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B8I3S9

- FTHS_CLOCE

UniProt

B8I3S9 - FTHS_CLOCE

Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Clostridium cellulolyticum (strain ATCC 35319 / DSM 5812 / JCM 6584 / H10)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 32 (01 Oct 2014)
      Sequence version 1 (03 Mar 2009)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi65 – 728ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. folic acid-containing compound biosynthetic process Source: InterPro
    2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciCCEL394503:GJET-20-MONOMER.
    UniPathwayiUPA00193.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
    Alternative name(s):
    Formyltetrahydrofolate synthetaseUniRule annotation
    Short name:
    FHSUniRule annotation
    Short name:
    FTHFSUniRule annotation
    Gene namesi
    Name:fhsUniRule annotation
    Ordered Locus Names:Ccel_0018
    OrganismiClostridium cellulolyticum (strain ATCC 35319 / DSM 5812 / JCM 6584 / H10)
    Taxonomic identifieri394503 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
    ProteomesiUP000001349: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 556556Formate--tetrahydrofolate ligasePRO_1000185252Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi394503.Ccel_0018.

    Structurei

    3D structure databases

    ProteinModelPortaliB8I3S9.
    SMRiB8I3S9. Positions 4-554.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2759.
    HOGENOMiHOG000040280.
    KOiK01938.
    OMAiLKHHGGV.
    OrthoDBiEOG6PCPSP.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    HAMAPiMF_01543. FTHFS.
    InterProiIPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF01268. FTHFS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B8I3S9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQTDIQIAQR CKMHHIADIA KNLGIDTEDI EFYGNYKAKL SDKLWDKVKN    50
    KKDGKLVLVT AINPTPAGEG KTTTTVGLGQ AMARIGKNAV IALREPSMGP 100
    VMGIKGGAAG GGYAQVVPME DINLHFTGDM HAITAANNLL SAAIDNHLQQ 150
    GNMLNIDSRQ IVWKRCMDMN DRALRNVIVG LGGKINGVPR EDGFNITVAS 200
    EIMAILCLAL DIKDLKKRLG RIIIGYTYEG KPVTAHDLKV DGAMTLLLKD 250
    AIKPNLVQTL EGTPALMHGG PFANIAHGCN SISATKLALK LSDYVITEAG 300
    FGADLGAEKF FDIKCRFAGF KPDAVVLVAT IRALKYNGGV RKEDLKEENI 350
    DALSKGFANA EKHIENLKQF GVPVMVAINH FDTDTEAEIK LIQEKCSSLG 400
    VEVAFSDVFL KGGEGGIELA EKLVALTDST VSNFAPIYDE KLPIKEKVQQ 450
    IVSKIYGGRN VIYNAAAEKS IAKIEEMGLD RLPICMAKTQ YSLSDNPALL 500
    GRPQDFDVTV KEVRISAGAG FLVVLTGDIM TMPGLPKVPA AERIDINESG 550
    VITGLF 556
    Length:556
    Mass (Da):59,961
    Last modified:March 3, 2009 - v1
    Checksum:i2A6328B365FD75A4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001348 Genomic DNA. Translation: ACL74406.1.
    RefSeqiWP_012634473.1. NC_011898.1.
    YP_002504386.1. NC_011898.1.

    Genome annotation databases

    EnsemblBacteriaiACL74406; ACL74406; Ccel_0018.
    GeneIDi7308941.
    KEGGicce:Ccel_0018.
    PATRICi19430753. VBICloCel57783_0020.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001348 Genomic DNA. Translation: ACL74406.1 .
    RefSeqi WP_012634473.1. NC_011898.1.
    YP_002504386.1. NC_011898.1.

    3D structure databases

    ProteinModelPortali B8I3S9.
    SMRi B8I3S9. Positions 4-554.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 394503.Ccel_0018.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACL74406 ; ACL74406 ; Ccel_0018 .
    GeneIDi 7308941.
    KEGGi cce:Ccel_0018.
    PATRICi 19430753. VBICloCel57783_0020.

    Phylogenomic databases

    eggNOGi COG2759.
    HOGENOMi HOG000040280.
    KOi K01938.
    OMAi LKHHGGV.
    OrthoDBi EOG6PCPSP.

    Enzyme and pathway databases

    UniPathwayi UPA00193 .
    BioCyci CCEL394503:GJET-20-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    HAMAPi MF_01543. FTHFS.
    InterProi IPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF01268. FTHFS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 35319 / DSM 5812 / JCM 6584 / H10.

    Entry informationi

    Entry nameiFTHS_CLOCE
    AccessioniPrimary (citable) accession number: B8I3S9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 28, 2009
    Last sequence update: March 3, 2009
    Last modified: October 1, 2014
    This is version 32 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3