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B8I0V0 (TRPC_CLOCE) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 34. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Indole-3-glycerol phosphate synthase

Short name=IGPS
EC=4.1.1.48
Gene names
Name:trpC
Ordered Locus Names:Ccel_3216
OrganismClostridium cellulolyticum (strain ATCC 35319 / DSM 5812 / JCM 6584 / H10) [Complete proteome] [HAMAP]
Taxonomic identifier394503 [NCBI]
Taxonomic lineageBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium

Protein attributes

Sequence length260 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-C-(3-indolyl)-glycerol 3-phosphate + CO2 + H2O. HAMAP-Rule MF_00134

Pathway

Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5. HAMAP-Rule MF_00134

Sequence similarities

Belongs to the TrpC family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Aromatic amino acid biosynthesis
Tryptophan biosynthesis
   Molecular functionDecarboxylase
Lyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processtryptophan biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionindole-3-glycerol-phosphate synthase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 260260Indole-3-glycerol phosphate synthase HAMAP-Rule MF_00134
PRO_1000198771

Sequences

Sequence LengthMass (Da)Tools
B8I0V0 [UniParc].

Last modified March 3, 2009. Version 1.
Checksum: 89176A0C3025A9F0

FASTA26028,230
        10         20         30         40         50         60 
MILDKIAAST KIRVENLKKE VSFSFVKSEA SKLVNKSPFA FEKAVKDGEL TFICEIKKAS 

        70         80         90        100        110        120 
PSKGLISENF PYIDIAKDYE AAGAGAISVL TEPEFFLGSD QYLKDVKKTV SIPVLRKDFT 

       130        140        150        160        170        180 
IDPYQIYEAA LIGADCVLLI CALLDTDTLK EYIKIADGLG LSCLVEAHDE NEVKSAIEAG 

       190        200        210        220        230        240 
SRIVGVNNRN LKTFEVDITN SIRLRELVPS DISFVSESGI RTAQDISALR RIGASAVLIG 

       250        260 
ETLMRSGDTG AELAKLRGSA 

« Hide

References

[1]"Complete sequence of Clostridium cellulolyticum H10."
US DOE Joint Genome Institute
Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Chertkov O., Saunders E., Brettin T., Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N. expand/collapse author list , Ivanova N., Zhou J., Richardson P.
Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 35319 / DSM 5812 / JCM 6584 / H10.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001348 Genomic DNA. Translation: ACL77506.1.
RefSeqYP_002507486.1. NC_011898.1.

3D structure databases

ProteinModelPortalB8I0V0.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING394503.Ccel_3216.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACL77506; ACL77506; Ccel_3216.
GeneID7311798.
KEGGcce:Ccel_3216.
PATRIC19437437. VBICloCel57783_3296.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0134.
HOGENOMHOG000230462.
KOK01609.
OMAGISYITD.
OrthoDBEOG6WT8JX.
ProtClustDBPRK00278.

Enzyme and pathway databases

BioCycCCEL394503:GJET-3282-MONOMER.
UniPathwayUPA00035; UER00043.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
HAMAPMF_00134_B. IGPS_B.
InterProIPR013785. Aldolase_TIM.
IPR013798. Indole-3-glycerol_P_synth.
IPR001468. Indole-3-GlycerolPSynthase_CS.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamPF00218. IGPS. 1 hit.
[Graphical view]
SUPFAMSSF51366. SSF51366. 1 hit.
PROSITEPS00614. IGPS. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTRPC_CLOCE
AccessionPrimary (citable) accession number: B8I0V0
Entry history
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 3, 2009
Last modified: February 19, 2014
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways