B8I3A3 (PPNK_CLOCE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable inorganic polyphosphate/ATP-NAD kinase
Short name=Poly(P)/ATP NAD kinase
EC=2.7.1.23

Gene names

Name:	ppnK
Ordered Locus Names:	Ccel_1898

Organism

Clostridium cellulolyticum (strain ATCC 35319 / DSM 5812 / JCM 6584 / H10) [Complete proteome] [HAMAP]

Taxonomic identifier

394503 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Clostridia › Clostridiales › Clostridiaceae › Clostridium

Protein attributes

Sequence length	286 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus By similarity. HAMAP MF_00361
Catalytic activity	ATP + NAD+ = ADP + NADP+. HAMAP MF_00361
Cofactor	Divalent metal ions By similarity. HAMAP MF_00361
Subcellular location	Cytoplasm By similarity HAMAP MF_00361.
Sequence similarities	Belongs to the NAD kinase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding NAD NADP Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW NAD+ kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 286	286	Probable inorganic polyphosphate/ATP-NAD kinase HAMAP MF_00361		PRO_1000133565

Sequences

	Sequence		Length	Mass (Da)
	B8I3A3 [UniParc]. Last modified March 3, 2009. Version 1. Checksum: 350DFB1B7702DAA7	FASTA	286	31,463
	10 20 30 40 50 60 MKKIGVITNR EKDKGLKYTN QLVESIEKHG GQAVLPTYDG SFQMDDIDNQ VVEICNNCDM 70 80 90 100 110 120 VICLGGDGTF LRTARTAYLY GLPMLGINLG SLGFLTDVEK GEIDKAVENI LNNRFCLEDR 130 140 150 160 170 180 IMLTSKLYKD GKLIARDVAI NDIVISRGGI PRILHLSTYI DNNLVEMFPG DGIVVATPTG 190 200 210 220 230 240 STAYSLSAGG PIVEPTSGLI LITPICPHIL SSRALITSDM RKIKICVSQG FEHKATVTVD 250 260 270 280 GQKNLEITGG DYLEIEKANS TVKIIRVNSK NFFTVLRSKI YERKEE

References

[1]

"Complete sequence of Clostridium cellulolyticum H10." US DOE Joint Genome Institute Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Chertkov O., Saunders E., Brettin T., Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N. , Ivanova N., Zhou J., Richardson P. Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 35319 / DSM 5812 / JCM 6584 / H10.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001348 Genomic DNA. Translation: ACL76246.1.
RefSeq	YP_002506226.1. NC_011898.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	B8I3A3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	7310621.
GenomeReviews	Gene locus Ccel_1898 in contig CP001348_GR.
KEGG	cce:Ccel_1898.
PATRIC	19434701. VBICloCel57783_1953.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG713904.
OMA	LLHLKNY.
ProtClustDB	CLSK2471709.
Family and domain databases
HAMAP	MF_00361. NAD_kinase. [Tree]
InterPro	IPR016064. ATP-NAD_kinase_PpnK-typ. IPR017438. ATP-NAD_kinase_PpnK-typ_a/b. IPR017437. ATP-NAD_kinase_PpnK-typ_all-b. IPR002504. polyP/ATP_NADK_prd. [Graphical view]
Gene3D	G3DSA:2.60.200.30. ATP-NAD_kinase_PpnK-typ. 1 hit. G3DSA:3.40.50.10330. ATP-NAD_kinase_PpnK-typ_a/b. 1 hit.
KO	K00858.
PANTHER	PTHR20275. ATP_NADK. 1 hit.
Pfam	PF01513. NAD_kinase. 1 hit. [Graphical view]
SUPFAM	SSF111331. ATP-NAD_kinase_PpnK-typ. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PPNK_CLOCE

Accession

Primary (citable) accession number: B8I3A3

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 28, 2009
Last sequence update:	March 3, 2009
Last modified:	January 25, 2012
This is version 21 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program