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B8I0V0

- TRPC_CLOCE

UniProt

B8I0V0 - TRPC_CLOCE

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Protein

Indole-3-glycerol phosphate synthase

Gene

trpC

Organism
Clostridium cellulolyticum (strain ATCC 35319 / DSM 5812 / JCM 6584 / H10)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-C-(3-indolyl)-glycerol 3-phosphate + CO2 + H2O.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. indole-3-glycerol-phosphate synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. tryptophan biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Amino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis

Enzyme and pathway databases

BioCyciCCEL394503:GJET-3282-MONOMER.
UniPathwayiUPA00035; UER00043.

Names & Taxonomyi

Protein namesi
Recommended name:
Indole-3-glycerol phosphate synthaseUniRule annotation (EC:4.1.1.48UniRule annotation)
Short name:
IGPSUniRule annotation
Gene namesi
Name:trpCUniRule annotation
Ordered Locus Names:Ccel_3216
OrganismiClostridium cellulolyticum (strain ATCC 35319 / DSM 5812 / JCM 6584 / H10)
Taxonomic identifieri394503 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
ProteomesiUP000001349: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 260260Indole-3-glycerol phosphate synthasePRO_1000198771Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi394503.Ccel_3216.

Structurei

3D structure databases

ProteinModelPortaliB8I0V0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TrpC family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0134.
HOGENOMiHOG000230462.
KOiK01609.
OMAiENGAAMI.
OrthoDBiEOG6WT8JX.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00134_B. IGPS_B.
InterProiIPR013785. Aldolase_TIM.
IPR013798. Indole-3-glycerol_P_synth.
IPR001468. Indole-3-GlycerolPSynthase_CS.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00218. IGPS. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.
PROSITEiPS00614. IGPS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B8I0V0 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MILDKIAAST KIRVENLKKE VSFSFVKSEA SKLVNKSPFA FEKAVKDGEL
60 70 80 90 100
TFICEIKKAS PSKGLISENF PYIDIAKDYE AAGAGAISVL TEPEFFLGSD
110 120 130 140 150
QYLKDVKKTV SIPVLRKDFT IDPYQIYEAA LIGADCVLLI CALLDTDTLK
160 170 180 190 200
EYIKIADGLG LSCLVEAHDE NEVKSAIEAG SRIVGVNNRN LKTFEVDITN
210 220 230 240 250
SIRLRELVPS DISFVSESGI RTAQDISALR RIGASAVLIG ETLMRSGDTG
260
AELAKLRGSA
Length:260
Mass (Da):28,230
Last modified:March 3, 2009 - v1
Checksum:i89176A0C3025A9F0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001348 Genomic DNA. Translation: ACL77506.1.
RefSeqiWP_015926564.1. NC_011898.1.
YP_002507486.1. NC_011898.1.

Genome annotation databases

EnsemblBacteriaiACL77506; ACL77506; Ccel_3216.
GeneIDi7311798.
KEGGicce:Ccel_3216.
PATRICi19437437. VBICloCel57783_3296.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001348 Genomic DNA. Translation: ACL77506.1 .
RefSeqi WP_015926564.1. NC_011898.1.
YP_002507486.1. NC_011898.1.

3D structure databases

ProteinModelPortali B8I0V0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 394503.Ccel_3216.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACL77506 ; ACL77506 ; Ccel_3216 .
GeneIDi 7311798.
KEGGi cce:Ccel_3216.
PATRICi 19437437. VBICloCel57783_3296.

Phylogenomic databases

eggNOGi COG0134.
HOGENOMi HOG000230462.
KOi K01609.
OMAi ENGAAMI.
OrthoDBi EOG6WT8JX.

Enzyme and pathway databases

UniPathwayi UPA00035 ; UER00043 .
BioCyci CCEL394503:GJET-3282-MONOMER.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_00134_B. IGPS_B.
InterProi IPR013785. Aldolase_TIM.
IPR013798. Indole-3-glycerol_P_synth.
IPR001468. Indole-3-GlycerolPSynthase_CS.
IPR011060. RibuloseP-bd_barrel.
[Graphical view ]
Pfami PF00218. IGPS. 1 hit.
[Graphical view ]
SUPFAMi SSF51366. SSF51366. 1 hit.
PROSITEi PS00614. IGPS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35319 / DSM 5812 / JCM 6584 / H10.

Entry informationi

Entry nameiTRPC_CLOCE
AccessioniPrimary (citable) accession number: B8I0V0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 3, 2009
Last modified: October 1, 2014
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3