YP_002504386.1. NC_011898.1.

3D structure databases

ProteinModelPortali B8I3S9.
SMRi B8I3S9. Positions 4-554.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 394503.Ccel_0018.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACL74406 ; ACL74406 ; Ccel_0018 .
GeneIDi 7308941.
KEGGi cce:Ccel_0018.
PATRICi 19430753. VBICloCel57783_0020.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi LKHHGGV.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci CCEL394503:GJET-20-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35319 / DSM 5812 / JCM 6584 / H10.

Entry informationi

Entry nameiFTHS_CLOCE
AccessioniPrimary (citable) accession number: B8I3S9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 3, 2009
Last modified: September 3, 2014
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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