B8HVV6 (G6PI_CYAP4) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glucose-6-phosphate isomerase
Short name=GPI
EC=5.3.1.9

Alternative name(s):
Phosphoglucose isomerase
Short name=PGI
Phosphohexose isomerase
Short name=PHI

Gene names

Name:	pgi
Ordered Locus Names:	Cyan7425_0747

Organism

Cyanothece sp. (strain PCC 7425 / ATCC 29141) [Complete proteome] [HAMAP]

Taxonomic identifier

395961 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Chroococcales › Cyanothece

Protein attributes

Sequence length	529 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	D-glucose 6-phosphate = D-fructose 6-phosphate. HAMAP MF_00473
Pathway	Carbohydrate biosynthesis; gluconeogenesis. HAMAP MF_00473 Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4. HAMAP MF_00473
Subcellular location	Cytoplasm By similarity HAMAP MF_00473.
Sequence similarities	Belongs to the GPI family.

Ontologies

Keywords
Biological process	Gluconeogenesis Glycolysis
Cellular component	Cytoplasm
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	gluconeogenesis Inferred from electronic annotation. Source: UniProtKB-KW glycolysis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	glucose-6-phosphate isomerase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 529	529	Glucose-6-phosphate isomerase HAMAP MF_00473		PRO_1000135523
Sites
	Active site	351	1	By similarity
	Active site	455	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	B8HVV6 [UniParc]. Last modified March 3, 2009. Version 1. Checksum: 66BDB8E51B9EA8A6	FASTA	529	57,954
	10 20 30 40 50 60 MDATALWQRY LEWLYYHPEL GIYLDVSRMR FDSAFVETLA PQFAKAFADM AALEAGAIAN 70 80 90 100 110 120 PDEHRQVGHY WLRAPEIAPT EELKTEIVET LEQIETFAAK VHHGQIHPTR GGLFTDIISV 130 140 150 160 170 180 GIGGSALGPQ FVSQSLAPER PPLDIHFLDN TDPDGIDRVL NRVEPRLSTT LVIIISKSGG 190 200 210 220 230 240 TPETRNGMLE VEKRFKDAGL NFAEHAVAIT SYGSKLAQIA ESAGWLAIFP MHDWVGGRTS 250 260 270 280 290 300 ELSAVGLLPA ALQGIPIREM LHGAKLMDEA TRVPDLKTNP AALLALSWYC AGEGKGKKDM 310 320 330 340 350 360 VVLPYKDSLQ LFSRYLQQLV MESLGKEKDL QGQVVHQGIA VYGNKGTTDQ HAYVQQLREG 370 380 390 400 410 420 LNNFFLTFIE VLQDRQGASV EVEPGITSGD YLSGLLLGTR QALYEKQRDS ITLTLPQVTP 430 440 450 460 470 480 LTVGALIALY ERTVGLYGFL INVNAYHQPG VEAGKKAAAA NLALQKQLLR ILSQEPQPIS 490 500 510 520 LMTLAAKVGA PEQTETIYLL LRHLAANGRG VSLQGPPEQP DRLLVRATA

References

[1]

"Complete sequence of chromosome Cyanothece sp. PCC 7425." US DOE Joint Genome Institute Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Sims D., Meineke L., Brettin T., Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N. , Ovchinnikova G., Liberton M., Stoeckel J., Banerjee A., Singh A., Page L., Sato H., Zhao L., Sherman L., Pakrasi H.B., Richardson P. Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: PCC 7425 / ATCC 29141.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001344 Genomic DNA. Translation: ACL43134.1.
RefSeq	YP_002481495.1. NC_011884.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	B8HVV6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	7286662.
GenomeReviews	Gene locus Cyan7425_0747 in contig CP001344_GR.
KEGG	cyn:Cyan7425_0747.
PATRIC	21562409. VBICyaSp30657_0733.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG285902.
OMA	RTSITSA.
PhylomeDB	B8HVV6.
ProtClustDB	PRK14096.
Family and domain databases
HAMAP	MF_00473. G6P_isomerase. [Tree]
InterPro	IPR001672. G6P_Isomerase. IPR018189. Phosphoglucose_isomerase_CS. [Graphical view]
KO	K01810.
PANTHER	PTHR11469. G6P_Isomerase. 1 hit.
Pfam	PF00342. PGI. 1 hit. [Graphical view]
PRINTS	PR00662. G6PISOMERASE.
PROSITE	PS00765. P_GLUCOSE_ISOMERASE_1. False negative. PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit. PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

G6PI_CYAP4

Accession

Primary (citable) accession number: B8HVV6

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 28, 2009
Last sequence update:	March 3, 2009
Last modified:	January 25, 2012
This is version 19 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program