B8HXG8 (B8HXG8_CYAP4) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
3-deoxy-manno-octulosonate cytidylyltransferase HAMAP MF_00057
EC=2.7.7.38 HAMAP MF_00057

Alternative name(s):
CMP-2-keto-3-deoxyoctulosonic acid synthase HAMAP MF_00057

Gene names

Name:	kdsB HAMAP MF_00057
Ordered Locus Names:	Cyan7425_4200

Organism

Cyanothece sp. (strain PCC 7425 / ATCC 29141) [Complete proteome] [HAMAP] EMBL ACL46513.1

Taxonomic identifier

395961 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Chroococcales › Cyanothece

Protein attributes

Sequence length	249 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria By similarity. HAMAP MF_00057
Catalytic activity	CTP + 3-deoxy-D-manno-octulosonate = diphosphate + CMP-3-deoxy-D-manno-octulosonate. HAMAP MF_00057
Pathway	Bacterial outer membrane biogenesis; lipopolysaccharide biosynthesis. HAMAP MF_00057 Nucleotide-sugar biosynthesis; CMP-3-deoxy-D-manno-octulosonate biosynthesis; CMP-3-deoxy-D-manno-octulosonate from 3-deoxy-D-manno-octulosonate and CTP: step 1/1. HAMAP MF_00057
Subcellular location	Cytoplasm By similarity HAMAP MF_00057.
Sequence similarities	Belongs to the KdsB family. HAMAP MF_00057

Ontologies

Keywords
Biological process	Lipopolysaccharide biosynthesis HAMAP MF_00057
Cellular component	Cytoplasm HAMAP MF_00057
Molecular function	Nucleotidyltransferase HAMAP MF_00057 EMBL ACL46513.1 Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	keto-3-deoxy-D-manno-octulosonic acid biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	3-deoxy-manno-octulosonate cytidylyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	B8HXG8 [UniParc]. Last modified March 3, 2009. Version 1. Checksum: 5E68CCE7627FBD09	FASTA	249	28,019
	10 20 30 40 50 60 MTHILAVIPA RYQSQRFPGK PLVLLQERPM IQWVYAAACS CSVFDQVIVA TEDERIAQVV 70 80 90 100 110 120 QNFGGTVELT QDTHPSGTDR VAEVAERHPE AEIVVNVQGD QPFVTAAMLT ELVRPYLSLS 130 140 150 160 170 180 DNWPVMTTLA CPLQTEADYT NPNVVKVICD QNQQALYFSR SPIPYYRNKI SAPVFHHLGL 190 200 210 220 230 240 YAFQRAFLQQ YTQLQPTPLE QCEGLEQLRV LEHGHRIFVG QTPTPILEIN TPEDHVAAQA YIRNGVLHG

References

[1]

"Complete sequence of chromosome Cyanothece sp. PCC 7425." Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Sims D., Meineke L., Brettin T., Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N. , Ovchinnikova G., Liberton M., Stoeckel J., Banerjee A., Singh A., Page L., Sato H., Zhao L., Sherman L., Pakrasi H.B., Richardson P. Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: PCC 7425 / ATCC 29141.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001344 Genomic DNA. Translation: ACL46513.1.
RefSeq	YP_002484874.1. NC_011884.1.
3D structure databases
ProteinModelPortal	B8HXG8.
ModBase	Search...
Protein-protein interaction databases
STRING	B8HXG8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	7290151.
GenomeReviews	Gene locus Cyan7425_4200 in contig CP001344_GR.
KEGG	cyn:Cyan7425_4200.
PATRIC	21569389. VBICyaSp30657_4186.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG637773.
OMA	INVQADE.
PhylomeDB	B8HXG8.
ProtClustDB	PRK05450.
Family and domain databases
HAMAP	MF_00057. CMP_KDO_synth. [Tree]
InterPro	IPR003329. Cytidylyl_trans. IPR004528. KdsB. [Graphical view]
KO	K00979.
PANTHER	PTHR21485:SF4. PTHR21485:SF4. 1 hit.
Pfam	PF02348. CTP_transf_3. 1 hit. [Graphical view]
TIGRFAMs	TIGR00466. KdsB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

B8HXG8_CYAP4

Accession

Primary (citable) accession number: B8HXG8

Entry history

Integrated into UniProtKB/TrEMBL:	March 3, 2009
Last sequence update:	March 3, 2009
Last modified:	December 14, 2011
This is version 22 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)