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B8HSA9

- ASSY_CYAP4

UniProt

B8HSA9 - ASSY_CYAP4

Protein

Argininosuccinate synthase

Gene

argG

Organism
Cyanothece sp. (strain PCC 7425 / ATCC 29141)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 42 (01 Oct 2014)
      Sequence version 1 (03 Mar 2009)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei38 – 381ATP; via amide nitrogen and carbonyl oxygenUniRule annotation
    Binding sitei89 – 891CitrullineUniRule annotation
    Binding sitei119 – 1191ATP; via amide nitrogenUniRule annotation
    Binding sitei121 – 1211AspartateUniRule annotation
    Binding sitei125 – 1251AspartateUniRule annotation
    Binding sitei125 – 1251CitrullineUniRule annotation
    Binding sitei126 – 1261AspartateUniRule annotation
    Binding sitei129 – 1291CitrullineUniRule annotation
    Binding sitei177 – 1771CitrullineUniRule annotation
    Binding sitei186 – 1861CitrullineUniRule annotation
    Binding sitei262 – 2621CitrullineUniRule annotation
    Binding sitei274 – 2741CitrullineUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi10 – 189ATPUniRule annotation

    GO - Molecular functioni

    1. argininosuccinate synthase activity Source: UniProtKB-HAMAP
    2. ATP binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. arginine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Amino-acid biosynthesis, Arginine biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciCSP395961:GJDE-1667-MONOMER.
    UniPathwayiUPA00068; UER00113.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Argininosuccinate synthaseUniRule annotation (EC:6.3.4.5UniRule annotation)
    Alternative name(s):
    Citrulline--aspartate ligaseUniRule annotation
    Gene namesi
    Name:argGUniRule annotation
    Ordered Locus Names:Cyan7425_1848
    OrganismiCyanothece sp. (strain PCC 7425 / ATCC 29141)
    Taxonomic identifieri395961 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesCyanothece
    ProteomesiUP000002511: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 401401Argininosuccinate synthasePRO_1000191891Add
    BLAST

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotation

    Protein-protein interaction databases

    STRINGi395961.Cyan7425_1848.

    Structurei

    3D structure databases

    ProteinModelPortaliB8HSA9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the argininosuccinate synthase family. Type 1 subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0137.
    HOGENOMiHOG000230093.
    KOiK01940.
    OMAiAPPEEAY.
    OrthoDBiEOG6K9QCV.

    Family and domain databases

    Gene3Di3.40.50.620. 1 hit.
    3.90.1260.10. 1 hit.
    HAMAPiMF_00005. Arg_succ_synth_type1.
    InterProiIPR001518. Arginosuc_synth.
    IPR018223. Arginosuc_synth_CS.
    IPR023434. Arginosuc_synth_type_1_subfam.
    IPR024074. AS_cat/multimer_dom_body.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view]
    PfamiPF00764. Arginosuc_synth. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00032. argG. 1 hit.
    PROSITEiPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
    PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B8HSA9-1 [UniParc]FASTAAdd to Basket

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    MGRAKKVVLA YSGGVDTSVC IPYLKHEWGV EEVITLAADL GQGDELEPIR    50
    QKALNSGAEI SLVADAKDSF IKEYAFAAIQ ANALYENRYP LSTALARPLI 100
    AKLLVDAAAE YGADAVAHGC TGKGNDQVRF DVSIAALNPN LKVLAPAREW 150
    GMSREQTIAY GERYGIPSPV KKSSPYSIDR NLLGRSIEAG PLEDPWTEPL 200
    EEIYVMTQAI ADTPNSPEYV EIGFERGIPV SLDGVAFSPV DLIDRLNQRV 250
    GIHGIGRIDM IENRLVGIKS REIYEAPALL VLIHAHRDLE SLTLTGDVSQ 300
    YKRGIEETYS KLVYNGLWYS PLKEALDAFI QQTQQRVSGT VRVKLFKGNA 350
    TIVGRKSANS LYSPDLATYG AEDQFDHKAA EGFIYVWGLP TRVWSQQVRT 400
    P 401
    Length:401
    Mass (Da):44,099
    Last modified:March 3, 2009 - v1
    Checksum:i5E425B2181280FB4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001344 Genomic DNA. Translation: ACL44215.1.
    RefSeqiWP_012627301.1. NC_011884.1.
    YP_002482576.1. NC_011884.1.

    Genome annotation databases

    EnsemblBacteriaiACL44215; ACL44215; Cyan7425_1848.
    GeneIDi7287772.
    KEGGicyn:Cyan7425_1848.
    PATRICi21564657. VBICyaSp30657_1848.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001344 Genomic DNA. Translation: ACL44215.1 .
    RefSeqi WP_012627301.1. NC_011884.1.
    YP_002482576.1. NC_011884.1.

    3D structure databases

    ProteinModelPortali B8HSA9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 395961.Cyan7425_1848.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACL44215 ; ACL44215 ; Cyan7425_1848 .
    GeneIDi 7287772.
    KEGGi cyn:Cyan7425_1848.
    PATRICi 21564657. VBICyaSp30657_1848.

    Phylogenomic databases

    eggNOGi COG0137.
    HOGENOMi HOG000230093.
    KOi K01940.
    OMAi APPEEAY.
    OrthoDBi EOG6K9QCV.

    Enzyme and pathway databases

    UniPathwayi UPA00068 ; UER00113 .
    BioCyci CSP395961:GJDE-1667-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.620. 1 hit.
    3.90.1260.10. 1 hit.
    HAMAPi MF_00005. Arg_succ_synth_type1.
    InterProi IPR001518. Arginosuc_synth.
    IPR018223. Arginosuc_synth_CS.
    IPR023434. Arginosuc_synth_type_1_subfam.
    IPR024074. AS_cat/multimer_dom_body.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view ]
    Pfami PF00764. Arginosuc_synth. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00032. argG. 1 hit.
    PROSITEi PS00564. ARGININOSUCCIN_SYN_1. 1 hit.
    PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Novel metabolic attributes of the genus Cyanothece, comprising a group of unicellular nitrogen-fixing Cyanobacteria."
      Bandyopadhyay A., Elvitigala T., Welsh E., Stockel J., Liberton M., Min H., Sherman L.A., Pakrasi H.B.
      MBio 2:E214-E214(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: PCC 7425 / ATCC 29141.

    Entry informationi

    Entry nameiASSY_CYAP4
    AccessioniPrimary (citable) accession number: B8HSA9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 28, 2009
    Last sequence update: March 3, 2009
    Last modified: October 1, 2014
    This is version 42 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3