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B8HRK7 (AROB_CYAP4) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 23. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
3-dehydroquinate synthase
EC=4.2.3.4
Gene names
Name:aroB
Ordered Locus Names:Cyan7425_3553
OrganismCyanothece sp. (strain PCC 7425 / ATCC 29141) [Complete proteome] [HAMAP]
Taxonomic identifier395961 [NCBI]
Taxonomic lineageBacteria › Cyanobacteria › Chroococcales › Cyanothece

Protein attributes

Sequence length369 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate = 3-dehydroquinate + phosphate. HAMAP MF_00110

Cofactor

Divalent metal cations By similarity. HAMAP MF_00110

NAD By similarity. HAMAP MF_00110

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7. HAMAP MF_00110

Subunit structure

Monomer By similarity. HAMAP MF_00110

Subcellular location

Cytoplasm By similarity HAMAP MF_00110.

Sequence similarities

Belongs to the dehydroquinate synthase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Aromatic amino acid biosynthesis
   Cellular componentCytoplasm
   LigandNAD
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processaromatic amino acid family biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular function3-dehydroquinate synthase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 3693693-dehydroquinate synthase HAMAP MF_00110
PRO_1000119079

Sequences

Sequence LengthMass (Da)Tools
B8HRK7 [UniParc].

Last modified March 3, 2009. Version 1.
Checksum: A78C01E006DE9E32

FASTA36940,113
        10         20         30         40         50         60 
MEKVIPVHLP HQSYAVVIAS GGLGQMGDYL QHQAHLKPGQ KVLVVSNPLI FKHYGEKVLV 

        70         80         90        100        110        120 
SLQRAGFATS TCLLPAGERY KTLKSVQQIY DCALEQRLER SSTILALGGG VIGDMAGFAA 

       130        140        150        160        170        180 
ATWLRGINVV QVPTTLLAMV DAAIGGKTGV NHPQGKNLIG AFHQPRLVLI DPDTLKTLPG 

       190        200        210        220        230        240 
REFRAALAEV IKYGVIWDGN LFQKLEAAER LDQYRTLSPQ LLADLLVHSC QAKVDVVTKD 

       250        260        270        280        290        300 
EKEAGLRAIL NYGHTIGHGI ESLTNYRKFN HGEAVGLGMV AVGQLAVDLG FWSQEECDRQ 

       310        320        330        340        350        360 
FSLIQKAHLP THIPADLDLN LLIDSLQTDK KVQAGQVRFI VPTAIGAVTI TDQIPTPAIV 


HVLKQMQKG

« Hide

References

[1]"Complete sequence of chromosome Cyanothece sp. PCC 7425."
US DOE Joint Genome Institute
Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Sims D., Meineke L., Brettin T., Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N. expand/collapse author list , Ovchinnikova G., Liberton M., Stoeckel J., Banerjee A., Singh A., Page L., Sato H., Zhao L., Sherman L., Pakrasi H.B., Richardson P.
Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: PCC 7425 / ATCC 29141.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001344 Genomic DNA. Translation: ACL45874.1.
RefSeqYP_002484235.1. NC_011884.1.

3D structure databases

ProteinModelPortalB8HRK7.
ModBaseSearch...

Protein-protein interaction databases

STRINGB8HRK7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID7289490.
GenomeReviewsGene locus Cyan7425_3553 in contig CP001344_GR.
KEGGcyn:Cyan7425_3553.
PATRIC21568059. VBICyaSp30657_3533.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG632303.
OMAVMALEMS.
PhylomeDBB8HRK7.

Family and domain databases

HAMAPMF_00110. DHQ_synthase.
[Tree]
InterProIPR016037. DHQ_synth_AroB.
[Graphical view]
KOK01735.
PANTHERPTHR21090:SF1. DHQ_synth_AroB. 1 hit.
PIRSFPIRSF001455. DHQ_synth. 1 hit.
TIGRFAMsTIGR01357. AroB. 1 hit.
ProtoNetSearch...

Entry information

Entry nameAROB_CYAP4
AccessionPrimary (citable) accession number: B8HRK7
Entry history
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 3, 2009
Last modified: January 25, 2012
This is version 23 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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