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B8HPV7

- PUR5_CYAP4

UniProt

B8HPV7 - PUR5_CYAP4

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Protein
Phosphoribosylformylglycinamidine cyclo-ligase
Gene
purM, Cyan7425_3341
Organism
Cyanothece sp. (strain PCC 7425 / ATCC 29141)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. phosphoribosylformylglycinamidine cyclo-ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Purine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCSP395961:GJDE-3171-MONOMER.
UniPathwayiUPA00074; UER00129.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoribosylformylglycinamidine cyclo-ligase (EC:6.3.3.1)
Alternative name(s):
AIR synthase
AIRS
Phosphoribosyl-aminoimidazole synthetase
Gene namesi
Name:purM
Ordered Locus Names:Cyan7425_3341
OrganismiCyanothece sp. (strain PCC 7425 / ATCC 29141)
Taxonomic identifieri395961 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesCyanothece
ProteomesiUP000002511: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 367367Phosphoribosylformylglycinamidine cyclo-ligaseUniRule annotation
PRO_1000148276Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi395961.Cyan7425_3341.

Structurei

3D structure databases

ProteinModelPortaliB8HPV7.

Family & Domainsi

Sequence similaritiesi

Belongs to the AIR synthase family.

Phylogenomic databases

eggNOGiCOG0150.
HOGENOMiHOG000229090.
KOiK01933.
OMAiVIGKIEH.
OrthoDBiEOG61CM1V.

Family and domain databases

Gene3Di3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPiMF_00741_B. AIRS_B.
InterProiIPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view]
PfamiPF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view]
SUPFAMiSSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 2 hits.
TIGRFAMsiTIGR00878. purM. 1 hit.

Sequencei

Sequence statusi: Complete.

B8HPV7-1 [UniParc]FASTAAdd to Basket

« Hide

MDYRDAGVDI QAGRDFVNRI KALVQQTTRS EVLGGLGGFG GCFQLPEGYR    50
QPVLVSGADG VGTKLKIAQA LNQHHTIGID LVAMCVNDVL TCGAEPLFFL 100
DYLATGHLEP EALTDVIAGI AQGCQQAGCA LLGGETAEMP GFYPVGEYDL 150
AGFCVGIVEK AEMLNGSQVR MGDRAIGLAS SGVHSNGYSL VRKIVDEFIG 200
PAAREQSEAG ATEALVSPWS ITPWAEREDL PPVDRQQSLG AALLTPTQIY 250
VKPVLAAQRS GLTLHGMAHI TGGGLPENLP RCLGEGQSVQ LDPQSWPAPP 300
IFDWIASTGS VPTAAMFDTF NMGIGFVLIV PPDEVESALR WFNTQQCPAY 350
GIGEVVAGAG EVLGLPG 367
Length:367
Mass (Da):38,605
Last modified:March 3, 2009 - v1
Checksum:i49D02BCD86FDD178
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001344 Genomic DNA. Translation: ACL45666.1.
RefSeqiWP_012628727.1. NC_011884.1.
YP_002484027.1. NC_011884.1.

Genome annotation databases

EnsemblBacteriaiACL45666; ACL45666; Cyan7425_3341.
GeneIDi7289277.
KEGGicyn:Cyan7425_3341.
PATRICi21567639. VBICyaSp30657_3323.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001344 Genomic DNA. Translation: ACL45666.1 .
RefSeqi WP_012628727.1. NC_011884.1.
YP_002484027.1. NC_011884.1.

3D structure databases

ProteinModelPortali B8HPV7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 395961.Cyan7425_3341.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACL45666 ; ACL45666 ; Cyan7425_3341 .
GeneIDi 7289277.
KEGGi cyn:Cyan7425_3341.
PATRICi 21567639. VBICyaSp30657_3323.

Phylogenomic databases

eggNOGi COG0150.
HOGENOMi HOG000229090.
KOi K01933.
OMAi VIGKIEH.
OrthoDBi EOG61CM1V.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00129 .
BioCyci CSP395961:GJDE-3171-MONOMER.

Family and domain databases

Gene3Di 3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPi MF_00741_B. AIRS_B.
InterProi IPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view ]
Pfami PF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view ]
SUPFAMi SSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 2 hits.
TIGRFAMsi TIGR00878. purM. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Novel metabolic attributes of the genus Cyanothece, comprising a group of unicellular nitrogen-fixing Cyanobacteria."
    Bandyopadhyay A., Elvitigala T., Welsh E., Stockel J., Liberton M., Min H., Sherman L.A., Pakrasi H.B.
    MBio 2:E214-E214(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PCC 7425 / ATCC 29141.

Entry informationi

Entry nameiPUR5_CYAP4
AccessioniPrimary (citable) accession number: B8HPV7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 3, 2009
Last modified: September 3, 2014
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3