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Protein

Pantothenate synthetase

Gene

panC

Organism
Clostridium cellulolyticum (strain ATCC 35319 / DSM 5812 / JCM 6584 / H10)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.UniRule annotation

Miscellaneous

The reaction proceeds by a bi uni uni bi ping pong mechanism.UniRule annotation

Catalytic activityi

ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate.UniRule annotation

Pathwayi: (R)-pantothenate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes (R)-pantothenate from (R)-pantoate and beta-alanine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Pantothenate synthetase (panC)
This subpathway is part of the pathway (R)-pantothenate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (R)-pantothenate from (R)-pantoate and beta-alanine, the pathway (R)-pantothenate biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei37Proton donorUniRule annotation1
Binding sitei60Beta-alanineUniRule annotation1
Binding sitei60PantoateUniRule annotation1
Binding sitei152PantoateUniRule annotation1
Binding sitei175ATP; via amide nitrogen and carbonyl oxygenUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi30 – 37ATPUniRule annotation8
Nucleotide bindingi146 – 149ATPUniRule annotation4
Nucleotide bindingi183 – 186ATPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processPantothenate biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCCEL394503:G1GUL-1819-MONOMER
UniPathwayiUPA00028; UER00005

Names & Taxonomyi

Protein namesi
Recommended name:
Pantothenate synthetaseUniRule annotation (EC:6.3.2.1UniRule annotation)
Short name:
PSUniRule annotation
Alternative name(s):
Pantoate--beta-alanine ligaseUniRule annotation
Pantoate-activating enzymeUniRule annotation
Gene namesi
Name:panCUniRule annotation
Ordered Locus Names:Ccel_1786
OrganismiClostridium cellulolyticum (strain ATCC 35319 / DSM 5812 / JCM 6584 / H10)
Taxonomic identifieri394503 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesRuminococcaceaeRuminiclostridium
Proteomesi
  • UP000001349 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001234081 – 281Pantothenate synthetaseAdd BLAST281

Proteomic databases

PRIDEiB8I2Z3

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi394503.Ccel_1786

Structurei

3D structure databases

ProteinModelPortaliB8I2Z3
SMRiB8I2Z3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the pantothenate synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108IAA Bacteria
COG0414 LUCA
HOGENOMiHOG000175517
KOiK01918
OMAiLFNMVQP
OrthoDBiPOG091H00FM

Family and domain databases

CDDicd00560 PanC, 1 hit
Gene3Di3.40.50.620, 1 hit
HAMAPiMF_00158 PanC, 1 hit
InterProiView protein in InterPro
IPR003721 Pantoate_ligase
IPR014729 Rossmann-like_a/b/a_fold
PANTHERiPTHR21299:SF1 PTHR21299:SF1, 1 hit
PfamiView protein in Pfam
PF02569 Pantoate_ligase, 1 hit
TIGRFAMsiTIGR00018 panC, 1 hit

Sequencei

Sequence statusi: Complete.

B8I2Z3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKSVNTIHEV KNIVKDWKKQ GLSVGLVPTM GYLHEGHGSL ILKARENSKV
60 70 80 90 100
VVSIFVNPMQ FGPTEDLEKY PRDLEKDLKY CEELGADLIF SPEPGEMYPE
110 120 130 140 150
GFCTSVDMSV LTEELCGLSR PSHFKGVCTI VNKLLNIVNP DRAYFGEKDA
160 170 180 190 200
QQLVIVKRMV RDLNMDIEIV GCPIIREKDG LAKSSRNTYL NSEERRAALV
210 220 230 240 250
LSKSIFTGKD MVKKGCRETD VLLKKMKAII DQEPLARIDY LKAVDTMTMQ
260 270 280
QVDTIDRPVL IAMAVYIGNV RLIDNFSFIP D
Length:281
Mass (Da):31,690
Last modified:March 3, 2009 - v1
Checksum:i0D2535F3A05E603D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001348 Genomic DNA Translation: ACL76136.1
RefSeqiWP_015925251.1, NC_011898.1

Genome annotation databases

EnsemblBacteriaiACL76136; ACL76136; Ccel_1786
KEGGicce:Ccel_1786

Similar proteinsi

Entry informationi

Entry nameiPANC_CLOCE
AccessioniPrimary (citable) accession number: B8I2Z3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 3, 2009
Last modified: May 23, 2018
This is version 56 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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