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B8I3S9

- FTHS_CLOCE

UniProt

B8I3S9 - FTHS_CLOCE

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Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Clostridium cellulolyticum (strain ATCC 35319 / DSM 5812 / JCM 6584 / H10)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi65 – 728ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCCEL394503:GJET-20-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetaseUniRule annotation
Short name:
FHSUniRule annotation
Short name:
FTHFSUniRule annotation
Gene namesi
Name:fhsUniRule annotation
Ordered Locus Names:Ccel_0018
OrganismiClostridium cellulolyticum (strain ATCC 35319 / DSM 5812 / JCM 6584 / H10)
Taxonomic identifieri394503 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
ProteomesiUP000001349: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 556556Formate--tetrahydrofolate ligasePRO_1000185252Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi394503.Ccel_0018.

Structurei

3D structure databases

ProteinModelPortaliB8I3S9.
SMRiB8I3S9. Positions 4-554.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiLKHHGGV.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B8I3S9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQTDIQIAQR CKMHHIADIA KNLGIDTEDI EFYGNYKAKL SDKLWDKVKN
60 70 80 90 100
KKDGKLVLVT AINPTPAGEG KTTTTVGLGQ AMARIGKNAV IALREPSMGP
110 120 130 140 150
VMGIKGGAAG GGYAQVVPME DINLHFTGDM HAITAANNLL SAAIDNHLQQ
160 170 180 190 200
GNMLNIDSRQ IVWKRCMDMN DRALRNVIVG LGGKINGVPR EDGFNITVAS
210 220 230 240 250
EIMAILCLAL DIKDLKKRLG RIIIGYTYEG KPVTAHDLKV DGAMTLLLKD
260 270 280 290 300
AIKPNLVQTL EGTPALMHGG PFANIAHGCN SISATKLALK LSDYVITEAG
310 320 330 340 350
FGADLGAEKF FDIKCRFAGF KPDAVVLVAT IRALKYNGGV RKEDLKEENI
360 370 380 390 400
DALSKGFANA EKHIENLKQF GVPVMVAINH FDTDTEAEIK LIQEKCSSLG
410 420 430 440 450
VEVAFSDVFL KGGEGGIELA EKLVALTDST VSNFAPIYDE KLPIKEKVQQ
460 470 480 490 500
IVSKIYGGRN VIYNAAAEKS IAKIEEMGLD RLPICMAKTQ YSLSDNPALL
510 520 530 540 550
GRPQDFDVTV KEVRISAGAG FLVVLTGDIM TMPGLPKVPA AERIDINESG

VITGLF
Length:556
Mass (Da):59,961
Last modified:March 3, 2009 - v1
Checksum:i2A6328B365FD75A4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001348 Genomic DNA. Translation: ACL74406.1.
RefSeqiWP_012634473.1. NC_011898.1.
YP_002504386.1. NC_011898.1.

Genome annotation databases

EnsemblBacteriaiACL74406; ACL74406; Ccel_0018.
GeneIDi7308941.
KEGGicce:Ccel_0018.
PATRICi19430753. VBICloCel57783_0020.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001348 Genomic DNA. Translation: ACL74406.1 .
RefSeqi WP_012634473.1. NC_011898.1.
YP_002504386.1. NC_011898.1.

3D structure databases

ProteinModelPortali B8I3S9.
SMRi B8I3S9. Positions 4-554.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 394503.Ccel_0018.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACL74406 ; ACL74406 ; Ccel_0018 .
GeneIDi 7308941.
KEGGi cce:Ccel_0018.
PATRICi 19430753. VBICloCel57783_0020.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi LKHHGGV.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci CCEL394503:GJET-20-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35319 / DSM 5812 / JCM 6584 / H10.

Entry informationi

Entry nameiFTHS_CLOCE
AccessioniPrimary (citable) accession number: B8I3S9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 3, 2009
Last modified: November 26, 2014
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3