B8HSF2 (B8HSF2_CYAP4) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Coproporphyrinogen-III oxidase, aerobic HAMAP MF_00333
Short name=Coprogen oxidase HAMAP MF_00333
Short name=Coproporphyrinogenase HAMAP MF_00333
EC=1.3.3.3 HAMAP MF_00333

Gene names

Name:	hemF HAMAP MF_00333
Ordered Locus Names:	Cyan7425_1891

Organism

Cyanothece sp. (strain PCC 7425 / ATCC 29141) [Complete proteome] [HAMAP] EMBL ACL44258.1

Taxonomic identifier

395961 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Chroococcales › Cyanothece

Protein attributes

Sequence length	345 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III By similarity. HAMAP MF_00333
Catalytic activity	Coproporphyrinogen-III + O2 + 2 H+ = protoporphyrinogen-IX + 2 CO2 + 2 H2O. HAMAP MF_00333
Pathway	Porphyrin metabolism; protoporphyrin-IX biosynthesis; protoporphyrinogen-IX from coproporphyrinogen-III (O2 route): step 1/1. HAMAP MF_00333
Subunit structure	Homodimer By similarity. HAMAP MF_00333
Subcellular location	Cytoplasm By similarity HAMAP MF_00333.
Sequence similarities	Belongs to the aerobic coproporphyrinogen-III oxidase family. HAMAP MF_00333

Ontologies

Keywords
Biological process	Porphyrin biosynthesis HAMAP MF_00333
Cellular component	Cytoplasm HAMAP MF_00333
Molecular function	Oxidoreductase HAMAP MF_00333 EMBL ACL44258.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	porphyrin-containing compound biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	coproporphyrinogen oxidase activity Inferred from electronic annotation. Source: HAMAP protein homodimerization activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Region	66 – 75	10	Important for dimerization By similarity HAMAP MF_00333
	Region	126 – 128	3	Substrate binding By similarity HAMAP MF_00333
	Region	279 – 314	36	Important for dimerization By similarity HAMAP MF_00333
	Region	297 – 302	6	Substrate binding By similarity HAMAP MF_00333
Sites
	Active site	124	1	Proton donor By similarity HAMAP MF_00333
	Binding site	110	1	Substrate By similarity HAMAP MF_00333
	Site	188	1	Important for dimerization By similarity HAMAP MF_00333

Sequences

	Sequence		Length	Mass (Da)
	B8HSF2 [UniParc]. Last modified March 3, 2009. Version 1. Checksum: 2D914B2D398A0345	FASTA	345	39,292
	10 20 30 40 50 60 MTISPAQIVN NSSQFTPPAD SRQRVSAFLR QLQDDICQGL EQIDGSGKFR EDAWERPEGG 70 80 90 100 110 120 GGRSRVMQSG TILEQGGVNF SEVWGEKLPP SILQQRPEAA GHGFYATGTS MVLHPRSPYI 130 140 150 160 170 180 PTVHLNYRYF EAGPVWWFGG GADLTPYYPF AEDAAHFHQT LKAACDRHHP QYYPTFKLWC 190 200 210 220 230 240 DEYFYLKHRQ ETRGVGGLFF DYQDGRGELY HGPNPQGPAG VYSAGLPPLE SRSWEDLFAF 250 260 270 280 290 300 INSCGSAFLN SYVPIVERRQ GLEYGERERQ FQLYRRGRYV EFNLVYDRGT IFGLQTNGRT 310 320 330 340 ESILMSLPPL VRWEYGYQPE PGSPEAVLYD TFLKPQDWAN WKPGS

References

[1]

"Complete sequence of chromosome Cyanothece sp. PCC 7425." Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Sims D., Meineke L., Brettin T., Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N. , Ovchinnikova G., Liberton M., Stoeckel J., Banerjee A., Singh A., Page L., Sato H., Zhao L., Sherman L., Pakrasi H.B., Richardson P. Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: PCC 7425 / ATCC 29141.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001344 Genomic DNA. Translation: ACL44258.1.
RefSeq	YP_002482619.1. NC_011884.1.
3D structure databases
ProteinModelPortal	B8HSF2.
ModBase	Search...
Protein-protein interaction databases
STRING	B8HSF2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	7287816.
GenomeReviews	Gene locus Cyan7425_1891 in contig CP001344_GR.
KEGG	cyn:Cyan7425_1891.
PATRIC	21564741. VBICyaSp30657_1889.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG631180.
OMA	VKAYLLD.
PhylomeDB	B8HSF2.
ProtClustDB	PRK05330.
Family and domain databases
HAMAP	MF_00333. Coprogen_oxidas. [Tree]
InterPro	IPR001260. Coprogen_oxidase_aer. IPR018375. Coprogen_oxidase_CS. [Graphical view]
Gene3D	G3DSA:3.40.1500.10. Coprogen_oxidas. 1 hit.
KO	K00228.
PANTHER	PTHR10755. Coprogen_oxidas. 1 hit.
Pfam	PF01218. Coprogen_oxidas. 1 hit. [Graphical view]
PIRSF	PIRSF000166. Coproporphyri_ox. 1 hit.
PRINTS	PR00073. COPRGNOXDASE.
SUPFAM	SSF102886. Coprogen_oxidas. 1 hit.
PROSITE	PS01021. COPROGEN_OXIDASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

B8HSF2_CYAP4

Accession

Primary (citable) accession number: B8HSF2

Entry history

Integrated into UniProtKB/TrEMBL:	March 3, 2009
Last sequence update:	March 3, 2009
Last modified:	December 14, 2011
This is version 21 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)