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B8I3A3

- NADK_CLOCE

UniProt

B8I3A3 - NADK_CLOCE

Protein

NAD kinase

Gene

nadK

Organism
Clostridium cellulolyticum (strain ATCC 35319 / DSM 5812 / JCM 6584 / H10)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 38 (01 Oct 2014)
      Sequence version 1 (03 Mar 2009)
      Previous versions | rss
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    Functioni

    Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

    Catalytic activityi

    ATP + NAD+ = ADP + NADP+.UniRule annotation

    Cofactori

    Divalent metal ions.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei67 – 671Proton acceptorUniRule annotation
    Binding sitei72 – 721NADUniRule annotation
    Binding sitei152 – 1521NADUniRule annotation
    Binding sitei171 – 1711NADUniRule annotation
    Binding sitei242 – 2421NADUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi67 – 682NADUniRule annotation
    Nucleotide bindingi141 – 1422NADUniRule annotation
    Nucleotide bindingi182 – 1876NADUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-HAMAP
    3. NAD+ kinase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. NAD metabolic process Source: InterPro
    2. NADP biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Ligandi

    ATP-binding, NAD, NADP, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciCCEL394503:GJET-1943-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
    Alternative name(s):
    ATP-dependent NAD kinaseUniRule annotation
    Gene namesi
    Name:nadKUniRule annotation
    Ordered Locus Names:Ccel_1898
    OrganismiClostridium cellulolyticum (strain ATCC 35319 / DSM 5812 / JCM 6584 / H10)
    Taxonomic identifieri394503 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
    ProteomesiUP000001349: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 286286NAD kinasePRO_1000133565Add
    BLAST

    Proteomic databases

    PRIDEiB8I3A3.

    Interactioni

    Protein-protein interaction databases

    STRINGi394503.Ccel_1898.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the NAD kinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0061.
    HOGENOMiHOG000227222.
    KOiK00858.
    OMAiRWEALCL.
    OrthoDBiEOG6PZXDR.

    Family and domain databases

    Gene3Di2.60.200.30. 1 hit.
    3.40.50.10330. 1 hit.
    HAMAPiMF_00361. NAD_kinase.
    InterProiIPR017438. ATP-NAD_kinase_dom_1.
    IPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
    IPR002504. PolyP/ATP_NADK.
    [Graphical view]
    PANTHERiPTHR20275. PTHR20275. 1 hit.
    PfamiPF01513. NAD_kinase. 1 hit.
    [Graphical view]
    SUPFAMiSSF111331. SSF111331. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B8I3A3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKKIGVITNR EKDKGLKYTN QLVESIEKHG GQAVLPTYDG SFQMDDIDNQ    50
    VVEICNNCDM VICLGGDGTF LRTARTAYLY GLPMLGINLG SLGFLTDVEK 100
    GEIDKAVENI LNNRFCLEDR IMLTSKLYKD GKLIARDVAI NDIVISRGGI 150
    PRILHLSTYI DNNLVEMFPG DGIVVATPTG STAYSLSAGG PIVEPTSGLI 200
    LITPICPHIL SSRALITSDM RKIKICVSQG FEHKATVTVD GQKNLEITGG 250
    DYLEIEKANS TVKIIRVNSK NFFTVLRSKI YERKEE 286
    Length:286
    Mass (Da):31,463
    Last modified:March 3, 2009 - v1
    Checksum:i350DFB1B7702DAA7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001348 Genomic DNA. Translation: ACL76246.1.
    RefSeqiWP_015925351.1. NC_011898.1.
    YP_002506226.1. NC_011898.1.

    Genome annotation databases

    EnsemblBacteriaiACL76246; ACL76246; Ccel_1898.
    GeneIDi7310621.
    KEGGicce:Ccel_1898.
    PATRICi19434701. VBICloCel57783_1953.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001348 Genomic DNA. Translation: ACL76246.1 .
    RefSeqi WP_015925351.1. NC_011898.1.
    YP_002506226.1. NC_011898.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 394503.Ccel_1898.

    Proteomic databases

    PRIDEi B8I3A3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACL76246 ; ACL76246 ; Ccel_1898 .
    GeneIDi 7310621.
    KEGGi cce:Ccel_1898.
    PATRICi 19434701. VBICloCel57783_1953.

    Phylogenomic databases

    eggNOGi COG0061.
    HOGENOMi HOG000227222.
    KOi K00858.
    OMAi RWEALCL.
    OrthoDBi EOG6PZXDR.

    Enzyme and pathway databases

    BioCyci CCEL394503:GJET-1943-MONOMER.

    Family and domain databases

    Gene3Di 2.60.200.30. 1 hit.
    3.40.50.10330. 1 hit.
    HAMAPi MF_00361. NAD_kinase.
    InterProi IPR017438. ATP-NAD_kinase_dom_1.
    IPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
    IPR002504. PolyP/ATP_NADK.
    [Graphical view ]
    PANTHERi PTHR20275. PTHR20275. 1 hit.
    Pfami PF01513. NAD_kinase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF111331. SSF111331. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 35319 / DSM 5812 / JCM 6584 / H10.

    Entry informationi

    Entry nameiNADK_CLOCE
    AccessioniPrimary (citable) accession number: B8I3A3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 28, 2009
    Last sequence update: March 3, 2009
    Last modified: October 1, 2014
    This is version 38 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3